Zinc acexamate (BioDeep_00000735686)
代谢物信息卡片
epsilon-Acetamidocaproic acid zinc salt
化学式: C16H28N2O6Zn (408.1238718)
中文名称: 醋氨己酸锌
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NCCCCCC(=O)[O-].CC(=O)NCCCCCC(=O)[O-].[Zn+2]
InChI: /q
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Najet Hadj Abdallah, Anna Baulies, Ahlem Bouhlel, Mohamed Bejaoui, Mohamed Amine Zaouali, Safa Ben Mimouna, Imed Messaoudi, José Carlos Fernandez-Checa, Carmen García Ruiz, Hassen Ben Abdennebi. The effect of zinc acexamate on oxidative stress, inflammation and mitochondria induced apoptosis in rat model of renal warm ischemia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Sep; 105(?):573-581. doi:
10.1016/j.biopha.2018.06.017. [PMID: 29890465] - Seung Yon Han, Si Hyung Yang, Insoo Yoon, Myung Gull Lee, Young Hee Choi. Reduced clearance of ε-acetamidocaproic acid in rats with acute renal failure induced by uranyl nitrate.
The Journal of pharmacy and pharmacology.
2012 Oct; 64(10):1452-60. doi:
10.1111/j.2042-7158.2012.01517.x. [PMID: 22943176] - U Lee, Y H Choi, Y G Kim, B K Lee, E Oh, M G Lee. ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation.
Xenobiotica; the fate of foreign compounds in biological systems.
2012 Mar; 42(3):310-5. doi:
10.3109/00498254.2011.619014. [PMID: 21992030] - Y H Choi, U Lee, J H Suh, Y G Kim, M Lee, E Oh, M G Lee. Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 May; 41(5):409-15. doi:
10.3109/00498254.2010.549250. [PMID: 21250786] - Y H Choi, U Lee, J H Suh, Y G Kim, E-Y Choi, E Oh, M G Lee. Pharmacokinetics and first-pass effects of epsilon-acetamidocaproic acid after administration of zinc acexamate in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2010 Jul; 40(7):485-98. doi:
10.3109/00498251003774745. [PMID: 20518623] - Seth Chitayat, Voula Kanelis, Marlys L Koschinsky, Steven P Smith. Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a).
Biochemistry.
2007 Feb; 46(7):1732-42. doi:
10.1021/bi061814g. [PMID: 17263558] - Satoshi Uchiyama, Masayoshi Yamaguchi. Alteration in serum and bone component findings induced in streptozotocin-diabetic rats is restored by zinc acexamate.
International journal of molecular medicine.
2003 Dec; 12(6):949-54. doi:
NULL. [PMID: 14612972] - Masayoshi Yamaguchi, Satoshi Uchiyama. Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss.
International journal of molecular medicine.
2003 Nov; 12(5):755-61. doi:
NULL. [PMID: 14533005] - A Igarashi, M Yamaguchi. Increase in bone growth factors with healing rat fractures: the enhancing effect of zinc.
International journal of molecular medicine.
2001 Oct; 8(4):433-8. doi:
10.3892/ijmm.8.4.433. [PMID: 11562784] - A Igarashi, M Yamaguchi. Increase in bone protein components with healing rat fractures: enhancement by zinc treatment.
International journal of molecular medicine.
1999 Dec; 4(6):615-20. doi:
10.3892/ijmm.4.6.615. [PMID: 10567672] - Y Tsutsui, Y Nakamura, S Yamaguchi, N Kawanaka, M Sato. Effects of zinc acexamate (NAS-501) on superoxide radicals and lipid peroxidation of rat gastric mucosa.
Pharmacology.
1999 Apr; 58(4):209-19. doi:
10.1159/000028283. [PMID: 10077740] - J F Wu, M W Wang, L S Song, Z F Liu. [Absorption, tissue distribution, and excretion of zinc acexamate in rats].
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1996 Jul; 17(4):375-8. doi:
NULL. [PMID: 9812729] - H Y Li, X M Liu, X J Ji. [Pharmacokinetics of zinc acexamate (ZAC) in rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
1995; 30(1):17-20. doi:
NULL. [PMID: 7660785] - J S Roth, J A Kelley, H G Chun, F T Ward. Simultaneous measurement of the cell-differentiating agent hexamethylene bisacetamide and its metabolites by gas chromatography.
Journal of chromatography.
1994 Feb; 652(2):149-59. doi:
10.1016/0378-4347(93)e0395-7. [PMID: 8006099] - B A Conley, G F Sewack, M J Egorin, B Subramanyam, J G Page, C K Grieshaber. The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide.
Cancer chemotherapy and pharmacology.
1991; 28(1):33-8. doi:
10.1007/bf00684953. [PMID: 2040031] - F Torres-Molina, A Martínez-Coscollá, S Gisbert, E Quintana, S Sendrós, J E Peris-Ribera, J M Plá-Delfina. Kinetics of the intestinal uptake of zinc acexamate in normal and zinc-depleted rats.
The Journal of pharmacy and pharmacology.
1990 Oct; 42(10):679-84. doi:
10.1111/j.2042-7158.1990.tb06558.x. [PMID: 1982137] - C Navarro, A Ramis, S Sendrós, O Bulbena, L Ferrer, G Escolar. Relationship between gastric levels and antiulcerogenic activity of zinc.
Archives internationales de pharmacodynamie et de therapie.
1990 Sep; 307(?):119-29. doi:
NULL. [PMID: 2095709]