Zoledronic acid hydrate (BioDeep_00000732715)
代谢物信息卡片
Zoledronic acid hydrate
化学式: C5H12N2O8P2 (290.0068892)
中文名称: 唑来磷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O
InChI: 1H2
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C2136 - Malignancy-Associated Hypercalcemia Inhibitor
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D01968
- PubChem: 121586
- ChEMBL: CHEMBL4303669
- MeSH: Zoledronic Acid
- CAS: 165800-06-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen. Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded, Randomized Study.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
2024 03; 40(3):714-722. doi:
10.1016/j.arthro.2023.09.033. [PMID: 37832742] - ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu. Cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis: A meta-analysis and systematic review.
Seminars in arthritis and rheumatism.
2024 Feb; 64(?):152304. doi:
10.1016/j.semarthrit.2023.152304. [PMID: 37984227] - Kun Huang, Xiao Tang, Fang Tang. Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices.
Drug development research.
2024 Feb; 85(1):e22147. doi:
10.1002/ddr.22147. [PMID: 38349271] - Xiaoxia Zheng, Jiangnan Ye, Qunzhang Zhan, Weifeng Zhao, Zhongqin Liao, Xiaolin Ye, Chongzheng Qu. Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: development and evaluation of a new nomogram.
BMC musculoskeletal disorders.
2023 Oct; 24(1):841. doi:
10.1186/s12891-023-06965-y. [PMID: 37880626] - Mei Liu, Shengqiang Qian, Jing Wu, Jing Xiao, Xiaohua Zeng. The effects of neoadjuvant zoledronic acid in breast cancer patients: A meta-analysis of randomized controlled trials.
Asian journal of surgery.
2023 Oct; 46(10):4124-4130. doi:
10.1016/j.asjsur.2023.01.049. [PMID: 36732184] - Houfu Leng, Anna Katharina Simon, Nicole J Horwood. Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease.
Autophagy.
2023 Sep; ?(?):1-3. doi:
10.1080/15548627.2023.2208931. [PMID: 37771244] - Kan Liu, Guanzhong Tan, Wei Sun, Qiang Lu, Jiaguang Tang, Dong Yu. Percutaneous kyphoplasty combined with zoledronic acid for the treatment of primary osteoporotic vertebral compression fracture: a prospective, multicenter study.
Archives of orthopaedic and trauma surgery.
2023 Jul; 143(7):3699-3706. doi:
10.1007/s00402-022-04557-4. [PMID: 35933563] - Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu. Dietary nitrate improves jaw bone remodelling in zoledronate-treated mice.
Cell proliferation.
2023 Jul; 56(7):e13395. doi:
10.1111/cpr.13395. [PMID: 36810909] - Sheng Wang, Maohua Huang, Minfeng Chen, Zhiting Sun, Yubo Jiao, Geni Ye, Jinghua Pan, Wencai Ye, Jianfu Zhao, Dongmei Zhang. Zoledronic acid and thymosin α1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells.
Journal for immunotherapy of cancer.
2023 06; 11(6):. doi:
10.1136/jitc-2022-006381. [PMID: 37295817] - Bao Liu, Qian Yang, Ying Cheng, Miao Liu, Qifeng Ji, Bangle Zhang, Zhifu Yang, Siyuan Zhou, Daozhou Liu. Calcium phosphate hybrid micelles inhibit orthotopic bone metastasis from triple negative breast cancer by simultaneously killing cancer cells and reprogramming the microenvironment of bone resorption and immunosuppression.
Acta biomaterialia.
2023 May; ?(?):. doi:
10.1016/j.actbio.2023.05.038. [PMID: 37236576] - Hong Jiacong, Yang Qirui, Li Haonan, Song Yichang, Chen Yan, Chen Keng. Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma.
Medical oncology (Northwood, London, England).
2023 Apr; 40(5):141. doi:
10.1007/s12032-023-01988-w. [PMID: 37036615] - Yi Cao, Bin Qiao, Qiaoqi Chen, Zhuoyan Xie, Xiaoyun Dou, Lihong Xu, Haitao Ran, Liang Zhang, Zhigang Wang. Tumor microenvironment remodeling via targeted depletion of M2-like tumor-associated macrophages for cancer immunotherapy.
Acta biomaterialia.
2023 04; 160(?):239-251. doi:
10.1016/j.actbio.2023.02.006. [PMID: 36774974] - Rezvan Adibi, Shiva Moein, Yousof Gheisari. Zoledronic acid targets chemo-resistant polyploid giant cancer cells.
Scientific reports.
2023 01; 13(1):419. doi:
10.1038/s41598-022-27090-1. [PMID: 36624105] - Pengfei Li, Xiaojian Wu, Ye Li, Jianhua Huang. Denosumab Versus Bisphosphonates for the Prevention of the Vertebral Fractures in Men with Osteoporosis: An Updated Network Meta-Analysis.
Clinical and investigative medicine. Medecine clinique et experimentale.
