Ceftiofur HCl (BioDeep_00000733361)
代谢物信息卡片
Ceftiofur hydrochloride
化学式: C19H18ClN5O7S3 (559.0057)
中文名称: 盐酸头孢噻呋
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CSC(=O)C4=CC=CO4)C(=O)O.Cl
InChI: /m1./s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Abraham Fikru Mechesso, Seok-Hyeon Na, Dong Chan Moon, Su-Jeong Kim, Ji-Hyun Choi, Hyun-Ju Song, Soon-Seek Yoon, Suk-Kyung Lim. Antibiotic Resistance Profiles and Molecular Characteristics of blaCTX-M-15-Carrying Salmonella enterica Serovar Enteritidis Isolates from Healthy and Diseased Chickens in Korea.
Foodborne pathogens and disease.
2022 10; 19(10):663-674. doi:
10.1089/fpd.2022.0033. [PMID: 36125409] - Kun Mi, Shanju Pu, Yixuan Hou, Lei Sun, Kaixiang Zhou, Wenjin Ma, Xiangyue Xu, Meixia Huo, Zhenli Liu, Changqing Xie, Wei Qu, Lingli Huang. Optimization and Validation of Dosage Regimen for Ceftiofur against Pasteurella multocida in Swine by Physiological Based Pharmacokinetic-Pharmacodynamic Model.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073722. [PMID: 35409082] - Zheng Z Lee, Rebecca Abraham, Mark O'Dea, Ali Harb, Kelly Hunt, Terence Lee, Sam Abraham, David Jordan. Validation of Selective Agars for Detection and Quantification of Escherichia coli Strains Resistant to Critically Important Antimicrobials.
Microbiology spectrum.
2021 12; 9(3):e0066421. doi:
10.1128/spectrum.00664-21. [PMID: 34756091] - Wanhe Luo, Dehai Wang, Hua Qin, Dongmei Chen, Yuanhu Pan, Wei Qu, Lingli Huang, Shuyu Xie. Formulation of a rational dosage regimen of ceftiofur hydrochloride oily suspension by pharmacokinetic-pharmacodynamic (PK-PD) model for treatment of swine Streptococcus suis infection.
Journal of veterinary science.
2021 Nov; 22(6):e41. doi:
10.4142/jvs.2021.22.e41. [PMID: 34854264] - Boyu An, Xiangyue Xu, Wenjin Ma, Meixia Huo, Hanyu Wang, Zhenli Liu, Guyue Cheng, Lingli Huang. The adsorption-desorption characteristics and degradation kinetics of ceftiofur in different agricultural soils.
Ecotoxicology and environmental safety.
2021 Oct; 222(?):112503. doi:
10.1016/j.ecoenv.2021.112503. [PMID: 34273851] - Miranda J Sadar, Sherry K Cox, Abigail Duvall, Michael P Jones. Pharmacokinetics of a Single Intramuscular Injection of Ceftiofur Crystalline Free Acid in Bald Eagles (Haliaeetus leucocephalus).
Journal of avian medicine and surgery.
2021 Sep; 35(3):290-294. doi:
10.1647/20-00038. [PMID: 34677027] - Alvaro G Bonilla, Lisa Causeret, Albert Torrent-Crosa. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses.
The Canadian veterinary journal = La revue veterinaire canadienne.
2021 09; 62(9):975-981. doi:
NULL. [PMID: 34475583] - Tara N Gaire, Jessica Salas, Kara M Dunmire, Chad B Paulk, Mike D Tokach, Tiruvoor G Nagaraja, Victoriya V Volkova. Faecal concentrations of ceftiofur metabolites in finisher pigs administered intramuscularly with ceftiofur.
Veterinary medicine and science.
2021 09; 7(5):1800-1806. doi:
10.1002/vms3.520. [PMID: 33991410] - Sofie Rutjens, Siska Croubels, Siegrid De Baere, Mathias Devreese. Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Methods for the Quantification of Cefquinome, Ceftiofur, and Desfuroylceftiofuracetamide in Porcine Feces with Emphasis on Analyte Stability.
Molecules (Basel, Switzerland).
2021 Jul; 26(15):. doi:
10.3390/molecules26154598. [PMID: 34361749] - Gizem Levent, Ashlynn Schlochtermeier, Samuel E Ives, Keri N Norman, Sara D Lawhon, Guy H Loneragan, Robin C Anderson, Javier Vinasco, Henk C den Bakker, H Morgan Scott. High-Resolution Genomic Comparisons within Salmonella enterica Serotypes Derived from Beef Feedlot Cattle: Parsing the Roles of Cattle Source, Pen, Animal, Sample Type, and Production Period.
Applied and environmental microbiology.
