Calcipotriene hydrate (BioDeep_00000727746)

   


代谢物信息卡片


Calcipotriol (monohydrate)

化学式: C27H42O4 (430.30829320000004)
中文名称: 钙泊三醇一水合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C.O
InChI: /m1./s1

描述信息

D018977 - Micronutrients > D014815 - Vitamins > D004100 - Dihydroxycholecalciferols
D018977 - Micronutrients > D014815 - Vitamins > D006887 - Hydroxycholecalciferols
D003879 - Dermatologic Agents

同义名列表

2 个代谢物同义名

Calcipotriol (monohydrate); Calcipotriene hydrate



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Zhicheng Yang, Wei Jiang, Chenwei Xiong, JingJing Shang, Yong Huang, Xindie Zhou, Su Zhang. Calcipotriol suppresses GPX4-mediated ferroptosis in OA chondrocytes by blocking the TGF-β1 pathway. Cytokine. 2023 11; 171(?):156382. doi: 10.1016/j.cyto.2023.156382. [PMID: 37782985]
  • Sunita Thakur, Md Meraj Anjum, Shweta Jaiswal, Anand Kumar, Payal Deepak, Sneha Anand, Sanjay Singh, Paruvathanahalli Siddalingam Rajinikanth. Novel Synergistic Approach: Tazarotene-Calcipotriol-Loaded-PVA/PVP-Nanofibers Incorporated in Hydrogel Film for Management and Treatment of Psoriasis. Molecular pharmaceutics. 2023 Feb; 20(2):997-1014. doi: 10.1021/acs.molpharmaceut.2c00713. [PMID: 36630478]
  • Jan Holmback, Anders Carlsson, Puneet Rinwa. Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris. Journal of drugs in dermatology : JDD. 2023 Feb; 22(2):197-202. doi: 10.36849/jdd.7151. [PMID: 36745360]
  • Zhen-Xiong Zhao, Yan-Qiu Zhang, Hui Sun, Zi-Qi Chen, Jin-Jia Chang, Xin Wang, Xu Wang, Cong Tan, Shu-Juan Ni, Wei-Wei Weng, Meng Zhang, Lei Wang, Dan Huang, Yun Feng, Wei-Qi Sheng, Mi-Die Xu. Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling. Acta pharmacologica Sinica. 2023 Jan; 44(1):178-188. doi: 10.1038/s41401-022-00927-1. [PMID: 35676532]
  • Junrong Ren, Qi Zhu, Siyao Wang, Xiaolong Li, Zhen Sun, Nan Li, Jian Feng, Haining Ding, Sitong Dong, Hongmei Wang. Clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment: a systematic review and meta-analysis. Archives of dermatological research. 2022 Sep; 314(7):633-641. doi: 10.1007/s00403-021-02272-5. [PMID: 34417633]
  • Victor R Lincha, Cheng-Hui Hsiao, Jun Zhao, Chun Li, Diana S-L Chow. Sensitive and rapid UHPLC-MS/MS assay for simultaneous quantifications of calcipotriol and paclitaxel in rat whole blood and plasma samples. Journal of pharmaceutical and biomedical analysis. 2021 Jan; 192(?):113685. doi: 10.1016/j.jpba.2020.113685. [PMID: 33099115]
  • Johanna A Huhtakangas, Jere Huovinen, Sakari Laaksonen, Hanna-Marja Voipio, Olli Vuolteenaho, Mikko A J Finnilä, Jérôme Thevenot, Petri P Lehenkari. A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats. PloS one. 2021; 16(4):e0250352. doi: 10.1371/journal.pone.0250352. [PMID: 33878143]
  • Di Wang, Lin Lin, Ke Lei, Jiaqi Zeng, Jialiang Luo, Yue Yin, Yao Li, Liyun Zhang, Xiaoli Nie, Daming Zuo, Ledong Sun. Vitamin D3 analogue facilitates epithelial wound healing through promoting epithelial-mesenchymal transition via the Hippo pathway. Journal of dermatological science. 2020 Nov; 100(2):120-128. doi: 10.1016/j.jdermsci.2020.08.015. [PMID: 32938565]
  • Lunfei Liu, Chunlei Zhang, Jinyan Wang, Kun Chen, Yangfeng Ding, Guofu Yan, Qianjin Lu, Wei Li, Hong Fang, Hao Cheng, Jianzhong Zhang, Yanling He, Wei Zhu, Yan Lu, Jinhua Huang, Weili Pan, Ming Li, Shuanglin Cao, Shanshan Li, Xiuping Han, Li He, Yayuan Chen, Min Zheng. Comparison of safety and efficacy between calcipotriol plus betamethasone dipropionate gel and calcipotriol scalp solution as long-term treatment for scalp psoriasis in Chinese patients: a national, multicentre, prospective, randomized, active-controlled phase 4 trial. European journal of dermatology : EJD. 2020 Oct; 30(5):580-590. doi: 10.1684/ejd.2020.3876. [PMID: 33052103]
