Argatroban (BioDeep_00000732733)
代谢物信息卡片
Argatroban monohydrate
化学式: C23H38N6O6S (526.2573408)
中文名称: 阿加曲班单水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCN(C(C1)C(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C.O
InChI: /m1./s1
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent > C173066 - Direct Thrombin Inhibitor
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D006401 - Hematologic Agents > D000925 - Anticoagulants > D000991 - Antithrombins
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xuting Zhang, Wansi Zhong, Rui Xue, Haidi Jin, Xiaoxian Gong, Yuhui Huang, Fujian Chen, Mozi Chen, Liqun Gu, Yebo Ge, Xiaodong Ma, Bifeng Zhong, Mengjie Wang, Haitao Hu, Zhicai Chen, Shenqiang Yan, Yi Chen, Xin Wang, Xiaoling Zhang, Dongjuan Xu, Yuping He, Minfang Lou, Aiju Wang, Xiong Zhang, Li Ma, Xiaodong Lu, Jianer Wang, Qiong Lou, Ping'an Qian, Guomin Xie, Xiaofen Zhu, Songbin He, Jin Hu, Xiongjie Wen, Yan Liu, Yanwen Wang, Jingjing Fu, Weinv Fan, David Liebeskind, Changzheng Yuan, Min Lou. Argatroban in Patients With Acute Ischemic Stroke With Early Neurological Deterioration: A Randomized Clinical Trial.
JAMA neurology.
2024 Feb; 81(2):118-125. doi:
10.1001/jamaneurol.2023.5093. [PMID: 38190136] - Haiyan Xie, Ying Chen, Wukun Ge, Xiuping Xu, Chengjiang Liu, Zhiyong Lan, Yina Yang. Can the combination of antiplatelet or alteplase thrombolytic therapy with argatroban benefit patients suffering from acute stroke? a systematic review, meta-analysis, and meta-regression.
PloS one.
2024; 19(2):e0298226. doi:
10.1371/journal.pone.0298226. [PMID: 38412157] - Hui-Sheng Chen, Yu Cui, Zhong-He Zhou, Ying-Jie Dai, Gao-Hua Li, Zhao-Long Peng, Yi Zhang, Xiao-Dong Liu, Zhi-Mei Yuan, Chang-Hao Jiang, Qing-Cheng Yang, Ying-Jie Duan, Guang-Bin Ma, Li-Wei Zhao, Rui-Xian Wang, Yuan-Lin Sun, Lei Shen, Er-Qiang Wang, Li-Hua Wang, Ye-Fang Feng, Feng-Yun Wang, Ren-Lin Zou, He-Ping Yang, Kai Wang, Duo-Lao Wang, Yi-Long Wang. Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial.
JAMA.
2023 02; 329(8):640-650. doi:
10.1001/jama.2023.0550. [PMID: 36757755] - Alberto Lázaro-García, Inés Martínez-Alfonzo, Rosa Vidal-Laso, Diego Velasco-Rodríguez, Marta Tomás-Mallebrera, Marta González-Rodríguez, Pilar Llamas-Sillero. A journey through anticoagulant therapies in the treatment of left ventricular thrombus in post-COVID-19 heparin-induced thrombocytopenia: a case report.
Hematology (Amsterdam, Netherlands).
2022 Dec; 27(1):318-321. doi:
10.1080/16078454.2022.2043572. [PMID: 35231200] - Mirjam Bachler, Lars M Asmis, Jürgen Koscielny, Thomas Lang, Hartmuth Nowak, Patrick Paulus, Jens-Christian Schewe, Christian von Heymann, Dietmar Fries. Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2022 Jul; 33(5):239-256. doi:
10.1097/mbc.0000000000001133. [PMID: 35703225] - Susan Guy, Steve Kitchen, Barbara Hopkins, Zunaid Chunara, Alex Stephenson-Brown, Joost J van Veen. Laboratory methods for monitoring argatroban in heparin-induced thrombocytopenia.
International journal of laboratory hematology.
2022 Apr; 44(2):399-406. doi:
10.1111/ijlh.13757. [PMID: 34755452] - Jenn Qian, Carla Lutchman, Edward Margolin. Papilledema due to Vaccine-Induced Thrombocytopenia.
Ophthalmology.
2022 02; 129(2):190. doi:
10.1016/j.ophtha.2021.07.016. [PMID: 35065733] - Virginie Siguret, Elodie Boissier, Emmanuel De Maistre, Isabelle Gouin-Thibault, Chloé James, Dominique Lasne, Christine Mouton, Alexandre Godon, Philippe Nguyen, Thomas Lecompte. GFHT proposals on the practical use of argatroban - With specifics regarding vaccine-induced immune thrombotic thrombocytopaenia (VITT).