2021 05; 87(12):e0048521. doi:
10.1128/aem.00485-21. [PMID: 33863705] - Marc T Valitutto, Alisa L Newton, Scott Wetzlich, Jennifer C Kishbaugh, Bonnie L Raphael, Paul P Calle, Lisa A Tell. PHARMACOKINETICS AND CLINICAL SAFETY OF A SUSTAINED-RELEASE FORMULATION OF CEFTIOFUR CRYSTALLINE FREE ACID IN RINGNECK DOVES (STREPTOPELIA RISORIA) AFTER A SINGLE INTRAMUSCULAR INJECTION.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Apr; 52(1):81-89. doi:
10.1638/2019-0122. [PMID: 33827164] - V S Machado, M L Celestino, E B Oliveira, F S Lima, M A Ballou, K N Galvão. The association of cow-related factors assessed at metritis diagnosis with metritis cure risk, reproductive performance, milk yield, and culling for untreated and ceftiofur-treated dairy cows.
Journal of dairy science.
2020 Oct; 103(10):9261-9276. doi:
10.3168/jds.2020-18643. [PMID: 32828506] - E B de Oliveira, F Cunha, R Daetz, C C Figueiredo, R C Chebel, J E Santos, C A Risco, K C Jeong, V S Machado, K N Galvão. Using chitosan microparticles to treat metritis in lactating dairy cows.
Journal of dairy science.
2020 Aug; 103(8):7377-7391. doi:
10.3168/jds.2019-18028. [PMID: 32505402] - Fang Yang, Fan Yang, Han Wang, Chao-Shuo Zhang, Zhe-Wen Song, Hao-Tian Shao, Mei Zhang. Pharmacokinetics of ceftiofur sodium in Peekapoo dogs following a single intravenous and subcutaneous injection.
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):325-330. doi:
10.1111/jvp.12866. [PMID: 32281146] - Md Akil Hossain, Hae-Chul Park, Kwang-Jick Lee, Sung-Won Park, Seung-Chun Park, JeongWoo Kang. In vitro synergistic potentials of novel antibacterial combination therapies against Salmonella enterica serovar Typhimurium.
BMC microbiology.
2020 05; 20(1):118. doi:
10.1186/s12866-020-01810-x. [PMID: 32410630] - Kwang Won Seo, Jong Bo Shim, Yeong Bin Kim, Se Hyun Son, Eun Bi Noh, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee. Impacts and characteristics of antimicrobial resistance of Escherichia coli isolates by administration of third-generation cephalosporins in layer hatcheries.
Veterinary microbiology.
2020 Apr; 243(?):108643. doi:
10.1016/j.vetmic.2020.108643. [PMID: 32273023] - Gizem Levent, Ashlynn Schlochtermeier, Samuel E Ives, Keri N Norman, Sara D Lawhon, Guy H Loneragan, Robin C Anderson, Javier Vinasco, H Morgan Scott. Population Dynamics of Salmonella enterica within Beef Cattle Cohorts Followed from Single-Dose Metaphylactic Antibiotic Treatment until Slaughter.
Applied and environmental microbiology.
2019 12; 85(23):. doi:
10.1128/aem.01386-19. [PMID: 31519659] - Davi Fernando Alba, Gilneia da Rosa, Dalana Hanauer, Thalia Festa Saldanha, Carine F Souza, Matheus D Baldissera, Daiane da Silva Dos Santos, Ana Paula Piovezan, Lilian Kolling Girardini, Aleksandro Schafer Da Silva. Subclinical mastitis in Lacaune sheep: Causative agents, impacts on milk production, milk quality , oxidative profiles and treatment efficacy of ceftiofur.
Microbial pathogenesis.
2019 Dec; 137(?):103732. doi:
10.1016/j.micpath.2019.103732. [PMID: 31505264] - Mei Zhang, Fang Yang, Hua-Jie Yu, Tian-Jing Kang, Yong-Hui Ding, Meng-Li Yu, Qian-Kun Wang, Yuan-Xin Zhu, Fan Yang. Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection.
Journal of veterinary pharmacology and therapeutics.
2019 Nov; 42(6):602-608. doi:
10.1111/jvp.12814. [PMID: 31529627] - Murielle Gaugain, Sophie Mompelat, Marie-Pierre Fourmond, Jacqueline Manceau, Jean-Guy Rolland, Michel Laurentie, Eric Verdon, Lise Bellanger, Dominique Hurtaud-Pessel. A non-targeted LC-HRMS approach for detecting exposure to illegal veterinary treatments: The case of cephalosporins in commercial laying Hens.
Journal of chromatography. A.
2019 Aug; 1599(?):161-171. doi:
10.1016/j.chroma.2019.04.022. [PMID: 31014576] - Xiao-Dong Li, Sheng-Qing Chi, Li-Yun Wu, Can Liu, Tong Sun, Juan Hong, Xun Chen, Xiao-Gang Chen, Guan-Song Wang, Dao-Jin Yu. PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs.
BMC veterinary research.
2019 Aug; 15(1):272. doi:
10.1186/s12917-019-2008-4. [PMID: 31370843] - Melissa A Fayette, Josephine B Rose, Robert P Hunter, Michelle R Bowman, Jeffry S Proudfoot. NAÏVE-POOLED PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID AFTER SINGLE INTRAMUSCULAR ADMINISTRATION IN SMOOTH DOGFISH (MUSTELUS CANIS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2019 Jun; 50(2):466-469. doi:
10.1638/2018-0104. [PMID: 31260216] - Sophie Emmanuelle Knafo, Jennifer E Graham, Bruce A Barton. Intravenous and intraosseous regional limb perfusion of ceftiofur sodium in an avian model.
