promethazine hydrochloride (BioDeep_00000731172)

   


代谢物信息卡片


promethazine hydrochloride

化学式: C17H21ClN2S (320.11138960000005)
中文名称: 盐酸异丙嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
InChI: 1H

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents

同义名列表

1 个代谢物同义名

promethazine hydrochloride



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Jiangjing Wang, Shunyi Wei, Yingfang Ao, Yuping Yang. [Comparison of the early analgesic efficacy of three different drugs after anterior cruciate ligament reconstruction]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2024 Apr; 56(2):293-298. doi: ". [PMID: 38595247]
  • Jia Lun, Wenying Zhang, Yu Zhao, Yongbo Song, Xingjie Guo. Enantiomeric Separation of Dioxopromethazine and its Stereoselective Pharmacokinetics in Rats by HPLC-MS/MS. Journal of pharmaceutical sciences. 2021 08; 110(8):3082-3090. doi: 10.1016/j.xphs.2021.04.015. [PMID: 33940025]
  • Daniel Brunnhoelzl, Alexander N Hanania, Alfredo Echeverria, Jan Sunde, Connie Tran, Michelle Ludwig. Paracervical blocks facilitate timely brachytherapy amidst COVID-19. Brachytherapy. 2021 Jan; 20(1):284-289. doi: 10.1016/j.brachy.2020.08.002. [PMID: 32891569]
  • Balamurugan Arumugam, Balamurugan Muthukutty, Shen-Ming Chen, Sayee Kannan Ramaraj, Jeyaraj Vinoth Kumar, E R Nagarajan. Ultrasonication-aided synthesis of nanoplates-like iron molybdate: Fabricated over glassy carbon electrode as an modified electrode for the selective determination of first generation antihistamine drug promethazine hydrochloride. Ultrasonics sonochemistry. 2020 Sep; 66(?):104977. doi: 10.1016/j.ultsonch.2020.104977. [PMID: 32315841]
  • M Zhu, K Hu, Z Zhu. Use of convalescent plasma in COVID-19 patients in China. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine. 2020 08; 27(3):168-169. doi: 10.1016/j.tracli.2020.05.001. [PMID: 32425645]
  • Wan Qiu Xia, Hui Cai Zhang, Geng Nan Wang, Jing Liu, Jian Ping Wang. A molecularly imprinted polymer based chemiluminescence array sensor for one-step determination of phenothiazines and benzodiazepines in pig urine. Luminescence : the journal of biological and chemical luminescence. 2019 Feb; 34(1):98-105. doi: 10.1002/bio.3584. [PMID: 30548788]
  • Cecilie Hurup Munkboel, Stine Bjerregaard Hasselstrøm, David Møbjerg Kristensen, Bjarne Styrishave. Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition. Toxicology in vitro : an international journal published in association with BIBRA. 2018 Apr; 48(?):302-309. doi: 10.1016/j.tiv.2018.01.026. [PMID: 29409762]
  • Boone M Prentice, Chad W Chumbley, Brian C Hachey, Jeremy L Norris, Richard M Caprioli. Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification. Analytical chemistry. 2016 10; 88(19):9780-9788. doi: 10.1021/acs.analchem.6b02821. [PMID: 27573922]
  • Kevin W Kastner, Jesús A Izaguirre. Accelerated molecular dynamics simulations of the octopamine receptor using GPUs: discovery of an alternate agonist-binding position. Proteins. 2016 10; 84(10):1480-9. doi: 10.1002/prot.25091. [PMID: 27318014]
  • Ling-Ling He, Zhi-Xin Wang, Yong-Xia Wang, Xian-Ping Liu, Yan-Jie Yang, Yan-Ping Gao, Xin Wang, Bin Liu, Xin Wang. Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques. Colloids and surfaces. B, Biointerfaces. 2016 Sep; 145(?):820-829. doi: 10.1016/j.colsurfb.2016.06.001. [PMID: 27315330]
  • C Bréhin, C Cessans, C Monchaud, M Lavit, C Majorel, I Claudet. A pseudoencephalitis presentation of a pediatric non-intentional intoxication. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 2016 May; 20(3):418-20. doi: 10.1016/j.ejpn.2016.02.010. [PMID: 26947545]
