Rokitamycin (BioDeep_00000732900)

   


代谢物信息卡片


[6-[6-[[(11E,13Z)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-2,4-dimethyl-4-propanoyloxyoxan-3-yl] butanoate

化学式: C42H69NO15 (827.4666963999999)
中文名称: 罗他霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(=O)OC1C(OC(CC1(C)OC(=O)CC)OC2C(OC(C(C2N(C)C)O)OC3C(CC(C(C=CC=CCC(OC(=O)CC(C3OC)O)C)O)C)CC=O)C)C
InChI: InChI=1S/C42H69NO15/c1-11-16-32(48)55-40-27(6)53-34(23-42(40,7)58-31(47)12-2)56-37-26(5)54-41(36(50)35(37)43(8)9)57-38-28(19-20-44)21-24(3)29(45)18-15-13-14-17-25(4)52-33(49)22-30(46)39(38)51-10/h13-15,18,20,24-30,34-41,45-46,50H,11-12,16-17,19,21-23H2,1-10H3/b14-13-,18-15+

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

3 个代谢物同义名

Rokitamycin; RICAMYCIN; [6-[6-[[(11E,13Z)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-2,4-dimethyl-4-propanoyloxyoxan-3-yl] butanoate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jong-Hyun Kim, Yang-Jin Lee, Hae-Jin Sohn, Kyoung-Ju Song, Daeho Kwon, Myung-Hee Kwon, Kyung-Il Im, Ho-Joon Shin. Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri. International journal of antimicrobial agents. 2008 Nov; 32(5):411-7. doi: 10.1016/j.ijantimicag.2008.05.018. [PMID: 18762406]
  • Kazufumi Hiramatsu, Junko Murakami, Kenji Kishi, Norio Hirata, Tohru Yamasaki, Jun-ichi Kadota, Tetsuo Shibata, Masaru Nasu. Treatment with rokitamycin suppresses the lethality in a murine model of Escherichia coli O157:H7 infection. International journal of antimicrobial agents. 2003 May; 21(5):471-7. doi: 10.1016/s0924-8579(03)00007-4. [PMID: 12727082]
  • X J Zhao, T Ishizaki. An in-vitro study on the metabolism of rokitamycin and possible interactions of the drug with rat liver microsomes. The Journal of pharmacy and pharmacology. 1999 Oct; 51(10):1167-74. doi: 10.1211/0022357991776705. [PMID: 10579688]
  • X J Zhao, E Koyama, T Ishizaki. An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals. 1999 Jul; 27(7):776-85. doi: . [PMID: 10383920]
  • S Tsuruta, K Nakamura, K Arimori, M Nakano. Inhibition of nifedipine metabolism in dogs by erythromycin: difference between the gut wall and the liver. The Journal of pharmacy and pharmacology. 1997 Dec; 49(12):1205-10. doi: 10.1111/j.2042-7158.1997.tb06071.x. [PMID: 9466344]
  • P C Braga, S Maci, M Dal Sasso, E Fonti, A Ghessi. Effects of rokitamycin on phagocytosis and release of oxidant radicals of human polymorphonuclear leukocytes. Chemotherapy. 1997 May; 43(3):190-7. doi: 10.1159/000239560. [PMID: 9142460]
  • H Yamamura, M Ohsugi, Y Kobayashi, M Sasaki. Effects of rokitamycin on bilirubin-albumin binding: a study in vitro. The Journal of toxicological sciences. 1993 Aug; 18(3):203-6. doi: 10.2131/jts.18.3_203. [PMID: 8246313]
  • H C Neu, N X Chin, J W Gu. The in-vitro activity of new streptogramins, RP 59500, RP 57669 and RP 54476, alone and in combination. The Journal of antimicrobial chemotherapy. 1992 Jul; 30 Suppl A(?):83-94. doi: 10.1093/jac/30.suppl_a.83. [PMID: 1328138]
