Alagebrium chloride (BioDeep_00000731565)
代谢物信息卡片
Alagebrium chloride
化学式: C13H14ClNOS (267.0484584)
中文名称: 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(SC=[N+]1CC(=O)C2=CC=CC=C2)C.[Cl-]
InChI: /p-1
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Neal X Chen, Shruthi Srinivasan, Kalisha O'Neill, Thomas L Nickolas, Joseph M Wallace, Matthew R Allen, Corinne E Metzger, Amy Creecy, Keith G Avin, Sharon M Moe. Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2020 03; 35(3):608-617. doi:
10.1002/jbmr.3925. [PMID: 31743501] - Bing Zhang, Kunlun He, Wei Chen, Xianfa Cheng, Hao Cui, Wu Zhong, Song Li, Lili Wang. Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2014 Oct; 37(10):901-7. doi:
10.1038/hr.2014.98. [PMID: 24965174] - Lin Wang, Wenjie Tian, Zaid Uwais, Guangyong Li, Huixi Li, Ruili Guan, Zhezhu Gao, Zhongcheng Xin. AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diabetic rats.
The journal of sexual medicine.
2014 Jun; 11(6):1452-62. doi:
10.1111/jsm.12533. [PMID: 24766706] - Indu Dhar, Arti Dhar, Lingyun Wu, Kaushik M Desai. Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats.
American journal of hypertension.
2014 Mar; 27(3):308-16. doi:
10.1093/ajh/hpt281. [PMID: 24436324] - Anna M D Watson, Stephen P Gray, Li Jiaze, Aino Soro-Paavonen, Benedict Wong, Mark E Cooper, Angelika Bierhaus, Raelene Pickering, Christos Tikellis, Despina Tsorotes, Merlin C Thomas, Karin A M Jandeleit-Dahm. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice.
Diabetes.
2012 Aug; 61(8):2105-13. doi:
10.2337/db11-1546. [PMID: 22698914] - Jehyun Park, Min Kyung Kwon, Joo Young Huh, Won Jun Choi, Lak Shin Jeong, Ryoji Nagai, Wan Young Kim, Jin Kim, Geun Taek Lee, Hi Bahl Lee, Hunjoo Ha. Renoprotective antioxidant effect of alagebrium in experimental diabetes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Nov; 26(11):3474-84. doi:
10.1093/ndt/gfr152. [PMID: 21478303] - Martina Krautwald, Dale Leech, Stacey Horne, Megan L Steele, Josephine Forbes, Anton Rahmadi, Renate Griffith, Gerald Münch. The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase.
Rejuvenation research.
2011 Aug; 14(4):383-91. doi:
10.1089/rej.2010.1143. [PMID: 21612515] - Brooke E Harcourt, Karly C Sourris, Melinda T Coughlan, Karen Z Walker, Sonia L Dougherty, Sofianos Andrikopoulos, Amy L Morley, Vicki Thallas-Bonke, Vibhasha Chand, Sally A Penfold, Maximilian P J de Courten, Merlin C Thomas, Bronwyn A Kingwell, Angelika Bierhaus, Mark E Cooper, Barbora de Courten, Josephine M Forbes. Targeted reduction of advanced glycation improves renal function in obesity.
Kidney international.
2011 Jul; 80(2):190-8. doi:
10.1038/ki.2011.57. [PMID: 21412218] - Richard D Semba, Emily J Nicklett, Luigi Ferrucci. Does accumulation of advanced glycation end products contribute to the aging phenotype?.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2010 Sep; 65(9):963-75. doi:
10.1093/gerona/glq074. [PMID: 20478906] - Adeline L Y Tan, Karly C Sourris, Brooke E Harcourt, Vicki Thallas-Bonke, Sally Penfold, Sofianos Andrikopoulos, Merlin C Thomas, Richard C O'Brien, Angelika Bierhaus, Mark E Cooper, Josephine M Forbes, Melinda T Coughlan. Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.
American journal of physiology. Renal physiology.
2010 Mar; 298(3):F763-70. doi:
10.1152/ajprenal.00591.2009. [PMID: 20015941] - Arti Dhar, Kaushik M Desai, Lingyun Wu. Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.
British journal of pharmacology.
2010 Jan; 159(1):166-75. doi:
10.1111/j.1476-5381.2009.00469.x. [PMID: 20002105] - Christos Tikellis, Merlin C Thomas, Brooke E Harcourt, Melinda T Coughlan, Josepha Pete, Katarzyna Bialkowski, Adeline Tan, Angelika Bierhaus, Mark E Cooper, Josephine M Forbes. Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.
American journal of physiology. Endocrinology and metabolism.
2008 Aug; 295(2):E323-30. doi:
10.1152/ajpendo.00024.2008. [PMID: 18477705] - E Nobécourt, J Zeng, M J Davies, B E Brown, S Yadav, P J Barter, K-A Rye. Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.
Diabetologia.
2008 Jun; 51(6):1008-17. doi:
10.1007/s00125-008-0986-z. [PMID: 18437350] - Karly C Sourris, Josephine M Forbes, Mark E Cooper. Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?.
Annals of the New York Academy of Sciences.