  • Sofie Svanberg, Zhiqiang Li, Pontus Öhlund, Ananya Roy, Magnus Åbrink. Mast Cells Limit Ear Swelling Independently of the Chymase Mouse Mast Cell Protease 4 in an MC903-Induced Atopic Dermatitis-Like Mouse Model. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21176311. [PMID: 32878208]
  • Muhanad Elhafiz, Guolin Zhao, Mohammed Ismail, Dengqiu Xu, Debanjan Das, Sisi Fan, Nong Cheng, Bashir A Yousef, Zhenzhou Jiang, Luyong Zhang. Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 06; 1865(6):158657. doi: 10.1016/j.bbalip.2020.158657. [PMID: 32045698]
  • Qingqing Lv, Aolin Yang, Wanying Shi, Feng Chen, Yixuan Liu, Ying Liu, Difei Wang. Calcipotriol and iBRD9 reduce obesity in Nur77 knockout mice by regulating the gut microbiota, improving intestinal mucosal barrier function. International journal of obesity (2005). 2020 05; 44(5):1052-1061. doi: 10.1038/s41366-020-0564-0. [PMID: 32203112]
  • P Alex, S Williams, L Sutton, T Yesudas, C Sutton, S Thomas, M Centola. Efficacy and safety of HAT1 compared with calcipotriol in the treatment of patients with mild to moderate chronic plaque psoriasis: results from an open-label randomized comparative pilot clinical study. Clinical and experimental dermatology. 2020 Apr; 45(3):318-322. doi: 10.1111/ced.14074. [PMID: 31419323]
  • Zhaoxia Chen, Dongmei Zhou, Yan Wang, Haibing Lan, Xingwu Duan, Bohua Li, Jingxia Zhao, Wei Li, Zhengrong Liu, Tingting Di, Xinwei Guo, Jinchao Zhang, Bo Li, Shuo Feng, Ping Li. Fire needle acupuncture or moxibustion for chronic plaque psoriasis: study protocol for a randomized controlled trial. Trials. 2019 Dec; 20(1):674. doi: 10.1186/s13063-019-3736-2. [PMID: 31801593]
  • Carolin Riegraf, Georg Reifferscheid, Shimshon Belkin, Liat Moscovici, Dror Shakibai, Henner Hollert, Sebastian Buchinger. Combination of yeast-based in vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds. Analytica chimica acta. 2019 Nov; 1081(?):218-230. doi: 10.1016/j.aca.2019.07.018. [PMID: 31446961]
  • Carolyn M Walsh, Rose Z Hill, Jamie Schwendinger-Schreck, Jacques Deguine, Emily C Brock, Natalie Kucirek, Ziad Rifi, Jessica Wei, Karsten Gronert, Rachel B Brem, Gregory M Barton, Diana M Bautista. Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. eLife. 2019 10; 8(?):. doi: 10.7554/elife.48448. [PMID: 31631836]
  • Moustafa A El Taieb, Eisa M Hegazy, Hassan M Ibrahim, Asmaa B Osman, Manal Abualhamd. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial. Archives of dermatological research. 2019 Oct; 311(8):629-636. doi: 10.1007/s00403-019-01943-8. [PMID: 31236672]
  • Dian-Dong Hou, Wei Zhang, Ya-Li Gao, Yu-Zhe Sun, He-Xiao Wang, Rui-Qun Qi, Hong-Duo Chen, Xing-Hua Gao. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. International immunopharmacology. 2019 Sep; 74(?):105676. doi: 10.1016/j.intimp.2019.105676. [PMID: 31181406]
  • Jingwen Deng, Chuanjian Lu, Yu Xiang, Hao Deng, Zehuai Wen, Danni Yao, Meiling Xuan, Yuhong Yan. Auricular acupressure as a complementary therapy for psoriasis vulgaris: study protocol for a multicenter randomized controlled trial. Trials. 2019 Jun; 20(1):358. doi: 10.1186/s13063-019-3475-4. [PMID: 31208470]
  • Kee W Tan, Angelina Sampson, Bremansu Osa-Andrews, Surtaj H Iram. Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells. Drug metabolism and disposition: the biological fate of chemicals. 2018 12; 46(12):1856-1866. doi: 10.1124/dmd.118.081612. [PMID: 30232176]
  • J Lu, M Chen, L Gao, Q Cheng, Y Xiang, J Huang, K Wu, J Huang, M Li. A preliminary study on topical ozonated oil in the therapeutic management of atopic dermatitis in murine. The Journal of dermatological treatment. 2018 Nov; 29(7):676-681. doi: 10.1080/09546634.2018.1443199. [PMID: 29466894]