2022 09; 45(3):E14-22. doi:
10.25011/cim.v45i3.38875. [PMID: 36149052] - Drake Winslow Williams, Katie Ho, Allison Lenon, Sol Kim, Terresa Kim, Yousang Gwack, Reuben H Kim. Long-Term Ligature-Induced Periodontitis Exacerbates Development of Bisphosphonate-Related Osteonecrosis of the Jaw in Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2022 Jul; 37(7):1400-1410. doi:
10.1002/jbmr.4614. [PMID: 35598324] - Lidija Chakuleska, Aleksandar Shkondrov, Georgi Popov, Nadya Zlateva-Panayotova, Reneta Petrova, Mariyana Atanasova, Ilina Krasteva, Irini Doytchinova, Rumyana Simeonova. Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits.
Acta pharmaceutica (Zagreb, Croatia).
2022 Jun; 72(2):289-302. doi:
10.2478/acph-2022-0012. [PMID: 36651509] - F Gossiel, A Ugur, N F A Peel, J S Walsh, R Eastell. The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Jun; 33(6):1357-1363. doi:
10.1007/s00198-022-06311-3. [PMID: 35102444] - Christophoros Christophoridis, Anastasios Kouroumalis, Dimitris Kletsas. Accumulation of zoledronic acid in rabbit intervertebral discs.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 May; 1197(?):123229. doi:
10.1016/j.jchromb.2022.123229. [PMID: 35349887] - Wei Luo, Jin Zhang, Ling Xu, Yao Zhou, Dan Xu, Qiuju Lv, Yi Xiao, Qin Yang. Use of zoledronic acid in antiosteoporosis treatment is associated with a decreased blood lipid level in postmenopausal women with osteoporosis: a cohort study in China.
Postgraduate medicine.
2022 May; 134(4):406-412. doi:
10.1080/00325481.2022.2051983. [PMID: 35264059] - Rachel Shulman, Abdallah S Geara, Jeffrey S Berns. Pamidronate versus zoledronic acid for the treatment of multiple myeloma-related hypercalcemia.
Kidney international.
2022 05; 101(5):1086. doi:
10.1016/j.kint.2021.12.033. [PMID: 35461601] - Ruri Ogawa, Yoshiyuki Minami, Junya Ono, Yoriaki Kanri, Eizaburo Kobayashi, Akira Tanaka, Yasuo Okada, Ichiro Ogura. Medication-related osteonecrosis of the jaw in a patient with multiple myeloma: an unusual case with tumor in the surgical specimen.
Oral radiology.
2022 04; 38(2):288-291. doi:
10.1007/s11282-021-00560-4. [PMID: 34387843] - Yongze Zhang, Peng Gao, Sunjie Yan, Qian Zhang, Ou Wang, Yan Jiang, Xiaoping Xing, Weibo Xia, Mei Li. Clinical, Biochemical, Radiological, and Genetic Analyses of a Patient with VCP Gene Variant-Induced Paget's Disease of Bone.
Calcified tissue international.
2022 04; 110(4):518-528. doi:
10.1007/s00223-021-00929-x. [PMID: 34800131] - M Schini, N Peel, L Toronjo-Urquiza, E Thomas, S Salam, A Khwaja, R Eastell, J S Walsh. Evaluation of estimated glomerular function (eGFR) versus creatinine clearance (CrCl) to predict acute kidney injury when using zoledronate for the treatment of osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Mar; 33(3):737-744. doi:
10.1007/s00198-021-06160-6. [PMID: 34654939] - Daniel Steller, Alexandra Scheibert, Tabea Sturmheit, Dorothee Rose, Samer G Hakim. Impact of PRP and PRF on Viability of Zoledronic Acid Treated Osteoblasts in 2D and 3D Cell Culture.
Anticancer research.
2022 Mar; 42(3):1295-1299. doi:
10.21873/anticanres.15596. [PMID: 35220219] - Hirotaka Miyashita, Christina Cruz, Vaibhav Patel. Risk factors of skeletal-related events in patients with bone metastatic castration-resistant prostate cancer undergoing treatment with zoledronate.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2022 Feb; 30(2):981-984. doi:
10.1007/s00520-021-06340-4. [PMID: 34373957] - Masafumi Kashii, Takashi Kamatani, Shingo Abe, Ayanori Yoshida, Kengo Yamamoto, Kota Koizumi, Naoko Mizuno, Kohji Kuriyama, Hideki Yoshikawa. Tolerability of the first infusion of once-yearly zoledronic acid within one to two weeks after hip fracture surgery.
Bone.
2022 02; 155(?):116298. doi:
10.1016/j.bone.2021.116298. [PMID: 34906743] - Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Eri Ito, Tatsuaki Matsumoto, Atsushi Kimura, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Mayu Morita, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto. Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics.
Scientific reports.
2022 01; 12(1):19. doi:
10.1038/s41598-021-03966-6. [PMID: 34997043] - Ryohei Kozutsumi, Shinichiro Kuroshima, Haruka Kaneko, Muneteru Sasaki, Akira Ishisaki, Takashi Sawase. Zoledronic Acid Deteriorates Soft and Hard Tissue Healing of Murine Tooth Extraction Sockets in a Dose-Dependent Manner.
Calcified tissue international.
