Amiloride HCl dihydrate (BioDeep_00000730694)
代谢物信息卡片
Amiloride hydrochloride dihydrate
化学式: C6H13Cl2N7O3 (301.0456888)
中文名称: 盐酸阿米洛利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
InChI: 1H
描述信息
D049990 - Membrane Transport Modulators > D026941 - Sodium Channel Blockers > D062686 - Epithelial Sodium Channel Blockers
D049990 - Membrane Transport Modulators > D026941 - Sodium Channel Blockers > D062646 - Acid Sensing Ion Channel Blockers
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49186 - Potassium-Sparing Diuretic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:2640
- KEGGdrug: D87944
- KEGGdrug: D00649
- PubChem: 68540
- ChEMBL: CHEMBL1398126
- MeSH: Amiloride
- CAS: 17440-83-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Noah H Somberg, João Medeiros-Silva, Hyunil Jo, Jun Wang, William F DeGrado, Mei Hong. Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface.
Protein science : a publication of the Protein Society.
2023 10; 32(10):e4755. doi:
10.1002/pro.4755. [PMID: 37632140] - Kiem Vu, Benjamin J Buckley, Richard S Bujaroski, Eduardo Blumwald, Michael J Kelso, Angie Gelli. Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs.
Frontiers in cellular and infection microbiology.
2023; 13(?):1101568. doi:
10.3389/fcimb.2023.1101568. [PMID: 36923593] - Juliana Pena Lopez, Mohammad-Zaman Nouri, Areej Ebrahim, Kevin M Chacko, Whitney C Schramm, Mohammed F Gholam, Tezcan Ozrazgat-Baslanti, Nancy D Denslow, Abdel A Alli. Lipid Profiles of Urinary Extracellular Vesicles Released during the Inactive and Active Phases of Aged Male Mice with Spontaneous Hypertension.
International journal of molecular sciences.
2022 Dec; 23(23):. doi:
10.3390/ijms232315397. [PMID: 36499728] - Babar Shahzad, Lana Shabala, Meixue Zhou, Gayatri Venkataraman, Celymar Angela Solis, David Page, Zhong-Hua Chen, Sergey Shabala. Comparing Essentiality of SOS1-Mediated Na+ Exclusion in Salinity Tolerance between Cultivated and Wild Rice Species.
International journal of molecular sciences.
2022 Aug; 23(17):. doi:
10.3390/ijms23179900. [PMID: 36077294] - ZhangFei Su, J Jay Leitch, Jacek Lipkowski. Effect of Lipid Composition on the Inhibition Mechanism of Amiloride on Alamethicin Ion Channels in Supported Phospholipid Bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2022 07; 38(27):8398-8406. doi:
10.1021/acs.langmuir.2c00953. [PMID: 35749587] - Bora Gulhan, Yağmur Ünsal, Demet Baltu, Nur Berna Çelik Ertaş, Gülşah Özdemir, Eda Utine, H Nursun Ozcan, Ali Duzova, Nazli Gönç. Apparent mineralocorticoid excess: A diagnosis beyond classical causes of severe hypertension in a child.
Blood pressure monitoring.
2022 Jun; 27(3):208-211. doi:
10.1097/mbp.0000000000000583. [PMID: 35044984] - Mahmoud Azzeh, Marco Battaglia, Simon Davies, John Strauss, Prashant Dogra, Venkata Yellepeddi. Novel intranasal treatment for anxiety disorders using amiloride, an acid-sensing ion channel antagonist: Pharmacokinetic modeling and simulation.
International journal of clinical pharmacology and therapeutics.
2022 Jun; 60(6):253-263. doi:
10.5414/cp204217. [PMID: 35445658] - Maria Mernea, Roxana Ștefania Ulăreanu, Dana Cucu, Jasim Hafedh Al-Saedi, Cristian-Emilian Pop, Sergiu Fendrihan, Giorgiana Diana Carmen Anghelescu, Dan Florin Mihăilescu. Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103271. [PMID: 35630748] - Deepika Anand, Edith Hummler, Olivia J Rickman. ENaC activation by proteases.
Acta physiologica (Oxford, England).
2022 05; 235(1):e13811. doi:
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Physiological reports.
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International journal of molecular sciences.