American journal of veterinary research.
2019 Jun; 80(6):539-546. doi:
10.2460/ajvr.80.6.539. [PMID: 31140842] - Derek M Foster, Megan E Jacob, Kyle A Farmer, Benjamin J Callahan, Casey M Theriot, Sophia Kathariou, Natalia Cernicchiaro, Timo Prange, Mark G Papich. Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers.
PloS one.
2019; 14(10):e0223378. doi:
10.1371/journal.pone.0223378. [PMID: 31584976] - Naomi Ohta, Bo Norby, Guy H Loneragan, Javier Vinasco, Henk C den Bakker, Sara D Lawhon, Keri N Norman, Harvey M Scott. Quantitative dynamics of Salmonella and E. coli in feces of feedlot cattle treated with ceftiofur and chlortetracycline.
PloS one.
2019; 14(12):e0225697. doi:
10.1371/journal.pone.0225697. [PMID: 31791047] - Ethan A Taylor, Ellen R Jordan, Jose A Garcia, Gerrit R Hagevoort, Keri N Norman, Sara D Lawhon, Juan M Piñeiro, Harvey M Scott. Effects of two-dose ceftiofur treatment for metritis on the temporal dynamics of antimicrobial resistance among fecal Escherichia coli in Holstein-Friesian dairy cows.
PloS one.
2019; 14(7):e0220068. doi:
10.1371/journal.pone.0220068. [PMID: 31329639] - Jincheng Xiong, Qianqian Zhu, Zhixin Lei, Shuaike Yang, Peiyuan Chen, Yaxin Zhao, Jiyue Cao, Yinsheng Qiu. Bioequivalence evaluation of two 5\% ceftiofur hydrochloride sterile suspension in pigs.
The Journal of veterinary medical science.
2018 Dec; 80(12):1847-1852. doi:
10.1292/jvms.18-0470. [PMID: 30381675] - Patrick J Gorden, Joshua A Ydstie, Michael D Kleinhenz, Troy A Brick, Joe S Smith, Ronald W Griffith, Larry W Wulf, Suzanne M Rajewski, Min Zhang, Pritam K Sidhu, Jonathan P Mochel, Johann F Coetzee. Comparative plasma and interstitial fluid pharmacokinetics and tissue residues of ceftiofur crystalline-free acid in cattle with induced coliform mastitis.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):848-860. doi:
10.1111/jvp.12688. [PMID: 29971798] - Margaret D Weinroth, H Morgan Scott, Bo Norby, Guy H Loneragan, Noelle R Noyes, Pablo Rovira, Enrique Doster, Xiang Yang, Dale R Woerner, Paul S Morley, Keith E Belk. Effects of Ceftiofur and Chlortetracycline on the Resistomes of Feedlot Cattle.
Applied and environmental microbiology.
2018 07; 84(13):. doi:
10.1128/aem.00610-18. [PMID: 29728379] - Dixie F Mollenkopf, Dimitria A Mathys, Sydnee M Feicht, Jason W Stull, Andrew S Bowman, Joshua B Daniels, Thomas E Wittum. Maintenance of Carbapenemase-Producing Enterobacteriaceae in a Farrow-to-Finish Swine Production System.
Foodborne pathogens and disease.
2018 06; 15(6):372-376. doi:
10.1089/fpd.2017.2355. [PMID: 29638168] - Mohamed Zeineldin, Brian Aldridge, Benjamin Blair, Katherine Kancer, James Lowe. Impact of parenteral antimicrobial administration on the structure and diversity of the fecal microbiota of growing pigs.
Microbial pathogenesis.
2018 May; 118(?):220-229. doi:
10.1016/j.micpath.2018.03.035. [PMID: 29578067] - J Wang, H Peng, J Kong, T Zhao, S Zhang, X Cao. Pharmacokinetic profile of Ceftiofur Hydrochloride Injection in lactating Holstein dairy cows.
Journal of veterinary pharmacology and therapeutics.
2018 Apr; 41(2):301-306. doi:
10.1111/jvp.12469. [PMID: 29159921] - Miranda J Sadar, Michelle G Hawkins, Ian T Taylor, Barbara A Byrne, Lisa A Tell. PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID STERILE SUSPENSION IN GREEN IGUANAS ( IGUANA IGUANA) AFTER SINGLE INTRAMUSCULAR ADMINISTRATION.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2018 Mar; 49(1):86-91. doi:
10.1638/2017-0163r.1. [PMID: 29517463] - P J Gorden, M D Kleinhenz, L W Wulf, S J Rajewski, C Wang, R Gehring, J F Coetzee. Comparative plasma and interstitial fluid pharmacokinetics of flunixin meglumine and ceftiofur hydrochloride following individual and co-administration in dairy cows.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):76-82. doi:
10.1111/jvp.12437. [PMID: 28731206] - M L Macpherson, S Giguère, M A Pozor, E Runcan, T W Vickroy, S A Benson, M H T Troedsson, J N Hatzel, J Larson, E Vanden Berg, A A Kelleman, L C Sanchez, M M LeBlanc. Pharmacokinetics of ceftiofur sodium in equine pregnancy.
