L-Ornithine L-aspartate (BioDeep_00000732736)
代谢物信息卡片
L-Ornithine L-aspartate salt
化学式: C9H19N3O6 (265.1274)
中文名称: L-鸟氨酸 L-天冬氨酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(C(=O)O)N)CN.C(C(C(=O)O)N)C(=O)O
InChI: 2-/m00/s1
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Laura Bainy Rodrigues de Freitas, Larisse Longo, Eduardo Filippi-Chiela, Valessa Emanoele Gabriel de Souza, Luiza Behrens, Matheus Henrique Mariano Pereira, Luiza Cecília Leonhard, Giulianna Zanettini, Carlos Eduardo Pinzon, Eduardo Luchese, Guilherme Jorge Semmelmann Pereira Lima, Carlos Thadeu Cerski, Carolina Uribe-Cruz, Mário Reis Álvares-da-Silva. Ornithine Aspartate and Vitamin-E Combination Has Beneficial Effects on Cardiovascular Risk Factors in an Animal Model of Nonalcoholic Fatty Liver Disease in Rats.
Biomolecules.
2022 11; 12(12):. doi:
10.3390/biom12121773. [PMID: 36551202] - Angela Horvath, Julia Traub, Benard Aliwa, Benjamin Bourgeois, Tobias Madl, Vanessa Stadlbauer. Oral Intake of L-Ornithine-L-Aspartate Is Associated with Distinct Microbiome and Metabolome Changes in Cirrhosis.
Nutrients.
2022 Feb; 14(4):. doi:
10.3390/nu14040748. [PMID: 35215398] - Yanlan Xu, Xinyu Yang, Hua Bian, Mingfeng Xia. Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clinical relationship and current management.
Lipids in health and disease.
2021 Oct; 20(1):126. doi:
10.1186/s12944-021-01564-z. [PMID: 34602072] - Abhijit Das, Dominik Fröhlich, Lavanya B Achanta, Benjamin D Rowlands, Gary D Housley, Matthias Klugmann, Caroline D Rae. L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism.
Neurochemical research.
2020 Jun; 45(6):1438-1450. doi:
10.1007/s11064-020-03044-9. [PMID: 32424601] - A O Buyeverov, P O Bogomolov, I V Mayev, M V Matsievich, O V Uvarova. Possibilities of therapeutic correction of hyperammonemia and minimal hepatic encephalopathy in patients with chronic hepatitis C at the pre-cirrhotic stage.
Terapevticheskii arkhiv.
2019 Mar; 91(2):52-58. doi:
10.26442/00403660.2019.02.000125. [PMID: 31094172] - Roger F Butterworth, Ali Canbay. Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease.
Digestive diseases (Basel, Switzerland).
2019; 37(1):63-68. doi:
10.1159/000491429. [PMID: 30016770] - Xiao-Jun Cai, Lei Wang, Chun-Mei Hu. Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
Journal of cellular biochemistry.
2018 11; 119(10):8336-8345. doi:
10.1002/jcb.26886. [PMID: 29932239] - Sandeep Singh Sidhu, Barjesh Chander Sharma, Omesh Goyal, Harsh Kishore, Navpreet Kaur. L-ornithine L-aspartate in bouts of overt hepatic encephalopathy.
Hepatology (Baltimore, Md.).
2018 02; 67(2):700-710. doi:
10.1002/hep.29410. [PMID: 28749571] - A G Evdokimova, A V Tomova, O I Tereshchenko, L V Zhukolenko, V V Evdokimov. [CLINICAL EFFICACY OF THE RECEPTOR BETA AND ALPHA BLOCKERS - CARVEDILOL AND ORNITHINE-ASPARTATE IN PATIENTS WITH CHD AND CHF COMBINED WITH ALCOHOLIC LIVER DISEASE].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology.
2016 ; ?(6):42-7. doi:
. [PMID: 30280552] - Tomasz Mikulski, Jan Dabrowski, Wojciech Hilgier, Andrzej Ziemba, Krzysztof Krzeminski. Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men.
Folia neuropathologica.
2015; 53(4):377-86. doi:
10.5114/fn.2015.56552. [PMID: 26785372] - Zehui Yan, Yuming Wang, Qing Mao, Xiaohong Wang, Xuqing Zhang, Yingjie Wang, Yegui Jiang, De-Dong Xiang, Li Jiang, Jie Wang. [Effect of L-ornithine L-aspartate granules in treating chronic liver disease in patients with high-level serum gamma-glutamyltransferase].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2014 Jul; 22(7):525-8. doi:
10.3760/cma.j.issn.1007-3418.2014.07.010. [PMID: 25203805] - M Bai, C He, Z Yin, J Niu, Z Wang, X Qi, L Liu, Z Yang, W Guo, J Tie, W Bai, J Xia, H Cai, J Wang, K Wu, D Fan, G Han. Randomised clinical trial: L-ornithine-L-aspartate reduces significantly the increase of venous ammonia concentration after TIPSS.
Alimentary pharmacology & therapeutics.
2014 Jul; 40(1):63-71. doi:
10.1111/apt.12795. [PMID: 24832463] - D E Kutepov, M G Vershinina, I N Pasechnik, P S Sal'nikov. [Comparative effectiveness of different treatment methods of liver failure].
