Eflornithine hydrochloride (BioDeep_00000732725)
代谢物信息卡片
Eflornithine (hydrochloride, hydrate)
化学式: C6H15ClF2N2O3 (236.0739)
中文名称: 依氟鸟氨酸盐酸盐 一水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(C(F)F)(C(=O)O)N)CN.O.Cl
InChI: 1H
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D065108 - Ornithine Decarboxylase Inhibitors
C471 - Enzyme Inhibitor > C2088 - Ornithine Decarboxylase Inhibitor
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:4762
- KEGGdrug: D00829
- PubChem: 441361
- ChEMBL: CHEMBL1201037
- MeSH: Eflornithine
- CAS: 96020-91-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Cancer chemotherapy and pharmacology.
2021 10; 88(4):607-617. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Sep; 258(?):119806. doi:
10.1016/j.saa.2021.119806. [PMID: 33933938] - Ognjen Perišić. Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein-Drug and Protein-Protein Structures: An Analysis of Kinetically Active Residues.
Biomolecules.
2020 09; 10(9):. doi:
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PloS one.
2020; 15(2):e0228996. doi:
10.1371/journal.pone.0228996. [PMID: 32053698] - Mitchell B Diccianni, Katarzyna Kempińska, Jon A Gangoti, Alice L Yu, Linda S Sorkin. Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO.
PloS one.
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Journal of pharmaceutical sciences.
2019 12; 108(12):3870-3878. doi:
10.1016/j.xphs.2019.09.015. [PMID: 31545969] - Nadine Schäfer, Prashanth Reddy Rikkala, Maike Veyhl-Wichmann, Thorsten Keller, Christian Ferdinand Jurowich, Dietmar Geiger, Hermann Koepsell. A Modified Tripeptide Motif of RS1 (RSC1A1) Down-Regulates Exocytotic Pathways of Human Na+-d-glucose Cotransporters SGLT1, SGLT2, and Glucose Sensor SGLT3 in the Presence of Glucose.
Molecular pharmacology.
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Food microbiology.
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Bulletin of experimental biology and medicine.
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FEBS letters.
2015 Jul; 589(16):2058-65. doi:
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Investigative ophthalmology & visual science.
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Antimicrobial agents and chemotherapy.
2015 Feb; 59(2):1299-307. doi:
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BMC plant biology.
2015 Jan; 15(?):3. doi:
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PloS one.
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The Biochemical journal.
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Molecular biology of the cell.
2013 May; 24(10):1529-43. doi:
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2013 Feb; 40(1):117-28. doi:
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The Journal of nutritional biochemistry.
2012 Oct; 23(10):1285-93. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2012 Jul; 35(7):1112-6. doi:
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British journal of pharmacology.
2012 Apr; 165(7):2152-66. doi:
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Nature.
2012 Jan; 482(7384):232-6. doi:
10.1038/nature10771. [PMID: 22278056] - Neeraj Gupta, Hu Zhang, Ping Liu. Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.
Pharmacology, biochemistry, and behavior.
2012 Jan; 100(3):464-73. doi:
10.1016/j.pbb.2011.10.011. [PMID: 22024160] - V G Bespalov, V A Aleksandrov, A L Semenov, E G Kovan'ko, S D Ivanov. [Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats].
Advances in gerontology = Uspekhi gerontologii.
2012; 25(2):293-300. doi:
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Phytochemistry.
2011 Nov; 72(16):2024-30. doi:
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Future microbiology.
2011 Sep; 6(9):1037-47. doi:
10.2217/fmb.11.88. [PMID: 21958143] - Rehana Rehman, Muhammad Aslam, Muhammad Saleh Soomro. Reversal of difluoromethylornithine effects by the administration of putrescine in rats.
JPMA. The Journal of the Pakistan Medical Association.
2011 Aug; 61(8):752-5. doi:
NULL. [PMID: 22355995] - Can Hu, Ru-Liu Li, Wen-Biao Lu, Yan-Qun Yang, Jing Wang, Wei-Wen Chen. Studies on cell migration model in intestinal epithelial restitution for pharmacological research.
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2011 May; 34(5):738-46. doi:
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Arzneimittel-Forschung.
2011; 61(5):317-25. doi:
10.1055/s-0031-1296205. [PMID: 21755816] - R Jansson-Löfmark, S Römsing, E Albers, M Ashton. Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-L-cysteine and liquid chromatography with UV detection.
Biomedical chromatography : BMC.
2010 Jul; 24(7):768-73. doi:
10.1002/bmc.1361. [PMID: 20020417] - Susanna Vuohelainen, Eija Pirinen, Marc Cerrada-Gimenez, Tuomo A Keinänen, Anne Uimari, Marko Pietilä, Alex R Khomutov, Juhani Jänne, Leena Alhonen. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal of cellular and molecular medicine.
