Epoprostenol sodium (BioDeep_00000728064)
代谢物信息卡片
sodium;(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoate
化学式: C20H31NaO5 (374.2069076)
中文名称: 前列腺素 I2 钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)[O-])O2)O)O.[Na+]
InChI: /q
描述信息
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Felix Rafael De Bie, Christopher Gates Halline, Travis Kotzur, Kevin Hayes, Christopher Copeland Rouse, Jonathan Chang, Abby Christine Larson, Sameer Ahmad Khan, Ashley Spina, Samantha Tilden, Francesca Maria Russo, Holly Lee Hedrick, Jan Deprest, Emily Anne Partridge. Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia.
EBioMedicine.
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Journal of intensive care medicine.
2022 Jul; 37(7):883-889. doi:
10.1177/08850666221081757. [PMID: 35195460] - Martin Vigstedt, Peter Søe-Jensen, Morten H Bestle, Niels E Clausen, Klaus T Kristiansen, Theis Lange, Jakob Stensballe, Anders Perner, Pär I Johansson. The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infection.
Journal of critical care.
2022 06; 69(?):154010. doi:
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Pharmacotherapy.
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2019 Oct; 33(5):903-910. doi:
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Journal of molecular medicine (Berlin, Germany).
2019 06; 97(6):777-791. doi:
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Journal of cardiovascular pharmacology.
2019 06; 73(6):383-393. doi:
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Pflugers Archiv : European journal of physiology.
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Biomedical chromatography : BMC.
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Archives of medical research.
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2019 Jan; 76(1):13-16. doi:
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The Journal of international medical research.
2019 Jan; 47(1):252-264. doi:
10.1177/0300060518800517. [PMID: 30270798] - Shanzana I Khan, Waled A Shihata, Karen L Andrews, Man K S Lee, Xiao-Lei Moore, Ann-Maree Jefferis, Antony Vinh, Tracey Gaspari, Dragana Dragoljevic, Garry L Jennings, Andrew J Murphy, Jaye P F Chin-Dusting. Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 01; 33(1):1510-1521. doi:
10.1096/fj.201701498rr. [PMID: 30156911] - Yu Zhou, Ling Du, Bo Tu, Qiquan Lai, Xiaonan Du, Bo Xu, Fan Zhang, Mingdong Zhao, Ziming Wan, Jiajie Lai. Comparing the vascular thromboembolic events following arteriovenous fistula in Chinese population with end-stage renal diseases receiving Clopidogrel versus Beraprost sodium therapy: a retrospective cohort study.
BMC nephrology.
2018 12; 19(1):376. doi:
10.1186/s12882-018-1166-0. [PMID: 30587157] - A Kij, K Kus, M Smeda, A Zakrzewska, B Proniewski, K Matyjaszczyk, A Jasztal, M Stojak, M Walczak, S Chlopicki. Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2018 Dec; 69(6):. doi:
10.26402/jpp.2018.6.05. [PMID: 30802213] - Franziska G Leifer, Donna M Konicek, Kuan-Ju Chen, Adam J Plaunt, Dany Salvail, Charles E Laurent, Michel R Corboz, Zhili Li, Richard W Chapman, Walter R Perkins, Vladimir S Malinin. Inhaled Treprostinil-Prodrug Lipid Nanoparticle Formulations Provide Long-Acting Pulmonary Vasodilation.
Drug research.
2018 Nov; 68(11):605-614. doi:
10.1055/s-0044-100374. [PMID: 29791923] - Kendall M Lawrence, Holly L Hedrick, Heather M Monk, Lisa Herkert, Lindsay N Waqar, Brian D Hanna, William H Peranteau, Natalie E Rintoul, Rachel K Hopper. Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia.
The Journal of pediatrics.
2018 09; 200(?):44-49. doi:
10.1016/j.jpeds.2018.04.052. [PMID: 29784517] - Tawfeq Naal, Batool Abuhalimeh, Ghaleb Khirfan, Raed A Dweik, W H Wilson Tang, Adriano R Tonelli. Serum Chloride Levels Track With Survival in Patients With Pulmonary Arterial Hypertension.
Chest.
2018 09; 154(3):541-549. doi:
10.1016/j.chest.2018.04.022. [PMID: 29698719] - Longfei Wang, Yong Li, Shenglan Lin, Zhiqiang Pu, Haiping Li, Zhili Tang. Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats.
