Barnidipine (BioDeep_00000732718)
代谢物信息卡片
Barnidipine hydrochloride
化学式: C27H30ClN3O6 (527.182303)
中文名称: 盐酸巴尼地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC2CCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
InChI: /m0./s1
描述信息
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31253
- KEGGdrug: D01104
- PubChem: 443868
- ChEMBL: CHEMBL2093893
- ChEMBL: CHEMBL2356712
- CAS: 104757-53-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- N Ozturk, D Ozturk, Z Pala-Kara, A Okyar. Pharmacokinetics of talinolol is modified by barnidipine: implication of P-glycoprotein modulation.
Die Pharmazie.
2017 Jan; 72(1):29-34. doi:
10.1691/ph.2017.6786. [PMID: 29441894] - Giuseppe Derosa, Amedeo Mugellini, Rosa Maria Pesce, Angela D'Angelo, Pamela Maffioli. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus.
BMC cardiovascular disorders.
2016 Apr; 16(?):66. doi:
10.1186/s12872-016-0237-z. [PMID: 27068332] - Giuseppe Derosa, Amedeo Mugellini, Rosa M Pesce, Angela D'Angelo, Pamela Maffioli. Perindopril and barnidipine alone or combined with simvastatin on hepatic steatosis and inflammatory parameters in hypertensive patients.
European journal of pharmacology.
2015 Nov; 766(?):31-6. doi:
10.1016/j.ejphar.2015.09.030. [PMID: 26407654] - F Ilkay Alp Yildirim, Deniz Eker Kizilay, Bülent Ergin, Özlem Balci Ekmekçi, Gökçe Topal, Mine Kucur, Cihan Demirci Tansel, B Sönmez Uydeş Doğan. Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats.
European journal of pharmacology.
2015 Oct; 764(?):433-442. doi:
10.1016/j.ejphar.2015.07.033. [PMID: 26187312] - Giuseppe Derosa, Fabrizio Querci, Ivano Franzetti, Pietro Dario Ragonesi, Angela D'Angelo, Pamela Maffioli. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus.
Hypertension research : official journal of the Japanese Society of Hypertension.
2015 Oct; 38(10):690-4. doi:
10.1038/hr.2015.57. [PMID: 25994603] - Giuseppe Derosa, Amedeo Mugellini, Fabrizio Querci, Ivano Franzetti, Rosa Maria Pesce, Angela D'Angelo, Pamela Maffioli. Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial.
Scientific reports.
2015 Aug; 5(?):12603. doi:
10.1038/srep12603. [PMID: 26243165] - Athanasia Spirou, Evangelos Rizos, Evangelos N Liberopoulos, Nikolaos Kolaitis, Apostolos Achimastos, Alexandros D Tselepis, Moses Elisaf. Effect of barnidipine on blood pressure and serum metabolic parameters in patients with essential hypertension: a pilot study.
Journal of cardiovascular pharmacology and therapeutics.
2006 Dec; 11(4):256-61. doi:
10.1177/1074248406296108. [PMID: 17220472] - T Yamamoto, Y Tomura, H Tanaka, F Kajiya. In vivo visualization of characteristics of renal microcirculation in hypertensive and diabetic rats.
American journal of physiology. Renal physiology.
2001 Sep; 281(3):F571-7. doi:
10.1152/ajprenal.2001.281.3.f571. [PMID: 11502605] - Y Ohya, I Abe, Y Ohta, U Onaka, K Fujii, S Kagiyama, Y Fujishima-Nakao, M Fujishima. Natriuretic effect of barnidipine, a long-acting dihydropyridine calcium channel blocker, in patients with essential hypertension.
International journal of clinical pharmacology and therapeutics.
2000 Jun; 38(6):304-8. doi:
10.5414/cpp38304. [PMID: 10890579] - M Hashimoto, T Yamauchi, T Ogura, T Oishi, Y Mimura, F Otsuka, N Kashihara, H Makino. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats.
American journal of nephrology.
1999; 19(5):615-21. doi:
10.1159/000013511. [PMID: 10575194] - M Pawula, D Watson, T Teramura, T Watanabe, S Higuchi, K N Cheng. Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for barnidipine in human plasma.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Nov; 719(1-2):113-23. doi:
10.1016/s0378-4347(98)00413-7. [PMID: 9869371] - I Kosegawa, M Inaba, T Morita, T Awata, S Katayama. Effect of the vasodilatory beta-blocker, nipradilol, and Ca-antagonist, barnidipine, on insulin sensitivity in patients with essential hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1998 Oct; 20(7):751-61. doi:
10.3109/10641969809052117. [PMID: 9764719] - L Argenziano, R Izzo, G Iovino, N De Luca, L Parrella, C Morisco, B Trimarco. Distinct vasodilation, without reflex neurohormonal activation, induced by barnidipine in hypertensive patients.