  • Akimichi Morita, Shinnosuke Muramatsu, Ryoji Kubo, Kyoko Ikumi, Yoko Sagawa, Chiyo Saito, Kan Torii, Emi Nishida. Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. The Journal of dermatological treatment. 2018 Aug; 29(5):496-500. doi: 10.1080/09546634.2017.1398394. [PMID: 29076379]
  • Agata Pawlik, Artur Anisiewicz, Beata Filip-Psurska, Marcin Nowak, Eliza Turlej, Justyna Trynda, Joanna Banach, Paweł Gretkierewicz, Joanna Wietrzyk. Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer. International journal of molecular sciences. 2018 Jul; 19(7):. doi: 10.3390/ijms19072116. [PMID: 30037009]
  • Nick Vandeghinste, Jürgen Klattig, Catherine Jagerschmidt, Stéphanie Lavazais, Florence Marsais, Jan D Haas, Marielle Auberval, Felix Lauffer, Tara Moran, Mate Ongenaert, Maarten Van Balen, Sonia Dupont, Liên Lepescheux, Teresa Garcia, Stefan Härtle, Kilian Eyerich, Padraic G Fallon, Reginald Brys, Stefan Steidl. Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis. The Journal of investigative dermatology. 2018 07; 138(7):1555-1563. doi: 10.1016/j.jid.2018.01.036. [PMID: 29474945]
  • Simon Ville, Diego Cantarovich. Belatacept and Autoimmune Adverse Events. Transplantation. 2018 07; 102(7):e355-e356. doi: 10.1097/tp.0000000000002247. [PMID: 29672443]
  • Kyosuke Satake, Toru Amano, Tadao Okamoto. Low systemic exposure and calcemic effect of calcipotriol/betamethasone ointment in rats with imiquimod-induced psoriasis-like dermatitis. European journal of pharmacology. 2018 May; 826(?):31-38. doi: 10.1016/j.ejphar.2018.02.032. [PMID: 29476878]
  • Peter Wallbaum, Sarah Rohde, Luise Ehlers, Falko Lange, Alexander Hohn, Carina Bergner, Sarah Marie Schwarzenböck, Bernd Joachim Krause, Robert Jaster. Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells. World journal of gastroenterology. 2018 Jan; 24(2):170-178. doi: 10.3748/wjg.v24.i2.170. [PMID: 29375203]
  • Artur Anisiewicz, Agata Pawlik, Beata Filip-Psurska, Eliza Turlej, Stanisław Dzimira, Magdalena Milczarek, Katarzyna Gdesz, Diana Papiernik, Joanna Jarosz, Dagmara Kłopotowska, Andrzej Kutner, Andrzej Mazur, Joanna Wietrzyk. Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer. International journal of oncology. 2018 Jan; 52(1):103-126. doi: 10.3892/ijo.2017.4185. [PMID: 29115583]
  • Tarun Narang, Manju Daroach, M Sendhil Kumaran. Efficacy and safety of topical calcipotriol in management of alopecia areata: A pilot study. Dermatologic therapy. 2017 May; 30(3):. doi: 10.1111/dth.12464. [PMID: 28133875]
  • Xiao-Jing Liu, Zhang-Lei Mu, Yan Zhao, Jian-Zhong Zhang. Topical Tetracycline Improves MC903-induced Atopic Dermatitis in Mice through Inhibition of Inflammatory Cytokines and Thymic Stromal Lymphopoietin Expression. Chinese medical journal. 2016 Jun; 129(12):1483-90. doi: 10.4103/0366-6999.183427. [PMID: 27270547]
  • Johanna Mihály, Janine Gericke, Renata Lucas, Angel R de Lera, Susana Alvarez, Dániel Törőcsik, Ralph Rühl. TSLP expression in the skin is mediated via RARγ-RXR pathways. Immunobiology. 2016 Feb; 221(2):161-5. doi: 10.1016/j.imbio.2015.09.013. [PMID: 26531761]
  • Aslı Aksu Çerman, Sezgi Sarıkaya Solak, İlknur Altunay, Nihal Aslı Küçükünal. Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study. Journal of drugs in dermatology : JDD. 2015 Jun; 14(6):616-20. doi: NULL. [PMID: 26091388]
  • Yin-Ku Lin, Ya-Ching Chang, Rosaline Chung-Yee Hui, Lai-Chu See, Chee-Jen Chang, Chih-Hsun Yang, Yu-Huei Huang. A Chinese Herb, Indigo Naturalis, Extracted in Oil (Lindioil) Used Topically to Treat Psoriatic Nails: A Randomized Clinical Trial. JAMA dermatology. 2015 Jun; 151(6):672-4. doi: 10.1001/jamadermatol.2014.5460. [PMID: 25738921]
