Arg-arg-pro-tyr-ile-leu (BioDeep_00000731124)
代谢物信息卡片
化学式: C38H64N12O8 (816.4969824)
中文名称: 神经降压素(8-13)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N
InChI: InChI=1S/C38H64N12O8/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45)
描述信息
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marc Sousbie, Mélanie Vivancos, Rebecca L Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Richard Leduc, Philippe Sarret, Éric Marsault. Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).
Journal of medicinal chemistry.
2018 08; 61(16):7103-7115. doi:
10.1021/acs.jmedchem.8b00175. [PMID: 30035538] - Katarzyna Kaczyńska, Ewelina Kogut, Dominika Zając, Monika Jampolska, Kryspin Andrzejewski, Dorota Sulejczak, Andrzej W Lipkowski, Patrycja Kleczkowska. Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Oct; 93(?):84-9. doi:
10.1016/j.ejps.2016.08.012. [PMID: 27509866] - Hongzhi Ye, Shifei Xia, Lishuang Yu, Xueqin Xu, Chunsong Zheng, Huifeng Xu, Lili Wang, Xianxiang Liu, Zongwei Cai, Guonan Chen. Solid-phase extraction-field-amplified sample injection coupled with CE-ESI-MS for online pre-concentration and quantitative analysis of brain-gut peptides.
Electrophoresis.
2011 Oct; 32(20):2823-9. doi:
10.1002/elps.201000591. [PMID: 22009770] - Chiara Falciani, Antonella Accardo, Jlenia Brunetti, Diego Tesauro, Barbara Lelli, Alessandro Pini, Luisa Bracci, Giancarlo Morelli. Target-selective drug delivery through liposomes labeled with oligobranched neurotensin peptides.
ChemMedChem.
2011 Apr; 6(4):678-85. doi:
10.1002/cmdc.201000463. [PMID: 21370475] - Rodrigo Teodoro, Bluma Linkowski Faintuch, Eutimio Gustavo Fernández Núñez, Rodrigo Guimarães Queiróz. Neurotensin(8-13) analogue: radiolabeling and biological evaluation using different chelators.
Nuclear medicine and biology.
2011 Jan; 38(1):113-20. doi:
10.1016/j.nucmedbio.2010.06.011. [PMID: 21220134] - Veronique Maes, Elisa Garcia-Garayoa, Peter Bläuenstein, Dirk Tourwé. Novel 99mTc-labeled neurotensin analogues with optimized biodistribution properties.
Journal of medicinal chemistry.
2006 Mar; 49(5):1833-6. doi:
10.1021/jm051172f. [PMID: 16509599] - Kyle P Kokko, M Kyle Hadden, Kevin S Orwig, Jean Mazella, Thomas A Dix. In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues.
Journal of medicinal chemistry.
2003 Sep; 46(19):4141-8. doi:
10.1021/jm0300633. [PMID: 12954066] - Eli-Anne B Gjerde, Edward T Wei, Rolf K Reed. The neurotensin fragment AcNT(8-13) inhibits lowering of interstitial fluid pressure in rat trachea.
American journal of physiology. Heart and circulatory physiology.
2002 Sep; 283(3):H933-40. doi:
10.1152/ajpheart.00086.2002. [PMID: 12181121] - Kyle P Kokko, Thomas A Dix. Monitoring neurotensin[8-13] degradation in human and rat serum utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analytical biochemistry.
2002 Sep; 308(1):34-41. doi:
10.1016/s0003-2697(02)00235-x. [PMID: 12234461] - Elisa García-Garayoa, Peter Bläuenstein, Matthias Bruehlmeier, Alain Blanc, Koen Iterbeke, Peter Conrath, Dirk Tourwé, P August Schubiger. Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2002 Mar; 43(3):374-83. doi:
NULL. [PMID: 11884498] - E García-Garayoa, L Allemann-Tannahill, P Bläuenstein, M Willmann, N Carrel-Rémy, D Tourwé, K Iterbeke, P Conrath, P A Schubiger. In vitro and in vivo evaluation of new radiolabeled neurotensin(8-13) analogues with high affinity for NT1 receptors.
Nuclear medicine and biology.
2001 Jan; 28(1):75-84. doi:
10.1016/s0969-8051(00)00190-6. [PMID: 11182567] - W Rowe, V Viau, M J Meaney, R Quirion. Stimulation of CRH-mediated ACTH secretion by central administration of neurotensin: evidence for the participation of the paraventricular nucleus.
Journal of neuroendocrinology.
1995 Feb; 7(2):109-17. doi:
10.1111/j.1365-2826.1995.tb00673.x. [PMID: 7767323] - A Shulkes, D R Fletcher, K J Hardy. Biological potency of neurotensin metabolites in vivo: importance of alcohol 'fixation' of blood.
Journal of gastroenterology and hepatology.
1989 Sep; 4(5):429-35. doi:
10.1111/j.1440-1746.1989.tb01740.x. [PMID: 2491208]