2022 01; 110(1):104-116. doi:
10.1007/s00223-021-00890-9. [PMID: 34363509] - Andrew Grey, Mark J Bolland, Anne Horne, Borislav Mihov, Greg Gamble, Ian R Reid. Bone Mineral Density and Bone Turnover 10 Years After a Single 5 mg Dose or Two 5-Yearly Lower Doses of Zoledronate in Osteopenic Older Women: An Open-Label Extension of a Randomized Controlled Trial.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2022 01; 37(1):3-11. doi:
10.1002/jbmr.4453. [PMID: 34585780] - Tatsuhiko Kuroda, Masataka Shiraki, Toshitaka Nakamura, Hiroaki Suzuki, Kazuki Hiraishi, Toshitsugu Sugimoto, Satoshi Tanaka. Relationship Between Changes in Serum Levels of Intact Parathyroid Hormone and Sclerostin After a Single Dose of Zoledronic Acid: Results of a Phase 1 Pharmacokinetic Study.
Calcified tissue international.
2022 01; 110(1):87-92. doi:
10.1007/s00223-021-00900-w. [PMID: 34427705] - David John Brewer, Michael Macfarlane, Erin O'Connell, Nicholas J Bacon. Toxicity of zoledronic acid after intravenous administration: A retrospective study of 95 dogs.
Journal of veterinary internal medicine.
2022 Jan; 36(1):253-258. doi:
10.1111/jvim.16335. [PMID: 34859920] - Laura E Flores, Lynn Mack, Christopher Wichman, Ashley A Weaver, Vishal Kothari, Laura D Bilek. Protocol for a pilot randomised controlled trial of zoledronic acid to prevent bone loss following sleeve gastrectomy surgery.
BMJ open.
2021 12; 11(12):e057483. doi:
10.1136/bmjopen-2021-057483. [PMID: 34887285] - Dileep Sharma, Stephen Hamlet, Cedryck Vaquette, Eugen Bogdan Petcu, Poornima Ramamurthy, Saso Ivanovski. Local delivery of hydrogel encapsulated vascular endothelial growth factor for the prevention of medication-related osteonecrosis of the jaw.
Scientific reports.
2021 12; 11(1):23371. doi:
10.1038/s41598-021-02637-w. [PMID: 34862395] - Masataka Shiraki, Tatsuhiko Kuroda, Yasuhiro Takeuchi, Toshitsugu Sugimoto, Satoshi Tanaka, Hiroaki Suzuki, Kazuki Hiraishi, Toshitaka Nakamura. Acute Phase Reactions After Intravenous Infusion of Zoledronic Acid in Japanese Patients with Osteoporosis: Sub-analyses of the Phase III ZONE Study.
Calcified tissue international.
2021 12; 109(6):666-674. doi:
10.1007/s00223-021-00884-7. [PMID: 34247263] - Shanshan Gao, Fraser Soares, Shiyan Wang, Chi Chun Wong, Huarong Chen, Zhenjie Yang, Weixin Liu, Minnie Y Y Go, Musaddeque Ahmed, Yong Zeng, Catherine Adell O'Brien, Joseph J Y Sung, Housheng Hansen He, Jun Yu. CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer.
Oncogene.
2021 12; 40(48):6601-6613. doi:
10.1038/s41388-021-01882-7. [PMID: 34621019] - J Zhao, H Qiu, Y Lin. Denosumab is not associated with risk of malignancy? More evidence is needed.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2021 10; 32(10):2133-2134. doi:
10.1007/s00198-021-05988-2. [PMID: 34383098] - Junichi Takada, Kousuke Iba, Osamu Yamamoto, Takayuki Dohke, Akira Saito, Megumu Yamamura, Tsuneo Takebayashi, Tomohiro Akatsuka, Toshihiko Yamashita. Early adverse events after the first administration of zoledronic acid in Japanese patients with osteoporosis.
Journal of bone and mineral metabolism.
2021 Sep; 39(5):903-910. doi:
10.1007/s00774-021-01231-4. [PMID: 33988758] - Camiel de Roij van Zuijdewijn, Wim van Dorp, Sandrine Florquin, Joris Roelofs, Kees Verburgh. Bisphosphonate nephropathy: A case series and review of the literature.
British journal of clinical pharmacology.
2021 09; 87(9):3485-3491. doi:
10.1111/bcp.14780. [PMID: 33595131] - R J Wang, Q T Zhao, Y J Yu, Y Q Zhou, S Y Wang. [Molecular mechanism of zoledronic acid inhibiting angiogenesis by semi flexible binding with vascular endothelial growth factor conformation].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology.
2021 Jul; 56(7):679-686. doi:
10.3760/cma.j.cn112144-20200729-00441. [PMID: 34275224] - Fernanda Gonçalves Basso, Laís Medeiros Cardoso, Isabela Massaro Ribeiro, Ellen Rizzi, Taisa Nogueira Pansani, Josimeri Hebling, Carlos Alberto de Souza Costa. Influence of bisphosphonates on oral implantology: Sodium alendronate and zoledronic acid enhance the synthesis and activity of matrix metalloproteinases by gingival fibroblasts seeded on titanium.
Archives of oral biology.
