Panipenem (BioDeep_00000730864)
代谢物信息卡片
Panipenem
化学式: C15H21N3O4S (339.1252706)
中文名称: 帕尼培南
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1C2CC(=C(N2C1=O)C(=O)O)SC3CCN(C3)C(=N)C)O
InChI: InChI=1S/C15H21N3O4S/c1-7(19)12-10-5-11(13(15(21)22)18(10)14(12)20)23-9-3-4-17(6-9)8(2)16/h7,9-10,12,16,19H,3-6H2,1-2H3,(H,21,22)/t7-,9+,10-,12-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:7911
- KEGGdrug: D01048
- PubChem: 72015
- ChEMBL: CHEMBL339323
- CAS: 87726-17-8
- CAS: 98167-70-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoyan Wang, Xien Gu, Changjun Zhang, Fen Zhao, Kai Deng. Structural and biochemical analyses of the LdtMt2-panipenem adduct provide new insights into the effect of the 1-β-methyl group on carbapenems.
Biochemical and biophysical research communications.
2020 02; 523(1):6-9. doi:
10.1016/j.bbrc.2019.12.020. [PMID: 31822344] - Ayako Kato, Jun Ueyama, Fumie Abe, Kazuo Hotta, Ikuto Tsukiyama, Taeyuki Oshima, Fumio Kondo, Hiroko Saito, Takaaki Hasegawa. Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and inactive metabolite SN-38 glucuronide (SN-38G) in rats.
Anticancer research.
2011 Sep; 31(9):2915-22. doi:
. [PMID: 21868538] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Yuji Kurihara, Junko Kizu, Seiji Hori. Simple and rapid determination of serum carbapenem concentrations by high-performance liquid chromatography.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Feb; 14(1):30-4. doi:
10.1007/s10156-007-0576-x. [PMID: 18297446] - Sang-Guk Lee, Jeong-Ho Kim, Jin Yang Joo, Oh Hun Kwon. [Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics].
The Korean journal of laboratory medicine.
2007 Oct; 27(5):338-43. doi:
10.3343/kjlm.2007.27.5.338. [PMID: 18094598] - Mineji Hayakawa, Yasuko Ito, Itaru Fujita, Ken Iseki, Satoshi Gando. Pharmacokinetics and the most suitable regimen of panipenem/beta mipron in critically ill patients receiving continuous renal replacement therapy: a pilot study.
ASAIO journal (American Society for Artificial Internal Organs : 1992).
2006 Jul; 52(4):398-403. doi:
10.1097/0.1mat.0000225268.28044.ae. [PMID: 16883119] - Naoyuki Tajima, Hitoshi Ishizuka, Hideo Naganuma. Population pharmacokinetic analysis of panipenem/betamipron in patients with various degrees of renal function.
Chemotherapy.
2006; 52(5):245-53. doi:
10.1159/000094745. [PMID: 16864999] - Naoyuki Tajima, Masako Soma, Hitoshi Ishizuka, Hideo Naganuma. Quantitative evaluation of effect of renal failure on the pharmacokinetics of panipenem in rats.
Biological & pharmaceutical bulletin.
2005 Nov; 28(11):2170-2. doi:
10.1248/bpb.28.2170. [PMID: 16272714] - Kei Omoda, Teruo Murakami, Ryoko Yumoto, Junya Nagai, Yorinobu Maeda, Yoshie Kiribayashi, Mikihisa Takano. Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human.
Journal of pharmaceutical sciences.
2005 Aug; 94(8):1685-93. doi:
10.1002/jps.20338. [PMID: 15986463] - Naro Ohashi, Toshihiko Uematsu, Satoru Nagashima, Mitsutaka Kanamaru, Naoyuki Tajima, Akashi Togawa, Akira Hishida. Pharmacokinetics of panipenem/betamipron in patients with end-stage renal disease.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2005 Feb; 11(1):24-31. doi:
10.1007/s10156-004-0359-6. [PMID: 15729484] - Toshimi Kimura, Keisuke Sunakawa, Nobuo Matsuura, Hiroaki Kubo, Shigehiko Shimada, Kazuo Yago. Population pharmacokinetics of arbekacin, vancomycin, and panipenem in neonates.
Antimicrobial agents and chemotherapy.
2004 Apr; 48(4):1159-67. doi:
10.1128/aac.48.4.1159-1167.2004. [PMID: 15047516] - Chika Ishii, Masayo Kakuta, Tomomi Abe, Takashi Fukuoka, Matsuhisa Inoue. [Rapid bactericidal activities of carbapenems against Pseudomonas aeruginosa in simulating human plasma concentrations].
The Japanese journal of antibiotics.