2022 Feb; 23(4):. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2022 01; 37(2):298-303. doi:
10.1093/ndt/gfab159. [PMID: 33914065] - Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde. Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2.
Communications biology.
2021 12; 4(1):1347. doi:
10.1038/s42003-021-02866-9. [PMID: 34853399] - Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi, Xinling Liang. The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study.
Renal failure.
2021 Dec; 43(1):452-459. doi:
10.1080/0886022x.2021.1892759. [PMID: 33657976] - Marc Yeste, Sandra Recuero, Carolina Maside, Albert Salas-Huetos, Sergi Bonet, Elisabeth Pinart. Blocking NHE Channels Reduces the Ability of In Vitro Capacitated Mammalian Sperm to Respond to Progesterone Stimulus.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
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Hypertension (Dallas, Tex. : 1979).
2021 11; 78(5):1335-1346. doi:
10.1161/hypertensionaha.121.17435. [PMID: 34601973] - Liga Skarda, Julia Kowal, Kaspar P Locher. Structure of the Human Cholesterol Transporter ABCG1.
Journal of molecular biology.
2021 10; 433(21):167218. doi:
10.1016/j.jmb.2021.167218. [PMID: 34461069] - Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang, Donghai Lin. Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.
Skeletal muscle.
2021 07; 11(1):17. doi:
10.1186/s13395-021-00274-5. [PMID: 34229732] - Sagar S Manoli, Kyle Kisor, Bradley A Webb, Diane L Barber. Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells.
American journal of physiology. Cell physiology.
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American journal of physiology. Renal physiology.
2021 06; 320(6):F1080-F1092. doi:
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International journal of molecular sciences.
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PLoS pathogens.
2021 05; 17(5):e1009519. doi:
10.1371/journal.ppat.1009519. [PMID: 34003853] - Benjamin J Buckley, Ashraf Aboelela, Hiwa Majed, Richard S Bujaroski, Karen L White, Andrew K Powell, Wen Wang, Kasiram Katneni, Jessica Saunders, David M Shackleford, Susan A Charman, Gregory M Cook, Michael J Kelso, Marie Ranson. Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Bioorganic & medicinal chemistry.
2021 05; 37(?):116116. doi:
10.1016/j.bmc.2021.116116. [PMID: 33799173] - Niklas Ayasse, Peder Berg, Jesper Frank Andersen, Samuel Levi Svendsen, Mads V Sørensen, Natalya U Fedosova, I Jeanette Lynch, Charles S Wingo, Jens Leipziger. Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases.
American journal of physiology. Renal physiology.
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International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22042205. [PMID: 33672216] - Mandakini Shinde, Kishor Kale, Keshav Kumar, Divya Ottoor. Effect of quercetin on the amiloride-bovine serum albumin interaction using spectroscopic methods, molecular docking and chemometric approaches.
Luminescence : the journal of biological and chemical luminescence.
2021 Feb; 36(1):129-141. doi:
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Physiological reports.
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10.14814/phy2.14668. [PMID: 33410279] - Wen Shen, Mohammed Alshehri, Sameer Desale, Christopher Wilcox. The Effect of Amiloride on Proteinuria in Patients with Proteinuric Kidney Disease.
American journal of nephrology.
2021; 52(5):368-377. doi:
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Cancer research.
2020 12; 80(24):5491-5501. doi:
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10.1016/j.bbrc.2020.07.107. [PMID: 32962857] - Venkata S Mandala, Matthew J McKay, Alexander A Shcherbakov, Aurelio J Dregni, Antonios Kolocouris, Mei Hong. Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers.
Nature structural & molecular biology.
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Journal of the American Heart Association.
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10.1161/jaha.120.016387. [PMID: 33215566] - Marc A Egerman, Jenny S Wong, Tian Runxia, Gohar Mosoyan, Kinsuk Chauhan, Joselyn Reyes-Bahamonde, Nanditha Anandakrishnan, Nicholas J Wong, Emilia Bagiella, Fadi Salem, Kristin Meliambro, Hong Li, Evren U Azeloglu, Steven G Coca, Kirk N Campbell, Leopoldo Raij. Plasminogenuria is associated with podocyte injury, edema, and kidney dysfunction in incident glomerular disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 12; 34(12):16191-16204. doi:
10.1096/fj.202000413r. [PMID: 33070369] - Mir S Adil, S Priya Narayanan, Payaningal R Somanath. Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis?.