Journal of veterinary pharmacology and therapeutics.
2017 Dec; 40(6):656-662. doi:
10.1111/jvp.12399. [PMID: 28317126] - Jennifer A Waldoch, Sherry K Cox, Douglas L Armstrong. Pharmacokinetics of a Single Intramuscular Injection of Long-Acting Ceftiofur Crystalline-Free Acid in Cattle Egrets ( Bubulcus ibis).
Journal of avian medicine and surgery.
2017 12; 31(4):314-318. doi:
10.1647/2016-222. [PMID: 29327960] - Naomi Ohta, Keri N Norman, Bo Norby, Sara D Lawhon, Javier Vinasco, Henk den Bakker, Guy H Loneragan, H Morgan Scott. Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle.
Scientific reports.
2017 10; 7(1):14310. doi:
10.1038/s41598-017-14751-9. [PMID: 29085049] - G S Waraich, P K Sidhu, P S Daundkar, G Kaur, S K Sharma. Pharmacokinetic and pharmacodynamic characterization of ceftiofur crystalline-free acid following subcutaneous administration in domestic goats.
Journal of veterinary pharmacology and therapeutics.
2017 Oct; 40(5):429-438. doi:
10.1111/jvp.12373. [PMID: 27943295] - Dachuan Lin, Kaichao Chen, Miaomiao Xie, Lianwei Ye, Edward Wai-Chi Chan, Sheng Chen. Effect of ceftiofur and enrofloxacin on E. coli sub-population in pig gastrointestinal tract.
Journal of global antimicrobial resistance.
2017 09; 10(?):126-130. doi:
10.1016/j.jgar.2017.05.010. [PMID: 28732789] - J W Sparks, L A Karriker, D N Day, L W Wulf, J Zhang, M L Stock, J L Bates, R Gehring, J F Coetzee. Vaccination mitigates the impact of PRRSv infection on the pharmacokinetics of ceftiofur crystalline-free acid in pigs.
Journal of veterinary pharmacology and therapeutics.
2017 Aug; 40(4):363-369. doi:
10.1111/jvp.12369. [PMID: 27885695] - Feray Altan, Kamil Uney, Ayse Er, Gul Cetin, Burak Dik, Enver Yazar, Muammer Elmas. Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy.
The Journal of veterinary medical science.
2017 Jul; 79(7):1245-1252. doi:
10.1292/jvms.16-0641. [PMID: 28579597] - Sara Gardhouse, David Sanchez-Migallon Guzman, Sherry Cox, Philip H Kass, Tracy L Drazenovich, Barbara A Byrne, Michelle G Hawkins. Pharmacokinetics and safety of ceftiofur crystalline free acid in New Zealand White rabbits (Oryctolagus cuniculus).
American journal of veterinary research.
2017 Jul; 78(7):796-803. doi:
10.2460/ajvr.78.7.796. [PMID: 28650231] - K S Cox, B B Nelson, L Wittenburg, J R Gold. Plasma, subcutaneous tissue and bone concentrations of ceftiofur sodium after regional limb perfusion in horses.
Equine veterinary journal.
2017 May; 49(3):341-344. doi:
10.1111/evj.12614. [PMID: 27458113] - C Marisa R Almeida, Filipa Santos, A Catarina F Ferreira, Carlos Rocha Gomes, M Clara P Basto, Ana P Mucha. Constructed wetlands for the removal of metals from livestock wastewater - Can the presence of veterinary antibiotics affect removals?.
Ecotoxicology and environmental safety.
2017 Mar; 137(?):143-148. doi:
10.1016/j.ecoenv.2016.11.021. [PMID: 27918945] - Dixie F Mollenkopf, Jason W Stull, Dimitria A Mathys, Andrew S Bowman, Sydnee M Feicht, Susan V Grooters, Joshua B Daniels, Thomas E Wittum. Carbapenemase-Producing Enterobacteriaceae Recovered from the Environment of a Swine Farrow-to-Finish Operation in the United States.
Antimicrobial agents and chemotherapy.
2017 02; 61(2):. doi:
10.1128/aac.01298-16. [PMID: 27919894] - Scott H Edwards, Shahid A Khalfan, Glenn A Jacobson, Adam D Pirie, Sharanne L Raidal. Pharmacokinetics of intravenous continuous rate infusions of sodium benzylpenicillin and ceftiofur sodium in adult horses.
American journal of veterinary research.
2017 Jan; 78(1):17-26. doi:
10.2460/ajvr.78.1.17. [PMID: 28029281] - N Pusterla, T L Hall, S E Wetzlich, G Monmaney, J R Collier, J A Hill, L A Tell. Pharmacokinetic parameters for single- and multi-dose regimens for subcutaneous administration of a high-dose ceftiofur crystalline-free acid to neonatal foals.
