dicarbine (BioDeep_00000726659)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C13H18N2 (202.1469908)
中文名称: 地卡宾
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC2=C(C=C1)NC3C2CN(CC3)C
InChI: InChI=1S/C13H18N2/c1-9-3-4-12-10(7-9)11-8-15(2)6-5-13(11)14-12/h3-4,7,11,13-14H,5-6,8H2,1-2H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D020011 - Protective Agents > D016587 - Antimutagenic Agents
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D009676 - Noxae > D013723 - Teratogens
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Zubeyir Elmazoglu, Marta Soltesova Prnova, Milan Stefek, Asli F Ceylan, Michael Aschner, Edgar Rangel-López, Abel Santamaria, Cimen Karasu. Protective Effects of Novel Substituted Triazinoindole Inhibitors of Aldose Reductase and Epalrestat in Neuron-like PC12 Cells and BV2 Rodent Microglial Cells Exposed to Toxic Models of Oxidative Stress: Comparison with the Pyridoindole Antioxidant Stobadine.
Neurotoxicity research.
2021 Jun; 39(3):588-597. doi:
10.1007/s12640-021-00349-7
. [PMID: 33713301] - Marina Cindric, Ana Cipak, Emilija Zapletal, Morana Jaganjac, Lidija Milkovic, Georg Waeg, Svorad Stolc, Neven Zarkovic, Sunjic Suzana Borovic. Stobadine attenuates impairment of an intestinal barrier model caused by 4-hydroxynonenal.
Toxicology in vitro : an international journal published in association with BIBRA.
2013 Feb; 27(1):426-32. doi:
10.1016/j.tiv.2012.08.005
. [PMID: 22906568] - Asli F Ceylan-Isik, Nuray Ari, Milan Stefek, Ruzena Sotnikova, Gülgün Ozansoy, Lubica Horakova, Çimen Karasu. Effects of a long-term treatment with an antioxidant pyridoindole on vascular responsiveness in diabetes-induced aging rats.
Current aging science.
2011 Jul; 4(2):150-7. doi:
10.2174/1874609811104020150
. [PMID: 21235493] - Agnieszka Augustyniak, Grzegorz Bartosz, Ana Cipak, Gunars Duburs, L'ubica Horáková, Wojciech Luczaj, Magdalena Majekova, Andreani D Odysseos, Lucia Rackova, Elzbieta Skrzydlewska, Milan Stefek, Miriam Strosová, Gunars Tirzitis, Petras Rimantas Venskutonis, Jana Viskupicova, Panagiota S Vraka, Neven Zarković. Natural and synthetic antioxidants: an updated overview.
Free radical research.
2010 Oct; 44(10):1216-62. doi:
10.3109/10715762.2010.508495
. [PMID: 20836663] - Ahmet Cumaoglu, Milan Stefek, Viktor Bauer, Nuray Ari, Aysel Aricioglu, Cimen Karasu. Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine.
Neuro endocrinology letters.
2010; 31(3):313-8. doi:
NULL
. [PMID: 20588243] - Silvester Ponist, Danica Mihalova, Viera Jancinova, Vladimír Snirc, Olga Ondrejickova, Cinzia Mascia, Giuseppe Poli, Maria Stancikova, Radomir Nosal, Katarína Bauerová. Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl.
Acta biochimica Polonica.
2010; 57(2):223-8. doi:
10.18388/abp.2010_2398
. [PMID: 20548970] - I Juranek, L Horakova, L Rackova, M Stefek. Antioxidants in treating pathologies involving oxidative damage: an update on medicinal chemistry and biological activity of stobadine and related pyridoindoles.
Current medicinal chemistry.
2010; 17(6):552-70. doi:
10.2174/092986710790416317
. [PMID: 20015031] - M Vician, J Olejnik, P Michalka, J Jakubovsky, I Brychta, M Gergel. Warm liver ischemia in experiment and lysosomal markers.
Bratislavske lekarske listy.
2009; 110(10):587-91. doi:
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. [PMID: 20017446] - Peter Voss, Martina Engels, Miriam Strosova, Tilman Grune, Lubica Horakova. Protective effect of antioxidants against sarcoplasmic reticulum (SR) oxidation by Fenton reaction, however without prevention of Ca-pump activity.
Toxicology in vitro : an international journal published in association with BIBRA.
2008 Oct; 22(7):1726-33. doi:
10.1016/j.tiv.2008.07.010
. [PMID: 18692562] - N Vrbjar, S Strelková, V Javorková, J Vlkovicová, L Mézesová, M Stefek, Z Kysel'ová, A Gajdosíková. Effect of the pyridoindole antioxidant stobadine on ATP-utilisation by renal Na,K-ATPase in rats with streptozotocin-induced diabetes.