Anaesthesia, critical care & pain medicine.
2021 12; 40(6):100963. doi:
10.1016/j.accpm.2021.100963. [PMID: 34673303] - Samuel Bersinger, Kevin Lagarde, Raphael Marlu, Gilles Pernod, Jean-Francois Payen. Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia.
Critical care medicine.
2021 09; 49(9):e870-e873. doi:
10.1097/ccm.0000000000005105. [PMID: 34049307] - Katharina Guetl, Thomas Gary, Reinhard B Raggam, Johannes Schmid, Albert Wölfler, Marianne Brodmann. SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia treated with immunoglobulin and argatroban.
Lancet (London, England).
2021 06; 397(10293):e19. doi:
10.1016/s0140-6736(21)01238-1. [PMID: 34126043] - Kholoud F Aliter, Rami A Al-Horani. Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19.
Cardiovascular drugs and therapy.
2021 Apr; 35(2):195-203. doi:
10.1007/s10557-020-07066-x. [PMID: 32870433] - Yiqin Wang, Chao Liu, Li Zhang, Jijun Li, Lei Zhang, Yong Wang, Hanyu Zhu, Xueying Cao, Di Wu, Jie Wu, Shupeng Lin, Zhe Feng, Guangyan Cai, Xiangmei Chen, Xuefeng Sun. Evaluating the safety and efficacy of argatroban locking solution in the prevention of the dysfunction of haemodialysis central venous catheters: a study protocol for a randomized controlled trial.
Annals of palliative medicine.
2021 Feb; 10(2):2260-2270. doi:
10.21037/apm-20-1641. [PMID: 33549029] - Puneet Gandotra, Azhar Supariwala, Samy Selim, Gregory Garra, Luis Gruberg. Aortic Arch Thrombus and Pulmonary Embolism in a COVID-19 Patient.
The Journal of emergency medicine.
2021 02; 60(2):223-225. doi:
10.1016/j.jemermed.2020.08.009. [PMID: 32917441] - Susan Guy, Steve Kitchen, Michael Makris, Rhona M Maclean, Giorgia Saccullo, Joost J Vanveen. Caution in Using the Activated Partial Thromboplastin Time to Monitor Argatroban in COVID-19 and Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT).
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2021 Jan; 27(?):10760296211066945. doi:
10.1177/10760296211066945. [PMID: 34905962] - Fergal McGlynn, Jennifer McGrath, Chithra Varghese, Barbara Ryan, Johnny McHugh, Arabella Fahy, Helen Enright. Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection.
Journal of thrombosis and thrombolysis.
2021 Jan; 51(1):243-245. doi:
10.1007/s11239-020-02251-z. [PMID: 32830309] - Yuhei Michiwaki, Tatsuya Tanaka, Tomihiro Wakamiya, Yusuke Tabei, Kazuhiro Samura, Eiichi Suehiro, Masatou Kawashima. Emergent Carotid Artery Stenting Following Intravenous Alteplase Infusion After Rapid Negative Diagnosis for COVID-19 by Loop-Mediated Isothermal Amplification Assay.
World neurosurgery.
2021 01; 145(?):356-359. doi:
10.1016/j.wneu.2020.09.166. [PMID: 33045450] - Divya Shankaranarayanan, Thangamani Muthukumar, Tarek Barbar, Aarti Bhasin, Supriya Gerardine, Perola Lamba, Lorenz Leuprecht, Sanjay P Neupane, Thalia Salinas, Daniil Shimonov, Elly Varma, Frank Liu. Anticoagulation Strategies and Filter Life in COVID-19 Patients Receiving Continuous Renal Replacement Therapy: A Single-Center Experience.
Clinical journal of the American Society of Nephrology : CJASN.
2020 12; 16(1):124-126. doi:
10.2215/cjn.08430520. [PMID: 32943397] - Frederic Arnold, Lukas Westermann, Siegbert Rieg, Elke Neumann-Haefelin, Paul Marc Biever, Gerd Walz, Johannes Kalbhenn, Yakup Tanriver. Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study.
BMC nephrology.
