Amphomycin (BioDeep_00000728979)
代谢物信息卡片
化学式: C58H91N13O20 (1289.6503006)
中文名称: 安福霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)CCCCCC=CCC(=O)NC(CC(=O)O)C(=O)NC(C(C)C(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(C(C)N)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(C)C2C(=O)N3CCCCC3C(=O)N2
InChI: InChI=1S/C58H91N13O20/c1-8-30(4)18-13-11-9-10-12-14-21-39(72)63-36(26-44(79)80)51(83)68-46(31(5)58(90)91)54(86)65-35(25-43(77)78)50(82)60-27-40(73)64-34(24-42(75)76)49(81)61-28-41(74)66-47(32(6)59)55(87)67-45(29(2)3)56(88)71-23-17-20-38(71)52(84)62-33(7)48-57(89)70-22-16-15-19-37(70)53(85)69-48/h12,14,29-38,45-48H,8-11,13,15-28,59H2,1-7H3,(H,60,82)(H,61,81)(H,62,84)(H,63,72)(H,64,73)(H,65,86)(H,66,74)(H,67,87)(H,68,83)(H,69,85)(H,75,76)(H,77,78)(H,79,80)(H,90,91)/b14-12+/t30?,31-,32+,33+,34+,35+,36+,37-,38+,45+,46+,47-,48+/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ian J Roney, David Z Rudner. Two broadly conserved families of polyprenyl-phosphate transporters.
Nature.
2023 Jan; 613(7945):729-734. doi:
10.1038/s41586-022-05587-z. [PMID: 36450357] - Leroy S Pakkiri, Beata A Wolucka, Eric J Lubert, Charles J Waechter. Structural and topological studies on the lipid-mediated assembly of a membrane-associated lipomannan in Micrococcus luteus.
Glycobiology.
2004 Jan; 14(1):73-81. doi:
10.1093/glycob/cwh012. [PMID: 14551219] - L Vargas-Rodríguez, J C Villagómez-Castro, A Flores-Carreón, E López-Romero. Identification and characterisation of early reactions of asparagine-linked oligosaccharide assembly in Entamoeba histolytica.
International journal for parasitology.
1998 Sep; 28(9):1333-40. doi:
10.1016/s0020-7519(98)00124-6. [PMID: 9770617] - B L Arroyo-Flores, C Calvo-Méndez, A Flores-Carreón, E López-Romero. Biosynthesis of glycoproteins in Candida albicans: solubilization and partial characterization of dolichol phosphate mannose synthase and protein mannosyl transferases.
Antonie van Leeuwenhoek.
1998 May; 73(4):289-97. doi:
10.1023/a:1000844806015. [PMID: 9850415] - J Rodríguez-Bonilla, L Vargas-Rodríguez, C Calvo-Méndez, A Flores-Carreón, E López-Romero. Biosynthesis of glycoproteins in Candida albicans: biochemical characterization of dolichol phosphate glucose synthase.
Antonie van Leeuwenhoek.
1998 May; 73(4):373-80. doi:
10.1023/a:1001714623355. [PMID: 9850421] - G S Besra, C B Morehouse, C M Rittner, C J Waechter, P J Brennan. Biosynthesis of mycobacterial lipoarabinomannan.
The Journal of biological chemistry.
1997 Jul; 272(29):18460-6. doi:
10.1074/jbc.272.29.18460. [PMID: 9218490] - B C Zhu, R R Drake, H Schweingruber, R A Laine. Inhibition of glycosylation by amphomycin and sugar nucleotide analogs PP36 and PP55 indicates that Haloferax volcanii beta-glucosylates both glycoproteins and glycolipids through lipid-linked sugar intermediates: evidence for three novel glycoproteins and a novel sulfated dihexosyl-archaeol glycolipid.
Archives of biochemistry and biophysics.
1995 Jun; 319(2):355-64. doi:
10.1006/abbi.1995.1305. [PMID: 7786016] - L A Camp, P Chauhan, J D Farrar, M A Lehrman. Defective mannosylation of glycosylphosphatidylinositol in Lec35 Chinese hamster ovary cells.
The Journal of biological chemistry.
1993 Mar; 268(9):6721-8. doi:
". [PMID: 8454644] - S Tomavo, J F Dubremetz, R T Schwarz. Biosynthesis of glycolipid precursors for glycosylphosphatidylinositol membrane anchors in a Toxoplasma gondii cell-free system.
The Journal of biological chemistry.
1992 Oct; 267(30):21446-58. doi:
". [PMID: 1328232] - D K Banerjee. Amphomycin inhibits mannosylphosphoryldolichol synthesis by forming a complex with dolichylmonophosphate.
The Journal of biological chemistry.
1989 Feb; 264(4):2024-8. doi:
. [PMID: 2464586] - J H Lakey, R Maget-Dana, M Ptak. Conformational change on calcium binding by the lipopeptide antibiotic amphomycin. A C.D. and monolayer study.
Biochemical and biophysical research communications.
1988 Jan; 150(1):384-90. doi:
10.1016/0006-291x(88)90532-3. [PMID: 3337719] - S V Kyosseva, V I Zhivkov. Biosynthesis of lipid-linked oligosaccharides in embryonic liver. Formation of mannose containing derivatives.
The International journal of biochemistry.
1985; 17(7):813-7. doi:
10.1016/0020-711x(85)90269-1. [PMID: 2414140] - A D Elbein. Inhibitors of the biosynthesis and processing of N-linked oligosaccharides.
CRC critical reviews in biochemistry.
1984; 16(1):21-49. doi:
10.3109/10409238409102805. [PMID: 6232113] - C R McFarland, J A Hoffman. Glycoprotein inhibitors and iodophilic polysaccharide storage in group A Streptococcus pyogenes.
Microbios.
1982; 33(133-34):169-80. doi:
". [PMID: 6757675] - W Chak, H K Kuramitsu. Effects of metabolic inhibitors on extracellular fructosyltransferase production in Actinomyces viscosus.
Infection and immunity.
1981 Dec; 34(3):930-7. doi:
10.1128/iai.34.3.930-937.1981. [PMID: 7333676] - M S Kang, A D Elbein. Incorporation of glucose into lipid-linked saccharides in aorta and its inhibition by amphomycin.
Archives of biochemistry and biophysics.
1979 Nov; 198(1):304-13. doi:
10.1016/0003-9861(79)90423-5. [PMID: 507847] - M S Kang, J P Spencer, A D Elbein. Amphomycin inhibition of mannose and GlcNAc incorporation into lipid-linked saccharides.
The Journal of biological chemistry.
1978 Dec; 253(24):8860-6. doi:
10.1016/s0021-9258(17)34257-6. [PMID: 721819] - M C Ericson, J T Gafford, A D Elbein. In vivo and in vitro inhibition of lipid-linked saccharide and glycoprotein synthesis in plants by amphomycin.
Archives of biochemistry and biophysics.
1978 Dec; 191(2):698-704. doi:
10.1016/0003-9861(78)90409-5. [PMID: 742895] - M S Kang, J P Spencer, A D Elbein. Amphomycin inhibits the incorporation of mannose and GlcNAc into lipid-linked saccharides by aorta extracts.
Biochemical and biophysical research communications.
1978 May; 82(2):568-74. doi:
10.1016/0006-291x(78)90912-9. [PMID: 666860]