Manidipine hydrochloride (BioDeep_00000732708)
代谢物信息卡片
Manidipine dihydrochloride
化学式: C35H40Cl2N4O6 (682.2324760000001)
中文名称: 盐酸马尼地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl
InChI: 2*1H
描述信息
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31800
- KEGGdrug: D01553
- PubChem: 150762
- ChEMBL: CHEMBL2362693
- CAS: 126229-12-7
- CAS: 89226-75-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohammad Hassan Baig, Tanuj Sharma, Irfan Ahmad, Mohammed Abohashrh, Mohammad Mahtab Alam, Jae-June Dong. Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study.
Molecules (Basel, Switzerland).
2021 Mar; 26(6):. doi:
10.3390/molecules26061678. [PMID: 33802860] - Isabela Teresa Santos Correa, Thais Alves da Costa-Silva, Andre Gustavo Tempone. Bioenergetics impairment of Trypanosoma cruzi by the antihypertensive manidipine: A drug repurposing strategy.
Acta tropica.
2021 Feb; 214(?):105768. doi:
10.1016/j.actatropica.2020.105768. [PMID: 33245907] - Vinayender Adireddy, Bhavani Prasanna Kumar Bimireddy, Venkateswarlu Ponneri. Enantioselective determination of R-(-)-manidipine and S-(+)-manidipine in human plasma by a sensitive and selective chiral LC-MS/MS assay.
Biomedical chromatography : BMC.
2017 Dec; 31(12):. doi:
10.1002/bmc.4027. [PMID: 28617978] - Alberto Montanari, Davide Lazzeroni, Giovanna Pelà, Antonio Crocamo, Yuliya Lytvyn, Luisa Musiari, Aderville Cabassi, David Z I Cherney. Calcium channel blockade blunts the renal effects of acute nitric oxide synthase inhibition in healthy humans.
American journal of physiology. Renal physiology.
2017 05; 312(5):F870-F878. doi:
10.1152/ajprenal.00568.2016. [PMID: 28179255] - Margarita Saiz-Satjes, Francisco Javier Martinez-Martin, Alex Roca-Cusachs. Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: differential effect of manidipine versus amlodipine.
Future cardiology.
2017 03; 13(2):143-151. doi:
10.2217/fca-2016-0046. [PMID: 27885840] - Evangelos N Liberopoulos, Elisavet Moutzouri, Christos V Rizos, Fotis Barkas, George Liamis, Moses S Elisaf. Effects of manidipine plus rosuvastatin versus olmesartan plus rosuvastatin on markers of insulin resistance in patients with impaired fasting glucose, hypertension, and mixed dyslipidemia.
Journal of cardiovascular pharmacology and therapeutics.
2013 Mar; 18(2):113-8. doi:
10.1177/1074248412463611. [PMID: 23113965] - Christian Ott, Markus P Schneider, Ulrike Raff, Martin Ritt, Kristina Striepe, Marco Alberici, Roland E Schmieder. Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension.
British journal of clinical pharmacology.
2013 Jan; 75(1):129-35. doi:
10.1111/j.1365-2125.2012.04336.x. [PMID: 23240643] - Piero Ruggenenti, Giuseppe Lauria, Ilian Petrov Iliev, Anna Fassi, Aneliya Parvanova Ilieva, Stefano Rota, Carlos Chiurchiu, Drazenka Pongrac Barlovic, Angelo Sghirlanzoni, Raffaella Lombardi, Paola Penza, Guido Cavaletti, Maria Luisa Piatti, Barbara Frigeni, Marco Filipponi, Nadia Rubis, Greta Noris, Nicola Motterlini, Bogdan Ene-Iordache, Flavio Gaspari, Annalisa Perna, Jelka Zaletel, Antonio Bossi, Alessandro Roberto Dodesini, Roberto Trevisan, Giuseppe Remuzzi. Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.
Hypertension (Dallas, Tex. : 1979).