2020 11; 21(1):486. doi:
10.1186/s12882-020-02150-8. [PMID: 33198670] - Lisa M Sagardia, Lisa M Daniels. Thrombolysis and use of argatroban for the treatment of massive pulmonary embolism following anticoagulation failure in a patient with COVID-19.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2020 11; 77(23):1961-1964. doi:
10.1093/ajhp/zxaa287. [PMID: 32780853] - Yoshihiko Ogawa, Toshihiko Nagata, Taisuke Akiyama, Koji Nishida, Junji Kumasawa, Michihiko Kohno, Hisakazu Kohata, Iwao Gohma. Argatroban therapy for heparin-induced thrombocytopenia in a patient with coronavirus disease 2019.
Journal of thrombosis and thrombolysis.
2020 Nov; 50(4):1012-1014. doi:
10.1007/s11239-020-02248-8. [PMID: 32780355] - Shumin Chen, Dongchun Cai, Peichu Huang, Jichang Liu, Yuzhi Lai, Jianfeng He, Liang Zhou, Hao Sun. Early and long-term outcomes of argatroban use in patients with acute noncardioembolic stroke.
Clinical neurology and neurosurgery.
2020 11; 198(?):106233. doi:
10.1016/j.clineuro.2020.106233. [PMID: 32977247] - Deepa J Arachchillage, Christopher Remmington, Alex Rosenberg, Tina Xu, Maurizio Passariello, Donna Hall, Mike Laffan, Brijesh V Patel. Anticoagulation with argatroban in patients with acute antithrombin deficiency in severe COVID-19.
British journal of haematology.
2020 09; 190(5):e286-e288. doi:
10.1111/bjh.16927. [PMID: 32516429] - Yuda Wei, Cheng Tian, Yongxu Zhao, Xiaojian Liu, Feng Liu, Shuang Li, Yanhao Chen, Yan Qiu, Zhuanghui Feng, Lanlan Chen, Tingting Zhou, Xiaoguang Ren, Chengwu Feng, Yan Liu, Wenqiang Yu, Hao Ying, Qiurong Ding. MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism.
Nature metabolism.
2020 05; 2(5):447-460. doi:
10.1038/s42255-020-0203-z. [PMID: 32694659] - Armando Tripodi, Veena Chantarangkul, Lidia Padovan, Marigrazia Clerici, Erica Scalambrino, Flora Peyvandi. Effect of emicizumab on global coagulation assays for plasma supplemented with apixaban or argatroban.
Journal of thrombosis and thrombolysis.
2020 Apr; 49(3):413-419. doi:
10.1007/s11239-019-01993-9. [PMID: 31728842] - Jacob T Beyer, Stuart E Lind, Sheila Fisher, Toby C Trujillo, Michael F Wempe, Tyree H Kiser. Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients.
Journal of thrombosis and thrombolysis.
2020 Feb; 49(2):259-267. doi:
10.1007/s11239-019-01961-3. [PMID: 31559512] - Aaron D Shmookler, Ruta Arays, Paul McCarthy. Inpatient management strategies in a severe case of heparin-induced thrombocytopenia.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2019 Aug; 58(4):525-528. doi:
10.1016/j.transci.2019.06.030. [PMID: 31327731] - Philip Fernandes, Michael O'Neil, Samantha Del Valle, Anita Cave, Dave Nagpal. A 24-hour perioperative case study on argatroban use for left ventricle assist device insertion during cardiopulmonary bypass and veno-arterial extracorporeal membrane oxygenation.
Perfusion.
2019 05; 34(4):337-344. doi:
10.1177/0267659118813043. [PMID: 30583712] - Jinfeng Lin, Xiaoying Huang, Weihua Zhou, Suyan Zhang, Weiwei Sun, Yadong Wang, Ke Ren, Lijun Tian, Junxian Xu, Zhilong Cao, Zunguo Pu, Xudong Han. Thrombosis in the portal venous system caused by hypereosinophilic syndrome: A case report.
Medicine.
2018 Nov; 97(48):e13425. doi:
10.1097/md.0000000000013425. [PMID: 30508952] - S Guy, S Kitchen, J J Van Veen. Argatroban is stable in citrated whole blood for 24 hours.
International journal of laboratory hematology.
2018 Aug; 40(4):484-487. doi:
10.1111/ijlh.12844. [PMID: 29707901] - Xiao Fu, Jian-Ping Ning. Synthesis and biocompatibility of an argatroban-modified polysulfone membrane that directly inhibits thrombosis.
Journal of materials science. Materials in medicine.
2018 May; 29(5):66. doi:
10.1007/s10856-018-6054-4. [PMID: 29744595] - Marijke Peetermans, Laurens Liesenborghs, Kathelijne Peerlinck, Eric Van Wijngaerden, Olivier Gheysens, Karolien E Goffin, Marc F Hoylaerts, Marc Jacquemin, Jan Verhaegen, Willy E Peetermans, Peter Verhamme, Thomas Vanassche. Targeting Coagulase Activity in Staphylococcus aureus Bacteraemia: A Randomized Controlled Single-Centre Trial of Staphylothrombin Inhibition.
