9-(4-Fluoro-3-(hydroxymethyl)butyl)guanine (BioDeep_00000733845)

   


代谢物信息卡片


6h-purin-6-one, 2-amino-9-[4-(fluoro)-3-(hydroxymethyl)butyl]-1,9-dihydro

化学式: C10H14FN5O2 (255.11314760000002)
中文名称: 6H-嘌呤-6-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC2=C(N1CCC(CO)CF)N=C(NC2=O)N
InChI: InChI=1S/C10H14FN5O2/c11-3-6(4-17)1-2-16-5-13-7-8(16)14-10(12)15-9(7)18/h5-6,17H,1-4H2,(H3,12,14,15,18)

描述信息

同义名列表

2 个代谢物同义名

6h-purin-6-one, 2-amino-9-[4-(fluoro)-3-(hydroxymethyl)butyl]-1,9-dihydro; 9-(4-Fluoro-3-(hydroxymethyl)butyl)guanine



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Wen-gui Xu, Dong Dai, Na Fang, Xiu-yu Song, Jian Wang, Yan-jia Zhu, Xiao-yuan Men. [Molecular imaging for PET-CT reporter gene in breast adenocarcinoma (HSV1-tk) of subcutaneous xenografts in living nude mice]. Zhonghua yi xue za zhi. 2009 Dec; 89(48):3420-4. doi: NULL. [PMID: 20223118]
  • Satish K Chitneni, Christophe M Deroose, Jan Balzarini, Rik Gijsbers, Sofie J L Celen, Tjibbe J de Groot, Zeger Debyser, Luc Mortelmans, Alfons M Verbruggen, Guy M Bormans. Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. Journal of medicinal chemistry. 2007 Mar; 50(5):1041-9. doi: 10.1021/jm060964m. [PMID: 17298046]
  • Shahriar S Yaghoubi, Marcelo A Couto, Chang-Cheng Chen, Lathasree Polavaram, Guanggen Cui, Luyi Sen, Sanjiv S Gambhir. Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk's expression. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006 Apr; 47(4):706-15. doi: NULL. [PMID: 16595506]
  • Leeta Alison Green, Khoi Nguyen, Bijan Berenji, Meera Iyer, Eileen Bauer, Jorge R Barrio, Mohammad Namavari, Nagichettiar Satyamurthy, Sanjiv S Gambhir. A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Sep; 45(9):1560-70. doi: NULL. [PMID: 15347725]
  • Juri Gelovani Tjuvajev, Mikhail Doubrovin, Timothy Akhurst, Shangde Cai, Julius Balatoni, Mian M Alauddin, Ronald Finn, William Bornmann, Howard Thaler, Peter S Conti, Ronald G Blasberg. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2002 Aug; 43(8):1072-83. doi: NULL. [PMID: 12163634]
  • M M Alauddin, A Shahinian, E M Gordon, J R Bading, P S Conti. Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2001 Nov; 42(11):1682-90. doi: . [PMID: 11696640]
  • S Yaghoubi, J R Barrio, M Dahlbom, M Iyer, M Namavari, N Satyamurthy, R Goldman, H R Herschman, M E Phelps, S S Gambhir. Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2001 Aug; 42(8):1225-34. doi: NULL. [PMID: 11483684]