Labetalol HCl (BioDeep_00000728594)
代谢物信息卡片
Labetalol hydrochloride
化学式: C19H25ClN2O3 (364.15536099999997)
中文名称: 柳胺苄心定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Labetalol hydrochloride is a mixed alpha/beta adrenergic antagonist that is used to treat high blood pressure.
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:6344
- KEGGdrug: D00600
- PubChem: 71412
- ChEMBL: CHEMBL1200323
- MeSH: Labetalol
- CAS: 72487-34-4
- CAS: 32780-64-6
- medchemexpress: HY-B1108
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li. Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.
Hypertension in pregnancy.
2024 Dec; 43(1):2329068. doi:
10.1080/10641955.2024.2329068. [PMID: 38488570] - Piya Chaemsaithong, Mohitosh Biswas, Waranyu Lertrut, Puntabut Warintaksa, Tuangsit Wataganara, Liona Cy Poon, Chonlaphat Sukasem. Pharmacogenomics of Preeclampsia therapies: Current evidence and future challenges for clinical implementation.
Best practice & research. Clinical obstetrics & gynaecology.
2024 Feb; 92(?):102437. doi:
10.1016/j.bpobgyn.2023.102437. [PMID: 38103508] - Hao-Cho Ou, Jou-Fang Deng, Chen-Chang Yang, Chin-Sheng Lin, Yan-Chiao Mao, Shih-Hung Tsai, Cheng-Hsuan Ho. A successful experience using labetalol and hemodialysis to treat near-fatal caffeine poisoning: A case report with toxicodynamics.
The American journal of emergency medicine.
2022 05; 55(?):224.e1-224.e4. doi:
10.1016/j.ajem.2021.11.049. [PMID: 34922795] - Onyinye Ohamadike, Stephanie L Lim, Anne Siegel, Gregory Zemtsov, Jeffrey A Kuller, Sarah Dotters-Katz. Hypertensive Disorders of Pregnancy: Common Clinical Conundrums.
Obstetrical & gynecological survey.
2022 Apr; 77(4):234-244. doi:
10.1097/ogx.0000000000000996. [PMID: 35395093] - Brian Pearlman, Bereket T Lodebo. Renin secreting tumour: a rare cause of secondary hypertension.
Lancet (London, England).
2021 09; 398(10305):1074. doi:
10.1016/s0140-6736(21)01696-2. [PMID: 34537092] - Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 05; 77(5):704-712. doi:
10.1053/j.ajkd.2020.07.023. [PMID: 33010357] - Robert H Friesen. In response.
Journal of cardiothoracic and vascular anesthesia.
2020 12; 34(12):3480-3481. doi:
10.1053/j.jvca.2020.07.001. [PMID: 32753324] - Gareth A Charlton, David R Ladd, Richard M Friesen, Robert H Friesen. Labetalol Infusion Attenuates Paradoxical Hypertension and Decreases Plasma Renin Activity After Repair of Coarctation of the Aorta in Children.
Journal of cardiothoracic and vascular anesthesia.
2020 Dec; 34(12):3348-3351. doi:
10.1053/j.jvca.2020.05.027. [PMID: 32593586] - Fotini Tsofliou, Yannis P Pitsiladis, Jose Lara, Marios Hadjicharalambous, Ian A Macdonald, Mike A Wallace, Mike E J Lean. The effects of moderate alterations in adrenergic activity on acute appetite regulation in obese women: A randomised crossover trial.
Nutrition and health.
2020 Dec; 26(4):311-322. doi:
10.1177/0260106020942117. [PMID: 32729763] - Pattraporn Chera-Aree, Pimrapat Tengtrakulcharoen, Jarunee Leetheeragul, Urai Sampaojarean, Supitchaya Surasereewong, Tuangsit Wataganara. Clinical Experiences of Intravenous Hydralazine and Labetalol for Acute Treatment of Severe Hypertension in Pregnant Thai Women.
Journal of clinical pharmacology.
2020 12; 60(12):1662-1670. doi:
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Drug and chemical toxicology.
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2020 Jun; 1146(?):122125. doi:
10.1016/j.jchromb.2020.122125. [PMID: 32371329] - Y Wu, D-J Wang, Y Zhang, Y-X Zhang, R Zhang. Regulation of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia.
European review for medical and pharmacological sciences.
2020 05; 24(9):5062-5070. doi:
10.26355/eurrev_202005_21199. [PMID: 32432770] - Marwa Zayed, Heba Nassar, Ahmed Hasanin, Amany H Saleh, Passaint Hassan, Dalia Saad, Sahar Mahmoud, Ghada Abo Bakr, Eman Fouad, Norhan Saleh, Maha Ismail, Hani El-Hadi. Effects of nitroglycerin versus labetalol on peripheral perfusion during deliberate hypotension for sinus endoscopic surgery: a randomized, controlled, double-blinded trial.
BMC anesthesiology.
2020 04; 20(1):85. doi:
10.1186/s12871-020-01006-w. [PMID: 32303182] - Pradeep Singh Rawat, Punna Rao Ravi, Laxman Kaswan, Rajeev Singh Raghuvanshi. Development and validation of a bio-analytical method for simultaneous quantification of nebivolol and labetalol in aqueous humor and plasma using LC-MS/MS and its application to ocular pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jan; 1136(?):121908. doi:
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American journal of therapeutics.
2019 Nov; 26(6):e748-e750. doi:
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2019 Jul; 17(?):12-14. doi:
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Biochemical and biophysical research communications.
2018 09; 503(1):209-214. doi:
10.1016/j.bbrc.2018.06.004. [PMID: 29879427] - Cheng-Juan Sun, Lin Li, Xue-Yan Li, Wei-Yuan Zhang, Xiao-Wei Liu. Associations of polymorphisms of CYP2D6 and CYP2C9 with early onset severe pre-eclampsia and response to labetalol therapy.
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2018 07; 298(1):125-132. doi:
10.1007/s00404-018-4791-8. [PMID: 29789925] - Mahmoud A Omar, Sayed M Derayea, Mohamed A Abdel-Lateef, Mohamed A El Hamd. Derivatization of labetalol hydrochloride for its spectrofluorimetric and spectrophotometric determination inhuman plasma: Application to stability study.
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Molecular pharmaceutics.
2015 May; 12(5):1456-66. doi:
10.1021/mp500783g. [PMID: 25816851] - Changfeng Li, Jianxia Feng, Huangxian Ju. Supramolecular interaction of labetalol with cucurbit[7]uril for its sensitive fluorescence detection.
The Analyst.
2015 Jan; 140(1):230-5. doi:
10.1039/c4an01601g. [PMID: 25412989] - Yuhuang Lang, Fengming Fu, Dalong Sun, Chenhui Xi, Fengyuan Chen. Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury.
PloS one.
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International journal of clinical pharmacy.
2014 Dec; 36(6):1130-3. doi:
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The American journal of emergency medicine.
2014 Aug; 32(8):833-6. doi:
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Clinical pharmacokinetics.
2014 Apr; 53(4):373-83. doi:
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Best practice & research. Clinical obstetrics & gynaecology.
2013 Dec; 27(6):877-84. doi:
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European journal of clinical pharmacology.
2013 Apr; 69(4):799-806. doi:
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Obstetrics and gynecology.
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