Thrombosis and haemostasis.
2018 05; 118(5):818-829. doi:
10.1055/s-0038-1639586. [PMID: 29614521] - Joanna Kolodziejczyk-Czepas, Malgorzata Sieradzka, Barbara Moniuszko-Szajwaj, Pawel Nowak, Wiesław Oleszek, Anna Stochmal. Phenolic fractions from nine Trifolium species modulate the coagulant properties of blood plasma in vitro without cytotoxicity towards blood cells.
The Journal of pharmacy and pharmacology.
2018 Mar; 70(3):413-425. doi:
10.1111/jphp.12872. [PMID: 29341135] - Holger Seidel, Hans-Jürgen Kolde. Monitoring of Argatroban and Lepirudin: What is the Input of Laboratory Values in 'Real Life'?.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2018 Mar; 24(2):287-294. doi:
10.1177/1076029617699087. [PMID: 28320219] - Martin Beiderlinden, Patrick Werner, Astrid Bahlmann, Johann Kemper, Tobias Brezina, Maximilian Schäfer, Klaus Görlinger, Holger Seidel, Peter Kienbaum, Tanja A Treschan. Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial.
BMC anesthesiology.
2018 02; 18(1):18. doi:
10.1186/s12871-018-0475-y. [PMID: 29426286] - L Zhang, J Yang, X Zheng, Q Fan, Z Zhang. Influences of argatroban on five fibrinogen assays.
International journal of laboratory hematology.
2017 Dec; 39(6):641-644. doi:
10.1111/ijlh.12719. [PMID: 28766891] - Yogesh Bulani, Shyam Sunder Sharma. Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression.
Cardiovascular drugs and therapy.
2017 Jun; 31(3):255-267. doi:
10.1007/s10557-017-6732-3. [PMID: 28695302] - Elizabeth M Van Cott, A Joshua Roberts, William E Dager. Laboratory Monitoring of Parenteral Direct Thrombin Inhibitors.
Seminars in thrombosis and hemostasis.
2017 Apr; 43(3):270-276. doi:
10.1055/s-0036-1597297. [PMID: 28052306] - Rui Xu, Qianqian Feng, Yang He, Fanyong Yan, Li Chen, Yiping Zhao. Dual functionalized poly(vinylidene fluoride) membrane with acryloylmorpholine and argatroban to improve antifouling and hemocompatibility.
Journal of biomedical materials research. Part A.
2017 01; 105(1):178-188. doi:
10.1002/jbm.a.35892. [PMID: 27588950] - Kentaro Takayama, Akihiro Taguchi, Fumika Yakushiji, Yoshio Hayashi. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U.
Biopolymers.
2016 Nov; 106(4):440-5. doi:
10.1002/bip.22770. [PMID: 26567043] - Jeremy B Chang, Kayla M Quinnies, Ronald Realubit, Charles Karan, Jacob H Rand, Nicholas P Tatonetti. A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient.
Scientific reports.
2016 07; 6(?):29387. doi:
10.1038/srep29387. [PMID: 27439480] - Cornelius Keyl, Emanuel Zimmer, Martin Johannes Bek, Michael Wiessner, Dietmar Trenk. Argatroban pharmacokinetics and pharmacodynamics in critically ill cardiac surgical patients with suspected heparin-induced thrombocytopenia.
Thrombosis and haemostasis.
2016 06; 115(6):1081-9. doi:
10.1160/th15-11-0847. [PMID: 26792118] - Elena Zavyalova, Nikita Ustinov, Andrey Golovin, Galina Pavlova, Alexey Kopylov. G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants.
Current medicinal chemistry.
2016; 23(21):2230-44. doi:
10.2174/0929867323666160517120126. [PMID: 27183984] - Jens Müller, Tobias Becher, Günter Mayer, Bernd Pötzsch. Aptamer-Based Enzyme Capture Assay for Measurement of Plasma Thrombin Levels.
Methods in molecular biology (Clifton, N.J.).
2016; 1380(?):179-89. doi:
10.1007/978-1-4939-3197-2_15. [PMID: 26552826] - S Guy, S Kitchen, R Maclean, J J Van Veen. Limitation of the activated partial thromboplastin time as a monitoring method of the direct thrombin inhibitor argatroban.
International journal of laboratory hematology.