2002 Apr; 55(2):187-95. doi:
NULL. [PMID: 12071096] - Shin Yamamoto, Yoshitsugu Kubota, Makoto Takaoka, Mami Ogura, Kazuyuki Tsuji, Kaori Yanagitani, Masaaki Shimatani, Nobuyuki Shibatani, Yoshihito Imai, Shoichiroh Takamidoh, Kyoichi Inoue. The effect of biliary decompression on antibiotic biliary excretion.
Hepato-gastroenterology.
2002 Mar; 49(44):330-4. doi:
NULL. [PMID: 11995444] - Kouji Hattori, Akira Yamada, Satoru Kuroda, Toshiyuki Chiba, Masayoshi Murata, Kazuo Sakane. Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems.
Bioorganic & medicinal chemistry letters.
2002 Feb; 12(3):383-6. doi:
10.1016/s0960-894x(01)00753-3. [PMID: 11814802] - T Kimura, H Kokubun, M Nowatari, N Matsuura, K Sunakawa, H Kubo. Population pharmacokinetics of panipenem in neonates and retrospective evaluation of dosage.
The Journal of antimicrobial chemotherapy.
2001 Jan; 47(1):51-9. doi:
10.1093/jac/47.1.51. [PMID: 11152431] - K Arita, K Daido, N Ohashi, K Nakamura, Y Takeshima, T Kohara. [Study on antibiotics susceptibility and mechanism of carbapenem-resistance in clinical isolates of Pseudomonas aeruginosa].
The Japanese journal of antibiotics.
1999 Jul; 52(7):491-6. doi:
NULL. [PMID: 10516928] - N Yamamura, K Imura, H Naganuma, K Nishimura. Panipenem, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats.
Drug metabolism and disposition: the biological fate of chemicals.
1999 Jun; 27(6):724-30. doi:
NULL. [PMID: 10348803] - Y Utsui, C Ishii, T Abe, M Kakuta, S Ohya. [Combination effect of teicoplanin and panipenem on highly resistant strains of MRSA].
The Japanese journal of antibiotics.
1999 Mar; 52(3):268-77. doi:
NULL. [PMID: 10367264] - S Kojima, M Nadai, K Kitaichi, L Wang, T Nabeshima, T Hasegawa. Possible mechanism by which the carbapenem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats.
Antimicrobial agents and chemotherapy.
1998 Dec; 42(12):3136-40. doi:
10.1128/aac.42.12.3136. [PMID: 9835504] - T Masuda, A Suzuki, M Obana, Y Matsuoka, S Irimajiri. [A case of infective endocarditis with purpura and macroscopic hematuria as initial manifestations].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
1996 Apr; 70(4):366-70. doi:
10.11150/kansenshogakuzasshi1970.70.366. [PMID: 8690952] - Y Hirouchi, H Naganuma, Y Kawahara, R Okada, A Kamiya, K Inui, R Hori. Preventive effect of betamipron on nephrotoxicity and uptake of carbapenems in rabbit renal cortex.
Japanese journal of pharmacology.
1994 Sep; 66(1):1-6. doi:
10.1254/jjp.66.1. [PMID: 7861655] - J Shimada, Y Kawahara. Overview of a new carbapenem, panipenem/betamipron.
Drugs under experimental and clinical research.
1994; 20(6):241-5. doi:
NULL. [PMID: 7758396] - H Kiyota, T Machida, S Onodera, H Suzuki, H Goto, S Takamizawa, H Mitani, M Kawahara, H Igarashi, K Endoh. [Influence of urine pH and cations on antimicrobial activities of penems].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
1993 May; 67(5):435-9. doi:
10.11150/kansenshogakuzasshi1970.67.435. [PMID: 8320460] - T Fukuoka, S Ohya, T Narita, M Katsuta, M Iijima, N Masuda, H Yasuda, J Trias, H Nikaido. Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane.
Antimicrobial agents and chemotherapy.
1993 Feb; 37(2):322-7. doi:
10.1128/aac.37.2.322. [PMID: 8452364] - A Kurihara, M Hisaoka, N Mikuni, K Kamoshida. Neurotoxicity of panipenem/betamipron, a new carbapenem, in rabbits: correlation to concentration in central nervous system.
Journal of pharmacobio-dynamics.
1992 Jul; 15(7):325-32. doi:
10.1248/bpb1978.15.325. [PMID: 1447679] - M Nakashima, A Kurihara, M Hisaoka. Prediction of human pharmacokinetics of panipenem, a new carbapenem antibiotic, from animal data.
Drugs under experimental and clinical research.
1992; 18(9):371-5. doi:
NULL. [PMID: 1299587] - N Loreau, C Lepreux, R Ardaillou. Calcitonin-sensitive adenylate cyclase in rat renal tubular membranes.
The Biochemical journal.
1975 Sep; 150(3):305-14. doi:
10.1042/bj1500305. [PMID: 2153]