  • Liang Qi, Li-Min Duan, Xiao-Huan Sun, Jing Zhang, Zhi-Qi Zhang. Simultaneous determination of three banned psychiatric drugs in pig feed and tissue using solid-phase reactor on-line oxidizing and HPLC-fluorescence detection. Biomedical chromatography : BMC. 2015 Oct; 29(10):1535-40. doi: 10.1002/bmc.3455. [PMID: 25810380]
  • Njiaza Joseph, Ngo Lemba Tom Esther, Nguelefack Télesphore Benoît, Dzeufiet Djomeni Paul Désiré, Aboubakar Oumarou Bibi-Farouck, Dimo Théophile, Kamtchouing Pierre. Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum. Journal of ethnopharmacology. 2015 Aug; 172(?):1-9. doi: 10.1016/j.jep.2015.05.047. [PMID: 26068425]
  • Kara L Lynch, Brad J Shapiro, Diana Coffa, Scott P Novak, Alex H Kral. Promethazine use among chronic pain patients. Drug and alcohol dependence. 2015 May; 150(?):92-7. doi: 10.1016/j.drugalcdep.2015.02.023. [PMID: 25754939]
  • Kyoko Uekusa, Makiko Hayashida, Youkichi Ohno. Forensic toxicological analyses of drugs in tissues in formalin solutions and in fixatives. Forensic science international. 2015 Apr; 249(?):165-72. doi: 10.1016/j.forsciint.2015.01.028. [PMID: 25700112]
  • Agota Simon, Tatiana Alexandru, Mihai Boni, Victor Damian, Alexandru Stoicu, Victoria Dutschk, Mihail Lucian Pascu. Interaction of solutions containing phenothiazines exposed to laser radiation with materials surfaces, in view of biomedical applications. International journal of pharmaceutics. 2014 Nov; 475(1-2):270-81. doi: 10.1016/j.ijpharm.2014.08.031. [PMID: 25148730]
  • E Verhoeven, A Capron, P Hantson. Pink urine. Clinical toxicology (Philadelphia, Pa.). 2014 Nov; 52(9):980-1. doi: 10.3109/15563650.2014.961068. [PMID: 25233954]
  • Zhou Xiang, Qu Yan-Liang, Song Xiao-Yang, Zhang Yan-Hui, Chen Min, Gan Guo-Shen, Wu Ming-Chun, Luo Zhong-Bing, Wang Qing-Li, Hu Guang-Jun, Qin Ming-Zhe, Tao Jun. Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children. Paediatric anaesthesia. 2014 Mar; 24(3):322-6. doi: 10.1111/pan.12305. [PMID: 24238032]
  • Steven M Selbst. Pediatric emergency medicine: legal briefs. Pediatric emergency care. 2013 Dec; 29(12):1295-7. doi: 10.1097/pec.0000000000000056. [PMID: 24300476]
  • Hulin Li, Kai Xu, Bingkun Li, Binshen Chen, Abai Xu, Yuanbo Chen, Yawen Xu, Yong Wen, Shaobo Zheng, Chunxiao Liu. Percutaneous nephrolithotomy under local infiltration anesthesia: a single-center experience of 2000 Chinese cases. Urology. 2013 Nov; 82(5):1020-5. doi: 10.1016/j.urology.2013.07.007. [PMID: 23992963]
  • Andrée E Gravel, Alexandre A Arnold, Erick J Dufourc, Isabelle Marcotte. An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome. Biochimica et biophysica acta. 2013 Jun; 1828(6):1494-502. doi: 10.1016/j.bbamem.2013.02.012. [PMID: 23473737]
  • Brad J Shapiro, Kara L Lynch, Tab Toochinda, Alexandra Lutnick, Helen Y Cheng, Alex H Kral. Promethazine misuse among methadone maintenance patients and community-based injection drug users. Journal of addiction medicine. 2013 Mar; 7(2):96-101. doi: 10.1097/adm.0b013e31827f9b43. [PMID: 23385449]
  • A K Tang, W K Tang, H J Liang, F Chan, S C Mak, G S Ungvari. Clinical characteristics of cough mixture abusers referred to three substance abuse clinics in Hong Kong: a retrospective study. East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan. 2012 Dec; 22(4):154-9. doi: NULL. [PMID: 23271584]
  • F G Sánchez, A Navas Díaz, E Sánchez Torreño, A Aguilar, I Medina Lama, M Algarra. Determination of enantiomeric excess by chiral liquid chromatography without enantiomerically pure starting standards. Biomedical chromatography : BMC. 2012 Oct; 26(10):1241-6. doi: 10.1002/bmc.2685. [PMID: 22311573]