2021 Jul; 127(?):105134. doi:
10.1016/j.archoralbio.2021.105134. [PMID: 33962330] - Ju Won Kim, Soohyeon Lee, Hye Sook Kim, Yoon Ji Choi, Jinho Yoo, Keon Uk Park, Seok Yun Kang, Yeon Hee Park, Kyung Hae Jung, Jin-Hee Ahn, Ho-Suk Oh, In Sil Choi, Hee Jun Kim, Kyung-Hun Lee, Suee Lee, Jae Hong Seo, In Hae Park, Kyung Eun Lee, Ho Young Kim, Kyong Hwa Park. Prognostic effects of cytokine levels on patients treated with taxane and zoledronic acid for metastatic breast cancer in bone (BEAT-ZO) (KCSG BR 10-13).
Cytokine.
2021 06; 142(?):155487. doi:
10.1016/j.cyto.2021.155487. [PMID: 33770643] - Evangelos Terpos, Ioannis Ntanasis-Stathopoulos. Controversies in the use of new bone-modifying therapies in multiple myeloma.
British journal of haematology.
2021 Jun; 193(6):1034-1043. doi:
10.1111/bjh.17256. [PMID: 33249579] - Gabriella Iannuzzo, Gianpaolo De Filippo, Daniela Merlotti, Veronica Abate, Alessio Buonaiuto, Marco Evangelista, Marco Gentile, Alfonso Giaquinto, Tommaso Picchioni, Matteo Nicola Dario Di Minno, Pasquale Strazzullo, Luigi Gennari, Domenico Rendina. Effects of Bisphosphonate Treatment on Circulating Lipid and Glucose Levels in Patients with Metabolic Bone Disorders.
Calcified tissue international.
2021 06; 108(6):757-763. doi:
10.1007/s00223-021-00811-w. [PMID: 33559705] - Andrew H Tam, Allison J Schepers, Angel Qin, Victoria R Nachar. Impact of Extended-Interval Versus Standard Dosing of Zoledronic Acid on Skeletal Events in Non-Small-Cell Lung Cancer and Small-Cell Lung Cancer Patients With Bone Metastases.
The Annals of pharmacotherapy.
2021 06; 55(6):697-704. doi:
10.1177/1060028020967629. [PMID: 33070623] - Xin-Jun Cai, Zeng Wang, Ying-Ying Xu, Gao-Yi Yang, Ruo-Ying Zhang, Yu Wang. Candesartan treatment enhances liposome penetration and anti-tumor effect via depletion of tumor stroma and normalization of tumor vessel.
Drug delivery and translational research.
2021 06; 11(3):1186-1197. doi:
10.1007/s13346-020-00842-0. [PMID: 32822012] - Lingling Ou, Huaishan Wang, Qin Liu, Jie Zhang, Hezhe Lu, Liangping Luo, Changzheng Shi, Shaoqiang Lin, Liyun Dong, Yeye Guo, Lili Huang, Jinjin Zhu, Xiangfan Yin, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Cathy Zheng, Yi Fan, Wei Guo, Xiaowei Xu. Dichotomous and stable gamma delta T-cell number and function in healthy individuals.
Journal for immunotherapy of cancer.
2021 05; 9(5):. doi:
10.1136/jitc-2020-002274. [PMID: 34011536] - Daisuke Watanabe, Takahiro Kimura, Ken Watanabe, Hiromitsu Takano, Yuko Uehara, Tadaaki Minowa, Akemi Yamashita, Seiichiro Yoshikawa, Akio Mizushima. Effects of once-yearly zoledronic acid on bone density and incident vertebral fractures in nonmetastatic castration-sensitive prostate cancer patients with osteoporosis.
BMC cancer.
2021 Apr; 21(1):422. doi:
10.1186/s12885-021-08177-w. [PMID: 33863312] - K Zhu, J Zhang, C Zhang, Z Zhao, J Gao, X Li, X Xia, X Xu, T Zhang, J Guan. Therapeutic efficacy of zoledronic acid combined with calcitriol in elderly patients receiving total hip arthroplasty or hemiarthroplasty for osteoporotic femoral neck fracture.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2021 Mar; 32(3):559-564. doi:
10.1007/s00198-020-05637-0. [PMID: 32989470] - Hirotaka Miyashita, Christina Cruz, Cardinale Smith. Risk factors of skeletal-related events in patients with bone metastasis from non-small cell lung cancer undergoing treatment with zoledronate-a post hoc analysis of a randomized clinical trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2021 Mar; 29(3):1629-1633. doi:
10.1007/s00520-020-05665-w. [PMID: 32747990] - Yasutomo Nakai, Tomohiro Kanaki, Akinaru Yamamoto, Ryo Tanaka, Yoshiyuki Yamamoto, Akira Nagahara, Masashi Nakayama, Ken-Ichi Kakimoto, Miki Ishibashi, Kazuo Nishimura. Antiresorptive agent-related osteonecrosis of the jaw in prostate cancer patients with bone metastasis treated with bone-modifying agents.
Journal of bone and mineral metabolism.
2021 Mar; 39(2):295-301. doi:
10.1007/s00774-020-01151-9. [PMID: 32886176] - Wei Lin, Xing-Fu Li, Dong-Cheng Ren, Meng Song, Li Duan, Jin-Zhu Liu, Zi-Rui Zhan. Administration of zoledronic acid alleviates osteoporosis in HIV patients by suppressing osteoclastogenesis via regulating RANKL expression.
Molecular medicine (Cambridge, Mass.).