Journal of veterinary pharmacology and therapeutics.
2017 Jan; 40(1):88-91. doi:
10.1111/jvp.12327. [PMID: 27292121] - Emilio Fernández-Varón, Carlos Cárceles-García, Juan Manuel Serrano-Rodríguez, Carlos M Cárceles-Rodríguez. Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats.
BMC veterinary research.
2016 Oct; 12(1):232. doi:
10.1186/s12917-016-0863-9. [PMID: 27737655] - Getahun E Agga, John W Schmidt, Terrance M Arthur. Antimicrobial-Resistant Fecal Bacteria from Ceftiofur-Treated and Nonantimicrobial-Treated Comingled Beef Cows at a Cow-Calf Operation.
Microbial drug resistance (Larchmont, N.Y.).
2016 Oct; 22(7):598-608. doi:
10.1089/mdr.2015.0259. [PMID: 26954009] - Waleed F Khalil, Hazem M Shaheen, Rania H Abdou. Ceftiofur pharmacokinetics in Nile tilapia Oreochromis niloticus after intracardiac and intramuscular administrations.
Diseases of aquatic organisms.
2016 Aug; 121(1):29-35. doi:
10.3354/dao03032. [PMID: 27596857] - S Jahanbakhsh, A Letellier, J M Fairbrother. Circulating of CMY-2 β-lactamase gene in weaned pigs and their environment in a commercial farm and the effect of feed supplementation with a clay mineral.
Journal of applied microbiology.
2016 Jul; 121(1):136-48. doi:
10.1111/jam.13166. [PMID: 27138244] - J S Woodrow, M Caldwell, S Cox, M Hines, B C Credille. Comparative plasma pharmacokinetics of ceftiofur sodium and ceftiofur crystalline-free acid in neonatal calves.
Journal of veterinary pharmacology and therapeutics.
2016 Jun; 39(3):271-6. doi:
10.1111/jvp.12275. [PMID: 26542633] - Haiying Nie, Xin Feng, Jianbo Peng, Liu Liang, Chunyan Lu, Roshan V Tiwari, Shusheng Tang, Jiakang He. Comparative pharmacokinetics of ceftiofur hydrochloride and ceftiofur sodium after administration to water buffalo (Bubalus bubalis).
American journal of veterinary research.
2016 Jun; 77(6):646-52. doi:
10.2460/ajvr.77.6.646. [PMID: 27227504] - Karla Cameron-Veas, Miguel A Moreno, Lorenzo Fraile, Lourdes Migura-Garcia. Shedding of cephalosporin resistant Escherichia coli in pigs from conventional farms after early treatment with antimicrobials.
Veterinary journal (London, England : 1997).
2016 May; 211(?):21-5. doi:
10.1016/j.tvjl.2016.02.017. [PMID: 27053016] - O A Chiesa, S Feng, P Kijak, E A Smith, H Li, J Qiu. Plasma pharmacokinetics of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in holstein steers: application of nonlinear mixed-effects modeling.
Journal of veterinary pharmacology and therapeutics.
2016 Apr; 39(2):149-56. doi:
10.1111/jvp.12245. [PMID: 26112893] - Sandrine Baron, Eric Jouy, Fabrice Touzain, Stéphanie Bougeard, Emeline Larvor, Claire de Boisseson, Michel Amelot, Alassane Keita, Isabelle Kempf. Impact of the administration of a third-generation cephalosporin (3GC) to one-day-old chicks on the persistence of 3GC-resistant Escherichia coli in intestinal flora: An in vivo experiment.
Veterinary microbiology.
2016 Mar; 185(?):29-33. doi:
10.1016/j.vetmic.2016.01.020. [PMID: 26931388] - Sarah E Hooper, Scott W Korte, Steeve Giguère, William H Fales, Jennifer L Davis, Lonny W Dixon. Pharmacokinetics of Ceftiofur Crystalline-Free Acid in Clinically Healthy Dogs (Canis lupus familiaris).
Journal of the American Association for Laboratory Animal Science : JAALAS.
2016 Mar; 55(2):224-9. doi:
NULL. [PMID: 27025816] - D M Foster, M E Jacob, C D Warren, M G Papich. Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteria.
Journal of veterinary pharmacology and therapeutics.
2016 Feb; 39(1):62-71. doi:
10.1111/jvp.12236. [PMID: 25989138] - Jinxin Liu, Zhe Zhao, Lisa Orfe, Murugan Subbiah, Douglas R Call. Soil-borne reservoirs of antibiotic-resistant bacteria are established following therapeutic treatment of dairy calves.
Environmental microbiology.
2016 Feb; 18(2):557-64. doi:
10.1111/1462-2920.13097. [PMID: 26486254] - Derek M Foster, Luke G Martin, Mark G Papich. Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or Tulathromycin.
PloS one.
2016; 11(2):e0149100. doi:
10.1371/journal.pone.0149100. [PMID: 26872361] - P J Gorden, M D Kleinhenz, L W Wulf, B KuKanich, C J Lee, C Wang, J F Coetzee. Altered plasma pharmacokinetics of ceftiofur hydrochloride in cows affected with severe clinical mastitis.