General physiology and biophysics.
2007 Sep; 26(3):207-13. doi:
NULL
. [PMID: 18063848] - Fatma Yülek, Meral Or, Candan Ozoğul, Asli Ceylan Isik, Nuray Ari, Milan Stefek, Victor Bauer, Cimen Karasu. Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress.
Archives of medical research.
2007 Jul; 38(5):503-11. doi:
10.1016/j.arcmed.2007.02.006
. [PMID: 17560455] - Galip Guz, Billur Demirogullari, Nuray N Ulusu, Cihangir Dogu, Arzu Demirtola, Mustafa Kavutcu, Suna Omeroglu, Milan Stefek, Cimen Karasu. Stobadine protects rat kidney against ischaemia/reperfusion injury.
Clinical and experimental pharmacology & physiology.
2007 Mar; 34(3):210-6. doi:
10.1111/j.1440-1681.2007.04574.x
. [PMID: 17250641] - S Stolc, V Snirc, M Májeková, Z Gáspárová, A Gajdosíková, S Stvrtina. Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress.
Cellular and molecular neurobiology.
2006 Oct; 26(7-8):1495-504. doi:
10.1007/s10571-006-9037-9
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General physiology and biophysics.
2006 Sep; 25(3):289-302. doi:
NULL
. [PMID: 17197727] - Peter Voss, Lubica Horakova, Manuela Jakstadt, Daniela Kiekebusch, Tilman Grune. Ferritin oxidation and proteasomal degradation: protection by antioxidants.
Free radical research.
2006 Jul; 40(7):673-83. doi:
10.1080/10715760500419357
. [PMID: 16983994] - Lenka Bartosíková, Jirí Necas, Ludĕk Benes, Eva Janostíková, Tomás Bartosík, Jarmila Klusáková, Tomás Florian, Marek Frydrych, Jan Jurica. Influence of antioxidant effect of stobadine derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in therapy).
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2005 Dec; 149(2):377-80. doi:
NULL
. [PMID: 16601792] - Jirí Necas, Lenka Bartosíková, Ludĕk Benes, Eva Janostíková, Tomás Bartosík, Jarmila Klusáková, Tomás Florian, Marek Frydrych, Jan Jurica. Influence of antioxidant effect of stobadine derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in prophylaxis).
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2005 Dec; 149(2):385-8. doi:
NULL
. [PMID: 16601794] - Zuzana Kyselova, Andrej Gajdosik, Alena Gajdosikova, Olga Ulicna, Danica Mihalova, Cimen Karasu, Milan Stefek. Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT.
Molecular vision.
2005 Jan; 11(?):56-65. doi:
NULL
. [PMID: 15682043] - Miriam Strosová, Mária Skuciová, L'ubica Horáková. Oxidative damage to Ca2+-ATPase sarcoplasmic reticulum by HOCl and protective effect of some antioxidants.
BioFactors (Oxford, England).
2005; 24(1-4):111-6. doi:
10.1002/biof.5520240113
. [PMID: 16403970] - Lubica Horáková, Miriam Strosová, Mária Skuciová. Antioxidants prevented oxidative injury of SR induced by Fe2+/H2O2/ascorbate system but failed to prevent Ca2+-ATPase activity decrease.
BioFactors (Oxford, England).
2005; 24(1-4):105-9. doi:
10.1002/biof.5520240112
. [PMID: 16403969] - N Vrbjar, S Strelková, M Stefek, Z Kyselová, A Gajdosíková. Effect of the pyridoindole antioxidant stobadine on sodium handling of renal Na,K-ATPase in rats with streptozotocin-induced diabetes.
Acta diabetologica.
2004 Dec; 41(4):172-8. doi:
10.1007/s00592-004-0162-y
. [PMID: 15660200] - Lucia Racková, Magdaléna Májeková, Daniela Kost'álová, Milan Stefek. Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects.
Bioorganic & medicinal chemistry.
2004 Sep; 12(17):4709-15. doi:
10.1016/j.bmc.2004.06.035
. [PMID: 15358297] - J Gallová, S Szalayová. The effect of stobadine on the copper-induced peroxidation of egg yolk phosphatidylcholine in multilamellar liposomes.
General physiology and biophysics.
2004 Sep; 23(3):297-306. doi:
"
. [PMID: 15638117] - J Navarová, E Ujházy, J Líska, M Dubovický. Determination of selective biochemical variables in pregnant and lactating mice after stobadine administration.
Methods and findings in experimental and clinical pharmacology.