  • M Tod, O Biarez, P Nicolas, O Petitjean. Sensitive determination of josamycin and rokitamycin in plasma by high-performance liquid chromatography with fluorescence detection. Journal of chromatography. 1992 Mar; 575(1):171-6. doi: 10.1016/0378-4347(92)80521-q. [PMID: 1517296]
  • M Cazzola, M G Matera, E Paternò, F Scaglione, G Santangelo, F Rossi. Impact of rokitamycin, a new 16-membered macrolide, on serum theophylline. Journal of chemotherapy (Florence, Italy). 1991 Aug; 3(4):240-4. doi: 10.1080/1120009x.1991.11739098. [PMID: 1779258]
  • T Motohiro, Y Yoshinaga, H Sasaki, M Aramaki, K Oda, A Kawakami, K Tanaka, T Koga, Y Shimada, S Tomita. [Effect of rokitamycin on bacterial flora in human feces]. The Japanese journal of antibiotics. 1990 Feb; 43(2):285-317. doi: NULL. [PMID: 2362352]
  • T Motohiro, M Aramaki, K Oda, A Kawakami, K Tanaka, T Koga, Y Shimada, S Tomita, M Koga, Y Sakata. [Clinical studies of rokitamycin dry syrup on Chlamydia trachomatis infections in the neonate and infant]. The Japanese journal of antibiotics. 1988 Oct; 41(10):1493-502. doi: NULL. [PMID: 3204656]
  • T Motohiro, M Aramaki, K Oda, A Kawakami, K Tanaka, T Koga, T Fujimoto, Y Sakata, F Yamashita, K Suzuki. [Microbiological, pharmacokinetic and clinical studies of rokitamycin dry syrup in the pediatric field]. The Japanese journal of antibiotics. 1988 Jul; 41(7):920-59. doi: . [PMID: 3050186]
  • T Nishimura, K Tabuki, S Aoki, M Takagi. [Laboratory and clinical studies of rokitamycin in pediatric fields]. The Japanese journal of antibiotics. 1988 Jul; 41(7):901-13. doi: NULL. [PMID: 3050185]
  • A Sakai, M Iwasaki, T Suzuki, M Morishita, S Muranishi. [Studies on the metabolic fate of 14C-rokitamycin. Absorption, distribution, metabolism and excretion in infant rats]. The Japanese journal of antibiotics. 1988 Jul; 41(7):797-808. doi: . [PMID: 3172452]
  • N Iwai, M Miyazu, H Nakamura, M Katayama, K Kasai. [Studies of rokitamycin in pediatrics]. The Japanese journal of antibiotics. 1988 Jul; 41(7):885-900. doi: NULL. [PMID: 3172462]
  • K Kuno, Y Nakao, N Yamamoto, F Hayakawa, H Ishikawa, H Kimura, H Takeuchi. [Laboratory and clinical studies of rokitamycin dry syrup in the field of pediatrics]. The Japanese journal of antibiotics. 1988 Jul; 41(7):875-84. doi: . [PMID: 3172461]
  • A Sakai, N Yasuda, S Endo, T Suzuki, M Morishita. [Studies on the absorption and excretion of rokitamycin in infant beagle dogs. Comparison with adult beagle dogs]. The Japanese journal of antibiotics. 1988 Jul; 41(7):809-12. doi: NULL. [PMID: 3172453]
  • T Suzuki, A Sakai, K Ohta, S Endo, N Yasuda, M Morishita, T Ishioka. [Studies on absorption and excretion of rokitamycin dry syrup in healthy volunteers]. The Japanese journal of antibiotics. 1988 Jul; 41(7):813-22. doi: NULL. [PMID: 3172454]
  • H Sakata, H Kakehashi, K Murono, K Fujita, H Yoshioka, N Sasaki, Y Mori, S Maruyama. [Clinical and pharmacokinetic evaluation of a +rokitamycin dry syrup in children]. The Japanese journal of antibiotics. 1988 Jun; 41(6):663-72. doi: . [PMID: 3221431]
  • R Fujii, T Shinozaki, H Meguro, O Arimasu, H Yoshioka, K Fujita, H Sakata, S Maruyama, Y Wagatasuma, N Fukushima. [Appraisal of rokitamycin in the pediatric field]. The Japanese journal of antibiotics. 1988 Jun; 41(6):646-62. doi: NULL. [PMID: 3221430]
