Ziconotide (BioDeep_00000731777)
Marine Natural Products
代谢物信息卡片
化学式: C102H172N36O32S7 (2637.0982792000004)
中文名称: 醋酸齐考诺肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)NC(C(=O)NCC(=O)NC(C(=O)N3)CO)C(C)O)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CCCNC(=N)N)CC(C)C)CCSC)CC4=CC=C(C=C4)O)CC(=O)O)C(=O)N)CCCCN)CO)CCCNC(=N)N)CCCCN
InChI: InChI=1S/C102H172N36O32S7/c1-50(2)34-63-91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(21-15-32-114-102(111)112)126-96(166)70-46-176-177-47-71(97(167)132-68(43-141)95(165)125-60(87(157)128-63)20-14-31-113-101(109)110)134-89(159)59(19-9-13-30-106)123-81(151)51(3)119-74(144)37-115-83(153)56(16-6-10-27-103)120-75(145)38-116-84(154)57(17-7-11-28-104)124-82(152)55(107)44-172-174-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D009676 - Noxae > D009498 - Neurotoxins > D020960 - omega-Conotoxins
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000700 - Analgesics
D009676 - Noxae > D011042 - Poisons > D008978 - Mollusk Venoms
D009676 - Noxae > D009498 - Neurotoxins > D020916 - Conotoxins
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
D009676 - Noxae > D011042 - Poisons > D014688 - Venoms
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
N - Nervous system > N02 - Analgesics
D020011 - Protective Agents
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:142406
- ChEBI: CHEBI:135912
- PubChem: 16135415
- PubChem: 16129690
- ChEMBL: CHEMBL4594214
- CAS: 150770-63-1
- CAS: 107452-89-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tony L Yaksh, Annelies de Kater, Robin Dean, Brookie M Best, George P Miljanich. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog.
Neuromodulation : journal of the International Neuromodulation Society.
2012 Nov; 15(6):508-19; discussion 519. doi:
10.1111/j.1525-1403.2012.00479.x. [PMID: 22748108] - Csaba D András, Csilla Albert, Szidónia Salamon, Judit Gálicza, Réka András, Emil András. Conus magus vs. Irukandji syndrome: a computational approach of a possible new therapy.
Brain research bulletin.
2011 Oct; 86(3-4):195-202. doi:
10.1016/j.brainresbull.2011.07.003. [PMID: 21777663] - Catherine Abbadie, Owen B McManus, Shu-Yu Sun, Randal M Bugianesi, Ge Dai, Rodolfo J Haedo, James B Herrington, Gregory J Kaczorowski, McHardy M Smith, Andrew M Swensen, Vivien A Warren, Brande Williams, Stephen P Arneric, Cyrus Eduljee, Terrance P Snutch, Elizabeth W Tringham, Nina Jochnowitz, Annie Liang, D Euan MacIntyre, Erin McGowan, Shruti Mistry, Valerie V White, Scott B Hoyt, Clare London, Kathryn A Lyons, Patricia B Bunting, Sylvia Volksdorf, Joseph L Duffy. Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
The Journal of pharmacology and experimental therapeutics.
2010 Aug; 334(2):545-55. doi:
10.1124/jpet.110.166363. [PMID: 20439438] - NULL. Ziconotide: new drug. Limited analgesic efficacy, too many adverse effects.
Prescrire international.
2008 Oct; 17(97):179-82. doi:
NULL. [PMID: 19530373] - David Craik. Animal, plant and microbial toxins - 15th World Congress.
IDrugs : the investigational drugs journal.
2006 Oct; 9(10):679-81. doi:
". [PMID: 17016770] - Kazuyoshi Hirota, David G Lambert. Measurement of [³H]PN200-110 and [¹²⁵I]ω-conotoxin MVIIA binding.
Methods in molecular biology (Clifton, N.J.).
2005; 312(?):147-59. doi:
10.1385/1-59259-949-4:147. [PMID: 21341097] - Daniel Wermeling, Michael Drass, David Ellis, Martha Mayo, Dawn McGuire, Damian O'Connell, Victoria Hale, Stella Chao. Pharmacokinetics and pharmacodynamics of intrathecal ziconotide in chronic pain patients.
Journal of clinical pharmacology.
2003 Jun; 43(6):624-36. doi:
10.1177/0091270003253349. [PMID: 12817525] - Shuji Kaneko, Conan B Cooper, Naoto Nishioka, Hironobu Yamasaki, Atsushi Suzuki, Scott E Jarvis, Akinori Akaike, Masamichi Satoh, Gerald W Zamponi. Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002 Jan; 22(1):82-92. doi:
10.1523/jneurosci.22-01-00082.2002. [PMID: 11756491] - K Zheng, D M Lubman, D T Rossi, G D Nordblom, C M Barksdale. Elucidation of peptide metabolism by on-line immunoaffinity liquid chromatography mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2000; 14(4):261-9. doi:
10.1002/(sici)1097-0231(20000229)14:4<261::aid-rcm868>3.0.co;2-x. [PMID: 10669885] - X Liang, D M Lubman, D T Rossi, G D Nordblom, C M Barksdale. On-probe immunoaffinity extraction by matrix-assisted laser desorption/ionization mass spectrometry.
Analytical chemistry.
1998 Feb; 70(3):498-503. doi:
10.1021/ac9708856. [PMID: 9470484] - G Wang, G Dayanithi, S Kim, D Hom, L Nadasdi, R Kristipati, J Ramachandran, E L Stuenkel, J J Nordmann, R Newcomb, J R Lemos. Role of Q-type Ca2+ channels in vasopressin secretion from neurohypophysial terminals of the rat.
The Journal of physiology.
1997 Jul; 502 ( Pt 2)(?):351-63. doi:
10.1111/j.1469-7793.1997.351bk.x. [PMID: 9263915] - S Bowersox, J Mandema, K Tarczy-Hornoch, G Miljanich, R R Luther. Pharmacokinetics of SNX-111, a selective N-type calcium channel blocker, in rats and cynomolgus monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
1997 Mar; 25(3):379-83. doi:
NULL. [PMID: 9172958] - J I Kim, M Takahashi, A Ohtake, A Wakamiya, K Sato. Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers.
Biochemical and biophysical research communications.
1995 Jan; 206(2):449-54. doi:
10.1006/bbrc.1995.1063. [PMID: 7826361]