Orbifloxacin (BioDeep_00000732711)
代谢物信息卡片
Orbifloxacin
化学式: C19H20F3N3O3 (395.1456686)
中文名称: 奥比沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)F)C(=O)C(=CN3C4CC4)C(=O)O)F
InChI: InChI=1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:183823
- KEGGdrug: D91881
- KEGGdrug: D08299
- PubChem: 60605
- DrugBank: DB11443
- ChEMBL: CHEMBL295433
- CAS: 113617-63-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fang Yang, Dan Liu, Chao Yang, Zhe-Wen Song, Hao-Tian Shao, Mei Zhang, Chao-Shuo Zhang, Zhen-Dong Zhang, Fan Yang. Development and application of a physiologically based pharmacokinetic model for orbifloxacin in crucian carp (Carassius auratus).
Journal of veterinary pharmacology and therapeutics.
2022 May; 45(3):311-319. doi:
10.1111/jvp.13049. [PMID: 35243644] - Tetsuro Kuramae, Shingo Ishikawa, Aki Kono, Seiji Hobo. Pharmacokinetics in plasma and alveolar regions of a healthy calf intramuscularly administered a single dose of orbifloxacin.
The Journal of veterinary medical science.
2022 Mar; 84(3):400-405. doi:
10.1292/jvms.21-0517. [PMID: 35095059] - F Yang, F Yang, W Shi, H Si, T Kong, G Wang, J Zhang. Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits.
Journal of veterinary pharmacology and therapeutics.
2018 Aug; 41(4):622-631. doi:
10.1111/jvp.12496. [PMID: 29457247] - F Yang, F Yang, G Wang, W Shi, T Kong, P Yang, D Bai, B Zhou. Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration.
Journal of veterinary pharmacology and therapeutics.
2018 Aug; 41(4):599-604. doi:
10.1111/jvp.12495. [PMID: 29465160] - Takae Shimizu, Kazuki Harada, Saki Manabe, Taku Tsukamoto, Norihiko Ito, Yoshiaki Hikasa. Assessment of urinary pharmacokinetics and pharmacodynamics of orbifloxacin in healthy dogs with ex vivo modelling.
Journal of medical microbiology.
2017 May; 66(5):616-621. doi:
10.1099/jmm.0.000476. [PMID: 28470147] - Kazuki Harada, Atsushi Sasaki, Takae Shimizu. Effects of oral orbifloxacin on fecal coliforms in healthy cats: a pilot study.
The Journal of veterinary medical science.
2016 Jan; 78(1):83-9. doi:
10.1292/jvms.15-0407. [PMID: 26311787] - Megan K Watson, Luke A Wittenburg, Christine T Bui, Kira A Jarosz, Daniel L Gustafson, Matthew S Johnston. Pharmacokinetics and bioavailability of orbifloxacin oral suspension in New Zealand White rabbits (Oryctolagus cuniculus).
American journal of veterinary research.
2015 Nov; 76(11):946-51. doi:
10.2460/ajvr.76.11.946. [PMID: 26512539] - G B Dudhatra, Avinash Kumar, M M Awale, D R Kamani, B N Chauhan, H B Patel, S K Mody. Determination of orbifloxacin in sheep plasma by high performance liquid chromatography with ultraviolet detection after intravenous and intramuscular administration.
Journal of pharmacological and toxicological methods.
2013 Jan; 67(1):50-3. doi:
10.1016/j.vascn.2012.11.002. [PMID: 23231925] - Elias Gebru Awji, Dereje Damte Tassew, Joong-Su Lee, Seung-Jin Lee, Myung-Jin Choi, Mohammad Ahsanur Reza, Man-Hee Rhee, Tae-Hwan Kim, Seung-Chun Park. Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius.
Veterinary dermatology.
2012 Aug; 23(4):376-80, e68. doi:
10.1111/j.1365-3164.2012.01038.x. [PMID: 22409306] - Huan Yu, Yanfei Tao, Dongmei Chen, Yuanhu Pan, Zhenli Liu, Yulian Wang, Lingli Huang, Menghong Dai, Dapeng Peng, Xu Wang, Zonghui Yuan. Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Feb; 885-886(?):150-9. doi:
10.1016/j.jchromb.2011.12.016. [PMID: 22230742] - M A Tohamy. Comparative pharmacokinetics of orbifloxacin in healthy and Pasteurella multocida infected ducks.
British poultry science.
2011 Oct; 52(5):639-44. doi:
10.1080/00071668.2011.616953. [PMID: 22029792] - A Goudah, H-J Cho, H-C Shin, J-H Shim, N L Regmi, M Shimoda, A M Abd El-Aty. Pharmacokinetics and milk distribution characteristics of orbifloxacin following intravenous and intramuscular injection in lactating ewes.
