LOXOPROFEN SODIUM SALT (BioDeep_00000729857)
代谢物信息卡片
Loxoprofen sodium dihydrate
化学式: C15H21NaO5 (304.1286616)
中文名称: 洛索洛芬钠二水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)[O-].O.O.[Na+]
InChI: +1
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Itsuro Kazama, Momono Senzaki. Does immunosuppressive property of non-steroidal anti-inflammatory drugs (NSAIDs) reduce COVID-19 vaccine-induced systemic side effects?.
Drug discoveries & therapeutics.
2021 Nov; 15(5):278-280. doi:
10.5582/ddt.2021.01094. [PMID: 34707073] - Georgios Malis, Elena Geromichalou, George D Geromichalos, Antonios G Hatzidimitriou, George Psomas. Copper(II) complexes with non-steroidal anti-inflammatory drugs: Structural characterization, in vitro and in silico biological profile.
Journal of inorganic biochemistry.
2021 11; 224(?):111563. doi:
10.1016/j.jinorgbio.2021.111563. [PMID: 34399232] - Mingxing Luo, Fangfang Xu, Qingze Wang, Wenli Luo. The inhibiting effect of glucosamine sulfate combined with loxoprofen sodium on chondrocyte apoptosis in rats with knee osteoarthritis.
Journal of musculoskeletal & neuronal interactions.
2021 03; 21(1):113-120. doi:
NULL. [PMID: 33657761] - Zhen-Wu Zhang, Di-Yang Ling, Jian Han, Cheng-Xiang Wu, Zhe-Yin Wang. [Therapeutic effect and mechanism of silver needle heat conduction therapy combined with loxoprofen sodium patch in patients with knee osteoarthritis].
Zhen ci yan jiu = Acupuncture research.
2021 Jan; 46(1):64-8. doi:
10.13702/j.1000-0607.200260. [PMID: 33559428] - Fumihiro Nishimura, Tomoko Ushijima, Masako Nojima, Shinsuke Hamada, Kazumasa Hara, Yasuyuki Hamada, Daisuke Kadowaki, Shigeyuki Miyamura, Kentaro Oniki, Junji Saruwatari. Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis.
Biological & pharmaceutical bulletin.
2021; 44(10):1427-1432. doi:
10.1248/bpb.b21-00215. [PMID: 34602552] - Takashi Sakaida, Isao Tanimoto, Akihiro Matsubara, Motoki Nakamura, Akimichi Morita. Unique skin manifestations of COVID-19: Is drug eruption specific to COVID-19?.
Journal of dermatological science.
2020 Jul; 99(1):62-64. doi:
10.1016/j.jdermsci.2020.05.002. [PMID: 32425356] - Takahiro Shinzato, Ken Ohara, Hiroaki Kaminaga, Taro Sugase, Takahiro Masuda, Daisuke Nagata, Katano Saki, Yoshitaka Kinoshita, Taro Kubo, Toshihiro Shimizu, Koji Nanmoku, Takashi Yagisawa. Acute Interstitial Nephritis and Acute Tubular Injury Due to a Transdermal Loxoprofen Patch.
Internal medicine (Tokyo, Japan).
2020; 59(21):2733-2736. doi:
10.2169/internalmedicine.4945-20. [PMID: 33132307] - Riya Shrestha, Sanjita Paudel, Piljoung Cho, Aarajana Shrestha, Tae Cheon Jeong, Eung-Seok Lee, Taeho Lee, Sangkyu Lee. Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat.
Biopharmaceutics & drug disposition.
2019 Jul; 40(7):234-241. doi:
10.1002/bdd.2196. [PMID: 31242324] - Muhammad Farooq, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Hanif, Shazia Naz, Lubna Bashir. Development and validation of liquidchromatographic method for quantitative determination of Loxoprofen in mobilephase and in human plasma.
Pakistan journal of pharmaceutical sciences.