Brazilian journal of cardiovascular surgery.
2018 Jul; 33(4):384-390. doi:
10.21470/1678-9741-2018-0059. [PMID: 30184036] - Remigiusz Kazimierczyk, Piotr Błaszczak, Krzysztof Kowal, Małgorzata Jasiewicz, Małgorzata Knapp, Anna Szpakowicz, Katarzyna Ptaszyńska-Kopczyńska, Bożena Sobkowicz, Ewa Waszkiewicz, Ryszard Grzywna, Włodzimierz J Musial, Karol A Kamiński. The significance of diminished sTWEAK and P-selectin content in platelets of patients with pulmonary arterial hypertension.
Cytokine.
2018 07; 107(?):52-58. doi:
10.1016/j.cyto.2017.11.014. [PMID: 29203267] - Zeming Zhang, Zheng Li, Lu Chen, Yancun Wang. The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits with acute massive pulmonary embolism1.
Acta cirurgica brasileira.
2018 Jul; 33(7):577-587. doi:
10.1590/s0102-865020180070000003. [PMID: 30110059] - Rasa Tamosiuniene, Olga Manouvakhova, Paul Mesange, Toshie Saito, Jin Qian, Mrinmoy Sanyal, Yu-Chun Lin, Linh P Nguyen, Amir Luria, Allen B Tu, Joshua M Sante, Marlene Rabinovitch, Desmond J Fitzgerald, Brian B Graham, Aida Habtezion, Norbert F Voelkel, Laure Aurelian, Mark R Nicolls. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension.
Circulation research.
2018 06; 122(12):1689-1702. doi:
10.1161/circresaha.117.312058. [PMID: 29545367] - E Buczek, A Denslow, L Mateuszuk, B Proniewski, T Wojcik, B Sitek, A Fedorowicz, A Jasztal, E Kus, A Chmura-Skirlinska, R Gurbiel, J Wietrzyk, S Chlopicki. Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation.
BMC cancer.
2018 May; 18(1):582. doi:
10.1186/s12885-018-4445-z. [PMID: 29788918] - M H Lundberg Slingsby, L Gliemann, M Thrane, N Rytter, J Egelund, M V Chan, P C Armstrong, T D Warner, Y Hellsten. Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels.
Acta physiologica (Oxford, England).
2018 05; 223(1):e13028. doi:
10.1111/apha.13028. [PMID: 29297976] - Shinji Toki, Weisong Zhou, Kasia Goleniewska, Sara Reiss, Daniel E Dulek, Dawn C Newcomb, William E Lawson, R Stokes Peebles. Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.
Prostaglandins & other lipid mediators.
2018 05; 136(?):33-43. doi:
10.1016/j.prostaglandins.2018.04.001. [PMID: 29660395] - Michel R Corboz, Jimin Zhang, Daniel LaSala, Keith DiPetrillo, Zhili Li, Vladimir Malinin, Jeremy Brower, Philip J Kuehl, Ted E Barrett, Walter R Perkins, Richard W Chapman. Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats.
Pulmonary pharmacology & therapeutics.
2018 04; 49(?):95-103. doi:
10.1016/j.pupt.2018.01.012. [PMID: 29408757] - Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Charles E Laurent, Han Yin, Dany Salvail, Chad Dziak, Walter R Perkins, Vladimir Malinin. Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil.
Pulmonary pharmacology & therapeutics.
2018 04; 49(?):104-111. doi:
10.1016/j.pupt.2018.02.002. [PMID: 29421665] - N McLewee, T Archer, R Wills, A Mackin, J Thomason. Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):60-67. doi:
10.1111/jvp.12432. [PMID: 28664658] - Xin-Fang Wang, Bei-Hao Zhang, Xiao-Qing Lu, Pei Wang. Beraprost Sodium, a Stable Analogue of PGI2, Inhibits the Renin-Angiotensin System in the Renal Tissues of Rats with Chronic Renal Failure.
Kidney & blood pressure research.
2018; 43(4):1231-1244. doi:
10.1159/000492405. [PMID: 30078019] - Jingfan Deng, Jiao Feng, Tong Liu, Xiya Lu, Wenwen Wang, Ning Liu, Yang Lv, Qing Liu, Chuanyong Guo, Yingqun Zhou. Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.
Drug design, development and therapy.