Journal of veterinary pharmacology and therapeutics.
2009 Aug; 32(4):338-44. doi:
10.1111/j.1365-2885.2008.01046.x. [PMID: 19614838] - G Elias, J-S Lee, M-H Hwang, Y-S Park, K-H Cho, Y-H Kim, S-C Park. Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle.
Journal of veterinary pharmacology and therapeutics.
2009 Jun; 32(3):219-28. doi:
10.1111/j.1365-2885.2008.01027.x. [PMID: 19646085] - A M Abd El-Aty, Jeong-Heui Choi, Ma-Wou Ko, Sathya Khay, Ayman Goudah, Ho-Chul Shin, Jin-Suk Kim, Byung-Joon Chang, Chi-Ho Lee, Jae-Han Shim. Approaches for application of sub and supercritical fluid extraction for quantification of orbifloxacin from plasma and milk: application to disposition kinetics.
Analytica chimica acta.
2009 Jan; 631(1):108-15. doi:
10.1016/j.aca.2008.10.023. [PMID: 19046687] - Tao Ding, Dongxu Shen, Jinzhong Xu, Bin Wu, Huilan Chen, Chongyu Shen, Weijian Shen, Zengyun Zhao, Hongzhen Lian. [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2009 Jan; 27(1):34-8. doi:
". [PMID: 19449537] - E J Llorent-Martínez, P Ortega-Barrales, A Molina-Díaz, A Ruiz-Medina. Implementation of terbium-sensitized luminescence in sequential-injection analysis for automatic analysis of orbifloxacin.
Analytical and bioanalytical chemistry.
2008 Dec; 392(7-8):1397-403. doi:
10.1007/s00216-008-2434-9. [PMID: 18958455] - P Marín, E Fernández-Varón, E Escudero, D Vancraeynest, C M Cárceles. Pharmacokinetic-pharmacodynamic integration of orbifloxacin in rabbits after intravenous, subcutaneous and intramuscular administration.
Journal of veterinary pharmacology and therapeutics.
2008 Feb; 31(1):77-82. doi:
10.1111/j.1365-2885.2007.00927.x. [PMID: 18177323] - P Marín, E Escudero, E Fernández-Varón, C M Cárceles. Pharmacokinetics and milk penetration of orbifloxacin after intravenous, subcutaneous, and intramuscular administration to lactating goats.
Journal of dairy science.
2007 Sep; 90(9):4219-25. doi:
10.3168/jds.2007-0071. [PMID: 17699040] - J L Davis, M G Papich, A Weingarten. The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration.
Journal of veterinary pharmacology and therapeutics.
2006 Jun; 29(3):191-7. doi:
10.1111/j.1365-2885.2006.00737.x. [PMID: 16669863] - N L Regmi, A M Abd El-Aty, M Kuroha, M Nakamura, M Shimoda. Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs.
Journal of veterinary pharmacology and therapeutics.
2005 Dec; 28(6):553-7. doi:
10.1111/j.1365-2885.2005.00698.x. [PMID: 16343288] - E Heinen. Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration.
Journal of veterinary pharmacology and therapeutics.
2002 Feb; 25(1):1-5. doi:
10.1046/j.1365-2885.2002.00381.x. [PMID: 11874520] - Patricia A Kay-Mugford, Allan J Weingarten, Maureen Ngoh, Robert Zolynas, Amy White, Terry Katz, Robert Simmons, Kanwal J Varma. Determination of plasma and skin concentrations of orbifloxacin in dogs with clinically normal skin and dogs with pyoderma.
Veterinary therapeutics : research in applied veterinary medicine.
2002; 3(4):402-8. doi:
NULL. [PMID: 12584677] - G R Haines, M P Brown, R R Gronwall, K A Merritt, L K Baltzley. Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2001 Jul; 65(3):181-7. doi:
NULL. [PMID: 11480524] - S Matsumoto, M Nakai, M Yoshida, H Katae. A study of metabolites isolated from urine samples of pigs and calves administered orbifloxacin.
Journal of veterinary pharmacology and therapeutics.
1999 Aug; 22(4):286-9. doi:
10.1046/j.1365-2885.1999.00223.x. [PMID: 10499242] - M A García, C Solans, J J Aramayona, S Rueda, M A Bregante. Determination of orbifloxacin in rabbit plasma by high-performance liquid chromatography with fluorescence detection.
Journal of chromatographic science.
1999 Jun; 37(6):199-202. doi:
10.1093/chromsci/37.6.199. [PMID: 10376341] - S Matsumoto, M Takahashi, N Kitadai, H Katae. A study of metabolites isolated from the urine samples of cats and dogs administered orbifloxacin.
The Journal of veterinary medical science.
1998 Nov; 60(11):1259-61. doi:
10.1292/jvms.60.1259. [PMID: 9853310]