  • Xufei Li, Yanying Yang, Kaowen Zhou. [Simultaneous determination of chlorpromazine and promethazine and their main metabolites by capillary electrophoresis with electrochemiluminescence]. Se pu = Chinese journal of chromatography. 2012 Sep; 30(9):938-42. doi: 10.3724/sp.j.1123.2012.04025. [PMID: 23285977]
  • Betty Lane, Kathi Cannella, Cathy Bowen, David Copelan, Grace Nteff, Katrina Barnes, Melanie Poudevigne, Jacqueline Lawson. Examination of the effectiveness of peppermint aromatherapy on nausea in women post C-section. Journal of holistic nursing : official journal of the American Holistic Nurses' Association. 2012 Jun; 30(2):90-104; quiz 105. doi: 10.1177/0898010111423419. [PMID: 22034523]
  • Min Huang, Jian-yi Gao, Zhi-gang Zhai, Qiong-lin Liang, Yi-ming Wang, Yan-qiang Bai, Guo-an Luo. An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness. Journal of pharmaceutical and biomedical analysis. 2012 Mar; 62(?):119-28. doi: 10.1016/j.jpba.2011.12.033. [PMID: 22264564]
  • Ling-Ling He, Xin Wang, Bin Liu, Jun Wang, Ya-Guang Sun, Shu-Kun Xu. Study on the sonodynamic activity and mechanism of promethazine hydrochloride by multi-spectroscopic techniques. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Oct; 81(1):698-705. doi: 10.1016/j.saa.2011.07.006. [PMID: 21788155]
  • Abbul Bashar Khan, Javed Masood Khan, Mohd Sajid Ali, Rizwan Hasan Khan, Kabir-ud Din. Spectroscopic approach of the interaction study of amphiphilic drugs with the serum albumins. Colloids and surfaces. B, Biointerfaces. 2011 Oct; 87(2):447-53. doi: 10.1016/j.colsurfb.2011.06.007. [PMID: 21726987]
  • M Nadeem Asghar, I Ullah Khan, N Bano. In vitro antioxidant and radical-scavenging capacities of Citrullus colocynthes (L) and Artemisia absinthium extracts using promethazine hydrochloride radical cation and contemporary assays. Food science and technology international = Ciencia y tecnologia de los alimentos internacional. 2011 Oct; 17(5):481-94. doi: 10.1177/1082013211399495. [PMID: 21954313]
  • Ling-Ling He, Xin Wang, Bin Liu, Jun Wang, Ya-Guang Sun, Shu-Kun Xu. Spectroscopic investigation on the synergistic effects of ultrasound and dioxopromethazine hydrochloride on protein. Journal of fluorescence. 2011 Sep; 21(5):1847-56. doi: 10.1007/s10895-011-0879-2. [PMID: 21424802]
  • Mihail-Lucian Pascu, Viorel Nastasa, Adriana Smarandache, Andra Militaru, Ana Martins, Miguel Viveiros, Mihai Boni, Ionut Relu Andrei, Alexandru Pascu, Angela Staicu, Joseph Molnar, Seamus Fanning, Leonard Amaral. Direct modification of bioactive phenothiazines by exposure to laser radiation. Recent patents on anti-infective drug discovery. 2011 May; 6(2):147-57. doi: 10.2174/157489111796064515. [PMID: 21517738]
  • Raissa Rr Aworet-Samseny, Alain Souza, Fidele Kpahé, Kiessoun Konaté, Jacques Y Datté. Dichrostachys cinerea (L.) Wight et Arn (Mimosaceae) hydro-alcoholic extract action on the contractility of tracheal smooth muscle isolated from guinea-pig. BMC complementary and alternative medicine. 2011 Mar; 11(?):23. doi: 10.1186/1472-6882-11-23. [PMID: 21414220]
  • Xia Xi, Liang Ming, Jie Liu. Voltammetric determination of promethazine hydrochloride at a multi-wall carbon nanotube modified glassy carbon electrode. Drug testing and analysis. 2011 Mar; 3(3):182-6. doi: 10.1002/dta.205. [PMID: 21125640]