2021 02; 27(1):19. doi:
10.1186/s10020-021-00276-5. [PMID: 33637048] - Xinlong Zang, Jingyi Zhou, Xiaoxu Zhang, Dawei Chen, Yantao Han, Xuehong Chen. Dual-targeting tumor cells and tumor associated macrophages with lipid coated calcium zoledronate for enhanced lung cancer chemoimmunotherapy.
International journal of pharmaceutics.
2021 Feb; 594(?):120174. doi:
10.1016/j.ijpharm.2020.120174. [PMID: 33338567] - Mariana Reza, Manfred Wirth, Teuvo Tammela, Virgilio Cicalese, Francisco Gomez Veiga, Peter Mulders, Kurt Miller, Andrea Tubaro, Frans Debruyne, Anup Patel, Christien Caris, Wim Witjes, Ola Thorsson, Per Wollmer, Lars Edenbrandt, Mattias Ohlsson, Elin Trägårdh, Anders Bjartell. Automated Bone Scan Index as an Imaging Biomarker to Predict Overall Survival in the Zometa European Study/SPCG11.
European urology oncology.
2021 02; 4(1):49-55. doi:
10.1016/j.euo.2019.05.002. [PMID: 31186177] - Kang Wei, Yuxing Qu, Yi Gao, Yong Ma. Comparison of Efficacy of Teriparatide (Parathyroid Hormone 1-34) Alone and in Combination with Zoledronic Acid for Osteoporosis in Postmenopausal Women.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2021 Feb; 31(2):240-242. doi:
10.29271/jcpsp.2021.02.240. [PMID: 33645201] - Hideyuki Harada, Naoto Shikama, Hitoshi Wada, Nobue Uchida, Miwako Nozaki, Kazushige Hayakawa, Kazunari Yamada, Hisayasu Nagakura, Hirofumi Ogawa, Kazunari Miyazawa, Hirohisa Katagiri, Naoki Nakamura. A phase II study of palliative radiotherapy combined with zoledronic acid hydrate for metastatic bone tumour from renal cell carcinoma.
Japanese journal of clinical oncology.
2021 Jan; 51(1):100-105. doi:
10.1093/jjco/hyaa158. [PMID: 32869095] - Gao Zhang, Hu Gong, Hanqiao Xu. Analysis of the Mechanism and Safety of Bisphosphonates in Patients with Lung Cancer and Bone Metastases.
Computational and mathematical methods in medicine.
2021; 2021(?):5343104. doi:
10.1155/2021/5343104. [PMID: 34938354] - Muhammad N A Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi. Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction.
Biological & pharmaceutical bulletin.
2021; 44(12):1902-1906. doi:
10.1248/bpb.b21-00717. [PMID: 34853276] - Kristin M D'Silva, Sara Jane Cromer, Elaine W Yu, Michael Fischer, Seoyoung C Kim. Risk of Incident Atrial Fibrillation With Zoledronic Acid Versus Denosumab: A Propensity Score-Matched Cohort Study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2021 01; 36(1):52-60. doi:
10.1002/jbmr.4174. [PMID: 33137852] - X-G Wu, D-Y Zhang, B-Q Zhu, A-M Li. Efficacy of zoledronic acid with percutaneous kyphoplasty/vertebroplasty in the treatment of osteoporotic vertebral compression fractures: a systematic review and meta-analysis.
European review for medical and pharmacological sciences.
2020 12; 24(23):12358-12367. doi:
10.26355/eurrev_202012_24030. [PMID: 33336756] - Hideomi Kondo, Nobukazu Okimoto, Toru Yoshioka, Shojiro Akahoshi, Yoshifumi Fuse, Takayuki Ogawa, Yuichi Okazaki, Yuji Katae, Manabu Tsukamoto, Yoshiaki Yamanaka, Makoto Kawasaki, Akinori Sakai. Zoledronic acid sequential therapy could avoid disadvantages due to the discontinuation of less than 3-year denosumab treatment.
Journal of bone and mineral metabolism.
2020 Nov; 38(6):894-902. doi:
10.1007/s00774-020-01126-w. [PMID: 32656645] - Ighovwerha Ofotokun, Lauren F Collins, Kehmia Titanji, Antonina Foster, Caitlin A Moran, Anandi N Sheth, Cecile D Lahiri, Jeffrey L Lennox, Laura Ward, Kirk A Easley, M Neale Weitzmann. Antiretroviral Therapy-Induced Bone Loss Is Durably Suppressed by a Single Dose of Zoledronic Acid in Treatment-Naive Persons with Human Immunodeficiency Virus Infection: A Phase IIB Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 10; 71(7):1655-1663. doi:
10.1093/cid/ciz1027. [PMID: 31621838] - Fatoumata Matokoma Sidibe, Moussa Bathily, Bourama Diarra, Aphou Sallé Kone, Koniba Diabate, Moussa Konate, Hamadoun Lamine Cisse, Ibrehima Guindo, Abdrahamane A Kone, Joseph Kone, Diakalia Berthe, Boubacar Z Ouattara, Yacouba Fofana, Aicha Sidibe, Abdou Aziz Akpa, Jean-Paul Dembele, Boubacari A Toure, Adama Diakite, Idrissa M Diarra, Abdoulaye C Kone, Modibo D Soumare, Daouda Minta, Soungalo Dao, Yacouba Toloba, Dapa A Diallo, Siaka Sidibe. [Gastrointestinal symptoms revealing COVID-19 in Malian breast cancer patient undergoing chemotherapy].