2011 Nov; 58(5):776-83. doi:
10.1161/hypertensionaha.111.174474. [PMID: 21931073] - Francisco J Martinez-Martin, Alicia Macias-Batista, Cristina Comi-Diaz, Herminia Rodriguez-Rosas, Paula Soriano-Perera, Pablo Pedrianes-Martin. Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study.
Clinical drug investigation.
2011; 31(3):201-12. doi:
10.2165/11587590-000000000-00000. [PMID: 21155616] - Nieves Martell-Claros, Juan Jose de la Cruz. Manidipine for hypertension not controlled by dual therapy in patients with diabetes mellitus: a non-comparative, open-label study.
Clinical drug investigation.
2011; 31(6):427-34. doi:
10.2165/11587400-000000000-00000. [PMID: 21528940] - M C Viñolo López, P C Gutiérrez Rivas, A Liébana Cañada, J M Gil Cunquero, E Merino García. Clinical case: Peritoneal dialysis patient with cloudy peritoneal fluid following administration of calcium antagonists.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2011; 31(5):624. doi:
10.3265/nefrologia.pre2011.jun.10968. [PMID: 21959742] - Francisco Javier Martínez Martín. Manidipine in hypertensive patients with metabolic syndrome: the MARIMBA study.
Expert review of cardiovascular therapy.
2009 Jul; 7(7):863-9. doi:
10.1586/erc.09.53. [PMID: 19589122] - Osvaldo Kohlmann, Alejandro Roca-Cusachs, Stéphane Laurent, Roland E Schmieder, René R Wenzel, Roberto Fogari. Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.
Advances in therapy.
2009 Mar; 26(3):313-24. doi:
10.1007/s12325-009-0015-8. [PMID: 19330493] - Luca Cavalieri, Giovanni Cremonesi. Metabolic effects of manidipine.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2009; 9(3):163-76. doi:
10.1007/bf03256573. [PMID: 19463022] - Giuseppe Rossoni, Barbara Manfredi, Maurizio Civelli, Ferruccio Berti, Roberta Razzetti. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats.
European journal of pharmacology.
2008 Jun; 587(1-3):224-30. doi:
10.1016/j.ejphar.2008.03.026. [PMID: 18442813] - Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Pierangelo Lazzari, Luca Corradi, Paola Preti, Amedeo Mugellini. Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients.
Internal medicine (Tokyo, Japan).
2008; 47(5):361-6. doi:
10.2169/internalmedicine.47.0449. [PMID: 18310964] - Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Andrea Rinaldi, Paola Preti, Pierangelo Lazzari, Amedeo Mugellini. Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jan; 31(1):43-50. doi:
10.1291/hypres.31.43. [PMID: 18360017] - Roberto Fogari, Luca Corradi, Annalisa Zoppi, Pierangelo Lazzari, Amedeo Mugellini, Paola Preti, Andrea Rinaldi. Addition of manidipine improves the antiproteinuric effect of candesartan in hypertensive patients with type II diabetes and microalbuminuria.
American journal of hypertension.
2007 Oct; 20(10):1092-6. doi:
10.1016/j.amjhyper.2007.05.012. [PMID: 17903693] - Jing Jing, Weichao Ren, Xijing Chen, Hui He, Wei Zhou, Xuping Zhu, Ya Sun, Guangji Wang. Determination and pharmacokinetics of manidipine in human plasma by HPLC/ESIMS.
Biomedical chromatography : BMC.
2007 Aug; 21(8):836-40. doi:
10.1002/bmc.827. [PMID: 17428020] - Tsukasa Uno, Tadashi Ohkubo, Shigeru Motomura, Kazunobu Sugawara. Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects.
British journal of clinical pharmacology.
2006 May; 61(5):533-7. doi:
10.1111/j.1365-2125.2006.02583.x. [PMID: 16669846] - Sylvain Richard. Vascular effects of calcium channel antagonists: new evidence.
Drugs.