2015 Dec; 37(6):834-43. doi:
10.1111/ijlh.12414. [PMID: 26305560] - Menglin Li. Urine reflection of changes in blood.
Advances in experimental medicine and biology.
2015; 845(?):13-9. doi:
10.1007/978-94-017-9523-4_2. [PMID: 25355565] - Fabrizio Vianello, Lucrezia Furian, Maurizio Nordio, Martina Treleani, Fabrizio Fabris. Concomitant use of argatroban and warfarin during hemodialysis in heparin-induced thrombocytopenia.
Hematology (Amsterdam, Netherlands).
2015 Jan; 20(1):48-9. doi:
10.1179/1607845414y.0000000157. [PMID: 24580134] - Stephan Kadauke, Bernard Khor, Elizabeth M Van Cott. Activated protein C resistance testing for factor V Leiden.
American journal of hematology.
2014 Dec; 89(12):1147-50. doi:
10.1002/ajh.23867. [PMID: 25293789] - Mirei Nagai, Kiyotaka Iwasaki, Mitsuo Umezu, Makoto Ozaki. Simultaneous comparison of thrombogenic reactions to different combinations of anticoagulants, activated clotting times, and materials.
Journal of biomedical materials research. Part B, Applied biomaterials.
2014 Nov; 102(8):1605-12. doi:
10.1002/jbm.b.33145. [PMID: 24652689] - B Rozec, E Boissier, A Godier, R Cinotti, F Stephan, Y Blanloeil. [Argatroban, a new antithrombotic treatment for heparin-induced thrombocytopenia application in cardiac surgery and in intensive care].
Annales francaises d'anesthesie et de reanimation.
2014 Sep; 33(9-10):514-23. doi:
10.1016/j.annfar.2014.06.006. [PMID: 25148720] - Terry C Major, Elizabeth J Brisbois, Anna M Jones, Margaux E Zanetti, Gail M Annich, Robert H Bartlett, Hitesh Handa. The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation.
Biomaterials.
2014 Aug; 35(26):7271-85. doi:
10.1016/j.biomaterials.2014.05.036. [PMID: 24927680] - MengLin Li, MinDi Zhao, YouHe Gao. Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma.
Science China. Life sciences.
2014 Jul; 57(7):649-56. doi:
10.1007/s11427-014-4661-y. [PMID: 24907934] - Matthias Klingele, Hagen Bomberg, Anne Lerner-Gräber, Danilo Fliser, Aaron Poppleton, Hans J Schäfers, Heinrich V Groesdonk. Use of argatroban: experiences in continuous renal replacement therapy in critically ill patients after cardiac surgery.
The Journal of thoracic and cardiovascular surgery.
2014 Jun; 147(6):1918-24. doi:
10.1016/j.jtcvs.2013.11.051. [PMID: 24485959] - Xavier de la Rosa, Alvaro Cervera, Anna K Kristoffersen, Claudia P Valdés, Hari M Varma, Carles Justicia, Turgut Durduran, Ángel Chamorro, Anna M Planas. Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice.
Stroke.
2014 May; 45(5):1453-9. doi:
10.1161/strokeaha.113.004111. [PMID: 24676774] - Stuart E Lind, Mary Ellen Boyle, Sheila Fisher, Jan Ishimoto, Toby C Trujillo, Tyree H Kiser. Comparison of the aPTT with alternative tests for monitoring direct thrombin inhibitors in patient samples.
American journal of clinical pathology.
2014 May; 141(5):665-74. doi:
10.1309/ajcpgtcex7k4gxqo. [PMID: 24713737] - Satoshi Sakakibara, Ritsuko Hirade, Toru Mihara, Junichi Ota, Tetsuro Nikai, Yoji Saito. [Recipient of living kidney transplantation during which heparin-induced thrombocytopenia (HIT) was suspected: a case report].
Masui. The Japanese journal of anesthesiology.
2014 Mar; 63(3):346-9. doi:
NULL. [PMID: 24724449] - Corey J Lum, Steven Azuma. A comparison of methods for estimating glomerular filtration rate for a population in Hawai'i with non-valvular atrial fibrillation.
Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health.
2013 Sep; 72(9 Suppl 4):27-9. doi:
NULL. [PMID: 24052915] - Dina M Kennedy, Cesar Alaniz. Apparent argatroban resistance in a patient with elevated factor VIII levels.
The Annals of pharmacotherapy.