  • M Gooderham, J-M Debarre, J Keddy-Grant, Z Xu, M Kurvits, M Goodfield. Safety and efficacy of calcipotriol plus betamethasone dipropionate gel in the treatment of scalp psoriasis in adolescents 12-17 years of age. The British journal of dermatology. 2014 Dec; 171(6):1470-7. doi: 10.1111/bjd.13235. [PMID: 24980277]
  • Shane Silver, Raj Tuppal, Aditya K Gupta, Fabrice Clonier, Martin Olesen, Randy Leeder, Victoria Taraska. Effect of calcipotriene plus betamethasone dipropionate topical suspension on the hypothalamic-pituitary-adrenal axis and calcium homeostasis in subjects with extensive psoriasis vulgaris: an open, non-controlled, 8-week trial. Journal of drugs in dermatology : JDD. 2013 Aug; 12(8):882-7. doi: NULL. [PMID: 23986161]
  • R Abdelmaksood, D Hashad. The impact of topical calcipotriol and betamethasone on human beta-defensin 2 expression and serum level in psoriatic patients. Clinical laboratory. 2013; 59(3-4):277-82. doi: 10.7754/clin.lab.2012.120207. [PMID: 23724615]
  • Naresh Punwani, Peggy Scherle, Robert Flores, Jack Shi, Jinjin Liang, Swamy Yeleswaram, Richard Levy, William Williams, Alice Gottlieb. Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis. Journal of the American Academy of Dermatology. 2012 Oct; 67(4):658-64. doi: 10.1016/j.jaad.2011.12.018. [PMID: 22281165]
  • Nina Østergaard Knudsen, Stine Rønholt, Ragnhild Djønne Salte, Lene Jorgensen, Thorsten Thormann, Line Hollesen Basse, Jens Hansen, Sven Frokjaer, Camilla Foged. Calcipotriol delivery into the skin with PEGylated liposomes. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2012 Aug; 81(3):532-9. doi: 10.1016/j.ejpb.2012.04.005. [PMID: 22538098]
  • Susana Coimbra, Hugo Oliveira, Flávio Reis, Luís Belo, Susana Rocha, Alexandre Quintanilha, Américo Figueiredo, Frederico Teixeira, Elisabeth Castro, Petronila Rocha-Pereira, Alice Santos-Silva. Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: a cross-sectional and longitudinal study. American journal of clinical dermatology. 2012 Feb; 13(1):37-47. doi: 10.2165/11592110-000000000-00000. [PMID: 21888450]
  • Nina Østergaard Knudsen, Lene Jorgensen, Jens Hansen, Charlotte Vermehren, Sven Frokjaer, Camilla Foged. Targeting of liposome-associated calcipotriol to the skin: effect of liposomal membrane fluidity and skin barrier integrity. International journal of pharmaceutics. 2011 Sep; 416(2):478-85. doi: 10.1016/j.ijpharm.2011.03.014. [PMID: 21419203]
  • Susana Coimbra, Hugo Oliveira, Flávio Reis, Luís Belo, Susana Rocha, Alexandre Quintanilha, Américo Figueiredo, Frederico Teixeira, Elisabeth Castro, Petronila Rocha-Pereira, Alice Santos-Silva. Psoriasis therapy and cardiovascular risk factors: a 12-week follow-up study. American journal of clinical dermatology. 2010 Dec; 11(6):423-32. doi: 10.2165/11319310-000000000-00000. [PMID: 20429617]
  • Yin-Ku Lin, Zih-Rou Huang, Rou-Zi Zhuo, Jia-You Fang. Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. International journal of nanomedicine. 2010 Mar; 5(?):117-28. doi: 10.2147/ijn.s9155. [PMID: 20309398]
  • ". Childhood psoriasis: often favorable outcome. Prescrire international. 2009 Dec; 18(104):275. doi: ". [PMID: 20027717]
  • Maxine E Whitton, Darren M Ashcroft, Urbà González. Therapeutic interventions for vitiligo. Journal of the American Academy of Dermatology. 2008 Oct; 59(4):713-7. doi: 10.1016/j.jaad.2008.06.023. [PMID: 18793940]
  • Anthony Romo, Sandra Benavides. Treatment options in insulin resistance obesity-related acanthosis nigricans. The Annals of pharmacotherapy. 2008 Jul; 42(7):1090-4. doi: 10.1345/aph.1k446. [PMID: 18492785]