2005; 65 Suppl 2(?):1-10. doi:
10.2165/00003495-200565002-00002. [PMID: 16398057] - Alex Roca-Cusachs, Filippos Triposkiadis. Antihypertensive effect of manidipine.
Drugs.
2005; 65 Suppl 2(?):11-9. doi:
10.2165/00003495-200565002-00003. [PMID: 16398058] - René R Wenzel. Renal protection in hypertensive patients: selection of antihypertensive therapy.
Drugs.
2005; 65 Suppl 2(?):29-39. doi:
10.2165/00003495-200565002-00005. [PMID: 16398060] - A Mugellini, P Preti, A Zoppi, L Corradi, E Fogari, G Derosa, R Fogari. Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus.
Journal of human hypertension.
2004 Oct; 18(10):687-91. doi:
10.1038/sj.jhh.1001726. [PMID: 15071488] - Hiroshi Yamanari, Kazufumi Nakamura, Mikio Kakishita, Tohru Ohe. Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.
Clinical cardiology.
2004 Sep; 27(9):523-7. doi:
10.1002/clc.4960270911. [PMID: 15471166] - Hajime Ueshiba, Yukitaka Miyachi. Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.
Internal medicine (Tokyo, Japan).
2004 Jul; 43(7):561-5. doi:
10.2169/internalmedicine.43.561. [PMID: 15335180] - Lucia Del Vecchio, Marco Pozzi, Antonio Salvetti, Giuseppe Maschio, Maurizio Fusaroli, Carlo Rovati, Francesco Antonucci, Carmelo Cascone, Flavio Scanferla, Vincenzo Panichi, Alessandra Sturani, Francesco Locatelli. Efficacy and tolerability of manidipine in the treatment of hypertension in patients with non-diabetic chronic kidney disease without glomerular disease. Prospective, randomized, double-blind study of parallel groups in comparison with enalapril.
Journal of nephrology.
2004 Mar; 17(2):261-9. doi:
NULL. [PMID: 15293527] - Guido Bellinghieri, Giampiero Mazzaglia, Vincenzo Savica, Domenico Santoro. Effects of manidipine and nifedipine on blood pressure and renal function in patients with chronic renal failure: a multicenter randomized controlled trial.
Renal failure.
2003 Sep; 25(5):681-9. doi:
10.1081/jdi-120024284. [PMID: 14575277] - Armel Stockis, Steven De Bruyn, Christophe Gengler, Fabienne Goethals, Simone Lens, Gianluigi Poli, Daniela Acerbi. Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.
Arzneimittel-Forschung.
2003; 53(8):554-61. doi:
10.1055/s-0031-1297149. [PMID: 13677245] - Armel Stockis, Christophe Gengler, Fabienne Goethals, Bernard Jeanbaptiste, Simone Lens, Gianluigi Poli, Daniela Acerbi. Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.
Arzneimittel-Forschung.
2003; 53(9):627-34. doi:
10.1055/s-0031-1297159. [PMID: 14558436] - Maurizio Sabbatini, Amedeo Leonardi, Rodolfo Testa, Daniele Tomassoni, Lucia Vitaioli, Francesco Amenta. Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
2002 Jan; 39(1):39-48. doi:
10.1097/00005344-200201000-00005. [PMID: 11743226] - O Kohlmann, A B Ribeiro. [Manidipine in the treatment of stage I and II essential hypertension patients with overweight or android obesity. A Brazilian multicentre study of efficacy, tolerability and metabolic effects].
Arquivos brasileiros de cardiologia.
2001 Nov; 77(5):463-70. doi:
NULL. [PMID: 11733819] - C Deerochanawong, P Kornthong, S Phongwiratchai, S Serirat. Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2001 Feb; 84(2):234-41. doi:
NULL. [PMID: 11336083] - S M Cheer, K McClellan. Manidipine: a review of its use in hypertension.
Drugs.