Drug discoveries & therapeutics.
2020 Nov; 14(5):256-258. doi:
10.5582/ddt.2020.03070. [PMID: 33116037] - Anindit Mukherjee, Kelvin D MacDonald, Jeonghwan Kim, Michael I Henderson, Yulia Eygeris, Gaurav Sahay. Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models.
Science advances.
2020 11; 6(47):. doi:
10.1126/sciadv.abc5911. [PMID: 33208364] - Caitlin Baumer-Harrison, Martin A Raymond, Thomas A Myers, Kolbe M Sussman, Spencer T Rynberg, Amanda P Ugartechea, Dean Lauterbach, Thomas G Mast, Joseph M Breza. Optogenetic Stimulation of Type I GAD65+ Cells in Taste Buds Activates Gustatory Neurons and Drives Appetitive Licking Behavior in Sodium-Depleted Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2020 10; 40(41):7795-7810. doi:
10.1523/jneurosci.0597-20.2020. [PMID: 32878902] - Luísa Nathália Bolda Mariano, Thaise Boeing, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza. The acute diuretic effects with low-doses of natural prenylated xanthones in rats.
European journal of pharmacology.
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10.1016/j.ejphar.2020.173432. [PMID: 32745607] - Roberta Benedetto, Raquel Centeio, Jiraporn Ousingsawat, Rainer Schreiber, Melanie Janda, Karl Kunzelmann. Transport properties in CFTR-/- knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption.
Pflugers Archiv : European journal of physiology.
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The FEBS journal.
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Chemical senses.
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Nutrients.
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American journal of physiology. Heart and circulatory physiology.
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Journal of cellular and molecular medicine.
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Talanta.
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
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Journal of clinical hypertension (Greenwich, Conn.).
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American journal of physiology. Renal physiology.
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American journal of hypertension.
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Journal of clinical hypertension (Greenwich, Conn.).
2019 07; 21(7):922-928. doi:
10.1111/jch.13567. [PMID: 31169971] - Ahmed A Khorshed, Mohamed Khairy, Craig E Banks. Electrochemical determination of antihypertensive drugs by employing costless and portable unmodified screen-printed electrodes.
Talanta.
2019 Jun; 198(?):447-456. doi:
10.1016/j.talanta.2019.01.117. [PMID: 30876585] - Xueyang Deng, Zhouye Ji, Bingru Xu, Liting Guo, Lixing Xu, Tingting Qin, Liang Feng, Zhanqiang Ma, Qiang Fu, Rong Qu, Qinglong Quo, Shiping Ma. Suppressing the Na+/H+ exchanger 1: a new sight to treat depression.
Cell death & disease.
2019 05; 10(5):370. doi:
10.1038/s41419-019-1602-5. [PMID: 31068571] - Mads Vaarby Sørensen, Bidisha Saha, Iben Skov Jensen, Peng Wu, Niklas Ayasse, Catherine E Gleason, Samuel Levi Svendsen, Wen-Hui Wang, David Pearce. Potassium acts through mTOR to regulate its own secretion.
JCI insight.
2019 04; 5(?):. doi:
10.1172/jci.insight.126910. [PMID: 31013253] - Erika Reus-Chavarría, Ivette Martínez-Vieyra, Cristina Salinas-Nolasco, Araceli Evangelina Chávez-Piña, Juan Vicente Méndez-Méndez, Edgar Oliver López-Villegas, Alejandro Sosa-Peinado, Doris Cerecedo. Enhanced expression of the Epithelial Sodium Channel in neutrophils from hypertensive patients.
Biochimica et biophysica acta. Biomembranes.
2019 02; 1861(2):387-402. doi:
10.1016/j.bbamem.2018.11.003. [PMID: 30423324] - Shinpei Uno, Hironori Kimura, Masatoshi Murai, Hideto Miyoshi. Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches.
The Journal of biological chemistry.