2018 Nov; 31(6 (Supplementary):2629-2633. doi:
NULL. [PMID: 30587471] - Youngbae Kim, Chan Seo, Suin Oh, Juhwan Kwak, Sumin Jung, Eunsu Sin, Hyunbin Kim, Moongi Ji, Hyeon-Seong Lee, Hyung-Jin Park, Gwang Lee, Jundong Yu, Minsoo Kim, Wonjae Lee, Man-Jeong Paik. Analysis of loxoprofen in tablets, patches, and equine urine as tert-butyldimethylsilyl derivative by gas chromatography-mass spectrometry.
Archives of pharmacal research.
2018 Apr; 41(4):459-466. doi:
10.1007/s12272-018-1023-5. [PMID: 29572683] - Taro Matsui, Keiichi Nakagawa, Keishi Yamazaki, Taishi Wada, Masato Kadoya, Kenichi Kaida. [An anti-RNP antibody-positive case of aseptic meningitis induced by non-steroidal anti-inflammatory drugs in a young woman].
Rinsho shinkeigaku = Clinical neurology.
2018 Jan; 58(1):25-29. doi:
10.5692/clinicalneurol.cn-001085. [PMID: 29269694] - Tae Hwan Kim, Soyoung Shin, Jürgen B Bulitta, Yu Seok Youn, Sun Dong Yoo, Beom Soo Shin. Development of a Physiologically Relevant Population Pharmacokinetic in Vitro-in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation.
Molecular pharmaceutics.
2017 01; 14(1):53-65. doi:
10.1021/acs.molpharmaceut.6b00677. [PMID: 27809538] - Tomoaki Kumagai, Nozomi Yamaguchi, Hiroyuki Hirai, Shigeyuki Kojima, Yoshiko Kodani, Akihiko Hashiguchi, Michiko Haida, Masataka Nakamura. Loxoprofen sodium induces the production of complement C5a in human serum.
International immunopharmacology.
2016 Apr; 33(?):55-62. doi:
10.1016/j.intimp.2016.01.025. [PMID: 26854577] - Makiko Hirosawa, Takehiko Sambe, Naoki Uchida, Xiao-Pen Lee, Keizo Sato, Shinichi Kobayashi. Determination of nonsteroidal anti-inflammatory drugs in human tear and plasma samples using ultra-fast liquid chromatography-tandem mass spectrometry.
Japanese journal of ophthalmology.
2015 Sep; 59(5):364-71. doi:
10.1007/s10384-015-0389-x. [PMID: 26088457] - Koichiro Abe, Takatsugu Yamamoto, Hiroto Kita, Yasushi Kuyama. Video of the month: Hemostasis for spurting bleeding from a gastric ulcer using argon plasma coagulation.
The American journal of gastroenterology.
2015 Feb; 110(2):221. doi:
10.1038/ajg.2014.418. [PMID: 25646906] - R Sawamura, M Kazui, A Kurihara, T Izumi. Pharmacokinetics of loxoprofen and its active metabolite after dermal application of loxoprofen gel to rats.
Die Pharmazie.
2015 Feb; 70(2):74-80. doi:
NULL. [PMID: 25997245] - Iva Boušová, Lenka Skálová, Pavel Souček, Petra Matoušková. The modulation of carbonyl reductase 1 by polyphenols.
Drug metabolism reviews.
2015; 47(4):520-33. doi:
10.3109/03602532.2015.1089885. [PMID: 26415702] - Zhihua Yue, Jinhai Shi, Pengli Jiang, He Sun. Acute kidney injury during concomitant use of valacyclovir and loxoprofen: detecting drug-drug interactions in a spontaneous reporting system.
Pharmacoepidemiology and drug safety.
2014 Nov; 23(11):1154-9. doi:
10.1002/pds.3626. [PMID: 24788910] - Ryoko Sawamura, Miho Kazui, Atsushi Kurihara, Takashi Izumi. Absorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Nov; 44(11):1026-38. doi:
10.3109/00498254.2014.926571. [PMID: 24916900] - Hisazumi Araki, Shogo Kuwagata, Mariko Soumura, Kosuke Yamahara, Yoshikata Morita, Shinji Kume, Keiji Isshiki, Shin-ichi Araki, Atsunori Kashiwagi, Hiroshi Maegawa, Takashi Uzu. Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy.
