4-Oxofenretinide (BioDeep_00000729344)

   


代谢物信息卡片


4-Oxofenretinide

化学式: C26H31NO3 (405.2303816)
中文名称: 4-氧代维甲酰酚胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(CCC1=O)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C
InChI: InChI=1S/C26H31NO3/c1-18(9-14-23-20(3)24(29)15-16-26(23,4)5)7-6-8-19(2)17-25(30)27-21-10-12-22(28)13-11-21/h6-14,17,28H,15-16H2,1-5H3,(H,27,30)/b8-6+,14-9+,18-7+,19-17+

描述信息

D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids

同义名列表

2 个代谢物同义名

4-Oxofenretinide; 4-oxo-4-HPR



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • N A Illingworth, A V Boddy, A K Daly, G J Veal. Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases. British journal of pharmacology. 2011 Feb; 162(4):989-99. doi: 10.1111/j.1476-5381.2010.01104.x. [PMID: 21054342]
  • Manuela Valsecchi, Massimo Aureli, Laura Mauri, Giuditta Illuzzi, Vanna Chigorno, Alessandro Prinetti, Sandro Sonnino. Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids. Journal of lipid research. 2010 Jul; 51(7):1832-40. doi: 10.1194/jlr.m004010. [PMID: 20194109]
  • Valentina Appierto, Paola Tiberio, Elena Cavadini, Patrizia Casalini, Graziella Cappelletti, Franca Formelli. Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. Molecular cancer therapeutics. 2009 Dec; 8(12):3360-8. doi: 10.1158/1535-7163.mct-09-0798. [PMID: 19996280]
  • Franca Formelli, Elena Cavadini, Roberto Luksch, Alberto Garaventa, Maria Grazia Villani, Valentina Appierto, Stefano Persiani. Pharmacokinetics of oral fenretinide in neuroblastoma patients: indications for optimal dose and dosing schedule also with respect to the active metabolite 4-oxo-fenretinide. Cancer chemotherapy and pharmacology. 2008 Sep; 62(4):655-65. doi: 10.1007/s00280-007-0649-7. [PMID: 18066548]
  • Maria Grazia Villani, Valentina Appierto, Elena Cavadini, Manuela Valsecchi, Sandro Sonnino, Robert W Curley, Franca Formelli. Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 Sep; 10(18 Pt 1):6265-75. doi: 10.1158/1078-0432.ccr-04-0655. [PMID: 15448016]