Bulletin du cancer.
2020 Oct; 107(10):1019-1023. doi:
10.1016/j.bulcan.2020.07.006. [PMID: 32972763] - Ofri Doppelt, Gal Cohen, Tal Tamari, Rina Elimelech, Nadin Sabbah, Hadar Zigdon-Giladi. Endothelial progenitors increase vascularization and improve fibroblasts function that prevent medication-related osteonecrosis of the jaw.
Oral diseases.
2020 Oct; 26(7):1523-1531. doi:
10.1111/odi.13412. [PMID: 32400918] - Andrea Giusti, Dario Camellino, Daniele Saverino, Erika Iervasi, Giuseppe Girasole, Gerolamo Bianchi, Socrates E Papapoulos. Zoledronate decreases CTLA-4 in vivo and in vitro independently of its action on bone resorption.
Bone.
2020 09; 138(?):115512. doi:
10.1016/j.bone.2020.115512. [PMID: 32603908] - Lucil Carril-Ajuria, Yuly A Remolina-Bonilla, Alberto Carretero-Gonzalez, Maricruz Martin-Soberon, Daniel Castellano, Christianne Bourlon, Guillermo de Velasco, Maria T Bourlon. Challenges of Treating a Patient With Advanced Prostate Cancer During the COVID-19 Pandemic.
Oncology (Williston Park, N.Y.).
2020 08; 34(8):317-319. doi:
10.46883/onc.2020.3408.0317. [PMID: 32785928] - Christina V Oleson, Ralph J Marino, Christopher S Formal, Christopher M Modlesky, Benjamin E Leiby. The effect of zoledronic acid on attenuation of bone loss at the hip and knee following acute traumatic spinal cord injury: a randomized-controlled study.
Spinal cord.
2020 Aug; 58(8):921-929. doi:
10.1038/s41393-020-0431-9. [PMID: 32055041] - Xavier Coutel, Guillaume Falgayrac, Guillaume Penel, Cécile Olejnik. Short-term high-dose zoledronic acid enhances crystallinity in mandibular alveolar bone in rats.
European journal of oral sciences.
2020 08; 128(4):284-291. doi:
10.1111/eos.12702. [PMID: 32430956] - J M Neves, J Cabete, C Fernandes. Nonuraemic cutaneous calciphylaxis: our experience with a challenging disease.
Clinical and experimental dermatology.
2020 Aug; 45(6):745-746. doi:
10.1111/ced.14242. [PMID: 32304580] - Ganesh Kasinathan. Primary plasma cell leukaemia in a 39-year-old man.
BMJ case reports.
2020 Jul; 13(7):. doi:
10.1136/bcr-2020-235543. [PMID: 32709663] - Celia Rodríguez-Olleros Rodríguez, Daniel Blanes Jacquart, Rosa Arboiro Pinel, Concha de la Piedra Gordo, María Jesús Moro Álvarez, Manuel Díaz Curiel. Long term effects on biochemical bone markers of a single infusion of zoledronic acid in Paget disease of bone.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.
2020 Jul; 25(4):715-718. doi:
10.1016/j.jos.2019.08.023. [PMID: 31669119] - Hirotaka Miyashita, Christina Cruz, Stephen Malamud. Risk factors for skeletal-related events in patients with bone metastasis from breast cancer undergoing treatment with zoledronate.
Breast cancer research and treatment.
2020 Jul; 182(2):381-388. doi:
10.1007/s10549-020-05712-4. [PMID: 32474744] - Xin Dai, Yongtao Deng, Yetao Luo, Jianghong Xie, Houxun Ma. Effect of different hydration doses on renal function in patients with primary osteoporosis treated with zoledronic acid: A hospital-based retrospective cohort study.
Medicine.
2020 Jun; 99(25):e20831. doi:
10.1097/md.0000000000020831. [PMID: 32569232] - Hiroshi Urakawa, Yuichi Ando, Tetsunari Hase, Toyone Kikumori, Eisuke Arai, Osamu Maeda, Ayako Mitsuma, Mihoko Sugishita, Tomoya Shimokata, Kunihiro Ikuta, Naoki Ishiguro, Yoshihiro Nishida. Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study.
International journal of cancer.
2020 06; 146(12):3504-3515. doi:
10.1002/ijc.32836. [PMID: 31846063] - Lijia Cui, Yuping Xu, Qiming Xu, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Weibo Xia. Atypical Femoral Fracture Associated With Overuse of Bisphosphonate Evaluated by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT).
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.
2020 Apr; 23(2):329-334. doi:
10.1016/j.jocd.2018.07.009. [PMID: 30172602] - S Demircan, S C Isler. Changes in serological bone turnover markers in bisphosphonate induced osteonecrosis of the jaws: A case control study.
Nigerian journal of clinical practice.
2020 Feb; 23(2):154-158. doi:
10.4103/njcp.njcp_374_19. [PMID: 32031088] - Taisuke Uchida, Hideki Yamaguchi, Chinami Kushima, Tadato Yonekawa, Masamitsu Nakazato. Elevated levels of circulating fibroblast growth factor 23 with hypercalcemia following discontinuation of denosumab.