2010 Jun; 14(6B):1683-92. doi:
10.1111/j.1582-4934.2009.00808.x. [PMID: 19538475] - Kevin J Helena, David D N'Da, Carl C Johansson, Jaco C Breytenbach, Michael Ashton. Effects of oral administration of synthesized delta-amides of eflornithine in the rat.
Arzneimittel-Forschung.
2010; 60(11):682-8. doi:
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Journal of alternative and complementary medicine (New York, N.Y.).
2009 Jul; 15(7):700-1. doi:
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Journal of Ayub Medical College, Abbottabad : JAMC.
2009 Apr; 21(2):87-9. doi:
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2009 Apr; 21(4):1017-21. doi:
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Bioorganic & medicinal chemistry.
2009 Mar; 17(6):2512-23. doi:
10.1016/j.bmc.2009.01.058. [PMID: 19250832] - Xiao-Ba Wu, Jing Wang, Ji-Hong Liu, Xiu-Xin Deng. Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol.
Journal of plant physiology.
2009 Jan; 166(1):52-62. doi:
10.1016/j.jplph.2008.02.005. [PMID: 18448195] - L Venkatachalam, N Bhagyalakshmi. Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana.
Applied biochemistry and biotechnology.
2008 Dec; 151(2-3):502-11. doi:
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Endocrinology.
2008 Oct; 149(10):5012-23. doi:
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American journal of physiology. Renal physiology.
2008 Oct; 295(4):F995-F1002. doi:
10.1152/ajprenal.00491.2007. [PMID: 18562630] - R Jansson, M Malm, C Roth, M Ashton. Enantioselective and nonlinear intestinal absorption of eflornithine in the rat.
Antimicrobial agents and chemotherapy.
2008 Aug; 52(8):2842-8. doi:
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Carcinogenesis.
2008 Aug; 29(8):1594-600. doi:
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Journal of cellular biochemistry.
2008 Mar; 103(4):1046-52. doi:
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The Journal of biological chemistry.
2007 Nov; 282(48):34700-6. doi:
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2007 Sep; 282(37):27115-27125. doi:
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Amino acids.
2007 Aug; 33(2):331-9. doi:
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International journal of molecular medicine.
2007 May; 19(5):765-70. doi:
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2007 Feb; 846(1-2):98-104. doi:
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Endocrinology.
2005 Feb; 146(2):666-74. doi:
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2004 Dec; 30(8):755-69. doi:
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2004 Apr; 148(16):771-6. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2003 Oct; 285(4):G704-13. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 May; 788(2):221-31. doi:
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International journal of cancer.
2003 Apr; 104(3):380-8. doi:
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Plant physiology.
2003 Jan; 131(1):359-66. doi:
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2002 Oct; 8(10):3105-17. doi:
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Journal of experimental botany.
2002 Jun; 53(373):1463-73. doi:
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Biochemical and biophysical research communications.
2002 Apr; 293(1):106-11. doi:
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Chinese medical journal.
2002 Apr; 115(4):518-20. doi:
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Investigative ophthalmology & visual science.
2002 Apr; 43(4):1228-33. doi:
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Cancer research.
2001 Oct; 61(20):7449-55. doi:
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Journal of clinical pharmacology.
2001 Sep; 41(9):972-8. doi:
10.1177/00912700122010951. [PMID: 11549102] - G Tonon, C Kevers, T Gaspar. Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model.
Tree physiology.
2001 Jul; 21(10):655-63. doi:
10.1093/treephys/21.10.655. [PMID: 11446994] - Y N Ye, E S Liu, V Y Shin, M W Koo, Y Li, E Q Wei, H Matsui, C H Cho. A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.
Biochemical pharmacology.
2001 Jun; 61(11):1439-48. doi:
10.1016/s0006-2952(01)00625-6. [PMID: 11331080] - E Matovu, J C Enyaru, D Legros, C Schmid, T Seebeck, R Kaminsky. Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.
Tropical medicine & international health : TM & IH.
2001 May; 6(5):407-11. doi:
10.1046/j.1365-3156.2001.00712.x. [PMID: 11348535] - P J Villano, P M Gallice, A E Nicoara, S G Honore, K Owczarczak, R G Favre, C M Briand. Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.
Cellular and molecular biology (Noisy-le-Grand, France).
2001 Mar; 47(2):305-12. doi:
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Anticancer research.
2001 Mar; 21(2A):1163-5. doi:
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Cardiovascular research.
2001 Feb; 49(2):408-16. doi:
10.1016/s0008-6363(00)00255-8. [PMID: 11164851] - J C Paz, F Sánchez-Jiménez, M A Medina. Characterization of spermine uptake by Ehrlich tumour cells in culture.
Amino acids.