2001; 61(12):1777-99. doi:
10.2165/00003495-200161120-00010. [PMID: 11693466] - R Fogari, A Zoppi, L Corradi, P Preti, G D Malalamani, A Mugellini. Effects of different dihydropyridine calcium antagonists on plasma norepinephrine in essential hypertension.
Journal of hypertension.
2000 Dec; 18(12):1871-5. doi:
10.1097/00004872-200018120-00023. [PMID: 11132613] - M Sabbatini, L Vitaioli, E Baldoni, F Amenta. Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats.
The Journal of pharmacology and experimental therapeutics.
2000 Sep; 294(3):948-54. doi:
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Journal of cardiovascular pharmacology.
2000 Jun; 35(6):926-31. doi:
10.1097/00005344-200006000-00015. [PMID: 10836728] - T Shiba, M Inoue, H Tada, Y Hayashi, Y Okuda, R Fujita, F Makino, C Takahasi, S Kageyama, S Kitamura, Y Iwamoto. Delapril versus manidipine in hypertensive therapy to halt the type-2-diabetes-mellitus-associated nephropathy.
Diabetes research and clinical practice.
2000 Feb; 47(2):97-104. doi:
10.1016/s0168-8227(99)00114-x. [PMID: 10670908] - X Deroubaix, R L Lins, S Lens, A Allemon, B Jeanbaptiste, G Poli, D Acerbi, A Stockis, P Ventura. Single dose pharmacokinetics of manidipine in hepatic impaired patients and healthy controls.
International journal of clinical pharmacology and therapeutics.
1998 Jul; 36(7):386-91. doi:
NULL. [PMID: 9707354] - D Rosillon, A Stockis, G Poli, D Acerbi, R Lins, B Jeanbaptiste. Food effect on the oral bioavailability of Manidipine: single dose, randomized, crossover study in healthy male subjects.
European journal of drug metabolism and pharmacokinetics.
1998 Apr; 23(2):197-202. doi:
10.1007/bf03189339. [PMID: 9725481] - M Fujimaki, M Nagase, S Uchida. Long-term effect of manidipine on renal function and structure in uninephrectomized spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology.
1997 Jul; 24(7):506-12. doi:
10.1111/j.1440-1681.1997.tb01236.x. [PMID: 9248669] - T Ohkubo, T Uno, K Sugawara. Liquid chromatographic determination of manidipine in serum with electrochemical detection.
Journal of chromatography. B, Biomedical applications.
1996 Dec; 687(2):413-8. doi:
10.1016/s0378-4347(96)00252-6. [PMID: 9017465] - T Wada, T Sanada, M Ojima, R Kanagawa, K Nishikawa, Y Inada. Combined effects of the angiotensin II antagonist candesartan cilexetil (TCV-116) and other classes of antihypertensive drugs in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
1996 Dec; 19(4):247-54. doi:
10.1291/hypres.19.247. [PMID: 8986455] - T Nishikawa, M Omura, T Iizuka, S Chiba. Effect of manidipine chloride on various aspects of endocrine function, including plasma levels of endothelin-1 and human atrial natriuretic peptide, in patients with essential hypertension.
Clinical therapeutics.
1996 Jul; 18(4):680-6. doi:
10.1016/s0149-2918(96)80218-9. [PMID: 8879896] - S Suzuki, M Ohtomo, Y Satoh, H Kawasaki, M Hirai, A Hirai, S Hirai, M Onoda, Y Hinokio, H Akai, T Toyota. Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension.
Diabetes research and clinical practice.
1996 Jun; 33(1):43-51. doi:
10.1016/0168-8227(96)01273-9. [PMID: 8877275] - A Hamaguchi, S Kim, H Wanibuchi, H Iwao. Angiotensin II and calcium blockers prevent glomerular phenotypic changes in remnant kidney model.
Journal of the American Society of Nephrology : JASN.
1996 May; 7(5):687-93. doi:
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Blood pressure. Supplement.