  • Anna Zampetti, Alessia Barone, Daniela Antuzzi, Paolo Amerio, Antonello Tulli, Claudio Feliciani, Pierluigi Amerio. Topical preparations for the treatment of psoriasis: results of a retrospective study over 15 years. The Journal of dermatological treatment. 2008; 19(3):134-40. doi: 10.1080/09546630701846087. [PMID: 18569269]
  • Joshua B DiCarlo, Erica A Gupta, Alvin R Solomon. A pediatric case of nephrogenic fibrosing dermopathy: improvement after combination therapy. Journal of the American Academy of Dermatology. 2006 May; 54(5):914-6. doi: 10.1016/j.jaad.2006.01.023. [PMID: 16635686]
  • F Urbina, C Misad, S González. Circumscribed palmar hypokeratosis: clinical evolution and ultrastructural study after prolonged treatment with topical calcipotriol. Journal of the European Academy of Dermatology and Venereology : JEADV. 2005 Jul; 19(4):491-4. doi: 10.1111/j.1468-3083.2005.01197.x. [PMID: 15987302]
  • G Duweb, J Alhaddar, M Abuhamida. Psoriasis vulgaris: once-versus twice-daily application of calcipotriol cream. International journal of tissue reactions. 2005; 27(4):155-8. doi: NULL. [PMID: 16440578]
  • G Duweb, J Alhaddar, B Elsherif, N Eljehawi, H Makhlouf. Calcipotriol-betamethasone ointment versus calcipotriol ointment in the treatment of psoriasis vulgaris. Drugs under experimental and clinical research. 2005; 31(5-6):175-9. doi: NULL. [PMID: 16425973]
  • Vikas Sharma, Inderjeet Kaur, Bhushan Kumar. Calcipotriol versus coal tar: a prospective randomized study in stable plaque psoriasis. International journal of dermatology. 2003 Oct; 42(10):834-8. doi: 10.1046/j.1365-4362.2003.01974.x. [PMID: 14521705]
  • G Duweb, S Aldebani, A Elzorghany, M Benghazil, J Alhaddar. Calcipotriol ointment versus cream in psoriasis vulgaris. International journal of clinical pharmacology research. 2003; 23(2-3):47-51. doi: NULL. [PMID: 15018018]
  • Monika Jensen, Lotte Groth, Gunhild Hølmer, Harald S Hansen, Ann Fullerton. The potential of the essential fatty acid-deficient hairless rat as a psoriasis screening model for topical anti-proliferative drugs. Skin pharmacology and applied skin physiology. 2002 Nov; 15(6):401-13. doi: 10.1159/000066453. [PMID: 12476014]
  • J V Smit, S Cox, W A M Blokx, P C M van de Kerhof, G J de Jongh, E M G J de Jong. Actinic keratoses in renal transplant recipients do not improve with calcipotriol cream and all-trans retinoic acid cream as monotherapies or in combination during a 6-week treatment period. The British journal of dermatology. 2002 Oct; 147(4):816-8. doi: 10.1046/j.1365-2133.2002.49297.x. [PMID: 12366444]
  • P C M Van de Kerkhof, C Green, K J Hamberg, P E Hutchinson, J K Jensen, P Kidson, K Kragballe, F G Larsen, C S Munro, D M Tillman. Safety and efficacy of combined high-dose treatment with calcipotriol ointment and solution in patients with psoriasis. Dermatology (Basel, Switzerland). 2002; 204(3):214-21. doi: 10.1159/000057884. [PMID: 12037450]
  • H G Pálmer, J M González-Sancho, J Espada, M T Berciano, I Puig, J Baulida, M Quintanilla, A Cano, A G de Herreros, M Lafarga, A Muñoz. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. The Journal of cell biology. 2001 Jul; 154(2):369-87. doi: 10.1083/jcb.200102028. [PMID: 11470825]
  • M Stücker, U Memmel, M Hoffmann, J Hartung, P Altmeyer. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology (Basel, Switzerland). 2001; 203(2):141-7. doi: 10.1159/000051729. [PMID: 11586013]
  • T Leivo, U Kiistala, M Vesterinen, K Owaribe, R E Burgeson, I Virtanen, A Oikarinen. Re-epithelialization rate and protein expression in the suction-induced wound model: comparison between intact blisters, open wounds and calcipotriol-pretreated open wounds. The British journal of dermatology. 2000 May; 142(5):991-1002. doi: 10.1046/j.1365-2133.2000.03484.x. [PMID: 10809861]