2018; 12(?):4067-4082. doi:
10.2147/dddt.s182292. [PMID: 30568428] - M Takenaka, A Iio, R Sato, T Sakamoto, H Kurumatani. A Double-blind, Placebo-controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease.
Journal of veterinary internal medicine.
2018 Jan; 32(1):236-248. doi:
10.1111/jvim.14839. [PMID: 29131397] - Kai-Lun Liang, Ping Fang, Qiu-Qiu Shi, Jie Su, Bo Li, Su-Hong Chen, Gui-Yuan Lv. [Antihypertensive effect and mechanism of Dendrobium officinale flos on high-blood pressure rats induced by high glucose and high fat compound alcohol].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Jan; 43(1):147-153. doi:
10.19540/j.cnki.cjcmm.20171027.020. [PMID: 29552825] - M H Lundberg Slingsby, M Nyberg, J Egelund, C M Mandrup, R Frikke-Schmidt, N S Kirkby, Y Hellsten. Aerobic exercise training lowers platelet reactivity and improves platelet sensitivity to prostacyclin in pre- and postmenopausal women.
Journal of thrombosis and haemostasis : JTH.
2017 12; 15(12):2419-2431. doi:
10.1111/jth.13866. [PMID: 29027349] - Michel R Corboz, Zhili Li, Vladimir Malinin, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Kuan-Ju Chen, Charles E Laurent, Han Yin, Marzena C Biernat, Dany Salvail, Jianguo Zhuang, Fadi Xu, Aidan Curran, Walter R Perkins, Richard W Chapman. Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
The Journal of pharmacology and experimental therapeutics.
2017 12; 363(3):348-357. doi:
10.1124/jpet.117.242099. [PMID: 28904003] - Hassan Esmaeili, Mozhdeh Sharifi, Mansour Esmailidehaj, Mohammad Ebrahim Rezvani, Zeynab Hafizibarjin. Vasodilatory effect of asafoetida essential oil on rat aorta rings: The role of nitric oxide, prostacyclin, and calcium channels.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Dec; 36(?):88-94. doi:
10.1016/j.phymed.2017.10.002. [PMID: 29157833] - Julia M Santos, Jung-A Park, Aby Joiakim, David A Putt, Robert N Taylor, Hyesook Kim. The role of soluble epoxide hydrolase in preeclampsia.
Medical hypotheses.
2017 Oct; 108(?):81-85. doi:
10.1016/j.mehy.2017.07.033. [PMID: 29055406] - Anne Brandolt Larré, Aline Parisotto, Bruna Fagundes Rockenbach, Débora Montenegro Pasin, Cláudia Capellari, Daniele Cristovão Escouto, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo. Phosphodiesterases and preeclampsia.
Medical hypotheses.
2017 Oct; 108(?):94-100. doi:
10.1016/j.mehy.2017.08.003. [PMID: 29055408] - Lasse Gliemann, Nicolai Rytter, Mads Lindskrog, Martina H Lundberg Slingsby, Thorbjörn Åkerström, Lykke Sylow, Erik A Richter, Ylva Hellsten. Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects.
The Journal of physiology.
2017 08; 595(16):5557-5571. doi:
10.1113/jp274623. [PMID: 28620941] - É Carrier, M Houde, M Grandbois, G Bkaily, T D Warner, P D'Orléans-Juste. Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice.
Canadian journal of physiology and pharmacology.
2017 Aug; 95(8):954-960. doi:
10.1139/cjpp-2017-0314. [PMID: 28704616] - Patrizia Amadio, Eva Tarantino, Leonardo Sandrini, Elena Tremoli, Silvia S Barbieri. Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice.
Thrombosis and haemostasis.
2017 07; 117(8):1486-1497. doi:
10.1160/th16-12-0968. [PMID: 28536720] - Miyeon Kim, Ji Ung Kim, So Mi Kim, HyunWoo Kim. Effectiveness of beraprost sodium in maintaining vascular access patency in patients on hemodialysis.
International urology and nephrology.
2017 Jul; 49(7):1287-1295. doi:
10.1007/s11255-017-1586-y. [PMID: 28409403] - Pengfei Chen, Hanchao Gao, Ying Lu, Huirong Nie, Zhaoming Liu, Yu Zhao, Nana Fan, Qingjian Zou, Yifan Dai, Aifa Tang, Hidetaka Hara, Zhiming Cai, David K C Cooper, Liangxue Lai, Lisha Mou. Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation.