2013 Jul; 47(7-8):e29. doi:
10.1345/aph.1r745. [PMID: 23737512] - Chihiro Sugita, Atsushi Yamashita, Yunosuke Matsuura, Takashi Iwakiri, Nozomi Okuyama, Shuntaro Matsuda, Tomoko Matsumoto, Osamu Inoue, Aya Harada, Takehisa Kitazawa, Kunihiro Hattori, Midori Shima, Yujiro Asada. Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor.
Thrombosis and haemostasis.
2013 Jul; 110(1):62-75. doi:
10.1160/th13-01-0069. [PMID: 23636277] - Matthew A Wanat, Sara R Hart, David Putney, Michael G Liebl, Wayne Chandler. Alternative monitoring of argatroban using plasma-diluted thrombin time.
The Annals of pharmacotherapy.
2013 Apr; 47(4):e18. doi:
10.1345/aph.1r644. [PMID: 23482736] - Lee M Ferguson, Albert W Dreisbach, Eva Csongrádi, Luis A Juncos, Tibor Fulop. Recurring extracorporeal circuit clotting during continuous renal replacement therapy in fungal sepsis: successful treatment with argatroban.
The American journal of the medical sciences.
2013 Mar; 345(3):256-8. doi:
10.1097/maj.0b013e3182711e59. [PMID: 23267232] - Brigitte Tardy-Poncet, Marion Combe, Michèle Piot, Céline Chapelle, Majid Akrour, Bernard Tardy. Effects of argatroban, danaparoid, and fondaparinux on trombin generation in heparin-induced thrombocytopenia.
Thrombosis and haemostasis.
2013 Mar; 109(3):504-9. doi:
10.1160/th12-05-0321. [PMID: 23328916] - Shu He, Håkan Wallèn, Niklas Bark, Margareta Blombäck. In vitro studies using a global hemostasis assay to examine the anticoagulation effects in plasma by the direct thrombin inhibitors: dabigatran and argatroban.
Journal of thrombosis and thrombolysis.
2013 Feb; 35(2):131-9. doi:
10.1007/s11239-012-0791-x. [PMID: 22843196] - Peter M Yarbrough, Amir Varedi, Amanda Walker, Matthew T Rondina. Argatroban dose reductions for suspected heparin-induced thrombocytopenia complicated by child-pugh class C liver disease.
The Annals of pharmacotherapy.
2012 Nov; 46(11):e30. doi:
10.1345/aph.1r226. [PMID: 23073302] - Karen M Kassel, Bradley P Sullivan, Wei Cui, Bryan L Copple, James P Luyendyk. Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.
The American journal of pathology.
2012 Oct; 181(4):1287-95. doi:
10.1016/j.ajpath.2012.06.011. [PMID: 22841818] - Joyce Curvers, Daan van de Kerkhof, An K Stroobants, Erik-Jan van den Dool, Volkher Scharnhorst. Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful?.
American journal of clinical pathology.
2012 Oct; 138(4):551-8. doi:
10.1309/ajcpqod9wfpeyy0h. [PMID: 23010710] - Erik E Abel, Sandra L Kane-Gill, Amy L Seybert, John A Kellum. Direct thrombin inhibitors for management of heparin-induced thrombocytopenia in patients receiving renal replacement therapy: comparison of clinical outcomes.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2012 Sep; 69(18):1559-67. doi:
10.2146/ajhp110540. [PMID: 22935938] - Heiko Rühl, Jens Müller, Ursula Harbrecht, Rolf Fimmers, Johannes Oldenburg, Günter Mayer, Bernd Pötzsch. Thrombin inhibition profiles in healthy individuals and thrombophilic patients.
Thrombosis and haemostasis.
2012 May; 107(5):848-53. doi:
10.1160/th11-10-0719. [PMID: 22274722] - Jeanne M Rhea, Marion L Snyder, Anne M Winkler, Charbel Abou-Diwan, Corinne R Fantz, James C Ritchie, Fania Szlam, Kenichi A Tanaka, Ross J Molinaro. Development of a fast and simple liquid chromatography-tandem mass spectrometry method for the quantitation of argatroban in patient plasma samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Apr; 893-894(?):168-72. doi:
10.1016/j.jchromb.2012.02.041. [PMID: 22425273] - Thaddaus R Hellwig, Gregory J Peitz, Michael P Gulseth. High-dose argatroban for treatment of heparin-induced thrombocytopenia with thrombosis: a case report and review of laboratory considerations.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2012 Mar; 69(6):490-5. doi:
10.2146/ajhp110147. [PMID: 22382479] - David A Garcia, Trevor P Baglin, Jeffrey I Weitz, Meyer Michel Samama. Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest.