  • L Barnes, P Altmeyer, L Fôrstrôm, M H Stenström. Long-term treatment of psoriasis with calcipotriol scalp solution and cream. European journal of dermatology : EJD. 2000 Apr; 10(3):199-204. doi: NULL. [PMID: 10725818]
  • P Kullavanijaya, P Gritiyarangsan, P Huiprasert, V Leenutaphong. Treatment of psoriasis vulgaris with topical vitamin D analogue (calcipotriol): open multicenter study. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 1999 Oct; 82(10):974-7. doi: NULL. [PMID: 10561958]
  • K Asadullah, S Prösch, H Audring, I Büttnerova, H D Volk, W Sterry, W D Döcke. A high prevalence of cytomegalovirus antigenaemia in patients with moderate to severe chronic plaque psoriasis: an association with systemic tumour necrosis factor alpha overexpression. The British journal of dermatology. 1999 Jul; 141(1):94-102. doi: 10.1046/j.1365-2133.1999.02926.x. [PMID: 10417521]
  • S B Park, D H Suh, J I Youn. A pilot study to assess the safety and efficacy of topical calcipotriol treatment in childhood psoriasis. Pediatric dermatology. 1999 Jul; 16(4):321-5. doi: 10.1046/j.1525-1470.1999.00084.x. [PMID: 10469423]
  • D Parsad, R Saini, R Nagpal. Calcipotriol in vitiligo: a preliminary study. Pediatric dermatology. 1999 Jul; 16(4):317-20. doi: 10.1046/j.1525-1470.1999.00083.x. [PMID: 10469422]
  • S Georgiou, D Tsambaos. Hypercalcaemia and hypercalciuria after topical treatment of psoriasis with excessive amounts of calcipotriol. Acta dermato-venereologica. 1999 Jan; 79(1):86. doi: 10.1080/000155599750011822. [PMID: 10086871]
  • B B Cunningham, I D Landells, C Langman, D E Sailer, A S Paller. Topical calcipotriene for morphea/linear scleroderma. Journal of the American Academy of Dermatology. 1998 Aug; 39(2 Pt 1):211-5. doi: 10.1016/s0190-9622(98)70077-5. [PMID: 9704831]
  • R Blum, E Schwartzel, S Siskin, W W Epinette. Evaluating the safety of calcipotriene 30 g per day in patients with psoriasis: a parallel group, vehicle-controlled study. Journal of clinical pharmacology. 1998 Apr; 38(4):368-72. doi: 10.1002/j.1552-4604.1998.tb04437.x. [PMID: 9590465]
  • M A de Rie, T A Out, J D Bos. Low-dose narrow-band UVB phototherapy combined with topical therapy is effective in psoriasis and does not inhibit systemic T-cell activation. Dermatology (Basel, Switzerland). 1998; 196(4):412-7. doi: 10.1159/000017934. [PMID: 9669117]
  • J P Dutz, H Lui. A comparative study of calcipotriol and anthralin for chronic plaque psoriasis in a day care treatment center. International journal of dermatology. 1998 Jan; 37(1):51-3. doi: 10.1046/j.1365-4362.1998.00410.x. [PMID: 9522242]
  • J F Bourke, R Mumford, P Whittaker, S J Iqbal, L W Le Van, A Trevellyan, P E Hutchinson. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. Journal of the American Academy of Dermatology. 1997 Dec; 37(6):929-34. doi: 10.1016/s0190-9622(97)70067-7. [PMID: 9418759]
  • J F Bourke, S J Iqbal, P E Hutchinson. The effects of UVB plus calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. Clinical and experimental dermatology. 1997 Nov; 22(6):259-61. doi: NULL. [PMID: 9604449]
  • N K Veien, J R Bjerke, I Rossmann-Ringdahl, H B Jakobsen. Once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol. A double-blind trial. The British journal of dermatology. 1997 Oct; 137(4):581-6. doi: 10.1111/j.1365-2133.1997.tb03790.x. [PMID: 9390335]
  • M Güzey, H F DeLuca. A group of deltanoids (vitamin D analogs) regulate cell growth and proliferation in small cell carcinoma cell lines. Research communications in molecular pathology and pharmacology. 1997 Oct; 98(1):3-18. doi: NULL. [PMID: 9434311]