  • P Agretti, A Dimida, G De Marco, E Ferrarini, J C Rodrìguez Gonzàlez, F Santini, P Vitti, A Pinchera, M Tonacchera. Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein. Journal of endocrinological investigation. 2011 Mar; 34(3):170-4. doi: 10.1007/bf03347061. [PMID: 20479570]
  • Justin M Holler, Shawn P Vorce, Pamela C McDonough-Bender, Joseph Magluilo, Carol J Solomon, Barry Levine. A drug toxicity death involving propylhexedrine and mitragynine. Journal of analytical toxicology. 2011 Jan; 35(1):54-9. doi: 10.1093/anatox/35.1.54. [PMID: 21219704]
  • Shang-Jin Shi, Steven H Platts, Michael G Ziegler, Janice V Meck. Effects of promethazine and midodrine on orthostatic tolerance. Aviation, space, and environmental medicine. 2011 Jan; 82(1):9-12. doi: 10.3357/asem.2888.2011. [PMID: 21235099]
  • Ahmed Khudhair Hassan, Bahruddin Saad, Sulaiman Ab Ghani, Rohana Adnan, Afidah Abdul Rahim, Norariza Ahmad, Marina Mokhtar, Suham Tawfiq Ameen, Suad Mustafa Al-Araji. Ionophore-based potentiometric sensors for the flow-injection determination of promethazine hydrochloride in pharmaceutical formulations and human urine. Sensors (Basel, Switzerland). 2011; 11(1):1028-42. doi: 10.3390/s110101028. [PMID: 22346617]
  • Hamid Reza Pazoki-Toroudi, Marjan Ajami, Rouhollah Habibey. Pre-medication and renal pre-conditioning: a role for alprazolam, atropine, morphine and promethazine. Fundamental & clinical pharmacology. 2010 Apr; 24(2):189-98. doi: 10.1111/j.1472-8206.2009.00743.x. [PMID: 19686533]
  • Hirokazu Doi, Toshiharu Horie. Salicylic acid-induced hepatotoxicity triggered by oxidative stress. Chemico-biological interactions. 2010 Feb; 183(3):363-8. doi: 10.1016/j.cbi.2009.11.024. [PMID: 19948161]
  • Aya Matsusue, Kenji Hara, Mitsuyoshi Kageura, Masayuki Kashiwagi, Wang Lu, Akiko Ishigami, Takako Gotohda, Itsuo Tokunaga, Akiyoshi Nisimura, Tomoko Sugimura, Shin-Ichi Kubo. An autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes. Journal of forensic and legal medicine. 2010 Jan; 17(1):46-9. doi: 10.1016/j.jflm.2009.07.020. [PMID: 20083051]
  • Ping Liu, Sun Liang, Ben-Jie Wang, Rui-Chen Guo. Development and validation of a sensitive LC-MS method for the determination of promethazine hydrochloride in human plasma and urine. European journal of drug metabolism and pharmacokinetics. 2009 Jul; 34(3-4):177-84. doi: 10.1007/bf03191171. [PMID: 20166436]
  • Ping Liu, Sun Liang, Ben-Jie Wang, Rui-Chen Guo. Development and validation of a sensitive LC-MS method for the determination of tramadol in human plasma and urine. European journal of drug metabolism and pharmacokinetics. 2009 Jul; 34(3-4):185-92. doi: 10.1007/bf03191172. [PMID: 20166437]
  • Ping Liu, Sun Liang, Ben-Jie Wang, Rui-Chen Guo. Pharmacokinetics, safety and tolerance of single- and multiple-dose of a novel compound tramadol hydrochloride injection (35 mg tramadol hydrochloride, 45 mgl promethazine hydrochloride) in Chinese healthy subjects. European journal of drug metabolism and pharmacokinetics. 2009 Jul; 34(3-4):193-200. doi: 10.1007/bf03191173. [PMID: 20166438]
  • Baiqing Yuan, Jianshe Huang, Jinying Sun, Tianyan You. A novel technique for NACE coupled with simultaneous electrochemiluminescence and electrochemical detection for fast analysis of tertiary amines. Electrophoresis. 2009 Feb; 30(3):479-86. doi: 10.1002/elps.200800253. [PMID: 19145593]
  • Joseph Molnár, Meltem Demirel Kars, Ufuk Gündüz, Helga Engi, Udo Schumacher, Els J Van Damme, Willy J Peumans, Josef Makovitzky, Nóra Gyémánt, Péter Molnár. Interaction of tomato lectin with ABC transporter in cancer cells: glycosylation confers functional conformation of P-gp. Acta histochemica. 2009; 111(4):329-33. doi: 10.1016/j.acthis.2008.11.010. [PMID: 19124148]