Endocrine journal.
2020 Jan; 67(1):31-35. doi:
10.1507/endocrj.ej19-0198. [PMID: 31527321] - Xin-Jun Cai, Wei-Dong Fei, Ying-Ying Xu, Hong Xu, Gao-Yi Yang, Jia-Wei Cao, Jian-Jun Ni, Kaiyi Tao, Zeng Wang. Liposome-Encapsulated Zoledronate Favors Tumor Vascular Normalization and Enhances Anticancer Efficacy of Cisplatin.
AAPS PharmSciTech.
2020 Jan; 21(2):57. doi:
10.1208/s12249-019-1614-6. [PMID: 31912318] - Erofili Papadopoulou, Ourania Nicolatou-Galitis, Ioannis Papassotiriou, Helena Linardou, Aikaterini Karagianni, Konstantinos Tsixlakis, Anthi Tarampikou, Kelly Michalakakou, Emmanouil Vardas, Dimitrios Bafaloukos. The use of crevicular fluid to assess markers of inflammation and angiogenesis, IL-17 and VEGF, in patients with solid tumors receiving zoledronic acid and/or bevacizumab.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2020 Jan; 28(1):177-184. doi:
10.1007/s00520-019-04793-2. [PMID: 31001696] - Shuaihao Huang, Xiaowen Zhu, Dan Xiao, Jianxiong Zhuang, Guoyan Liang, Changxiang Liang, Xiaoqing Zheng, Yuhong Ke, Yunbing Chang. Therapeutic effect of percutaneous kyphoplasty combined with anti-osteoporosis drug on postmenopausal women with osteoporotic vertebral compression fracture and analysis of postoperative bone cement leakage risk factors: a retrospective cohort study.
Journal of orthopaedic surgery and research.
2019 Dec; 14(1):452. doi:
10.1186/s13018-019-1499-9. [PMID: 31852483] - Tal Tamari, Rina Elimelech, Gal Cohen, Talia Cohen, Ofri Doppelt, Lana Eskander-Hashoul, Hadar Zigdon-Giladi. Endothelial Progenitor Cells inhibit jaw osteonecrosis in a rat model: A major adverse effect of bisphosphonate therapy.
Scientific reports.
2019 12; 9(1):18896. doi:
10.1038/s41598-019-55383-5. [PMID: 31827217] - Jun Xie, Shaohua Li, Lianbo Xiao, Guilin Ouyang, Lin Zheng, Yubiao Gu, Chengxin Gao, Xiuwei Han. Zoledronic acid ameliorates the effects of secondary osteoporosis in rheumatoid arthritis patients.
Journal of orthopaedic surgery and research.
2019 Dec; 14(1):421. doi:
10.1186/s13018-019-1492-3. [PMID: 31823822] - Marielly Sierra, Milliette Alvarado, Margarita Ramírez, Loida González, Solalba Bueno. Hypercalcemia of Malignancy in a Patient with Hypoparathyroidism: A Complicated but Treatable Condition.
Puerto Rico health sciences journal.
2019 12; 38(4):275-277. doi:
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Computational biology and chemistry.
2019 Dec; 83(?):107097. doi:
10.1016/j.compbiolchem.2019.107097. [PMID: 31446368] - Andrew Carr, Stephen J Kerr, Robyn Richardson, Peter Ebeling, Nicholas Pocock, Jhon Rojas, Esteban Martinez, Jennifer Hoy. Prolonged Effect of Zoledronic Acid on Bone Mineral Density and Turnover in HIV-Infected Adults on Tenofovir: A Randomized, Open-Label Study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2019 12; 34(12):2192-2197. doi:
10.1002/jbmr.3834. [PMID: 31361922] - Daniel Steller, Nele Herbst, Ralph Pries, David Juhl, Matthias Klinger, Samer G Hakim. Impacts of platelet-rich fibrin and platelet-rich plasma on primary osteoblast adhesion onto titanium implants in a bisphosphonate in vitro model.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2019 Nov; 48(10):943-950. doi:
10.1111/jop.12944. [PMID: 31400171] - Lizhi Tang, Guangwen Chen, Qin Wang, Jobin John, Chunyan Lu. Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report.
Medicine.
2019 Nov; 98(48):e18161. doi:
10.1097/md.0000000000018161. [PMID: 31770261] - Elizabeth A Swallow, Mohammad W Aref, Corinne E Metzger, Spencer Sacks, Demi R Lehmkuhler, Neal Chen, Max A Hammond, Paul R Territo, Thomas L Nickolas, Sharon M Moe, Matthew R Allen. Skeletal levels of bisphosphonate in the setting of chronic kidney disease are independent of remodeling rate and lower with fractionated dosing.
Bone.
2019 10; 127(?):419-426. doi:
10.1016/j.bone.2019.07.007. [PMID: 31299384] - Takuya Imatoh, Kimie Sai, Mayu Takeyama, Katsunori Segawa, Takanori Yamashita, Naoki Nakashima, Yoko Kataoka, Hideto Yokoi, Tatsuo Hiramatsu, Kazuhiko Ohe, Michio Kimura, Katsuhito Hori, Junichi Kawakami, Yoshiro Saito. Evaluating the impact of regulatory action on denosumab-induced hypocalcaemia in Japan.