  • Y S López-Boado, X S Puente, S Alvarez, J Tolivia, L Binderup, C López-Otín. Growth inhibition of human breast cancer cells by 1,25-dihydroxyvitamin D3 is accompanied by induction of apolipoprotein D expression. Cancer research. 1997 Sep; 57(18):4091-7. doi: NULL. [PMID: 9307298]
  • J F Bourke, S J Iqbal, P E Hutchinson. A randomized double-blind comparison of the effects on systemic calcium homeostasis of topical calcitriol (3 micrograms/g) and calcipotriol (50 micrograms/g) in the treatment of chronic plaque psoriasis vulgaris. Acta dermato-venereologica. 1997 May; 77(3):228-30. doi: 10.2340/0001555577228230. [PMID: 9188878]
  • L Molin, T P Cutler, I Helander, B Nyfors, N Downes. Comparative efficacy of calcipotriol (MC903) cream and betamethasone 17-valerate cream in the treatment of chronic plaque psoriasis. A randomized, double-blind, parallel group multicentre study. Calcipotriol Study Group. The British journal of dermatology. 1997 Jan; 136(1):89-93. doi: NULL. [PMID: 9039301]
  • C Hemmingsen, M Staun, E Lewin, P K Nielsen, K Olgaard. Effect of vitamin D metabolites and analogs on renal and intestinal calbindin-D in the rat. Calcified tissue international. 1996 Nov; 59(5):371-6. doi: 10.1007/s002239900142. [PMID: 8849404]
  • C R Darley, W J Cunliffe, C M Green, P E Hutchinson, M R Klaber, N Downes. Safety and efficacy of calcipotriol ointment (Dovonex) in treating children with psoriasis vulgaris. The British journal of dermatology. 1996 Sep; 135(3):390-3. doi: NULL. [PMID: 8949431]
  • T Kitagaki, T Suzuki, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. [A 4-week repeated percutaneous dose toxicity study of calcipotriol (MC903) followed by a 4-week recovery test in rats]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):287-307. doi: 10.2131/jts.21.supplementii_287. [PMID: 8741416]
  • T Imaizumi, M Tsuruta, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. A 4-week repeated percutaneous dose toxicity study of calcipotriol (MC903) followed by a 4-week recovery test in dogs. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):309-23. doi: 10.2131/jts.21.supplementii_309. [PMID: 8741417]
  • T Kitagaki, T Suzuki, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. [A 26-week repeated subcutaneous dose toxicity study of calcipotriol (MC903) followed by a 5-week recovery test in rats]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):325-43. doi: 10.2131/jts.21.supplementii_325. [PMID: 8741418]
  • T Kitagaki, T Suzuki, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. [A 26-week repeated percutaneous dose toxicity study of calcipotriol (MC903) in rats]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):345-63. doi: 10.2131/jts.21.supplementii_345. [PMID: 8741419]
  • T Imaizumi, M Tsuruta, T Kitagaki, M Ono, K Shirakawa, M Nagata, R Konishi. [Single dose toxicity studies of calcipotriol (MC903) in rats and dogs]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):277-85. doi: 10.2131/jts.21.supplementii_277. [PMID: 8741415]
  • T Suzuki, H Uchiyama, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. [Reproductive and developmental toxicity studies of calcipotriol (MC903): (1)--A fertility study in rats by subcutaneous administration]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):389-401. doi: 10.2131/jts.21.supplementii_389. [PMID: 8741421]
  • H Uchiyama, T Suzuki, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. [Reproductive and developmental toxicity studies of calcipotriol (MC903): (3)--A teratogenicity study in rabbits by subcutaneous administration]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):425-38. doi: 10.2131/jts.21.supplementii_425. [PMID: 8741423]
  • T Imaizumi, M Tsuruta, Y Koike, M Ono, K Shirakawa, M Nagata, R Konishi. [A 26-week repeated percutaneous dose toxicity study of calcipotriol (MC903) in dogs]. The Journal of toxicological sciences. 1996 Jul; 21 Suppl 2(?):365-87. doi: 10.2131/jts.21.supplementii_365. [PMID: 8741420]
