Me2-APD (BioDeep_00000728988)
代谢物信息卡片
化学式: C5H15NO7P2 (263.032374)
中文名称: 奥潘膦酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
InChI: InChI=1S/C5H15NO7P2/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13)
描述信息
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Susana Morelli, Paola Scodelaro Bilbao, Sebastian Katz, Virginia Lezcano, Emilio Roldán, Ricardo Boland, Graciela Santillan. Protein phosphatases: possible bisphosphonate binding sites mediating stimulation of osteoblast proliferation.
Archives of biochemistry and biophysics.
2011 Mar; 507(2):248-53. doi:
10.1016/j.abb.2010.12.013
. [PMID: 21167123] - Gretel G Pellegrini, Chaves Macarena Gonzales, Julia C Somoza, Silvia M Friedman, Susana N Zeni. Correlation between salivary and serum markers of bone turnover in osteopenic rats.
Journal of periodontology.
2008 Jan; 79(1):158-65. doi:
10.1902/jop.2008.070168
. [PMID: 18166106] - Max Weissglas, Clemens Löwik, Denis Schamhart, Harry Theuns, Karl-Heinz Kurth, Socrates Papapoulos. Bone resorption and renal calcium reabsorption in renal cell carcinoma-bearing mice: the effects of bisphosphonate.
BJU international.
2007 Jun; 99(6):1530-3. doi:
10.1111/j.1464-410x.2007.06862.x
. [PMID: 17428243] - Meng Yang, Doug W Burton, Jack Geller, Darren J Hillegonds, Randolph H Hastings, Leonard J Deftos, Robert M Hoffman. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2006 Apr; 12(8):2602-6. doi:
10.1158/1078-0432.ccr-05-2050
. [PMID: 16638872] - A Tomat, C A Gamba, P Mandalunis, M C De Grandi, J Somoza, S Friedman, S Zeni. Changes in bone volume and bone resorption by olpadronate treatment in an experimental model of uremic bone disease.
Journal of musculoskeletal & neuronal interactions.
2005 Jun; 5(2):174-81. doi:
NULL
. [PMID: 15951635] - Marelise E M W Eekhoff, Aeilko H Zwinderman, Dorien M A D Haverkort, Serge C L M Cremers, Neveen A T Hamdy, Socrates E Papapoulos. Determinants of induction and duration of remission of Paget's disease of bone after bisphosphonate (olpadronate) therapy.
Bone.
2003 Nov; 33(5):831-8. doi:
10.1016/j.bone.2003.03.001
. [PMID: 14623059] - Serge C L M Cremers, Marelise E M W Eekhoff, Jan Den Hartigh, Neveen A T Hamdy, Pieter Vermeij, Socrates E Papapoulos. Relationships between pharmacokinetics and rate of bone turnover after intravenous bisphosphonate (olpadronate) in patients with Paget's disease of bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2003 May; 18(5):868-75. doi:
10.1359/jbmr.2003.18.5.868
. [PMID: 12733726] - Leo Widler, Knut A Jaeggi, Markus Glatt, Klaus Müller, Rolf Bachmann, Michael Bisping, Anne-Ruth Born, Reto Cortesi, Gabriela Guiglia, Heidi Jeker, Rémy Klein, Ueli Ramseier, Johann Schmid, Gerard Schreiber, Yves Seltenmeyer, Jonathan R Green. Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).
Journal of medicinal chemistry.
2002 Aug; 45(17):3721-38. doi:
10.1021/jm020819i
. [PMID: 12166945] - Susana N Zeni, S Gregorio, A C Gomez, J Somoza, C Mautalen. Olpadronate prevents the bone loss induced by cyclosporine in the rat.
Calcified tissue international.
2002 Jan; 70(1):48-53. doi:
10.1007/s00223-001-1085-z
. [PMID: 11907707] - R W Sparidans, J den Hartig, S Cremers, J H Beijnen, P Vermeij. Semi-automatic liquid chromatographic analysis of olpadronate in urine and serum using derivatization with (9-fluorenylmethyl)chloroformate.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Feb; 738(2):331-41. doi:
10.1016/s0378-4347(99)00532-0
. [PMID: 10718651] - D C González, C A Mautalen. Short-term therapy with oral olpadronate in active Paget's disease of bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1999 Dec; 14(12):2042-7. doi:
10.1359/jbmr.1999.14.12.2042
. [PMID: 10620063] - R C Pelger, N A Hamdy, A H Zwinderman, A A Lycklama à Nijeholt, S E Papapoulos. Effects of the bisphosphonate olpadronate in patients with carcinoma of the prostate metastatic to the skeleton.
Bone.
1998 Apr; 22(4):403-8. doi:
10.1016/s8756-3282(97)00289-5
. [PMID: 9556142] - S Zeni, C Gomez-Acotto, C Mautalen. The effect of olpadronate in ovariectomized thyroxine-treated rats.
Bone.
1997 Oct; 21(4):329-33. doi:
10.1016/s8756-3282(97)00146-4
. [PMID: 9315336] - D González, M Pastrana, C Mautalen. [Treatment of Paget's disease with olpadronate. Its efficacy in partial responders to oral pamidronate].
Medicina.
1997; 57 Suppl 1(?):25-31. doi:
. [PMID: 9567351]
- D H Schweitzer, M Oostendorp-van de Ruit, G Van der Pluijm, C W Löwik, S E Papapoulos. Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1995 Jun; 10(6):956-62. doi:
10.1002/jbmr.5650100617
. [PMID: 7572320] - K Hoekman, Y I Tjandra, S E Papapoulos. The role of 1,25-dihydroxyvitamin D in the maintenance of hypercalcemia in a patient with an ovarian carcinoma producing parathyroid hormone-related protein.
Cancer.
1991 Aug; 68(3):642-7. doi:
10.1002/1097-0142(19910801)68:3<642::aid-cncr2820680334>3.0.co;2-a
. [PMID: 2065286] - S E Papapoulos, K Hoekman, C W Löwik, P Vermeij, O L Bijvoet. Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1989 Oct; 4(5):775-81. doi:
10.1002/jbmr.5650040518
. [PMID: 2816519]