  • Nelson Leung, Alfonso Eirin, Maria V Irazabal, Daniel E Maddox, Heidi D Gunderson, Fernando C Fervenza, Vesna D Garovic. Acute kidney injury in patients with inactive cytochrome P450 polymorphisms. Renal failure. 2009; 31(8):749-52. doi: 10.3109/08860220903118608. [PMID: 19814645]
  • Simone Campos Cavalher-Machado, Elaine Cruz Rosas, Fabiola de Almeida Brito, Alan Patrick Heringe, Rodrigo Rodrigues de Oliveira, Maria Auxiliadora Coelho Kaplan, Maria Raquel Figueiredo, Maria das Graças Müller de Oliveira Henriques. The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy. International immunopharmacology. 2008 Nov; 8(11):1552-60. doi: 10.1016/j.intimp.2008.06.012. [PMID: 18672096]
  • J Jose, K Saravu, B A Shastry, B Jimmy. Drug use in porphyria: a therapeutic dilemma. Singapore medical journal. 2008 Oct; 49(10):e272-5. doi: NULL. [PMID: 18946596]
  • Hua-Xin Zhang, Xing Huang, Min Zhang. Thermodynamic studies on the interaction of dioxopromethazine to beta-cyclodextrin and bovine serum albumin. Journal of fluorescence. 2008 May; 18(3-4):753-60. doi: 10.1007/s10895-008-0348-8. [PMID: 18297374]
  • G O Gbotosho, C T Happi, A Sijuade, O A T Ogundahunsi, A Sowunmi, A M J Oduola. Comparative study of interactions between chloroquine and chlorpheniramine or promethazine in healthy volunteers: a potential combination-therapy phenomenon for resuscitating chloroquine for malaria treatment in Africa. Annals of tropical medicine and parasitology. 2008 Jan; 102(1):3-9. doi: 10.1179/136485908x252179. [PMID: 18186973]
  • Lisa B E Shields, John C Hunsaker Iii, Tracey S Corey, Michael K Ward, Donna Stewart. Methadone toxicity fatalities: a review of medical examiner cases in a large metropolitan area. Journal of forensic sciences. 2007 Nov; 52(6):1389-95. doi: 10.1111/j.1556-4029.2007.00565.x. [PMID: 18093068]
  • Stacy E F Melanson, Elizabeth Lee-Lewandrowski, David A Griggs, William H Long, James G Flood. Reduced interference by phenothiazines in amphetamine drug of abuse immunoassays. Archives of pathology & laboratory medicine. 2006 Dec; 130(12):1834-8. doi: 10.5858/2006-130-1834-ribpia. [PMID: 17149959]
  • G O Gbotosho, O A Ogundahunsi, C T Happi, D E Kyle, L Gerena, W K Milhous, A Sowunmi, A M J Oduola, L A Salako. The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum. Annals of tropical medicine and parasitology. 2006 Oct; 100(7):571-8. doi: 10.1179/136485906x118486. [PMID: 16989682]
  • Peggy Gandia, Sylvie Saivin, Anne Pavy Le-Traon, Antonio Guell, Georges Houin. Influence of simulated weightlessness on the intramuscular and oral pharmacokinetics of promethazine in 12 human volunteers. Journal of clinical pharmacology. 2006 Sep; 46(9):1008-16. doi: 10.1177/0091270006291032. [PMID: 16920895]
  • Oliver H Wittekindt, Alexander Schmitz, Frank Lehmann-Horn, Wolfram Hänsel, Stephan Grissmer. The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine. Neuropharmacology. 2006 Mar; 50(4):458-67. doi: 10.1016/j.neuropharm.2005.10.005. [PMID: 16310228]
  • Luciana de Matos Alves Pinto, Sônia Valéria Pinheiro Malheiros, Antônio Carlos Senges Lino, Eneida de Paula, Maria Angélica Perillo. Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface. Biophysical chemistry. 2006 Feb; 119(3):247-55. doi: 10.1016/j.bpc.2005.09.006. [PMID: 16233945]
  • A Horvat, T Momić, S Petrović, G Nikezić, M Demajo. Selective inhibition of brain Na,K-ATPase by drugs. Physiological research. 2006; 55(3):325-338. doi: 10.33549/physiolres.930696. [PMID: 16083303]
