Protriptyline hydrochloride (BioDeep_00000728990)
代谢物信息卡片
Protriptyline hydrochloride
化学式: C19H22ClN (299.14406820000005)
中文名称: 盐酸普罗替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:8598
- KEGGdrug: D00484
- PubChem: 6603149
- ChEMBL: CHEMBL1200332
- MeSH: Protriptyline
- CAS: 1435934-21-6
- CAS: 1225-55-4
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jin Ryeol An, Hojung Kang, Hongliang Li, Mi Seon Seo, Hee Seok Jung, Won-Kyo Jung, Il-Whan Choi, Sook Won Ryu, Hongzoo Park, Young Min Bae, Se Min Ryu, Won Sun Park. Protriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.
Acta biochimica et biophysica Sinica.
2020 Mar; 52(3):320-327. doi:
10.1093/abbs/gmz159. [PMID: 32060505] - He-Hsiung Cheng, Chiang-Ting Chou, Wei-Zhe Liang, Chun-Chi Kuo, Pochuen Shieh, Jue-Long Wang, Chung-Ren Jan. Effect of Protriptyline on [Ca²⁺]i and Viability in MDCK Renal Tubular Cells.
The Chinese journal of physiology.
2017 Apr; 60(2):114-123. doi:
10.4077/cjp.2017.baf459. [PMID: 28468029] - Zaorui Zhao, Han-Ting Zhang, Elianna Bootzin, Mark J Millan, James M O'Donnell. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 May; 34(6):1467-81. doi:
10.1038/npp.2008.183. [PMID: 18923402] - Su-Hyun Jo, Hee-Kyung Hong, Seon Ha Chong, Han Choe. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel.
Life sciences.
2008 Jan; 82(5-6):331-40. doi:
10.1016/j.lfs.2007.12.004. [PMID: 18191158] - T Miyoshi, R Yamamichi, T Maruyama, A Takadate, M Otagiri. Further characterization of reversal of signs of induced cotton effects of dicumarol derivatives-alpha 1-acid glycoprotein systems by protriptyline.
Biochemical pharmacology.
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1983 Oct; 29(10):1793-5. doi:
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1977 Dec; 55(3):217-23. doi:
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Clinical pharmacology and therapeutics.
1977 Sep; 22(3):269-73. doi:
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1977 May; 60(1):11-9. doi:
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1977 Apr; 134(1):182-6. doi:
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1977; 11(1):51-6. doi:
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1976 Jun; 65(6):810-5. doi:
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1976 Feb; 68(3):814-20. doi:
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