  • S Cavicchini, A Brezzi, G Gasparini, R Caputo. Skin ultrastructure after calcipotriol treatment: a transmission electron microscopic and freeze-fracture study on psoriatic patients. Acta dermato-venereologica. 1996 May; 76(3):186-9. doi: 10.2340/0001555576186189. [PMID: 8800296]
  • R Lammers, J van Harten. Toxicokinetics of topically applied calcitriol and calcipotriol in rats. The journal of investigative dermatology. Symposium proceedings. 1996 Apr; 1(1):64-7. doi: NULL. [PMID: 9627695]
  • J T Mortensen, J Lichtenberg, L Binderup. Toxicity of 1,25-dihydroxyvitamin D3, tacalcitol, and calcipotriol after topical treatment in rats. The journal of investigative dermatology. Symposium proceedings. 1996 Apr; 1(1):60-3. doi: NULL. [PMID: 9627694]
  • C Guzzo, G Lazarus, B S Goffe, H I Katz, N J Lowe, S H Pincus. Topical calcipotriene has no short-term effect on calcium and bone metabolism of patients with psoriasis. Journal of the American Academy of Dermatology. 1996 Mar; 34(3):429-33. doi: 10.1016/s0190-9622(96)90434-x. [PMID: 8609254]
  • S J Iqbal, P Whittaker, J Bourke, R Mumford, P Huthinson, L W Le Van. Possible interference with calcipotriol on new IDS RIA for 1,25-dihydroxyvitamin D. Clinical chemistry. 1996 Jan; 42(1):112-3. doi: NULL. [PMID: 8565209]
  • K Kragballe, P M Steijlen, H H Ibsen, P C van de Kerkhof, J Esmann, L H Sorensen, M B Axelsen. Efficacy, tolerability, and safety of calcipotriol ointment in disorders of keratinization. Results of a randomized, double-blind, vehicle-controlled, right/left comparative study. Archives of dermatology. 1995 May; 131(5):556-60. doi: NULL. [PMID: 7741542]
  • A Highton, J Quell. Calcipotriene ointment 0.005\% for psoriasis: a safety and efficacy study. Calcipotriene Study Group. Journal of the American Academy of Dermatology. 1995 Jan; 32(1):67-72. doi: 10.1016/0190-9622(95)90186-8. [PMID: 7822519]
  • D Gumowski-Sunek, R Rizzoli, J H Saurat. Oral calcium tolerance test in extensive psoriasis treated with topical calcipotriol. Dermatology (Basel, Switzerland). 1995; 190(1):43-7. doi: 10.1159/000246633. [PMID: 7894096]
  • S N Tham, K C Lun, W K Cheong. A comparative study of calcipotriol ointment and tar in chronic plaque psoriasis. The British journal of dermatology. 1994 Nov; 131(5):673-7. doi: 10.1111/j.1365-2133.1994.tb04981.x. [PMID: 7999599]
  • K E McKenna, D Burrows. Hypercalciuria and topical calcipotriol therapy. The British journal of dermatology. 1994 Oct; 131(4):588-9. doi: 10.1111/j.1365-2133.1994.tb08574.x. [PMID: 7947224]
  • J F Bourke, J Berth-Jones, R Mumford, S J Iqbal, P E Hutchinson. High dose topical calcipotriol consistently reduces serum parathyroid hormone levels. Clinical endocrinology. 1994 Sep; 41(3):295-7. doi: 10.1111/j.1365-2265.1994.tb02548.x. [PMID: 7955435]
  • H C Hoeck, G Laurberg, P Laurberg. Hypercalcaemic crisis after excessive topical use of a vitamin D derivative. Journal of internal medicine. 1994 Mar; 235(3):281-2. doi: 10.1111/j.1365-2796.1994.tb01074.x. [PMID: 8120527]
  • S Masuda, S Strugnell, M J Calverley, H L Makin, R Kremer, G Jones. In vitro metabolism of the anti-psoriatic vitamin D analog, calcipotriol, in two cultured human keratinocyte models. The Journal of biological chemistry. 1994 Feb; 269(7):4794-803. doi: 10.1016/s0021-9258(17)37614-7. [PMID: 8106449]
  • C A Ramsay, J Berth-Jones, G Brundin, W J Cunliffe, L Dubertret, P C van de Kerkhof, T Menne, E Wegmann. Long-term use of topical calcipotriol in chronic plaque psoriasis. Dermatology (Basel, Switzerland). 1994; 189(3):260-4. doi: 10.1159/000246851. [PMID: 7949479]