Khirurgiia.
2014; ?(3):32-6. doi:
NULL. [PMID: 24781068] - Li-yan Tian, Lun-gen Lu, Cheng-wei Tang, Yan Xie, He-sheng Luo, Shi-yun Tan, Zhi Pang, Ya-li Zhang, Lan-bo Gong, You-ming Li, Shao-hua Chen, Jun-ping Shi. [Aspartate-ornithine granules in the treatment of nonalcoholic steatohepatitis: a multiple-dose parallel controlled clinical trial].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2013 Jul; 21(7):528-32. doi:
10.3760/cma.j.issn.1007-3418.2013.07.013. [PMID: 24074713] - Ming Bai, Zhiping Yang, Xingshun Qi, Daiming Fan, Guohong Han. l-ornithine-l-aspartate for hepatic encephalopathy in patients with cirrhosis: a meta-analysis of randomized controlled trials.
Journal of gastroenterology and hepatology.
2013 May; 28(5):783-92. doi:
10.1111/jgh.12142. [PMID: 23425108] - Claudia Isabel Blanco Vela, Jorge Luis Poo Ramírez. Efficacy of oral L-ornithine L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy.
Annals of hepatology.
2011 Jun; 10 Suppl 2(?):S55-9. doi:
10.1016/s1665-2681(19)31608-4. [PMID: 22228883] - José Luis Pérez Hernández, Fátima Higuera de la Tijera, Aurora Elizabeth Serralde-Zúñiga, Juan Miguel Abdo Francis. Critical analysis of studies evaluating the efficacy of infusion of L-ornithine L-aspartate in clinical hepatic encephalopathy in patients with liver failure.
Annals of hepatology.
2011 Jun; 10 Suppl 2(?):S66-9. doi:
10.1016/s1665-2681(19)31610-2. [PMID: 22228885] - Gavin Wright, Lorette Noiret, Steven W M Olde Damink, Rajiv Jalan. Interorgan ammonia metabolism in liver failure: the basis of current and future therapies.
Liver international : official journal of the International Association for the Study of the Liver.
2011 Feb; 31(2):163-75. doi:
10.1111/j.1478-3231.2010.02302.x. [PMID: 20673233] - A G Evdokimova, A É Radzevich, A V Tomova, V V Evdokimov, E V Kovalenko, L V Zhukolenko. [Optimization of treatment of patients with chronic cardiac insufficiency of the ischemic genesis and hobnail liver].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
2011; 56(5-6):64-8. doi:
NULL. [PMID: 22145233] - Suzanna Ndraha, Marcellus Simadibrata. Normal protein diet and L-ornithine-L-aspartate for hepatic encephalopathy.
Acta medica Indonesiana.
2010 Jul; 42(3):158-61. doi:
NULL. [PMID: 20724770] - P Kowalski, M Bieniecki. Pharmacokinetics and bioavailability study of L-ornithine-L-aspartate in healthy volunteers--a comparative study of two oral formulations.
Journal of pharmaceutical and biomedical analysis.
2006 Jun; 41(3):1061-4. doi:
10.1016/j.jpba.2006.01.049. [PMID: 16524681] - P Kowalski, M Bieniecki, I Oledzka, H Lamparczyk. Validated method for L-ornithine-L-aspartate analysis in human plasma by capillary electrophoresis.
Biomedical chromatography : BMC.
2006 Feb; 20(2):185-94. doi:
10.1002/bmc.551. [PMID: 16078310] - M Maneesh, H Jayalekshmi. Effect of ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats.
Indian journal of physiology and pharmacology.
2005 Oct; 49(4):422-6. doi:
NULL. [PMID: 16579395] - M Romero Gómez, J D Bautista, L Grande, R M Ramos Guerrero, D Sánchez Muñoz. [New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].
Gastroenterologia y hepatologia.
2004 Feb; 27 Suppl 1(?):40-8. doi:
NULL. [PMID: 15195533] - C Rose, A Michalak, K V Rao, G Quack, G Kircheis, R F Butterworth. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.
Hepatology (Baltimore, Md.).
1999 Sep; 30(3):636-40. doi:
10.1002/hep.510300311. [PMID: 10462368] - R Gebhardt, G Beckers, F Gaunitz, W Haupt, D Jonitza, S Klein, L Scheja. Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels.
The Journal of pharmacology and experimental therapeutics.
1997 Oct; 283(1):1-6. doi:
NULL. [PMID: 9336301] - B A Vogels, O T Karlsen, M A Mass, W M Boveé, R A Chamuleau. L-ornithine vs. L-ornithine-L-aspartate as a treatment for hyperammonemia-induced encephalopathy in rats.
Journal of hepatology.
1997 Jan; 26(1):174-82. doi:
10.1016/s0168-8278(97)80024-4. [PMID: 9148009] - U Staedt, H Leweling, R Gladisch, C Kortsik, E Hagmüller, E Holm. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design.
Journal of hepatology.
1993 Nov; 19(3):424-30. doi:
10.1016/s0168-8278(05)80553-7. [PMID: 8151104]