2001; 21(3):271-9. doi:
10.1007/s007260170013. [PMID: 11764408] - S C Thomson, A Deng, D Bao, J Satriano, R C Blantz, V Vallon. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.
The Journal of clinical investigation.
2001 Jan; 107(2):217-24. doi:
10.1172/jci10963. [PMID: 11160138] - T H Hostetter. Hypertrophy and hyperfunction of the diabetic kidney.
The Journal of clinical investigation.
2001 Jan; 107(2):161-2. doi:
10.1172/jci12066. [PMID: 11160131] - P P Carbone, J A Douglas, J Thomas, K Tutsch, M Pomplun, M Hamielec, D Pauk. Bioavailability study of oral liquid and tablet forms of alpha-difluoromethylornithine.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2000 Oct; 6(10):3850-4. doi:
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Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.
2000 Sep; 9(5):273-80. doi:
10.1016/s1054-8807(00)00038-7. [PMID: 11064274] - J A Rillema, S Collins, C H Williams. Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
2000 May; 224(1):41-4. doi:
10.1046/j.1525-1373.2000.22363.x. [PMID: 10782045] - A B da Rocha, D R Mans, G Lenz, A K Fernandes, C de Lima, V F Monteiro, D Gonçalves, J C Moreira, A L Brunetto, R Rodnight, G Schwartsmann. Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.
Pathobiology : journal of immunopathology, molecular and cellular biology.
2000 May; 68(3):113-23. doi:
10.1159/000055911. [PMID: 11174068] - I Veress, S Haghighi, A Pulkka, A Pajunen. Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs.
The Biochemical journal.
2000 Feb; 346 Pt 1(?):185-91. doi:
10.1042/bj3460185. [PMID: 10657256] - M Ketteler, R Westenfeld, A Gawlik, E de Heer, A Distler. Acute glomerular upregulation of ornithine decarboxylase is not essential for mesangial cell proliferation and matrix expansion in anti-Thy-1-nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2000 Jan; 15(1):16-22. doi:
10.1093/ndt/15.1.16. [PMID: 10607762] - H Hrselová, M Gryndler. Effect of spermine on proliferation of hyphae of Glomus fistulosum, an arbuscular mycorrhizal fungus, in maize roots.
Folia microbiologica.
2000; 45(2):167-71. doi:
10.1007/bf02817418. [PMID: 11271827] - J A O'Shaughnessy, L M Demers, S E Jones, J Arseneau, P Khandelwal, T George, R Gersh, D Mauger, A Manni. Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1999 Nov; 5(11):3438-44. doi:
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The Journal of biological chemistry.
1999 Oct; 274(40):28113-20. doi:
10.1074/jbc.274.40.28113. [PMID: 10497162] - S Hernández, S Schwarcz de Tarlovsky. Arginine decarboxylase in Trypanosoma cruzi, characteristics and kinetic properties.
Cellular and molecular biology (Noisy-le-Grand, France).
1999 Jun; 45(4):383-91. doi:
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The American journal of physiology.
1999 04; 276(4):C946-54. doi:
10.1152/ajpcell.1999.276.4.c946. [PMID: 10199827] - A R Patel, J Y Wang. Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells.
The American journal of physiology.
1999 02; 276(2):G441-50. doi:
10.1152/ajpgi.1999.276.2.g441. [PMID: 9950818] - A P Brown, R L Morrissey, J A Crowell, B S Levine. Difluoromethylornithine in combination with tamoxifen in female rats: 13-week oral toxicity study.
Cancer chemotherapy and pharmacology.
1999; 44(6):475-83. doi:
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British journal of pharmacology.
1998 Dec; 125(7):1511-6. doi:
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
1998 Oct; 7(10):907-12. doi:
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Parasite (Paris, France).
1998 Sep; 5(3):239-46. doi:
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Journal of pharmaceutical and biomedical analysis.
1998 Sep; 17(6-7):1205-13. doi:
10.1016/s0731-7085(98)00086-7. [PMID: 9884211] - G Capano, K J Bloch, E A Carter, J A Dascoli, D Schoenfeld, P R Harmatz. Polyamines in human and rat milk influence intestinal cell growth in vitro.
Journal of pediatric gastroenterology and nutrition.
1998 Sep; 27(3):281-6. doi:
10.1097/00005176-199809000-00002. [PMID: 9740197] - J Levêque, F Burtin, V Catros-Quemener, R Havouis, J P Moulinoux. The gastrointestinal polyamine source depletion enhances DFMO induced polyamine depletion in MCF-7 human breast cancer cells in vivo.
Anticancer research.
1998 Jul; 18(4A):2663-8. doi:
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European journal of gastroenterology & hepatology.
1998 Jun; 10(6):503-7. doi:
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The American journal of physiology.
1998 06; 274(6):F1020-8. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
1998 Feb; 4(2):303-10. doi:
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