  • Maria A Martinez-Gomez, Rosa M Villanueva-Camañas, Salvador Sagrado, Maria J Medina-Hernández. Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique. Electrophoresis. 2005 Nov; 26(21):4116-26. doi: 10.1002/elps.200500304. [PMID: 16252317]
  • Veronika V Sapozhnikova, Vladislav A Kamensky, Roman V Kuranov, Irina Kutis, Ludmila B Snopova, Aleksey V Myakov. In vivo visualization of Tradescantia leaf tissue and monitoring the physiological and morphological states under different water supply conditions using optical coherence tomography. Planta. 2004 Aug; 219(4):601-9. doi: 10.1007/s00425-004-1276-8. [PMID: 15133665]
  • M Gwamaka, J A Matovelo, M M A Mtambo, G K Mbassa, R M Maselle, S Boniphace. The effect of dexamethasone and promethazine in combination with buparvaquone in the management of East Coast fever. The Onderstepoort journal of veterinary research. 2004 Jun; 71(2):119-28. doi: 10.4102/ojvr.v71i2.274. [PMID: 15373334]
  • Karla A Moore, Tasha L Zemrus, Vera Ramcharitar, Barry Levine, David R Fowler. Mixed drug intoxication involving zaleplon ('Sonata'). Forensic science international. 2003 Jul; 134(2-3):120-2. doi: 10.1016/s0379-0738(03)00130-0. [PMID: 12850405]
  • Akihito Suzuki, Norio Yasui-Furukori, Kazuo Mihara, Tsuyoshi Kondo, Hanako Furukori, Yoshimasa Inoue, Sunao Kaneko, Koichi Otani. Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Therapeutic drug monitoring. 2003 Apr; 25(2):192-6. doi: 10.1097/00007691-200304000-00008. [PMID: 12657913]
  • Marina D Rukhadze, Maka M Alexishvili, Maya V Gonashvili, Nathela V Okujava, Maya V Sebiskveradze. Interaction of carbamazepine and promethazine in rabbits. Biomedical chromatography : BMC. 2003 Jan; 17(1):62-9. doi: 10.1002/bmc.209. [PMID: 12583009]
  • Tung Si Ho, Stig Pedersen-Bjergaard, Knut Einar Rasmussen. Recovery, enrichment and selectivity in liquid-phase microextraction comparison with conventional liquid-liquid extraction. Journal of chromatography. A. 2002 Jul; 963(1-2):3-17. doi: 10.1016/s0021-9673(02)00215-7. [PMID: 12187984]
  • Tung Si Ho, Stig Pedersen-Bjergaard, Knut E Rasmussen. Liquid-phase microextraction of protein-bound drugs under non-equilibrium conditions. The Analyst. 2002 May; 127(5):608-13. doi: 10.1039/b110105f. [PMID: 12081037]
  • K Yamamoto, Y Masubuchi, S Narimatsu, S Kobayashi, T Horie. Toxicity of ethacrynic acid in isolated rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2002 Apr; 16(2):151-8. doi: 10.1016/s0887-2333(01)00107-2. [PMID: 11869877]
  • Rudiger Gröning, Jörg Breitkreutz, Volker Baroth, Rotraut Stephanie Müller. Nanoparticles in plant extracts: influence of drugs on the formation of nanoparticles and precipitates in black tea infusions. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2002 Mar; 15(2):149-55. doi: 10.1016/s0928-0987(01)00194-4. [PMID: 11849911]
  • Nu He, Wen-Qi Zhang, Dolores Shockley, Timi Edeki. Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes. European journal of clinical pharmacology. 2002 Feb; 57(12):847-51. doi: 10.1007/s00228-001-0399-0. [PMID: 11936702]
  • P Radev. [The activity of enzymes and free radical oxidation in acute and chronic fetal hypoxia in general anesthesia during cesarean section]. Akusherstvo i ginekologiia. 2002; 41(6):12-6. doi: NULL. [PMID: 12577498]
  • Wojciech Mańkowski, Bogusław Krupiński, Katarzyna Skret. [Suicidal attempts with old (currently unused) drug]. Przeglad lekarski. 2002; 59(4-5):390-1. doi: . [PMID: 12184019]
