Epristeride (BioDeep_00000728068)
代谢物信息卡片
化学式: C25H37NO3 (399.2773)
中文名称: 爱普列特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CC=C4C3(CCC(=C4)C(=O)O)C
InChI: InChI=1S/C25H37NO3/c1-23(2,3)26-21(27)20-9-8-18-17-7-6-16-14-15(22(28)29)10-12-24(16,4)19(17)11-13-25(18,20)5/h6,14,17-20H,7-13H2,1-5H3,(H,26,27)(H,28,29)/t17-,18-,19-,20+,24-,25-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058891 - 5-alpha Reductase Inhibitors
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C242 - Anti-Androgen
C471 - Enzyme Inhibitor > C2319 - 5 Alpha-Reductase Inhibitor
C1892 - Chemopreventive Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31552
- KEGGdrug: D01134
- PubChem: 68741
- ChEMBL: CHEMBL138225
- ChEMBL: CHEMBL290823
- CAS: 119169-78-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xiao-feng Zhao, Yong Yang, Wei Wang, Zhi Qiu, Peng Zhang, Biao Wang. Effects of competitive and noncompetitive 5α-reductase inhibitors on serum and intra-prostatic androgens in beagle dogs.
Chinese medical journal.
2013 Feb; 126(4):711-5. doi:
NULL
. [PMID: 23422194] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j
. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479
. [PMID: 18426954] - Ning-chen Li, Shi-liang Wu, Jie Jin, Shao-peng Qiu, Chui-ze Kong, Yong-sheng Song, Zhang-qun Ye, Guang Sun, Ying-hao Sun, Yu-cheng Sun, Xiao-feng Wang, Yan-qun Na. [Comparison of different drugs on the treatment of benign prostate hyperplasia].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2007 Jul; 45(14):947-50. doi:
. [PMID: 17961376]
- Xiao-dong Wang, Yue Jia, Yu-gui Cui, Xing-hai Wang, Jian-sun Tong, Ding-zhi Ma, Rui-fen Cai, Fu-song Di. [Effect of large-dosage of 5alpha-reductase inhibitors on the spermatogenesis of male rats].
Zhonghua nan ke xue = National journal of andrology.
2005 Sep; 11(9):652-4. doi:
NULL
. [PMID: 16209201] - Xiao-Bing Ju, Hong-Fei Wu, Li-Xin Hua, Wei Zhang, Jie Li. [The clinical efficacy of epristeride in the treatment of benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2002; 8(1):42-4. doi:
NULL
. [PMID: 12479047] - G L Wei, S H Xiao, C X Liu. [Pharmacokinetics of epristeride in rats and beagle dogs].
Yao xue xue bao = Acta pharmaceutica Sinica.
2000 Oct; 35(10):721-4. doi:
NULL
. [PMID: 11372434] - N Yasuda, K Fujino, T Shiraji, F Nambu, K Kondo. Effects of steroid 5alpha-reductase inhibitor ONO-9302 and anti-androgen allylestrenol on the prostatic growth, and plasma and prostatic hormone levels in rats.
Japanese journal of pharmacology.
1997 Jul; 74(3):243-52. doi:
10.1254/jjp.74.243
. [PMID: 9268084] - L J Benincosa, P R Audet, D Lundberg, N Zariffa, D K Jorkasky. Pharmacokinetics and absolute bioavailability of epristeride in healthy male subjects.
Biopharmaceutics & drug disposition.
1996 Apr; 17(3):249-58. doi:
10.1002/(sici)1099-081x(199604)17:3<249::aid-bdd952>3.0.co;2-e
. [PMID: 8983399] - V K Boppana, C Miller-Stein, G R Rhodes. Normal-phase high-performance liquid chromatographic determination of epristeride, a prostatic steroid 5 alpha-reductase enzyme inhibitor, in human plasma.
Journal of chromatography.
1993 Feb; 631(1-2):251-4. doi:
10.1016/0021-9673(93)80529-h
. [PMID: 8450017] - J C Lamb, M A Levy, R K Johnson, J T Isaacs. Response of rat and human prostatic cancers to the novel 5 alpha-reductase inhibitor, SK&F 105657.
The Prostate.
1992; 21(1):15-34. doi:
10.1002/pros.2990210103
. [PMID: 1641369]