Clinical and experimental nephrology.
2014 Jun; 18(3):487-91. doi:
10.1007/s10157-013-0850-4. [PMID: 23921417] - Hiroaki Kikuchi, Makoto Aoyagi, Kiyotaka Nagahama, Yu Yajima, Chisato Yamamura, Yohei Arai, Suguru Hirasawa, Shota Aki, Naoto Inaba, Hiroyuki Tanaka, Teiichi Tamura. Nephrotic-range proteinuria and interstitial nephritis associated with the use of a topical loxoprofen patch.
Internal medicine (Tokyo, Japan).
2014; 53(11):1131-5. doi:
10.2169/internalmedicine.53.1669. [PMID: 24881736] - Satoko Okazaki-Sakai, Sachiko Yoshimoto, Kunimasa Yagi, Takanobu Wakasugi, Yoshiyu Takeda, Masakazu Yamagishi. Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium.
Internal medicine (Tokyo, Japan).
2013; 52(21):2447-51. doi:
10.2169/internalmedicine.52.0570. [PMID: 24190150] - Hidenori Kanazawa, Atsushi Kotoda, Tetsu Akimoto, Takeshi Shinozaki, Makoto Inoue, Hideharu Sugimoto, Eiji Kusano. Serial Tc-99m MAG3 renography evaluating the recovery of acute kidney injury associated with minimal change nephrotic syndrome.
Internal medicine (Tokyo, Japan).
2013; 52(9):987-91. doi:
10.2169/internalmedicine.52.9204. [PMID: 23648719] - Naoki Yamakawa, Shintaro Suemasu, Hiroshi Watanabe, Kayoko Tahara, Ken-ichiro Tanaka, Yoshinari Okamoto, Masami Ohtsuka, Toru Maruyama, Tohru Mizushima. Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.
Drug metabolism and pharmacokinetics.
2013; 28(2):118-24. doi:
10.2133/dmpk.dmpk-12-rg-050. [PMID: 22892443] - Tomohiro Mizuno, Kazuma Ito, Yasuhiro Miyagawa, Kazuhiro Ishikawa, Yasuhiro Suzuki, Masashi Mizuno, Yasuhiko Ito, Yasuhito Funahashi, Ryohei Hattori, Momokazu Gotoh, Kiyofumi Yamada, Yukihiro Noda. Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients.
Japanese journal of clinical oncology.
2012 Nov; 42(11):1073-8. doi:
10.1093/jjco/hys145. [PMID: 22952294] - Yuuki Akagi, Yuta Nio, Shuji Shimada, Takao Aoyama. Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats.
Biological & pharmaceutical bulletin.
2011; 34(2):233-7. doi:
10.1248/bpb.34.233. [PMID: 21415533] - Hye Won Lee, Hye Young Ji, Dong Hwan Sohn, Se-Mi Kim, Yong Bok Lee, Hye Suk Lee. Liquid chromatography-tandem mass spectrometry method of loxoprofen in human plasma.
Biomedical chromatography : BMC.
2009 Jul; 23(7):714-8. doi:
10.1002/bmc.1175. [PMID: 19296517] - Hiroaki Matsuo, Sakae Kaneko, Yoshio Tsujino, Sakae Honda, Kunie Kohno, Hitoshi Takahashi, Shoji Mihara, Michihiro Hide, Kenichi Aburatani, Tsutomu Honjoh, Eishin Morita. Effects of non-steroidal anti-inflammatory drugs (NSAIDs) on serum allergen levels after wheat ingestion.
Journal of dermatological science.