Journal of clinical pharmacy and therapeutics.
2019 Oct; 44(5):788-795. doi:
10.1111/jcpt.13004. [PMID: 31282013] - Reham Hussein Mohamed, Maha Tarek, Ghada Galal Hamam, Samar F Ezzat. Zoledronic acid prevents the hepatic changes associated with high fat diet in rats; the potential role of mevalonic acid pathway in nonalcoholic steatohepatitis.
European journal of pharmacology.
2019 Sep; 858(?):172469. doi:
10.1016/j.ejphar.2019.172469. [PMID: 31233751] - Stefanie de Groot, Hanno Pijl, Ayoub Charehbili, Saskia van de Ven, Vincent T H B M Smit, Elma Meershoek-Klein Kranenbarg, Joan B Heijns, Laurence J C van Warmerdam, Lonneke W Kessels, M Wouter Dercksen, Manon J A E Pepels, Hanneke W M van Laarhoven, Birgit E P J Vriens, Hein Putter, Marta Fiocco, Gerrit-Jan Liefers, Jacobus J M van der Hoeven, Johan W R Nortier, Judith R Kroep. Addition of zoledronic acid to neoadjuvant chemotherapy is not beneficial in patients with HER2-negative stage II/III breast cancer: 5-year survival analysis of the NEOZOTAC trial (BOOG 2010-01).
Breast cancer research : BCR.
2019 08; 21(1):97. doi:
10.1186/s13058-019-1180-6. [PMID: 31455425] - Tingting Zhang, Fubin Feng, Yan Yao, Lingyu Qi, Jinhui Tian, Chao Zhou, Shengjie Dong, Xue Wang, Changgang Sun. Efficacy and acceptability of neoadjuvant endocrine therapy in patients with hormone receptor-positive breast cancer: A network meta-analysis.
Journal of cellular physiology.
2019 08; 234(8):12393-12403. doi:
10.1002/jcp.28068. [PMID: 30652307] - C M Gordon, R H Cleveland, K Baltrusaitis, J Massaro, R B D'Agostino, M G Liang, B Snyder, M Walters, X Li, D T Braddock, M E Kleinman, M W Kieran, L B Gordon. Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.
Bone.
2019 08; 125(?):103-111. doi:
10.1016/j.bone.2019.05.008. [PMID: 31077852] - Wentong Sun, Kun Ge, Yan Jin, Yu Han, Haisong Zhang, Guoqiang Zhou, Xinjian Yang, Dandan Liu, Huifang Liu, Xing-Jie Liang, Jinchao Zhang. Bone-Targeted Nanoplatform Combining Zoledronate and Photothermal Therapy To Treat Breast Cancer Bone Metastasis.
ACS nano.
2019 07; 13(7):7556-7567. doi:
10.1021/acsnano.9b00097. [PMID: 31259530] - J Zhang, T Zhang, X Xu, Q Cai, D Zhao. Zoledronic acid combined with percutaneous kyphoplasty in the treatment of osteoporotic compression fracture in a single T12 or L1 vertebral body in postmenopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2019 Jul; 30(7):1475-1480. doi:
10.1007/s00198-019-04896-w. [PMID: 30976888] - Marisela Tan, Evan Kalin-Hajdu, Rupa Narayan, Sandy W Wong, Thomas G Martin. Zoledronic acid-induced orbital inflammation in a patient with multiple myeloma.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2019 Jul; 25(5):1253-1257. doi:
10.1177/1078155218785967. [PMID: 30005587] - Daniel Steller, Nele Herbst, Ralph Pries, David Juhl, Samer G Hakim. Positive impact of Platelet-rich plasma and Platelet-rich fibrin on viability, migration and proliferation of osteoblasts and fibroblasts treated with zoledronic acid.
Scientific reports.
2019 06; 9(1):8310. doi:
10.1038/s41598-019-43798-z. [PMID: 31165745] - Zhong Liu, Chun-Wen Li, Yi-Fan Mao, Kang Liu, Bo-Cheng Liang, Lian-Guo Wu, Xiao-Lin Shi. Study on Zoledronic Acid Reducing Acute Bone Loss and Fracture Rates in Elderly Postoperative Patients with Intertrochanteric Fractures.
Orthopaedic surgery.
2019 Jun; 11(3):380-385. doi:
10.1111/os.12460. [PMID: 31058448] - Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian C Gaertner, Markus Essler, Ralph A Bundschuh. Preliminary results of biodistribution and dosimetric analysis of [68Ga]Ga-DOTAZOL: a new zoledronate-based bisphosphonate for PET/CT diagnosis of bone diseases.
Annals of nuclear medicine.
2019 Jun; 33(6):404-413. doi:
10.1007/s12149-019-01348-7. [PMID: 30877560] - Congcong Wu, Wenjun Chen, Jian Wu, Xi Zhang, Xuanzhang Huang, Ruifang Lin, Baoling Zhu, Hua Jiang. Effect of bisphosphonates on overall survival in subgroups of patients with prostate cancer.
Clinical & experimental metastasis.
2019 06; 36(3):199-209. doi:
10.1007/s10585-019-09963-4. [PMID: 30963355]