Journal of dairy science.
2016 Jan; 99(1):505-14. doi:
10.3168/jds.2015-10239. [PMID: 26601579] - Miranda J Sadar, Michelle G Hawkins, Barbara A Byrne, Andrew N Cartoceti, Kevin Keel, Tracy L Drazenovich, Lisa A Tell. Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in red-tailed hawks (Buteo jamaicensis).
American journal of veterinary research.
2015 Dec; 76(12):1077-84. doi:
10.2460/ajvr.76.12.1077. [PMID: 26618733] - E F Garrett, L Dirikolu, G S Grover. Milk and serum concentration of ceftiofur following intramammary infusion in goats.
Journal of veterinary pharmacology and therapeutics.
2015 Dec; 38(6):569-74. doi:
10.1111/jvp.12217. [PMID: 25707268] - C Grosset, E S Weber, R Gehring, D Sanchez-Migallon Guzman, L A Campbell, C Enz, J M Groff, L A Tell. Evaluation of an extended-release formulation of ceftiofur crystalline-free acid in koi (Cyprinus carpio).
Journal of veterinary pharmacology and therapeutics.
2015 Dec; 38(6):606-15. doi:
10.1111/jvp.12227. [PMID: 25876672] - Anne Beyer, Sven Baumann, Gesine Scherz, Jessica Stahl, Martin von Bergen, Anika Friese, Uwe Roesler, Manfred Kietzmann, Walther Honscha. Effects of ceftiofur treatment on the susceptibility of commensal porcine E.coli--comparison between treated and untreated animals housed in the same stable.
BMC veterinary research.
2015 Oct; 11(?):265. doi:
10.1186/s12917-015-0578-3. [PMID: 26472561] - D N Day, J W Sparks, L A Karriker, K J Stalder, L W Wulf, J Zhang, J M Kinyon, M L Stock, R Gehring, C Wang, J Ellingson, J F Coetzee. Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs.
Journal of veterinary pharmacology and therapeutics.
2015 Oct; 38(5):475-81. doi:
10.1111/jvp.12209. [PMID: 25689130] - Gregory W Salyards, Heather K Knych, Ashley E Hill, Kristi R Kelly, Kari L Christe. Pharmacokinetics of Ceftiofur Crystalline Free Acid in Male Rhesus Macaques (Macaca mulatta) after Subcutaneous Administration.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2015 Sep; 54(5):557-63. doi:
NULL. [PMID: 26424255] - Zoltan S Gyimesi, Roy B Burns, Erdal Erol, Steven R Bolin. ACUTE CLINICAL LEPTOSPIROSIS (GRIPPOTYPHOSA SEROVAR) IN AN ADULT DROMEDARY CAMEL (CAMELUS DROMEDARIUS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2015 Sep; 46(3):605-8. doi:
10.1638/2014-0186.1. [PMID: 26352970] - Sophie Mompelat, Marie-Pierre Fourmond, Michel Laurentie, Eric Verdon, Dominique Hurtaud-Pessel, Jean-Pierre Abjean. Validation of a liquid chromatography-high-resolution mass spectrometry method for the analysis of ceftiofur in poultry muscle, kidneys and plasma: A unique accuracy profile for each and every matrix.
Journal of chromatography. A.
2015 Aug; 1407(?):119-29. doi:
10.1016/j.chroma.2015.06.043. [PMID: 26152526] - L Fultz, S Giguère, L J Berghaus, G S Grover, D A Merritt. Pulmonary pharmacokinetics of desfuroylceftiofur acetamide after nebulisation or intramuscular administration of ceftiofur sodium to weanling foals.
Equine veterinary journal.
2015 Jul; 47(4):473-7. doi:
10.1111/evj.12316. [PMID: 24975449] - Jack Kottwitz, Alice Blue-McLendon, Christopher Monarski, James Jensen, Dawn Boothe. DISPOSITION OF CEFTIOFUR AND ITS ACTIVE METABOLITES IN FALLOW DEER (DAMA DAMA) FOLLOWING SINGLE-DOSE INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2015 Jun; 46(2):255-61. doi:
10.1638/2014-0250r.1. [PMID: 26056876] - Karla Cameron-Veas, Marc Solà-Ginés, Miguel A Moreno, Lorenzo Fraile, Lourdes Migura-Garcia. Impact of the use of β-lactam antimicrobials on the emergence of Escherichia coli isolates resistant to cephalosporins under standard pig-rearing conditions.
Applied and environmental microbiology.
2015 Mar; 81(5):1782-7. doi:
10.1128/aem.03916-14. [PMID: 25548055] - Marcio C Costa, Henry R Stämpfli, Luis G Arroyo, Emma Allen-Vercoe, Roberta G Gomes, J Scott Weese. Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs.
BMC veterinary research.
2015 Feb; 11(?):19. doi:
10.1186/s12917-015-0335-7. [PMID: 25644524] - Lindsey W Kissell, Teresa L Leavens, Ronald E Baynes, Jim E Riviere, Geof W Smith. Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis.
