Tetramic acid (BioDeep_00000731291)
代谢物信息卡片
Tetramic acid
化学式: C4H5NO2 (99.032)
中文名称: 1,5-二氢-4-羟基-2H-吡咯-2-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=CC(=O)N1)O
InChI: InChI=1S/C4H5NO2/c6-3-1-4(7)5-2-3/h1,6H,2H2,(H,5,7)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yaojie Guo, Fabiano J Contesini, Xinhui Wang, Simone Ghidinelli, Ditte S Tornby, Thomas E Andersen, Uffe H Mortensen, Thomas O Larsen. Biosynthesis of Calipyridone A Represents a Fungal 2-Pyridone Formation without Ring Expansion in Aspergillus californicus.
Organic letters.
2022 01; 24(3):804-808. doi:
10.1021/acs.orglett.1c03792. [PMID: 35045257] - Yangle Gao, Mengsi Xie, Cui Yu, Mingliang Zhang, Jianzhong Huang, Qin Li, Huaidong Zhang, Li Li. Heterologous Expression of Macrollins from Phytopathogenic Macrophomina phaseolina Revealed a Cytochrome P450 Mono-oxygenase in the Biosynthesis of β-Hydroxyl Tetramic Acid.
Journal of agricultural and food chemistry.
2021 Dec; 69(50):15175-15183. doi:
10.1021/acs.jafc.1c05304. [PMID: 34881573] - Péter János Berek-Nagy, Gergő Tóth, Szilvia Bősze, Lilla Borbála Horváth, András Darcsi, Sándor Csíkos, Dániel G Knapp, Gábor M Kovács, Imre Boldizsár. The grass root endophytic fungus Flavomyces fulophazii: An abundant source of tetramic acid and chlorinated azaphilone derivatives.
Phytochemistry.
2021 Oct; 190(?):112851. doi:
10.1016/j.phytochem.2021.112851. [PMID: 34217043] - Gian Primahana, Abolfazl Narmani, Frank Surup, Rémy Bertrand Teponno, Mahdi Arzanlou, Marc Stadler. Five Tetramic Acid Derivatives Isolated from the Iranian Fungus Colpoma quercinum CCTU A372.
Biomolecules.
2021 05; 11(6):. doi:
10.3390/biom11060783. [PMID: 34067463] - Lukas Martin Wingen, Marvin Rausch, Tanja Schneider, Dirk Menche. Synthesis of Tetramic Acid Fragments Derived from Vancoresmycin Showing Inhibitory Effects towards S. aureus.
ChemMedChem.
2020 08; 15(15):1390-1393. doi:
10.1002/cmdc.202000241. [PMID: 32497343] - Shuangshuang Wang, Longzhu Bao, Di Song, Jingjing Wang, Xiufang Cao, Shaoyong Ke. Amino acid-oriented poly-substituted heterocyclic tetramic acid derivatives as potential antifungal agents.
European journal of medicinal chemistry.
2019 Oct; 179(?):567-575. doi:
10.1016/j.ejmech.2019.06.078. [PMID: 31279291] - Jie Zhang, Le Qian, Miaomiao Teng, Xiyan Mu, Suzhen Qi, Xiangguang Chen, Yimeng Zhou, Yi Cheng, Sen Pang, Xuefeng Li, Chengju Wang. The lipid metabolism alteration of three spirocyclic tetramic acids on zebrafish (Danio rerio) embryos.
Environmental pollution (Barking, Essex : 1987).
2019 May; 248(?):715-725. doi:
10.1016/j.envpol.2019.02.035. [PMID: 30849589] - Frederike Stock, Michail Syrpas, Shiri Graff van Creveld, Simon Backx, Lander Blommaert, Lachlan Dow, Willem Stock, Ewout Ruysbergh, Bernard Lepetit, Benjamin Bailleul, Koen Sabbe, Norbert De Kimpe, Anne Willems, Peter G Kroth, Assaf Vardi, Wim Vyverman, Sven Mangelinckx. N-Acyl Homoserine Lactone Derived Tetramic Acids Impair Photosynthesis in Phaeodactylum tricornutum.
ACS chemical biology.
2019 02; 14(2):198-203. doi:
10.1021/acschembio.8b01101. [PMID: 30694649] - Shasha Zhao, Shenxi Chen, Bo Wang, Shubin Niu, Wenping Wu, Liangdong Guo, Yongsheng Che. Four new tetramic acid and one new furanone derivatives from the plant endophytic fungus Neopestalotiopsis sp.
Fitoterapia.
2015 Jun; 103(?):106-12. doi:
10.1016/j.fitote.2015.03.023. [PMID: 25818228] - John G Ondeyka, Scott K Smith, Deborah L Zink, Francisca Vicente, Angela Basilio, Gerald F Bills, Jon D Polishook, Charles Garlisi, Debra Mcguinness, Elizabeth Smith, Hongchen Qiu, Charles J Gill, Robert G K Donald, John W Phillips, Michael A Goetz, Sheo B Singh. Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin.
The Journal of antibiotics.
2014 Jul; 67(7):527-31. doi:
10.1038/ja.2014.33. [PMID: 24690911] - Ikuro Abe. Novel applications of plant polyketide synthases.
Current opinion in chemical biology.
2012 Apr; 16(1-2):179-85. doi:
10.1016/j.cbpa.2011.12.016. [PMID: 22245533] - Toshiyuki Wakimoto, Hiroyuki Morita, Ikuro Abe. Engineering of plant type III polyketide synthases.
Methods in enzymology.
2012; 515(?):337-58. doi:
10.1016/b978-0-12-394290-6.00016-1. [PMID: 22999181] - B M Davis, J L Richens, P O'Shea. Label-free critical micelle concentration determination of bacterial quorum sensing molecules.
Biophysical journal.
2011 Jul; 101(1):245-54. doi:
10.1016/j.bpj.2011.05.033. [PMID: 21723835] - Toshiyuki Wakimoto, Takahiro Mori, Hiroyuki Morita, Ikuro Abe. Cytotoxic tetramic acid derivative produced by a plant type-III polyketide synthase.
Journal of the American Chemical Society.
2011 Apr; 133(13):4746-9. doi:
10.1021/ja2006737. [PMID: 21391603] - Bernhard Biersack, Randi Diestel, Carsten Jagusch, Florenz Sasse, Rainer Schobert. Metal complexes of natural melophlins and their cytotoxic and antibiotic activities.
Journal of inorganic biochemistry.
2009 Jan; 103(1):72-6. doi:
10.1016/j.jinorgbio.2008.09.005. [PMID: 18951635]