2019 01; 294(2):679-696. doi:
10.1074/jbc.ra118.006056. [PMID: 30425100] - Rikke Ydegaard, Henrik Andersen, Christina S Oxlund, Ib A Jacobsen, Pernille B L Hansen, Jonathan F Jürgensen, Antonio Augusto Peluso, Paul M Vanhoutte, Mette Staehr, Per Svenningsen, Boye L Jensen. The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice.
Acta physiologica (Oxford, England).
2019 01; 225(1):e13189. doi:
10.1111/apha.13189. [PMID: 30240139] - Simiat O Elias, Olusoga A Sofola, Smith I Jaja. Epithelial sodium channel blockade and new β-ENaC polymorphisms among normotensive and hypertensive adult Nigerians.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2019; 41(2):144-151. doi:
10.1080/10641963.2018.1451538. [PMID: 29580127] - Anastasia V Sudarikova, Valeria Y Vasileva, Irina O Vassilieva, Yuri A Negulyaev, Elena A Morachevskaya, Vladislav I Chubinskiy-Nadezhdin. Extracellular protease trypsin activates amiloride-insensitive sodium channels in human leukemia cells.
Journal of cellular biochemistry.
2019 01; 120(1):461-469. doi:
10.1002/jcb.27402. [PMID: 30203535] - Harilaos Filippakis, Amine Belaid, Brian Siroky, Constance Wu, Nicola Alesi, Thomas Hougard, Julie Nijmeh, Hilaire C Lam, Elizabeth P Henske. Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.
Scientific reports.
2018 09; 8(1):14161. doi:
10.1038/s41598-018-32256-x. [PMID: 30242175] - Gustavo Frindt, Lei Yang, Krister Bamberg, Lawrence G Palmer. Na restriction activates epithelial Na channels in rat kidney through two mechanisms and decreases distal Na+ delivery.
The Journal of physiology.
2018 08; 596(16):3585-3602. doi:
10.1113/jp275988. [PMID: 29737520] - Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
The lancet. Diabetes & endocrinology.
2018 06; 6(6):464-475. doi:
10.1016/s2213-8587(18)30071-8. [PMID: 29655877] - Gitte R Hinrichs, Line A Mortensen, Boye L Jensen, Claus Bistrup. Amiloride resolves resistant edema and hypertension in a patient with nephrotic syndrome; a case report.
Physiological reports.
2018 06; 6(12):e13743. doi:
10.14814/phy2.13743. [PMID: 29939487] - Fabile Schlickmann, Thaise Boeing, Luisa Nathália Bolda Mariano, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Luisa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza, Valdir Cechinel-Filho. Gallic acid, a phenolic compound isolated from Mimosa bimucronata (DC.) Kuntze leaves, induces diuresis and saluresis in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 06; 391(6):649-655. doi:
10.1007/s00210-018-1502-8. [PMID: 29663016] - Masayoshi Nanami, Truyen D Pham, Young Hee Kim, Baoli Yang, Roy L Sutliff, Olivier Staub, Janet D Klein, Karen I Lopez-Cayuqueo, Regine Chambrey, Annie Y Park, Xiaonan Wang, Vladimir Pech, Jill W Verlander, Susan M Wall. The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.
Journal of the American Society of Nephrology : JASN.
2018 06; 29(6):1706-1719. doi:
10.1681/asn.2017080826. [PMID: 29773687] - Autumn N Harris, P Richard Grimm, Hyun-Wook Lee, Eric Delpire, Lijuan Fang, Jill W Verlander, Paul A Welling, I David Weiner. Mechanism of Hyperkalemia-Induced Metabolic Acidosis.
Journal of the American Society of Nephrology : JASN.
2018 05; 29(5):1411-1425. doi:
10.1681/asn.2017111163. [PMID: 29483157] - A M Assmus, M K Mansley, L J Mullins, A Peter, J J Mullins. mCCDcl1 cells show plasticity consistent with the ability to transition between principal and intercalated cells.
American journal of physiology. Renal physiology.
2018 05; 314(5):F820-F831. doi:
10.1152/ajprenal.00354.2017. [PMID: 29357433] - Jeannine Witte, Josephine Lampe, Anna Koenen, Ines Urbaneck, Antje Steinbach, Rainer Rettig, Olaf Grisk. The role of distal tubule and collecting duct sodium reabsorption in sunitinib-induced hypertension.