2009 Mar; 53(3):241-3. doi:
10.1016/j.jdermsci.2008.09.004. [PMID: 18947983] - Takao Hidaka, Tomoko Shima, Kiyofumi Nagira, Masahiro Ieki, Takafumi Nakamura, Yukiko Aono, Yasushi Kuraishi, Takashi Arai, Shigeru Saito. Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.
European journal of pain (London, England).
2009 Jan; 13(1):22-7. doi:
10.1016/j.ejpain.2008.03.003. [PMID: 18472288] - Takeshi Ichikawa, Hiroko Sato, Kyoichi Kaira, Shinsuke Oh-I, Satoru Kakizaki, Ken Sato, Hitoshi Takagi, Masatomo Mori. Prolonged intrahepatic cholestasis after exposure to loxoprofen.
Clinical therapeutics.
2008 Dec; 30(12):2402-6. doi:
10.1016/j.clinthera.2008.12.012. [PMID: 19167598] - Tohru Araki, Teruhiko Yokoyama, Motoo Araki, Seiji Furuya. A clinical investigation of the mechanism of loxoprofen, a non-steroidal anti-inflammatory drug, for patients with nocturia.
Acta medica Okayama.
2008 Dec; 62(6):373-8. doi:
10.18926/amo/30949. [PMID: 19122682] - Shinsuke Okada, Hideki Watanabe, Yoshiyuki Kojima, Yoshimasa Yanai, Shoichi Sasaki, Kenjiro Kohri. Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production.
International journal of urology : official journal of the Japanese Urological Association.
2008 May; 15(5):462-4. doi:
10.1111/j.1442-2042.2008.02021.x. [PMID: 18452468] - Ok Hwa Jhee, Min Ho Lee, Leslie M Shaw, Seo Eun Lee, Jin Hee Park, Ju Seop Kang. Pharmacokinetics and bioequivalence study of two brands of loxoprofen tablets in healthy volunteers.
Arzneimittel-Forschung.
2007; 57(8):542-6. doi:
10.1055/s-0031-1296646. [PMID: 17915642] - Takashi Nakazawa, Takeo Shimo, Noriko Chikamatsu, Takako Igarashi, Osamu Nagata, Masaharu Yamamoto. Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig.
Archives of toxicology.
2006 Jul; 80(7):442-8. doi:
10.1007/s00204-006-0063-7. [PMID: 16474960] - Hea-Young Cho, Chan-Ho Park, Yong-Bok Lee. Direct and simultaneous analysis of loxoprofen and its diastereometric alcohol metabolites in human serum by on-line column switching liquid chromatography and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 May; 835(1-2):27-34. doi:
10.1016/j.jchromb.2006.02.058. [PMID: 16563885] - Tae-Sung Koo, Dae-Hyun Kim, Sung-Hoon Ahn, Kang-Pil Kim, In-Wha Kim, Seung-Yong Seo, Young-Ger Suh, Dae-Duk Kim, Chang-Koo Shim, Suk-Jae Chung. Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism.
Journal of pharmaceutical sciences.
2005 Oct; 94(10):2187-97. doi:
10.1002/jps.20451. [PMID: 16136574] - Motoaki Saito, Masahito Kawatani, Yukako Kinoshita, Keisuke Satoh, Ikuo Miyagawa. Effectiveness of an anti-inflammatory drug, loxoprofen, for patients with nocturia.
International journal of urology : official journal of the Japanese Urological Association.
2005 Aug; 12(8):779-82. doi:
10.1111/j.1442-2042.2005.01138.x. [PMID: 16174058] - Akio Kanda, Satoru Ebihara, Hidenori Takahashi, Hidetada Sasaki. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor.
Acta oncologica (Stockholm, Sweden).
2003; 42(1):62-70. doi:
10.1080/0891060310002258. [PMID: 12665333] - Katsutaro Nagata. [A study of logotherapy for chronic low back pain patients].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.
2003; 105(4):459-67. doi:
NULL. [PMID: 12806908] - In-Wha Kim, Suk-Jae Chung, Chang-Koo Shim. Altered metabolism of orally administered loxoprofen in human subjects after an oral administration of loxoprofen for three consecutive days followed by a seven-day washout.
