Nefazodone hydrochloride (BioDeep_00000732712)
代谢物信息卡片
Nefazodone hydrochloride
化学式: C25H33Cl2N5O2 (505.2011)
中文名称: 奈法唑酮盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:7495
- KEGGdrug: D00819
- PubChem: 54911
- ChEMBL: CHEMBL1200492
- CAS: 82752-99-6
- medchemexpress: HY-B1396
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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1995 Oct; 58(4):390-8. doi:
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Journal of clinical psychopharmacology.
1995 Oct; 15(5):320-6. doi:
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Journal of clinical pharmacology.
1995 Oct; 35(10):974-84. doi:
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British journal of clinical pharmacology.
1995 Aug; 40(2):161-5. doi:
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Journal of clinical pharmacology.
1995 Aug; 35(8):830-9. doi:
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Journal of clinical pharmacology.
1995 Jul; 35(7):730-8. doi:
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Journal of clinical psychopharmacology.
1995 Feb; 15(1):30-40. doi:
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European journal of clinical pharmacology.
1995; 49(3):221-8. doi:
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European journal of clinical pharmacology.
1995; 49(3):229-35. doi:
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Life sciences.
1995; 57(24):PL373-80. doi:
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1994 Aug; 14(4):268-73. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1994 Mar; 22(2):304-11. doi:
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Fundamental & clinical pharmacology.
1994; 8(5):463-73. doi:
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1994; 55(7):479-83. doi:
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Journal of pharmaceutical and biomedical analysis.
1993 Nov; 11(11-12):1109-13. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1993 May; 21(3):502-7. doi:
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Biological psychiatry.
1993 Jan; 33(2):115-9. doi:
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European journal of drug metabolism and pharmacokinetics.
1992 Oct; 17(4):309-18. doi:
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European journal of drug metabolism and pharmacokinetics.
1992 Oct; 17(4):301-8. doi:
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