Journal of hypertension.
2018 04; 36(4):892-903. doi:
10.1097/hjh.0000000000001650. [PMID: 29283974] - Kai Liu, Fang Qin, Xiaolu Sun, Yang Zhang, Jizheng Wang, Yajie Wu, Wenjun Ma, Wei Wang, Xueyi Wu, Ying Qin, Huimin Zhang, Xianliang Zhou, Haiying Wu, Rutai Hui, Yubao Zou, Xiongjing Jiang, Lei Song. Analysis of the genes involved in Mendelian forms of low-renin hypertension in Chinese early-onset hypertensive patients.
Journal of hypertension.
2018 03; 36(3):502-509. doi:
10.1097/hjh.0000000000001556. [PMID: 28915228] - Xuechun Wang, Zhongqing Jiang, Jian An, Xiaodan Mao, Fen Lin, Pengming Sun. Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro.
Molecular medicine reports.
2018 03; 17(3):4273-4280. doi:
10.3892/mmr.2018.8414. [PMID: 29328476] - Jonathan M Berman, Elena Mironova, James D Stockand. Physiological regulation of the epithelial Na+ channel by casein kinase II.
American journal of physiology. Renal physiology.
2018 03; 314(3):F367-F372. doi:
10.1152/ajprenal.00469.2017. [PMID: 29021227] - Devinder Sandhu, Manju V Pudussery, Rakesh Kaundal, Donald L Suarez, Amita Kaundal, Rajandeep S Sekhon. Molecular characterization and expression analysis of the Na+/H+ exchanger gene family in Medicago truncatula.
Functional & integrative genomics.
2018 Mar; 18(2):141-153. doi:
10.1007/s10142-017-0581-9. [PMID: 29280022] - Morag K Mansley, Christoph Korbmacher, Marko Bertog. Inhibitors of the proteasome stimulate the epithelial sodium channel (ENaC) through SGK1 and mimic the effect of aldosterone.
Pflugers Archiv : European journal of physiology.
2018 02; 470(2):295-304. doi:
10.1007/s00424-017-2060-5. [PMID: 28861610] - Priyakshi Kalita-De Croft, Jennifer J Bedford, John P Leader, Robert J Walker. Amiloride modifies the progression of lithium-induced renal interstitial fibrosis.
Nephrology (Carlton, Vic.).
2018 Jan; 23(1):20-30. doi:
10.1111/nep.12929. [PMID: 27682266] - Dorota L Stankowska, Brett H Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas. Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents.
Current eye research.
2018 01; 43(1):84-95. doi:
10.1080/02713683.2017.1383442. [PMID: 29111855] - Rie Marunaka, Akiyuki Taruno, Toshiro Yamamoto, Narisato Kanamura, Yoshinori Marunaka. Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 50(1):363-377. doi:
10.1159/000494012. [PMID: 30308504] - Thalia R Segal, Lidia Mínguez-Alarcón, Yu-Han Chiu, Paige L Williams, Feiby L Nassan, Ramace Dadd, María Ospina, Antonia M Calafat, Russ Hauser. Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center.
Human reproduction (Oxford, England).
2017 Dec; 32(12):2532-2539. doi:
10.1093/humrep/dex327. [PMID: 29077936] - Hong Wang, Cesar A Romero, J X Masjoan Juncos, Sumit R Monu, Edward L Peterson, Oscar A Carretero. Effect of salt intake on afferent arteriolar dilatation: role of connecting tubule glomerular feedback (CTGF).
American journal of physiology. Renal physiology.
2017 Dec; 313(6):F1209-F1215. doi:
10.1152/ajprenal.00320.2017. [PMID: 28835421] - Tanya L Henshall, Jantina A Manning, Omri S Alfassy, Pranay Goel, Natasha A Boase, Hiroshi Kawabe, Sharad Kumar. Deletion of Nedd4-2 results in progressive kidney disease in mice.
Cell death and differentiation.
2017 12; 24(12):2150-2160. doi:
10.1038/cdd.2017.137. [PMID: 28862701] - Oleg Palygin, Vladislav Levchenko, Daria V Ilatovskaya, Tengis S Pavlov, Oleh M Pochynyuk, Howard J Jacob, Aron M Geurts, Matthew R Hodges, Alexander Staruschenko. Essential role of Kir5.1 channels in renal salt handling and blood pressure control.