2012 Feb; 141(2 Suppl):e24S-e43S. doi:
10.1378/chest.11-2291. [PMID: 22315264] - Hao Chen, Yuji Teramura, Hiroo Iwata. Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization.
Biomaterials.
2011 Nov; 32(31):7971-7. doi:
10.1016/j.biomaterials.2011.07.002. [PMID: 21794908] - Boris Ivandic, Markus Zorn. Monitoring of the anticoagulants argatroban and lepirudin: a comparison of laboratory methods.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2011 Oct; 17(5):549-55. doi:
10.1177/1076029610382651. [PMID: 20834029] - Xuefeng Sun, Yunshuang Chen, Qing Xiao, Yong Wang, Jianhui Zhou, Zhifang Ma, Jing Xiang, Xiangmei Chen. Effects of argatroban as an anticoagulant for intermittent veno-venous hemofiltration (IVVH) in patients at high risk of bleeding.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Sep; 26(9):2954-9. doi:
10.1093/ndt/gfq805. [PMID: 21303963] - Kei Akimoto, Ute Klinkhardt, Andreas Zeiher, Margit Niethammer, Sebastian Harder. Anticoagulation with argatroban for elective percutaneous coronary intervention: population pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of coagulation parameters.
Journal of clinical pharmacology.
2011 Jun; 51(6):805-18. doi:
10.1177/0091270010372627. [PMID: 20663996] - Andreas Link, J Pöss, M Böhm. [Diagnosis and treatment of heparin-induced thrombocytopenia].
Deutsche medizinische Wochenschrift (1946).
2011 May; 136(18):953-62; quiz 963. doi:
10.1055/s-0031-1275831. [PMID: 21526460] - Zhong-xin ZHOU, Chun-qiu PAN, Fang-yong FU, Zhi-qi LIN, Zheng-jun LIU. [Efficacy of regional administration of urokinase and argatroban via small saphenous vein catheter for treatment of acute deep venous thrombosis in the lower limb].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2011 Mar; 31(3):539-43. doi:
NULL. [PMID: 21421502] - Rajanikanth Madabushi, Donna S Cox, Mohammad Hossain, Duane A Boyle, Bela R Patel, Guy Young, Young-Moon Choi, Jogarao V S Gobburu. Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics.
Journal of clinical pharmacology.
2011 Jan; 51(1):19-28. doi:
10.1177/0091270010365550. [PMID: 20421511] - Vance G Nielsen, Ejaz S Khan, James K Kirklin, James F George. Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban.
Anesthesia and analgesia.
2010 Dec; 111(6):1347-52. doi:
10.1213/ane.0b013e3181fbc120. [PMID: 21048101] - Walter P Jeske, Jawed Fareed, Debra A Hoppensteadt, Bruce Lewis, Jeanine M Walenga. Pharmacology of argatroban.
Expert review of hematology.
2010 Oct; 3(5):527-39. doi:
10.1586/ehm.10.53. [PMID: 21083469] - Anne Godier, Claire Flaujac, Marie-Hélène Horellou, Marine De Mesmay, Xavier Bécanne, Marion Parisot, Rémy Gauzit, Charles-Marc Samama. Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report.
Thrombosis research.
2010 Aug; 126(2):e141-3. doi:
10.1016/j.thromres.2009.12.018. [PMID: 20116834] - Pancras C Wong, Xiaosui Jiang. Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.
Thrombosis and haemostasis.
2010 Aug; 104(2):302-10. doi:
10.1160/th10-02-0097. [PMID: 20589316] - Shu He, Margareta Blombäck, Niklas Bark, Hans Johnsson, N Hakan Wallén. The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis.
Thrombosis and haemostasis.
2010 May; 103(5):1076-84. doi:
10.1160/th09-05-0306. [PMID: 20216982] - Jonathan R Genzen, Jawed Fareed, Debra Hoppensteadt, Viji Kurup, Paul Barash, Michael Coady, Yan Yun Wu. Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis.
Transfusion.
2010 Apr; 50(4):801-7. doi:
10.1111/j.1537-2995.2009.02531.x. [PMID: 20003049] - Toru Okamura, Toshiharu Shin'oka, Nobuyuki Ishibashi, Hikaru Ishii, Hiromi Kurosawa. Simultaneous use of argatroban and heparin during cardiopulmonary bypass.
Asian cardiovascular & thoracic annals.
2010 Feb; 18(1):22-6. doi:
10.1177/0218492309352034. [PMID: 20124292] - Masatomo Mihara, Ken-ichi Aihara, Yasumasa Ikeda, Sumiko Yoshida, Mizuho Kinouchi, Kiyoe Kurahashi, Yuichi Fujinaka, Masashi Akaike, Toshio Matsumoto. Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice.