Journal of the American Veterinary Medical Association.
2015 Jan; 246(1):118-25. doi:
10.2460/javma.246.1.118. [PMID: 25517334] - Lindsey Chambers, Ying Yang, Heather Littier, Partha Ray, Tong Zhang, Amy Pruden, Michael Strickland, Katharine Knowlton. Metagenomic Analysis of Antibiotic Resistance Genes in Dairy Cow Feces following Therapeutic Administration of Third Generation Cephalosporin.
PloS one.
2015; 10(8):e0133764. doi:
10.1371/journal.pone.0133764. [PMID: 26258869] - D Scofield, J Black, L Wittenburg, D Gustafson, R Ferris, J Hatzel, J Traub-Dargatz, P McCue. Endometrial tissue and blood plasma concentration of ceftiofur and metabolites following intramuscular administration of ceftiofur crystalline free acid to mares.
Equine veterinary journal.
2014 Sep; 46(5):606-10. doi:
10.1111/evj.12192. [PMID: 24111546] - Bruce D Erickson, Christopher A Elkins, Lisa B Mullis, Thomas M Heinze, R Doug Wagner, Carl E Cerniglia. A metallo-β-lactamase is responsible for the degradation of ceftiofur by the bovine intestinal bacterium Bacillus cereus P41.
Veterinary microbiology.
2014 Aug; 172(3-4):499-504. doi:
10.1016/j.vetmic.2014.05.032. [PMID: 24972871] - Shixia Feng, Oscar A Chiesa, Philip Kijak, Chaitali Chattopadhaya, Vicki Lancaster, Elizabeth A Smith, Lauren Girard, Sara Sklenka, Hui Li. Determination of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in bovine tissues using liquid chromatography-tandem mass spectrometry as a surrogate marker residue for ceftiofur.
Journal of agricultural and food chemistry.
2014 Jun; 62(22):5011-9. doi:
10.1021/jf405423e. [PMID: 24819974] - Neena Kanwar, H Morgan Scott, Bo Norby, Guy H Loneragan, Javier Vinasco, Jennifer L Cottell, Gabhan Chalmers, Muckatira M Chengappa, Jianfa Bai, Patrick Boerlin. Impact of treatment strategies on cephalosporin and tetracycline resistance gene quantities in the bovine fecal metagenome.
Scientific reports.
2014 May; 4(?):5100. doi:
10.1038/srep05100. [PMID: 24872333] - Sarah M Churgin, Kari E Musgrave, Sherry K Cox, Kurt K Sladky. Pharmacokinetics of subcutaneous versus intramuscular administration of ceftiofur crystalline-free acid to bearded dragons (Pogona vitticeps).
American journal of veterinary research.
2014 May; 75(5):453-9. doi:
10.2460/ajvr.75.5.453. [PMID: 24762017] - L Fultz, S Giguère, L J Berghaus, J L Davis. Plasma and pulmonary pharmacokinetics of desfuroylceftiofur acetamide after weekly administration of ceftiofur crystalline free acid to adult horses.
Equine veterinary journal.
2014 Mar; 46(2):252-5. doi:
10.1111/evj.12107. [PMID: 23679100] - Sarai Rivera-Garcia, John A Angelos, Joan D Rowe, Barbara A Byrne, Scott E Wetzlich, Dana B Van Liew, Lisa A Tell. Pharmacokinetics of ceftiofur crystalline-free acid following subcutaneous administration of a single dose to sheep.
American journal of veterinary research.
2014 Mar; 75(3):290-5. doi:
10.2460/ajvr.75.3.290. [PMID: 24564315] - Shuna A Jones, Robert S Salter, Tim Goldsmith, Julio Quintana, Paul Rapnicki, Karen Shuck, Jim E Wells, Marilyn J Schneider, Dee Griffin. Development and model testing of antemortem screening methodology to predict required drug withholds in heifers.
Journal of food protection.
2014 Feb; 77(2):292-8. doi:
10.4315/0362-028x.jfp-13-267. [PMID: 24490924] - Jenny Meegan, Wendy T Collard, G Scott Grover, Nicola Pussini, William G Van Bonn, Frances M D Gulland. Pharmacokinetics of ceftiofur crystalline-free acid (EXCEDE sterile suspension) administered via intramuscular injection in wild California sea lions (Zalophus californianus).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2013 Sep; 44(3):714-20. doi:
10.1638/2013-0001r.1. [PMID: 24063100] - Zhihui Hao, Leilei Wang, Kefeng Xiao, Yongda Zhao, Ming Zou, Qidi Zhang, Zhaopeng Ding, Fenfang Yang, Baohan Qu. In vivo investigation of ceftiofur-loaded gelatin and PLGA microspheres in beagle dogs.
Journal of materials science. Materials in medicine.
2013 Apr; 24(4):903-10. doi:
10.1007/s10856-012-4846-5. [PMID: 23354736] - John W Schmidt, Dee Griffin, Larry A Kuehn, Dayna M Brichta-Harhay. Influence of therapeutic ceftiofur treatments of feedlot cattle on fecal and hide prevalences of commensal Escherichia coli resistant to expanded-spectrum cephalosporins, and molecular characterization of resistant isolates.