JCI insight.
2017 09; 2(18):. doi:
10.1172/jci.insight.92331. [PMID: 28931751] - Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Yusuke Sata, Michael James Turner, Masafumi Fukumitsu, Hiromi Yamamoto, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi. Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits.
The journal of physiological sciences : JPS.
2017 Sep; 67(5):587-593. doi:
10.1007/s12576-016-0489-5. [PMID: 27660058] - Kaustubh Sharma, Masudul Haque, Richard Guidry, Yoichi Ueta, Ryoichi Teruyama. Effect of dietary salt intake on epithelial Na+ channels (ENaC) in vasopressin magnocellular neurosecretory neurons in the rat supraoptic nucleus.
The Journal of physiology.
2017 09; 595(17):5857-5874. doi:
10.1113/jp274856. [PMID: 28714095] - Darrice S Montgomery, Ling Yu, Zinah M Ghazi, Tiffany L Thai, Otor Al-Khalili, He-Ping Ma, Douglas C Eaton, Abdel A Alli. ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins.
American journal of physiology. Cell physiology.
2017 Jul; 313(1):C42-C53. doi:
10.1152/ajpcell.00244.2016. [PMID: 28468944] - Gustavo Frindt, Lei Yang, Shinichi Uchida, Alan M Weinstein, Lawrence G Palmer. Responses of distal nephron Na+ transporters to acute volume depletion and hyperkalemia.
American journal of physiology. Renal physiology.
2017 07; 313(1):F62-F73. doi:
10.1152/ajprenal.00668.2016. [PMID: 28356292] - Juan Bai, Billy K C Chow. Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2017 04; 31(4):1689-1697. doi:
10.1096/fj.201600911r. [PMID: 28082350] - Lei Yang, Gustavo Frindt, Florian Lang, Dietmar Kuhl, Volker Vallon, Lawrence G Palmer. SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone.
American journal of physiology. Renal physiology.
2017 01; 312(1):F65-F76. doi:
10.1152/ajprenal.00257.2016. [PMID: 27413200] - Linda M Polfus, Eric Boerwinkle, Richard A Gibbs, Ginger Metcalf, Donna Muzny, Narayanan Veeraraghavan, Megan Grove, Sanjay Shete, Stephanie Wallace, Dianna Milewicz, Neil Hanchard, James R Lupski, Syed Shahrukh Hashmi, Monesha Gupta-Malhotra. Whole-exome sequencing reveals an inherited R566X mutation of the epithelial sodium channel β-subunit in a case of early-onset phenotype of Liddle syndrome.
Cold Spring Harbor molecular case studies.
2016 11; 2(6):a001255. doi:
10.1101/mcs.a001255. [PMID: 27900368] - Alemu Regassa, Kye Won Park, Woo Kyun Kim. Phenamil enhances the adipogenic differentiation of hen preadipocytes.
Cell biology international.
2016 Oct; 40(10):1123-8. doi:
10.1002/cbin.10651. [PMID: 27460177] - Jason C George, Deepak Vedamurthy, Maria Bermudez, John W Kennedy. Quiz Page October 2016: Severe Hypokalemia, Metabolic Alkalosis, and Malignancy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2016 10; 68(4):A17-A19. doi:
10.1053/j.ajkd.2016.06.015. [PMID: 27664476] - I S Jensen, C K Larsen, J Leipziger, M V Sørensen. Na(+) dependence of K(+) -induced natriuresis, kaliuresis and Na(+) /Cl(-) cotransporter dephosphorylation.
Acta physiologica (Oxford, England).
2016 09; 218(1):49-61. doi:
10.1111/apha.12707. [PMID: 27172453] - Bruns A Watts, Thampi George, Andrew Badalamenti, David W Good. High-mobility group box 1 inhibits HCO3- absorption in the medullary thick ascending limb through RAGE-Rho-ROCK-mediated inhibition of basolateral Na+/H+ exchange.
American journal of physiology. Renal physiology.
2016 09; 311(3):F600-13. doi:
10.1152/ajprenal.00185.2016. [PMID: 27358052]