Blood pressure. Supplement.
1998; 1(?):9-14. doi:
10.1080/080370598438546. [PMID: 9660521] - T Teramura, Y Fukunaga, E J Van Hoogdalem, T Watanabe, S Higuchi. Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker.
Xenobiotica; the fate of foreign compounds in biological systems.
1997 Sep; 27(9):885-900. doi:
10.1080/004982597240064. [PMID: 9381730] - T Teramura, T Watanabe, S Higuchi, K Hashimoto. Metabolism and pharmacokinetics of barnidipine hydrochloride, a calcium channel blocker, in man following oral administration of its sustained release formulation.
Xenobiotica; the fate of foreign compounds in biological systems.
1997 Feb; 27(2):203-16. doi:
10.1080/004982597240695. [PMID: 9058533] - T Teramura, T Tokunaga, H Matsumoto, T Watanabe, S Higuchi. Metabolism of barnidipine hydrochloride, a potent calcium antagonist, in rat and dog.
Xenobiotica; the fate of foreign compounds in biological systems.
1996 Feb; 26(2):177-87. doi:
10.3109/00498259609046698. [PMID: 8868001] - M Saitoh, C Kasai, J Ishikawa, K Masaki, M Asano. Effect of barnidipine on blood flow to major organs and renal function in anaesthetized dogs and spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement.
1995 Dec; 22(1):S339-40. doi:
10.1111/j.1440-1681.1995.tb02945.x. [PMID: 9072419] - T Teramura, T Watanabe, S Higuchi, K Hashimoto. Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human.
Xenobiotica; the fate of foreign compounds in biological systems.
1995 Nov; 25(11):1237-46. doi:
10.3109/00498259509046679. [PMID: 8592872] - K Takamura, H M Abdel-Wadood, F Kusu, I H Rafaat, G A Saleh, N A el-Rabbat, M Otagiri. Determination of barnidipine in human serum and dog plasma by HPLC with electrochemical detection.
Biological & pharmaceutical bulletin.
1995 Oct; 18(10):1311-4. doi:
10.1248/bpb.18.1311. [PMID: 8593428] - K Kaizu, Q Y Ling, K Uriu, M Ikeda, S Eto. Acute effect of calcium blocker on renal hemodynamics in diabetic spontaneously hypertensive rat.
Journal of diabetes and its complications.
1995 Oct; 9(4):301-3. doi:
10.1016/1056-8727(95)80027-c. [PMID: 8573752] - M Shibasaki, O Inagaki, T Takenaka. Hemodynamic effects of barnidipine hydrochloride in conscious squirrel monkeys.
General pharmacology.
1994 May; 25(3):565-8. doi:
10.1016/0306-3623(94)90215-1. [PMID: 7926606] - S Yamada, Y Matsuoka, R Kimura. Correlation between the plasma concentration of mepirodipine and its occupancy of Ca2+ antagonist receptors in rats.
Pharmaceutical research.
1993 Sep; 10(9):1346-9. doi:
10.1023/a:1018982116273. [PMID: 8234175] - S Yamada, Y Matsuoka, N Suzuki, N Sugimoto, Y Kato, R Kimura. Determination of a novel calcium channel antagonist, mepirodipine, in plasma by radioreceptor assay using (+)-[3H]PN 200-110.
Pharmaceutical research.
1992 Sep; 9(9):1227-30. doi:
10.1023/a:1015876411015. [PMID: 1329069] - S Yamada, Y Matsuoka, Y Kato, R Kimura, O Inagaki. A sustained occupancy in vivo of cardiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats.
The Journal of pharmacology and experimental therapeutics.
1992 Aug; 262(2):589-94. doi:
NULL. [PMID: 1323654] - K Kawashima, H Toda, H Oohata, K Fujimoto, T Suzuki, O Inagaki. Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats.
General pharmacology.
1991; 22(2):263-6. doi:
10.1016/0306-3623(91)90444-b. [PMID: 2055418] - T Teramura, S Kobayashi, S Higuchi. Determination of mepirodipine in plasma by capillary column gas chromatography-negative-ion chemical ionization mass spectrometry.
Journal of chromatography.
1990 Jun; 528(1):191-8. doi:
10.1016/s0378-4347(00)82375-0. [PMID: 2384553]