1996; 5(?):10-5. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1995 Nov; 106(5):327-37. doi:
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Japanese heart journal.
1995 Nov; 36(6):797-805. doi:
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Journal of diabetes and its complications.
1995 Oct; 9(4):215-9. doi:
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The Journal of laboratory and clinical medicine.
1995 May; 125(5):572-80. doi:
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Nihon Jinzo Gakkai shi.
1995 Feb; 37(2):119-26. doi:
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The American journal of the medical sciences.
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Biochemical and biophysical research communications.
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Nihon Jinzo Gakkai shi.
1994 Nov; 36(11):1216-20. doi:
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Nihon Jinzo Gakkai shi.
1994 Mar; 36(3):239-45. doi:
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Hypertension (Dallas, Tex. : 1979).
1994 Jan; 23(1 Suppl):I97-101. doi:
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Blood pressure. Supplement.
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Clinical nephrology.
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American heart journal.
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American heart journal.
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American heart journal.
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American heart journal.
1993 Feb; 125(2 Pt 2):582-8. doi:
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American heart journal.
1993 Feb; 125(2 Pt 2):626-9. doi:
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American heart journal.
1993 Feb; 125(2 Pt 2):578-81. doi:
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American heart journal.
1993 Feb; 125(2 Pt 2):609-19. doi:
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American heart journal.
1993 Feb; 125(2 Pt 2):620-5. doi:
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European journal of clinical pharmacology.
1993; 45(4):321-5. doi:
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Journal of cardiovascular pharmacology.
1992 Dec; 20(6):895-9. doi:
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Clinical therapeutics.
1992 Nov; 14(6):813-20. doi:
NULL. [PMID: 1286488] - M Yamaguchi, K Yamashita, I Aoki, T Tabata, S Hirai, T Yashiki. Determination of manidipine enantiomers in human serum using chiral chromatography and column-switching liquid chromatography.
Journal of chromatography.
1992 Mar; 575(1):123-9. doi:
10.1016/0378-4347(92)80512-o. [PMID: 1517288] - M Maki, H Kawamura, K Hara, H Mitsubayashi, K Suzuki, S Itou, W Usui, T Yasugi. The effect of manidipine on renal hemodynamics in essential hypertensive patients: responses to acute stress.
Blood pressure. Supplement.
1992; 3(?):106-13. doi:
NULL. [PMID: 1343277] - S Takishita, H Muratani, N Kawazoe, M Tozawa, Y Kimura, K Fukiyama. Acute effects of manidipine on renal blood flow and sympathetic nerve activity in conscious, spontaneously hypertensive rats.
Blood pressure. Supplement.
1992; 3(?):53-9. doi:
NULL. [PMID: 1343291] - H Muratani, S Takishita, N Kawazoe, M Tozawa, K Fukiyama. Renal vascular responses in spontaneously hypertensive rats chronically treated with manidipine.
Blood pressure. Supplement.
1992; 3(?):60-7. doi:
NULL. [PMID: 1343293] - H He, T Tamaki, Y Aki, H Kiyomoto, H Iwao, A Miyatake, Y Abe. Effects of the calcium antagonist manidipine on renal hemodynamics and function in dogs: comparison with nifedipine.
Blood pressure. Supplement.
1992; 3(?):68-74. doi:
NULL. [PMID: 1343294] - H Ikenaga, H Suzuki, T Saruta. Effects of manidipine on blood pressure and renal function in salt-loaded, spontaneously hypertensive rats.
Blood pressure. Supplement.
1992; 3(?):75-9. doi:
NULL. [PMID: 1343295] - S Kobayashi, A Hishida. Manidipine attenuates a progressive renal injury in remnant kidneys of rats.
Blood pressure. Supplement.
1992; 3(?):80-4. doi:
NULL. [PMID: 1343296] - K Murakami, G Kimura, M Imanishi, T Sanai, Y Kawano, S Kojima, K Yoshida, H Abe, T Ashida, H Yoshimi. Effect of manidipine, a new calcium antagonist, on intrarenal hemodynamics in essential hypertension.