Endocrinology.
2010 Feb; 151(2):513-9. doi:
10.1210/en.2009-0661. [PMID: 19966184] - Ross J Molinaro. Quantitation of argatroban in plasma using liquid chromatography electrospray tandem mass spectrometry (UPLC-ESI-MS/MS).
Methods in molecular biology (Clifton, N.J.).
2010; 603(?):57-63. doi:
10.1007/978-1-60761-459-3_6. [PMID: 20077059] - Bernd Saugel, Veit Phillip, Georg Moessmer, Roland M Schmid, Wolfgang Huber. Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study.
Critical care (London, England).
2010; 14(3):R90. doi:
10.1186/cc9024. [PMID: 20487559] - Masaaki Ichinoe, Tetuo Mikami, Sachiko Ujiie, Kosuke Suzuki, Isao Okayasu. Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: autopsy case after long-term follow up.
Pathology international.
2009 Oct; 59(10):757-61. doi:
10.1111/j.1440-1827.2009.02440.x. [PMID: 19788623] - Atsushi Yamashita, Shuntaro Matsuda, Tomoko Matsumoto, Sayaka Moriguchi-Goto, Misaki Takahashi, Chihiro Sugita, Takahiro Sumi, Takuroh Imamura, Midori Shima, Kazuo Kitamura, Yujiro Asada. Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.
Atherosclerosis.
2009 Oct; 206(2):418-26. doi:
10.1016/j.atherosclerosis.2009.03.014. [PMID: 19371874] - Shaun P Keegan, Neil E Ernst, Eric W Mueller. Argatroban for anticoagulation in continuous renal replacement therapy.
Critical care medicine.
2009 Jun; 37(6):2139; author reply 2139-40. doi:
10.1097/ccm.0b013e3181a60793. [PMID: 19448479] - Angela Maldonado. Argatroban and catheter-directed thrombolysis with alteplase for limb- and graft-threatening thromboses in a patient with a history of HIT.
American journal of hematology.
2009 Apr; 84(4):251-3. doi:
10.1002/ajh.21367. [PMID: 19260122] - Thomas A Aloia, John A Goss. A report of outcomes after orthotopic liver transplant with allografts from heparin antibody-positive donors.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2009 Mar; 7(1):13-7. doi:
NULL. [PMID: 19364306] - Stanley Chia, Elizabeth M Van Cott, O Christopher Raffel, Ik-Kyung Jang. Comparison of activated clotting times obtained using Hemochron and Medtronic analysers in patients receiving anti-thrombin therapy during cardiac catheterisation.
Thrombosis and haemostasis.
2009 Mar; 101(3):535-40. doi:
10.1160/th08-08-0528. [PMID: 19277416] - Andreas Link, Matthias Girndt, Simina Selejan, Alexander Mathes, Michael Böhm, Hauke Rensing. Argatroban for anticoagulation in continuous renal replacement therapy.
Critical care medicine.
2009 Jan; 37(1):105-10. doi:
10.1097/ccm.0b013e3181932394. [PMID: 19050602] - Vance G Nielsen, James K Kirklin. Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2008 Dec; 19(8):793-800. doi:
10.1097/mbc.0b013e328317f5aa. [PMID: 19002046] - Rose Faratro, Celine D'Gama, Christopher Chan. The use of alternative anti-coagulation strategies for a nocturnal home hemodialysis patient with heparin-induced thrombocytopenia.
CANNT journal = Journal ACITN.
2008 Oct; 18(4):32-5. doi:
NULL. [PMID: 19175190] - Jack Hirsh, Kenneth A Bauer, Maria B Donati, Michael Gould, Meyer M Samama, Jeffrey I Weitz. Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Chest.
2008 Jun; 133(6 Suppl):141S-159S. doi:
10.1378/chest.08-0689. [PMID: 18574264] - Robert Siegmund, Klas Boer, Katrin Poeschel, Gunter Wolf, Thomas Deufel, Michael Kiehntopf. Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals, patients under oral anticoagulation therapy and patients with liver dysfunction.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2008 Jun; 19(4):288-93. doi:
10.1097/mbc.0b013e3282fe73ec. [PMID: 18469550] - Edith A Nutescu, Nancy L Shapiro, Aimee Chevalier. New anticoagulant agents: direct thrombin inhibitors.
Cardiology clinics.
2008 May; 26(2):169-87, v. doi:
10.1016/j.ccl.2007.12.005. [PMID: 18406993]