2008 Apr; 1126(?):101-6. doi:
10.1196/annals.1433.048. [PMID: 18448801] - M T Coughlan, J M Forbes, M E Cooper. Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes.
Kidney international. Supplement.
2007 Aug; ?(106):S54-60. doi:
10.1038/sj.ki.5002387. [PMID: 17653212] - A Hoang, A J Murphy, M T Coughlan, M C Thomas, J M Forbes, R O'Brien, M E Cooper, J P F Chin-Dusting, D Sviridov. Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties.
Diabetologia.
2007 Aug; 50(8):1770-9. doi:
10.1007/s00125-007-0718-9. [PMID: 17579831] - Susan J Zieman, Vojtech Melenovsky, Lia Clattenburg, Mary C Corretti, Anne Capriotti, Gary Gerstenblith, David A Kass. Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.
Journal of hypertension.
2007 Mar; 25(3):577-83. doi:
10.1097/hjh.0b013e328013e7dd. [PMID: 17278974] - Melinda T Coughlan, Vicki Thallas-Bonke, Josefa Pete, David M Long, Anna Gasser, David C K Tong, Maryann Arnstein, Suzanne R Thorpe, Mark E Cooper, Josephine M Forbes. Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?.
Endocrinology.
2007 Feb; 148(2):886-95. doi:
10.1210/en.2006-1300. [PMID: 17110423] - Mustafa F Usta, Muammer Kendirci, Serap Gur, Neale A Foxwell, Trinity J Bivalacqua, Selim Cellek, Wayne J G Hellstrom. The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment.
The journal of sexual medicine.
2006 Mar; 3(2):242-50; discussion 250. doi:
10.1111/j.1743-6109.2006.00217.x. [PMID: 16490017] - Melpomeni Peppa, Harold Brem, Weijing Cai, Jiang-Gang Zhang, John Basgen, Zhu Li, Helen Vlassara, Jaime Uribarri. Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711).
American journal of nephrology.
2006; 26(5):430-6. doi:
10.1159/000095786. [PMID: 16974073] - Mark E Williams, Katherine R Tuttle. The next generation of diabetic nephropathy therapies: an update.
Advances in chronic kidney disease.
2005 Apr; 12(2):212-22. doi:
10.1053/j.ackd.2005.01.011. [PMID: 15822057] - Mark E Cooper. Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease.
American journal of hypertension.
2004 Dec; 17(12 Pt 2):31S-38S. doi:
10.1016/j.amjhyper.2004.08.021. [PMID: 15607433] - Vicki Thallas-Bonke, Carsten Lindschau, Bishoy Rizkalla, Leon A Bach, Geoffrey Boner, Matthias Meier, Hermann Haller, Mark E Cooper, Josephine M Forbes. Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.
Diabetes.
2004 Nov; 53(11):2921-30. doi:
10.2337/diabetes.53.11.2921. [PMID: 15504973] - Markus Lassila, Kwee K Seah, Terri J Allen, Vicki Thallas, Merlin C Thomas, Riccardo Candido, Wendy C Burns, Josephine M Forbes, Anna C Calkin, Mark E Cooper, Karin A M Jandeleit-Dahm. Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products.
Journal of the American Society of Nephrology : JASN.
2004 Aug; 15(8):2125-38. doi:
10.1097/01.asn.0000133025.23732.46. [PMID: 15284298] - Dinko Susic, Jasmina Varagic, Jwari Ahn, Edward D Frohlich. Crosslink breakers: a new approach to cardiovascular therapy.
Current opinion in cardiology.
2004 Jul; 19(4):336-40. doi:
10.1097/01.hco.0000127135.73849.4f. [PMID: 15218393] - Josephine M Forbes, Louis Teo Loon Yee, Vicki Thallas, Markus Lassila, Riccardo Candido, Karin A Jandeleit-Dahm, Merlin C Thomas, Wendy C Burns, Elizabeth K Deemer, Susan R Thorpe, Susan M Thorpe, Mark E Cooper, Terri J Allen. Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.
Diabetes.
2004 Jul; 53(7):1813-23. doi:
10.2337/diabetes.53.7.1813. [PMID: 15220206] - Dinko Susic, Jasmina Varagic, Jwari Ahn, Edward D Frohlich. Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats.
American journal of hypertension.
2004 Apr; 17(4):328-33. doi:
10.1016/j.amjhyper.2003.12.015. [PMID: 15062886] - George Jerums, Sianna Panagiotopoulos, Josephine Forbes, Tanya Osicka, Mark Cooper. Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease.
Archives of biochemistry and biophysics.
2003 Nov; 419(1):55-62. doi:
10.1016/j.abb.2003.08.017. [PMID: 14568009] - Josephine M Forbes, Vicki Thallas, Merlin C Thomas, Hank W Founds, Wendy C Burns, George Jerums, Mark E Cooper. The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Sep; 17(12):1762-4. doi:
10.1096/fj.02-1102fje. [PMID: 12958202] - S Hiramatsu, K Inoue, Y Tajirl, V Grill. Improvement by aminoguanidine of insulin secretion from pancreatic islets grafted to syngeneic diabetic rats.
Biochemical pharmacology.
2000 Jul; 60(2):263-8. doi:
10.1016/s0006-2952(00)00318-x. [PMID: 10825471]