Applied and environmental microbiology.
2013 Apr; 79(7):2273-83. doi:
10.1128/aem.03592-12. [PMID: 23354706] - Mototaka Hiki, Masaru Usui, Akemi Kojima, Manao Ozawa, Yoshikazu Ishii, Tetsuo Asai. Diversity of plasmid replicons encoding the bla(CMY-2) gene in broad-spectrum cephalosporin-resistant Escherichia coli from livestock animals in Japan.
Foodborne pathogens and disease.
2013 Mar; 10(3):243-9. doi:
10.1089/fpd.2012.1306. [PMID: 23489047] - M L Macpherson, S Giguère, J N Hatzel, M Pozor, S Benson, M Diaw, L C Sanchez, T W Vickroy, L Tell, S Wetzlich, J Sims. Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of ceftiofur crystalline free acid (CCFA) to pony mares with placentitis.
Journal of veterinary pharmacology and therapeutics.
2013 Feb; 36(1):59-67. doi:
10.1111/j.1365-2885.2012.01392.x. [PMID: 22449008] - X von Krueger, P Scherpenisse, S Roiger, W Heuwieser. Determination of ceftiofur derivatives in serum, endometrial tissue, and lochia in puerperal dairy cows with fever or acute puerperal metritis after subcutaneous administration of ceftiofur crystalline free acid.
Journal of dairy science.
2013 Feb; 96(2):1054-62. doi:
10.3168/jds.2012-6034. [PMID: 23261383] - Jennifer L Cottell, Neena Kanwar, Lucrecia Castillo-Courtade, Gabhan Chalmers, H Morgan Scott, Bo Norby, Guy H Loneragan, Patrick Boerlin. blaCTX-M-32 on an IncN plasmid in Escherichia coli from beef cattle in the United States.
Antimicrobial agents and chemotherapy.
2013 Feb; 57(2):1096-7. doi:
10.1128/aac.01750-12. [PMID: 23165469] - Neena Kanwar, H Morgan Scott, Bo Norby, Guy H Loneragan, Javier Vinasco, Matthew McGowan, Jennifer L Cottell, Muckatira M Chengappa, Jianfa Bai, Patrick Boerlin. Effects of ceftiofur and chlortetracycline treatment strategies on antimicrobial susceptibility and on tet(A), tet(B), and bla CMY-2 resistance genes among E. coli isolated from the feces of feedlot cattle.
PloS one.
2013; 8(11):e80575. doi:
10.1371/journal.pone.0080575. [PMID: 24260423] - Y Sasaki, A Ikeda, K Ishikawa, M Murakami, M Kusukawa, T Asai, Y Yamada. Prevalence and antimicrobial susceptibility of Salmonella in Japanese broiler flocks.
Epidemiology and infection.
2012 Nov; 140(11):2074-81. doi:
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Foodborne pathogens and disease.
2012 Nov; 9(11):1022-7. doi:
10.1089/fpd.2012.1198. [PMID: 22985052] - Michael J Adkesson, Randall E Junge, Matthew C Allender, Tomás Martín-Jiménez. Pharmacokinetics of a long-acting ceftiofur crystalline-free acid formulation in Asian elephants (Elephas maximus).
American journal of veterinary research.
2012 Oct; 73(10):1512-8. doi:
10.2460/ajvr.73.10.1512. [PMID: 23013176] - Julia Jeremejeva, Toomas Orro, Andres Waldmann, Kalle Kask. Treatment of dairy cows with PGF2α or NSAID, in combination with antibiotics, in cases of postpartum uterine inflammation.
Acta veterinaria Scandinavica.
2012 Aug; 54(?):45. doi:
10.1186/1751-0147-54-45. [PMID: 22883439] - Dixie F Mollenkopf, Matthew F Weeman, Joshua B Daniels, Melanie J Abley, Jennifer L Mathews, Wondwossen A Gebreyes, Thomas E Wittum. Variable within- and between-herd diversity of CTX-M cephalosporinase-bearing Escherichia coli isolates from dairy cattle.
Applied and environmental microbiology.
2012 Jul; 78(13):4552-60. doi:
10.1128/aem.00373-12. [PMID: 22544245] - Pedro N Carvalho, M Clara P Basto, C Marisa R Almeida. Potential of Phragmites australis for the removal of veterinary pharmaceuticals from aquatic media.
Bioresource technology.
2012 Jul; 116(?):497-501. doi:
10.1016/j.biortech.2012.03.066. [PMID: 22522014] - Marie-Hélène Dufresne, Elaheh Marouf, Yvonne Kränzlin, Marc A Gauthier, Jean-Christophe Leroux. Lipase is essential for the study of in vitro release kinetics from organogels.
Molecular pharmaceutics.
2012 Jun; 9(6):1803-11. doi:
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Journal of veterinary pharmacology and therapeutics.
2012 Jun; 35(3):259-64. doi:
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