Journal of pharmaceutical sciences.
2002 Apr; 91(4):973-9. doi:
10.1002/jps.10040. [PMID: 11948535] - Hideko Kanazawa, Akane Tsubayashi, Yoshiko Nagata, Yoshikazu Matsushima, Chiharu Mori, Junko Kizu, Megumu Higaki. Stereospecific analysis of loxoprofen in plasma by chiral column liquid chromatography with a circular dichroism-based detector.
Journal of chromatography. A.
2002 Mar; 948(1-2):303-8. doi:
10.1016/s0021-9673(01)01312-7. [PMID: 12831206] - K S Choo, I W Kim, J K Jung, Y G Suh, S J Chung, M H Lee, C K Shim. Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method.
Journal of pharmaceutical and biomedical analysis.
2001 Jun; 25(3-4):639-50. doi:
10.1016/s0731-7085(00)00583-5. [PMID: 11377045] - I W Kim, K S Choo, T G Han, K S Kim, S J Chung, M H Lee, C K Shim. Decreased oral bioavailability of loxoprofen at second administration in human subjects.
International journal of clinical pharmacology and therapeutics.
2000 Jan; 38(1):10-4. doi:
10.5414/cpp38010. [PMID: 10667831] - C Kurata, A Uehara, T Sugi, K Yamazaki. Syncope caused by nonsteroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors.
Japanese circulation journal.
1999 Dec; 63(12):1002-3. doi:
10.1253/jcj.63.1002. [PMID: 10614849] - Y Imamura, T Koga, T Higuchi, M Otagiri, E Sugino, S Hibino. Inhibitory effect of drugs with a ketone group on reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney.
Journal of enzyme inhibition.
1997 Feb; 11(4):285-92. doi:
10.3109/14756369709027657. [PMID: 9208371] - Y Hakozaki, M Katou, K Nakagawa, T Shirahama, T Matsumoto. Improvement of inflammatory pseudotumor of the liver after nonsteroidal anti-inflammatory agent therapy.
The American journal of gastroenterology.
1993 Jul; 88(7):1121-2. doi:
NULL. [PMID: 8317419] - W Takasaki, Y Tanaka. Application of antibody-mediated extraction for the stereoselective determination of the active metabolite of loxoprofen in human and rat plasma.
Chirality.
1992; 4(5):308-15. doi:
10.1002/chir.530040509. [PMID: 1503853] - H Naganuma, Y Kawahara. High-performance liquid chromatographic determination of loxoprofen and its diastereomeric alcohol metabolites in biological fluids by fluorescence labelling with 4-bromomethyl-6,7-methylenedioxycoumarin.
Journal of chromatography.
1990 Sep; 530(2):387-96. doi:
10.1016/s0378-4347(00)82341-5. [PMID: 2079513] - H Nagashima, Y Tanaka, R Hayashi. Column liquid chromatography for the simultaneous determination of the enantiomers of loxoprofen sodium and its metabolites in human urine.
Journal of chromatography.
1985 Dec; 345(2):373-9. doi:
10.1016/0378-4347(85)80174-2. [PMID: 4086605] - K Matsuda, Y Tanaka, S Ushiyama, K Ohnishi, M Yamazaki. Inhibition of prostaglandin synthesis by sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dihydrate (CS-600), a new anti-inflammatory drug, and its active metabolite in vitro and in vivo.
Biochemical pharmacology.
1984 Aug; 33(15):2473-8. doi:
10.1016/0006-2952(84)90720-2. [PMID: 6431982] - S Naruto, Y Tanaka, R Hayashi, A Terada. Structural determination of rat urinary metabolites of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new anti-inflammatory agent.
Chemical & pharmaceutical bulletin.
1984 Jan; 32(1):258-67. doi:
10.1248/cpb.32.258. [PMID: 6722952]