Nefazodone hydrochloride (BioDeep_00000732712)
代谢物信息卡片
Nefazodone hydrochloride
化学式: C25H33Cl2N5O2 (505.2011178)
中文名称: 奈法唑酮盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:7495
- KEGGdrug: D00819
- PubChem: 54911
- ChEMBL: CHEMBL1200492
- CAS: 82752-99-6
- medchemexpress: HY-B1396
分类词条
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代谢反应
0 个相关的代谢反应过程信息。
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文献列表
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Journal of clinical psychopharmacology.
1995 Oct; 15(5):320-6. doi:
10.1097/00004714-199510000-00003. [PMID: 8830062] - R H Barbhaiya, P H Marathe, D S Greene, R F Mayol, U A Shukla, R R Gammans, K A Pittman, D Robinson. Safety, tolerance, and preliminary pharmacokinetics of nefazodone after administration of single and multiple oral doses to healthy adult male volunteers: a double-blind, phase I study.
Journal of clinical pharmacology.
1995 Oct; 35(10):974-84. doi:
10.1002/j.1552-4604.1995.tb04013.x. [PMID: 8568015] - R H Barbhaiya, U A Shukla, D S Greene. Lack of interaction between nefazodone and cimetidine: a steady state pharmacokinetic study in humans.
British journal of clinical pharmacology.
1995 Aug; 40(2):161-5. doi:
10.1111/j.1365-2125.1995.tb05771.x. [PMID: 8562300] - S Kaul, U A Shukla, R H Barbhaiya. Nonlinear pharmacokinetics of nefazodone after escalating single and multiple oral doses.
Journal of clinical pharmacology.
1995 Aug; 35(8):830-9. doi:
10.1002/j.1552-4604.1995.tb04127.x. [PMID: 8522641] - D E Salazar, R C Dockens, R L Milbrath, R H Raymond, I E Fulmor, P C Chaikin, H D Uderman. Pharmacokinetic and pharmacodynamic evaluation of warfarin and nefazodone coadministration in healthy subjects.
Journal of clinical pharmacology.
1995 Jul; 35(7):730-8. doi:
10.1002/j.1552-4604.1995.tb04114.x. [PMID: 7560254] - M W van Laar, A P van Willigenburg, E R Volkerts. Acute and subchronic effects of nefazodone and imipramine on highway driving, cognitive functions, and daytime sleepiness in healthy adult and elderly subjects.
Journal of clinical psychopharmacology.
1995 Feb; 15(1):30-40. doi:
10.1097/00004714-199502000-00006. [PMID: 7714226] - R H Barbhaiya, U A Shukla, D S Greene. Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment.
European journal of clinical pharmacology.
1995; 49(3):221-8. doi:
10.1007/bf00192383. [PMID: 8665999] - R H Barbhaiya, M E Brady, U A Shukla, D S Greene. Steady-state pharmacokinetics of nefazodone in subjects with normal and impaired renal function.
European journal of clinical pharmacology.
1995; 49(3):229-35. doi:
10.1007/bf00192384. [PMID: 8666000] - M J Owens, J R Ieni, D L Knight, K Winders, C B Nemeroff. The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies.
Life sciences.
1995; 57(24):PL373-80. doi:
10.1016/0024-3205(95)02222-5. [PMID: 7475971] - A E Walsh, P J Cowen. Attenuation of the prolactin-stimulating and hyperthermic effects of nefazodone after subacute treatment.
Journal of clinical psychopharmacology.
1994 Aug; 14(4):268-73. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1994 Mar; 22(2):304-11. doi:
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Fundamental & clinical pharmacology.
1994; 8(5):463-73. doi:
10.1111/j.1472-8206.1994.tb00827.x. [PMID: 7875642] - S K Hemrick-Luecke, H D Snoddy, R W Fuller. Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo.
Life sciences.
1994; 55(7):479-83. doi:
10.1016/0024-3205(94)00739-x. [PMID: 8041227] - M Franklin. Determination of nefazodone and its metabolites in plasma by high-performance liquid chromatography with coulometric detection.
Journal of pharmaceutical and biomedical analysis.
1993 Nov; 11(11-12):1109-13. doi:
10.1016/0731-7085(93)80090-n. [PMID: 8123721] - U A Shukla, P H Marathe, K A Pittman, R H Barbhaiya. Pharmacokinetics, absolute bioavailability, and disposition of [14C]nefazodone in the dog.
Drug metabolism and disposition: the biological fate of chemicals.
1993 May; 21(3):502-7. doi:
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Biological psychiatry.
1993 Jan; 33(2):115-9. doi:
10.1016/0006-3223(93)90310-a. [PMID: 8382534] - U A Shukla, S Kaul, P H Marathe, K A Pittman, R H Barbhaiya. Pharmacokinetics of nefazodone following multiple escalating oral doses in the dog.
European journal of drug metabolism and pharmacokinetics.
1992 Oct; 17(4):309-18. doi:
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European journal of drug metabolism and pharmacokinetics.
1992 Oct; 17(4):301-8. doi:
10.1007/bf03190163. [PMID: 1301360] - J E Franc, G F Duncan, R H Farmen, K A Pittman. High-performance liquid chromatographic method for the determination of nefazodone and its metabolites in human plasma using laboratory robotics.
Journal of chromatography.
1991 Sep; 570(1):129-38. doi:
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