2-Amino-1,3,4-thiadiazole (BioDeep_00000730339)
代谢物信息卡片
化学式: C2H3N3S (101.0047678)
中文名称: 2-氨基-1,3,4-噻二唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NN=C(S1)N
InChI: InChI=1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
描述信息
C471 - Enzyme Inhibitor > C2087 - Inosine Monophosphate Dehydrogenase Inhibitor
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tara B Hendry-Hofer, Patrick C Ng, Alison M McGrath, David Mukai, Matthew Brenner, Sari Mahon, Joseph K Maddry, Gerry R Boss, Vikhyat S Bebarta. Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model.
Annals of the New York Academy of Sciences.
2020 11; 1479(1):159-167. doi:
10.1111/nyas.14339. [PMID: 32233102] - Małgorzata Korycka-Machała, Anna Brzostek, Bożena Dziadek, Malwina Kawka, Tomasz Popławski, Zbigniew J Witczak, Jarosław Dziadek. Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives.
Molecules (Basel, Switzerland).
2017 May; 22(5):. doi:
10.3390/molecules22050812. [PMID: 28509874] - Ella Meltzer-Mats, Gali Babai-Shani, Lily Pasternak, Neta Uritsky, Tamar Getter, Olga Viskind, Jürgen Eckel, Erol Cerasi, Hanoch Senderowitz, Shlomo Sasson, Arie Gruzman. Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
Journal of medicinal chemistry.
2013 Jul; 56(13):5335-50. doi:
10.1021/jm4001488. [PMID: 23750537] - Palraj Kalimuthu, S Abraham John. Selective determination of homocysteine at physiological pH using nanostructured film of aminothiadiazole modified electrode.
Bioelectrochemistry (Amsterdam, Netherlands).
2010 Oct; 79(2):168-72. doi:
10.1016/j.bioelechem.2010.02.006. [PMID: 20409759] - Palraj Kalimuthu, S Abraham John. Simultaneous determination of ascorbic acid, dopamine, uric acid and xanthine using a nanostructured polymer film modified electrode.
Talanta.
2010 Mar; 80(5):1686-91. doi:
10.1016/j.talanta.2009.10.007. [PMID: 20152397] - K Aruna, R Rukkumani, P Sureshvarma, V P Menon. Role of an aminothiazole derivative on ethanol- and thermally oxidized sunflower oil-induced toxicity.
Polish journal of pharmacology.
2004 Mar; 56(2):233-40. doi:
NULL. [PMID: 15156074] - P J Elson, L K Kvols, S E Vogl, D J Glover, R G Hahn, D L Trump, P P Carbone, J D Earle, T E Davis. Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
Investigational new drugs.
1988 Jun; 6(2):97-103. doi:
10.1007/bf00195367. [PMID: 3170135] - J A Stewart, C C Ackerly, C F Myers, R A Newman, I H Krakoff. Clinical and clinical pharmacologic studies of 2-amino-1,3,4-thiadiazole (A-TDA:NSC 4728).
Cancer chemotherapy and pharmacology.
1986; 16(3):287-91. doi:
10.1007/bf00293994. [PMID: 2938841] - C C Ackerly, R A Newman, C Myers, J J McCormack. Liquid chromatographic separation and quantitation of 2-amino-1,3,4-thiadiazole (NSC-4728) from human and murine serum.
Journal of chromatography.
1982 Jun; 230(1):175-80. doi:
10.1016/s0378-4347(00)81446-2. [PMID: 7107759] - K Lu, T L Loo. The pharmacologic fate of the antitumor agent 2-amino-1,3,4-thiadiazole in the dog.
Cancer chemotherapy and pharmacology.
1980; 4(4):275-9. doi:
10.1007/bf00255274. [PMID: 7438330] - F G King, R L Dedrick. Pharmacokinetic model for 2-amino-1,3,4-thiadiazole in mouse, dog, and monkey.
Cancer treatment reports.
1979 Nov; 63(11-12):1939-47. doi:
NULL. [PMID: 118803] - S M El Darrer, K F Tillery, D L Hill. Distribution and metabolism of 2-amino-1,3,4-thiadiazole in mice, dogs, and monkeys.
Cancer treatment reports.
1978 Jan; 62(1):75-83. doi:
NULL. [PMID: 414836]