p-MPPI (BioDeep_00000728493)
代谢物信息卡片
化学式: C25H27IN4O2 (542.1179)
中文名称: 对-MPPI三盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4=CC=C(C=C4)I
InChI: InChI=1S/C25H27IN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - G Aditya Kumar, Parijat Sarkar, Md Jafurulla, Shishu Pal Singh, Gunda Srinivas, Gopal Pande, Amitabha Chattopadhyay. Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin1A Receptor.
Biochemistry.
2019 06; 58(22):2628-2641. doi:
10.1021/acs.biochem.9b00033. [PMID: 30896156] - Kinzo Matsumoto, Ryo Morishige, Yukihisa Murakami, Michihisa Tohda, Hiromitsu Takayama, Iwao Sakakibara, Hiroshi Watanabe. Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.
European journal of pharmacology.
2005 Jul; 517(3):191-9. doi:
10.1016/j.ejphar.2005.05.015. [PMID: 15963493] - N K Popova, T G Amstislavskaya. Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice.
Psychoneuroendocrinology.
2002 Jul; 27(5):609-18. doi:
10.1016/s0306-4530(01)00097-x. [PMID: 11965359] - X W Fu, D Wang, J Pan, S M Farragher, V Wong, E Cutz. Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor.
American journal of physiology. Lung cellular and molecular physiology.
2001 Oct; 281(4):L931-40. doi:
10.1152/ajplung.2001.281.4.l931. [PMID: 11557597] - Q Li, C Wichems, A Heils, L D Van De Kar, K P Lesch, D L Murphy. Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice.
The Journal of pharmacology and experimental therapeutics.
1999 Dec; 291(3):999-1007. doi:
NULL. [PMID: 10565817] - J Yamada, Y Sugimoto, T Yoshikawa. p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.
European journal of pharmacology.
1998 Oct; 359(2-3):185-90. doi:
10.1016/s0014-2999(98)00639-6. [PMID: 9832390] - D S Lorrain, L Matuszewich, E M Hull. 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats.
Brain research.
1998 Apr; 790(1-2):217-23. doi:
10.1016/s0006-8993(98)00065-1. [PMID: 9593901] - B Ahlemeyer, J Krieglstein. Stimulation of 5-HT1A receptor inhibits apoptosis induced by serum deprivation in cultured neurons from chick embryo.
Brain research.
1997 Nov; 777(1-2):179-86. doi:
10.1016/s0006-8993(97)01109-8. [PMID: 9449427]