  • Q Song, L Putcha. Quantitation of promethazine and metabolites in urine samples using on-line solid-phase extraction and column-switching. Journal of chromatography. B, Biomedical sciences and applications. 2001 Nov; 763(1-2):9-20. doi: 10.1016/s0378-4347(01)00351-6. [PMID: 11710587]
  • J J A Masucci, G G W Caldwell, W W J Jones, S S J Juzwin, P P J Sasso, M Evangelisto. The use of on-line and off-line chromatographic extraction techniques coupled with mass spectrometry for support of in vivo and in vitro assays in drug discovery. Current topics in medicinal chemistry. 2001 Nov; 1(5):463-71. doi: 10.2174/1568026013394985. [PMID: 11899108]
  • S R Vanapalli, S P Kambhampati, L Putcha, D W Bourne. A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors. Journal of chromatographic science. 2001 Feb; 39(2):70-2. doi: 10.1093/chromsci/39.2.70. [PMID: 11245229]
  • S Scaccianoce, K Lombardo, R Nicolai, D Affricano, L Angelucci. Studies on the involvement of histamine in the hypothalamic-pituitary-adrenal axis activation induced by nerve growth factor. Life sciences. 2000 Nov; 67(26):3143-52. doi: 10.1016/s0024-3205(00)00899-7. [PMID: 11191621]
  • K Fu, R J Konrad, R W Hardy, R M Brissie, C A Robinson. An unusual multiple drug intoxication case involving citalopram. Journal of analytical toxicology. 2000 Oct; 24(7):648-50. doi: 10.1093/jat/24.7.648. [PMID: 11043674]
  • L C Strenkoski-Nix, J Ermer, S DeCleene, W Cevallos, P R Mayer. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2000 Aug; 57(16):1499-505. doi: 10.1093/ajhp/57.16.1499. [PMID: 10965395]
  • W Jin, Q Xu, W Li. A new capillary electrophoresis end-column amperometric detection system without the need for capillary/electrode alignment. Electrophoresis. 2000 May; 21(8):1527-34. doi: 10.1002/(sici)1522-2683(20000501)21:8<1527::aid-elps1527>3.0.co;2-z. [PMID: 10832883]
  • S Amos, P A Akah, C J Odukwe, K S Gamaniel, C Wambede. The pharmacological effects of an aqueous extract from Acacia nilotica seeds. Phytotherapy research : PTR. 1999 Dec; 13(8):683-5. doi: 10.1002/(sici)1099-1573(199912)13:8<683::aid-ptr534>3.0.co;2-x. [PMID: 10594939]
  • R Wang, X Lu, M Wu, E Wang. Separation of promethazine and thioridazine using capillary electrophoresis with end-column amperometric detection. Journal of chromatography. B, Biomedical sciences and applications. 1999 Jan; 721(2):327-32. doi: 10.1016/s0378-4347(98)00485-x. [PMID: 10052707]
  • N Ohashi, S Furuuchi, M Yoshikawa. Usefulness of the hydrogen--deuterium exchange method in the study of drug metabolism using liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 1998 Nov; 18(3):325-34. doi: 10.1016/s0731-7085(98)00092-2. [PMID: 10096827]
  • S Schauder. Dioxopromethazine-induced photoallergic contact dermatitis followed by persistent light reaction. American journal of contact dermatitis : official journal of the American Contact Dermatitis Society. 1998 Sep; 9(3):182-7. doi: ". [PMID: 9744913]
  • M Yamazaki, M Terada, Y Mitsukuni, M Yoshimura. [An autopsy case of poisoning by neuropsychopharmaceuticals including zopiclone]. Nihon hoigaku zasshi = The Japanese journal of legal medicine. 1998 Aug; 52(4):245-52. doi: NULL. [PMID: 9893443]
  • A M Oduola, A Sowunmi, W K Milhous, T G Brewer, D E Kyle, L Gerena, R N Rossan, L A Salako, B G Schuster. In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine. The American journal of tropical medicine and hygiene. 1998 May; 58(5):625-9. doi: 10.4269/ajtmh.1998.58.625. [PMID: 9598452]
  • J P Lallès, C Duvaux-Ponter, J W Sissons, R Toullec. Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. Veterinary research. 1998 Jan; 29(1):59-72. doi: NULL. [PMID: 9559521]
