Ibacitabine (BioDeep_00000733331)

   

Chemicals and Drugs


代谢物信息卡片


5-Iodo-2-deoxycytidine

化学式: C9H12IN3O4 (352.98725420000005)
中文名称: 5-碘-2-脱氧胞苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC1N2C=C(C(=NC2=O)N)I)CO)O
InChI: InChI=1S/C9H12IN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h2,5-7,14-15H,1,3H2,(H2,11,12,16)/t5-,6+,7+/m0/s1

描述信息

D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

2 个代谢物同义名

5-Iodo-2-deoxycytidine; Ibacitabine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S A Koch, K B Sloan. N-Mannich-base prodrugs of 5-iodo-2'-deoxycytidine as topical delivery enhancers. Pharmaceutical research. 1987 Aug; 4(4):317-20. doi: 10.1023/a:1016497204211. [PMID: 3508538]
  • R B Van Dyke, J D Connor. Uptake of [125I]iododeoxycytidine by cells infected with herpes simplex virus: a rapid screening test for resistance to acyclovir. The Journal of infectious diseases. 1985 Dec; 152(6):1206-11. doi: 10.1093/infdis/152.6.1206. [PMID: 2999258]
  • J Wepierre, J P Marty, J L Chanal, D Sincholle. Percutaneous absorption of 5-iodo-2' deoxycytidine in the hairless rat and in man. European journal of drug metabolism and pharmacokinetics. 1984 Jan; 9(1):79-83. doi: 10.1007/bf03189608. [PMID: 6714272]
  • J Campisi, J Hafner, R Boorstein, A B Pardee. Hereditary orotic aciduria, Lesch-Nyhan syndrome, and xeroderma pigmentosum probed by herpes simplex virus: 125I-iododeoxycytidine incorporation as an assay for viral growth. Journal of cellular physiology. 1983 Jan; 114(1):21-8. doi: 10.1002/jcp.1041140105. [PMID: 6826658]
  • L E Bockstahler, C D Lytle, A S Lubiniecki, J M Cantwell, J A Galleshaw. Mutagenic virus replication in human tumor cells. Cancer letters. 1982 Nov; 17(2):141-5. doi: 10.1016/0304-3835(82)90026-x. [PMID: 6299510]
  • A Hampton, F Kappler, R R Chawla. Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase. Journal of medicinal chemistry. 1979 Jun; 22(6):621-31. doi: 10.1021/jm00192a005. [PMID: 458818]
  • W A CREASEY. Studies on the metabolism of 5-iodo-2'-deoxycytidine in vitro. Purification of nucleoside deaminase from mouse kidney. The Journal of biological chemistry. 1963 May; 238(?):1772-6. doi: 10.1016/s0021-9258(18)81136-x. [PMID: 14023749]