Cell biology international.
2017 Jul; 41(7):798-808. doi:
10.1002/cbin.10782. [PMID: 28462511] - Meryem Temiz-Resitoglu, Sefika Pinar Kucukkavruk, Demet Sinem Guden, Pelin Cecen, Ayse Nihal Sari, Bahar Tunctan, Aysegul Gorur, Lulufer Tamer-Gumus, Cuneyt Kemal Buharalioglu, Kafait U Malik, Seyhan Sahan-Firat. Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats.
European journal of pharmacology.
2017 May; 802(?):7-19. doi:
10.1016/j.ejphar.2017.02.034. [PMID: 28228357] - Masahiro Shimamura, Jun Miyakawa, Masaaki Doi, Kiyonobu Okada, Hajimu Kurumatani, Yoshitaka Mori, Keiyu Oshida, Ikumi Nakajo, Keishi Oikawa, Fumihiko Ushigome, Aiji Miyashita, Masanao Isono, Yohei Miyamoto. The Pharmacokinetics of Beraprost Sodium Following Single Oral Administration to Subjects With Impaired Kidney Function.
Journal of clinical pharmacology.
2017 04; 57(4):524-535. doi:
10.1002/jcph.835. [PMID: 27681484] - Takanori Watanabe, Kohtaro Abe, Koshin Horimoto, Kazuya Hosokawa, Kisho Ohtani, Hiroyuki Tsutsui. Subcutaneous treprostinil was effective and tolerable in a patient with severe pulmonary hypertension associated with chronic kidney disease on hemodialysis.
Heart & lung : the journal of critical care.
2017 Mar; 46(2):129-130. doi:
10.1016/j.hrtlng.2017.01.004. [PMID: 28189266] - Sparkle Russell-Puleri, Nathaniel G Dela Paz, Diana Adams, Mitali Chattopadhyay, Limary Cancel, Eno Ebong, A Wayne Orr, John A Frangos, John M Tarbell. Fluid shear stress induces upregulation of COX-2 and PGI2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38.
American journal of physiology. Heart and circulatory physiology.
2017 Mar; 312(3):H485-H500. doi:
10.1152/ajpheart.00035.2016. [PMID: 28011582] - Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin, Bosede Bukola Afolabi. Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy.
PloS one.
2017; 12(9):e0184345. doi:
10.1371/journal.pone.0184345. [PMID: 28880908] - Nina Sarah Gowert, Meike Klier, Maria Reich, Friedrich Reusswig, Lili Donner, Verena Keitel, Dieter Häussinger, Margitta Elvers. Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(6):2133-2149. doi:
10.1159/000475566. [PMID: 28441661] - Alexandra Boivin, Mélanie Burban, Raphaël Clere-Jehl, Pierrick Le Borgne, Hamid Merdji, Cyril Auger, Valérie Schini-Kerth, Ferhat Meziani, Julie Helms. Docosahexaenoic acid, but not eicosapentaenoic acid, improves septic shock-induced arterial dysfunction in rats.
PloS one.
2017; 12(12):e0189658. doi:
10.1371/journal.pone.0189658. [PMID: 29261735] - Guimei Ran, Yixuan Wang, Haochen Liu, Chunxiang Wei, Tao Zhu, Haidong Wang, Hua He, Xiaoquan Liu. A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk.
Disease markers.
2017; 2017(?):9506527. doi:
10.1155/2017/9506527. [PMID: 28630527] - Paul A Gurbel, Kevin P Bliden, Rahul Chaudhary, Jeff Patrick, Fang Liu, Gailing Chen, Christopher McLeod, Udaya S Tantry. Antiplatelet Effect Durability of a Novel, 24-Hour, Extended-Release Prescription Formulation of Acetylsalicylic Acid in Patients With Type 2 Diabetes Mellitus.
The American journal of cardiology.
2016 Dec; 118(12):1941-1947. doi:
10.1016/j.amjcard.2016.08.088. [PMID: 27769511] - Nannan Li, Jie Yin, Weidong Cai, Jingjing Liu, Na Zhang, Suhua Yan, Lucheng Song, Xiaolu Li. Coupling Factor 6 Is Upregulated in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
The American journal of the medical sciences.
2016 Dec; 352(6):631-636. doi:
10.1016/j.amjms.2016.08.002. [PMID: 27916219]