Blood pressure. Supplement.
1992; 3(?):114-8. doi:
NULL. [PMID: 1343278] - Y Kitami, T Okura, R Wakamiya, K Marumoto, T Iwata, K Hiwada. Regulation of the gene expression of type-1 angiotensin II receptor in spontaneously hypertensive rats.
Blood pressure. Supplement.
1992; 3(?):12-6. doi:
NULL. [PMID: 1343280] - T Okura, Y Kitami, R Wakamiya, K Marumoto, T Iwata, K Hiwada. Renal and extra-renal renin gene expression in spontaneously hypertensive rats.
Blood pressure. Supplement.
1992; 3(?):6-11. doi:
NULL. [PMID: 1343292] - H Hirakata, K Iino, I Ishida, M Kashiwagi, M Yoshinari, S Okuda, S Fujita, M Fujishima. Effects of a new calcium antagonist, manidipine, on the renal hemodynamics and the vasoactive humoral factors in patients with diabetes mellitus.
Blood pressure. Supplement.
1992; 3(?):124-9. doi:
NULL. [PMID: 1343281] - K Atarashi, M Takagi, M Minami, Y Kimura, H Matsuoka, T Sugimoto. Effects of manidipine and delapril on glucose and lipid metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus.
Blood pressure. Supplement.
1992; 3(?):130-4. doi:
NULL. [PMID: 1343282] - Y Fujiwara, S Ochi, M Izumi, K Yokoyama, M Arai, A Ando, A Nagaoka, T Kamada, N Ueda. Mesangial cell growth in genetically hypertensive rats and effect of calcium antagonists upon this growth.
Blood pressure. Supplement.
1992; 3(?):22-6. doi:
NULL. [PMID: 1343284] - K Mizuno, H Haga, M Takahashi, Y Watanabe, S Fukuchi. Clinical evaluation of the efficacy and safety of manidipine in hypertensive patients with renal disorders.
Blood pressure. Supplement.
1992; 3(?):119-23. doi:
NULL. [PMID: 1343279] - M Okamura, Y Konishi, M Nishimura, N Negoro, N Umetani, T Inoue, Y Kanayama, T Takeda. Platelet-derived growth factor gene expression in the kidney of malignant hypertension.
Blood pressure. Supplement.
1992; 3(?):17-21. doi:
. [PMID: 1285293] - NULL. Nephroprotective actions and other tissue protective effects of manidipine in the management of hypertension.
Blood pressure. Supplement.
1992; 3(?):5-139. doi:
NULL. [PMID: 1343290] - S Morimoto, T Ohyama, K Hisaki, Y Matsumura. Effects of CV-4093, a new dihydropyridine calcium channel blocker, on renal hemodynamics and function in stroke-prone spontaneously hypertensive rats (SHRSP).
Japanese journal of pharmacology.
1989 Oct; 51(2):257-65. doi:
10.1254/jjp.51.257. [PMID: 2593383] - A Nagaoka, M Shibota. Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Japanese journal of pharmacology.
1989 Oct; 51(2):299-301. doi:
10.1254/jjp.51.299. [PMID: 2593386] - T Miyabayashi, K Yamashita, I Aoki, M Motohashi, T Yashiki, K Yatani. Determination of manidipine and its pyridine metabolite in human serum by high-performance liquid chromatography with ultraviolet detection and column switching.
Journal of chromatography.
1989 Sep; 494(?):209-17. doi:
10.1016/s0378-4347(00)82670-5. [PMID: 2584318] - Y Shibouta, T Kitayoshi, G Kitoh, K Nishikawa. Calcium channel blocking action of franidipine hydrochloride (CV-4093.2HCl) in vitro and in vivo.
Japanese journal of pharmacology.
1988 Dec; 48(4):463-72. doi:
10.1254/jjp.48.463. [PMID: 2854177]