  • N Yamashita, T Oikawa, M Osano. [Studies on plasma levels and clinical efficacy of rokitamycin in pediatrics]. The Japanese journal of antibiotics. 1988 Jun; 41(6):739-44. doi: NULL. [PMID: 3221436]
  • K Kawauchi, Y Sato, S Kimura, S Yonesaka, M Yokoyama, A Onishi, T Asuka, T Okamoto, Y Takebe, T Tsushima. [Clinical results of a rokitamycin dry syrup in pediatric infections]. The Japanese journal of antibiotics. 1988 Jun; 41(6):673-85. doi: NULL. [PMID: 3221432]
  • T Suzuki, A Sakai, M Morishita, T Ishioka, K Shimizu. [Studies on concentrations in body fluids of 16-membered ring macrolide antibiotics upon oral administration to healthy volunteers. Effects of their metabolites on bioassay values]. The Japanese journal of antibiotics. 1988 May; 41(5):510-22. doi: NULL. [PMID: 3216473]
  • H Yamamura, M Ohsugi, S Sakurai, Y Kobayashi, M Sasaki, H Yamamoto. Effects of rokitamycin on young rats with hyperbilirubinemia--determination of unbound and brain bilirubin levels and examination for localized yellow discoloration of brain tissue. The Journal of toxicological sciences. 1988 Feb; 13(1):49-59. doi: 10.2131/jts.13.49. [PMID: 3385811]
  • M Morishita, A Sakai, S Endo, T Suzuki. [Effect of metabolites on the human plasma concentration as total activity after oral administration of rokitamycin. Comparison of three different bioassay methods]. The Japanese journal of antibiotics. 1987 Mar; 40(3):553-60. doi: NULL. [PMID: 3302343]
  • A Sakai, K Serizawa, M Watanabe, S Endo, T Suzuki, M Morishita. [Absorption and distribution of rokitamycin in beagle dogs]. The Japanese journal of antibiotics. 1987 Mar; 40(3):493-7. doi: NULL. [PMID: 3613073]
  • T Suzuki, A Sakai, M Morishita, S Muranishi. [Studies on the metabolic fate of 14C-rokitamycin. I. Absorption, distribution, metabolism and excretion in rats]. The Japanese journal of antibiotics. 1987 Mar; 40(3):499-518. doi: . [PMID: 3613074]
  • Y Nakano, Y Kobayashi, M Tsujino, K Hayano. [Antigenicity study of rokitamycin]. The Japanese journal of antibiotics. 1987 Mar; 40(3):608-12. doi: NULL. [PMID: 3613081]
  • M Miura, T Morino, H Endo, K Shiraiwa, K Matsumoto, K Hayano. [Comparative toxicity study of rokitamycin and josamycin in rats]. The Japanese journal of antibiotics. 1987 Mar; 40(3):588-601. doi: . [PMID: 3613079]
  • T Suzuki, A Sakai, M Morishita, S Muranishi. [Studies on the metabolic fate of 14C-rokitamycin. II. Accumulation of radioactivity in rats after consecutive oral administration]. The Japanese journal of antibiotics. 1987 Mar; 40(3):519-30. doi: NULL. [PMID: 3613075]
  • T Suzuki, A Sakai, M Morishita, S Muranishi. [Studies on the metabolic fate of 14C-rokitamycin. IV. Absorption, metabolism and excretion in dogs]. The Japanese journal of antibiotics. 1987 Mar; 40(3):539-52. doi: NULL. [PMID: 3613077]
  • H Sakakibara, O Okekawa, T Fujiwara, M Otani, S Omura. Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q). The Journal of antibiotics. 1981 Aug; 34(8):1001-10. doi: 10.7164/antibiotics.34.1001. [PMID: 7319915]