  • W Yang, A Y Sun. Paraquat-induced free radical reaction in mouse brain microsomes. Neurochemical research. 1998 Jan; 23(1):47-53. doi: 10.1023/a:1022497319548. [PMID: 9482266]
  • J Liu, J T Stewart. Quantitation of promethazine enantiomers in human serum using a chiralcel OJ-R column and mixed-mode disc solid-phase extraction. Journal of pharmaceutical and biomedical analysis. 1997 Oct; 16(2):303-9. doi: 10.1016/s0731-7085(97)00065-4. [PMID: 9408848]
  • T E Brown, D L Eckberg. Promethazine affects autonomic cardiovascular mechanisms minimally. The Journal of pharmacology and experimental therapeutics. 1997 Aug; 282(2):839-44. doi: NULL. [PMID: 9262349]
  • J P Chippaux, V S Rakotonirina, A Rakotonirina, G Dzikouk. [Drug or plant substances which antagonize venoms or potentiate antivenins]. Bulletin de la Societe de pathologie exotique (1990). 1997; 90(4):282-5. doi: ". [PMID: 9479470]
  • F Anjum, A R Shakoori. Sublethal effects of hexavalent chromium on the body growth rate and liver function enzymes of phenobarbitone-pretreated and promethazine-pretreated rabbits. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 1997; 16(1):51-9. doi: NULL. [PMID: 9256933]
  • F Kilár. Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis. Electrophoresis. 1996 Dec; 17(12):1950-3. doi: 10.1002/elps.1150171224. [PMID: 9034781]
  • K Nakamura, T Yokoi, K Inoue, N Shimada, N Ohashi, T Kume, T Kamataki. CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. 1996 Oct; 6(5):449-57. doi: 10.1097/00008571-199610000-00009. [PMID: 8946477]
  • B J Adegunloye, J O Omoniyi, O A Owolabi, O P Ajagbonna, O A Sofola, H A Coker. Mechanisms of the blood pressure lowering effect of the calyx extract of Hibiscus sabdariffa in rats. African journal of medicine and medical sciences. 1996 Sep; 25(3):235-8. doi: ". [PMID: 10457797]
  • R C Zimmermann, L Krahn, G Klee, P Y Lu, S J Ory, S C Lin. The impact of gender on alpha-methyl-para-tyrosine mediated changes in prolactin secretion and 6-hydroxymelatonin sulfate excretion. Psychoneuroendocrinology. 1996 Jul; 21(5):469-78. doi: 10.1016/0306-4530(95)00049-6. [PMID: 8888369]
  • L Galzigna, V Rizzoli, M P Schiappelli, M P Rigobello, M Scarpa, A Rigo. Horseradish peroxidase-catalyzed sulfoxidation of promethazine and properties of promethazine sulfoxide. Free radical biology & medicine. 1996; 20(6):807-11. doi: 10.1016/0891-5849(95)02213-9. [PMID: 8728028]
  • J A Hey, M Del Prado, F M Cuss, R W Egan, J Sherwood, C C Lin, W Kreutner. Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea-pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1995 Oct; 25(10):974-84. doi: 10.1111/j.1365-2222.1995.tb00400.x. [PMID: 8556569]
  • G W Ponder, J T Stewart. A liquid chromatographic method for the determination of promethazine enantiomers in human urine and serum using solid-phase extraction and fluorescence detection. Journal of pharmaceutical and biomedical analysis. 1995 Aug; 13(9):1161-6. doi: 10.1016/0731-7085(95)01527-r. [PMID: 8573643]
  • S Y Pan. Features of memory on novel situation and avoidance response: evidence from comparisons between open-field behavior and step-through task. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1995 Mar; 16(2):125-9. doi: ". [PMID: 7597911]
  • U Burkhardt, B Vetter, L Wild, D Olthoff. [Plasma catecholamine level and clinical parameters--quality criteria for premedication in childhood]. Anaesthesiologie und Reanimation. 1995; 20(4):88-96. doi: NULL. [PMID: 7575957]