2003 Nov; 25(9):717-21. doi:
NULL
. [PMID: 14685299] - Nuray N Ulusu, Meral Sahilli, Aslihan Avci, Orhan Canbolat, Gülgün Ozansoy, Nuray Ari, Musa Bali, Milan Stefek, Svorad Stolc, Andrej Gajdosik, Cimen Karasu. Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E.
Neurochemical research.
2003 Jun; 28(6):815-23. doi:
10.1023/a:1023202805255
. [PMID: 12718433] - Z Kyselova, L Rackova, M Stefek. Pyridoindole antioxidant stobadine protected bovine serum albumin against the hydroxyl radical mediated cross-linking in vitro.
Archives of gerontology and geriatrics.
2003 May; 36(3):221-9. doi:
10.1016/s0167-4943(02)00167-x
. [PMID: 12849078] - Lubica Horáková, Anke Licht, Grit Sandig, Manuela Jakstadt, Zdena Duracková, Tilman Grune. Standardized extracts of flavonoids increase the viability of PC12 cells treated with hydrogen peroxide: effects on oxidative injury.
Archives of toxicology.
2003 Jan; 77(1):22-9. doi:
10.1007/s00204-002-0409-8
. [PMID: 12491037] - M Stefek, A Gajdosik, N Tribulova, J Navarova, K Volkovova, P Weismann, A Gajdosikova, J Drimal, D Mihalova. The pyridoindole antioxidant stobadine attenuates albuminuria, enzymuria, kidney lipid peroxidation and matrix collagen cross-linking in streptozotocin-induced diabetic rats.
Methods and findings in experimental and clinical pharmacology.
2002 Nov; 24(9):565-71. doi:
NULL
. [PMID: 12616702] - Bilgehan Pekiner, Nuray N Ulusu, Net Das-Evcimen, Meral Sahilli, Fugen Aktan, Milan Stefek, Svorad Stolc, Cimen Karasu. In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+ -ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E.
Biochimica et biophysica acta.
2002 Oct; 1588(1):71-8. doi:
10.1016/s0925-4439(02)00141-2
. [PMID: 12379316] - Milan Stefek, Narcis Tribulova, Andrej Gajdosik, Alena Gajdosikova. The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of streptozotocin-induced diabetic rats.
Acta histochemica.
2002; 104(4):413-7. doi:
10.1078/0065-1281-00681
. [PMID: 12553712] - L Horáková, O Ondrejicková, K Bachratá, M Vajdová. Preventive effect of several antioxidants after oxidative stress on rat brain homogenates.
General physiology and biophysics.
2000 Jun; 19(2):195-205. doi:
"
. [PMID: 11156442] - P Kaplán, M Doval, Z Majerová, J Lehotský, P Racay. Iron-induced lipid peroxidation and protein modification in endoplasmic reticulum membranes. Protection by stobadine.
The international journal of biochemistry & cell biology.
2000 May; 32(5):539-47. doi:
10.1016/s1357-2725(99)00147-8
. [PMID: 10736569] - M Stefek, R Sotnikova, L Okruhlicova, K Volkovova, J Kucharska, A Gajdosik, A Gajdosikova, D Mihalova, R Hozova, N Tribulova, A Gvozdjakova. Effect of dietary supplementation with the pyridoindole antioxidant stobadine on antioxidant state and ultrastructure of diabetic rat myocardium.
Acta diabetologica.
2000; 37(3):111-7. doi:
10.1007/s005920070012
. [PMID: 11277310] - K Bauerová, P Bohov, M Durisová, S Bezek. Bioavailability and pharmacokinetic studies in the development of an oral formulation of stobadine dipalmitate.
Methods and findings in experimental and clinical pharmacology.
1999 Sep; 21(7):499-503. doi:
NULL
. [PMID: 10544395] - K Bauerová. Overview of stobadine bioanalysis: evaluation and application in pharmacokinetics.
European journal of drug metabolism and pharmacokinetics.
1999 Jul; 24(3):237-42. doi:
10.1007/bf03190026
. [PMID: 10716062] - K Drábiková, J Pecivová, T Macicková, K Kotuliaková, R Nosál, E Danihelová. Effect of stobadine on human stimulated polymorphonuclear leukocytes.
Methods and findings in experimental and clinical pharmacology.
1999 Mar; 21(2):75-8. doi:
10.1358/mf.1999.21.2.529232
. [PMID: 10327386] - J Navarová, T Macicková, K Horáková, M Urbancíková. Stobadine inhibits lysosomal enzyme release in vivo and in vitro.
Life sciences.
1999; 65(18-19):1905-7. doi:
10.1016/s0024-3205(99)00445-2
. [PMID: 10576435] - O Ondrejicková, L Horáková, I Juránek, A Ziegelhoeffer, S Stolc. Effect of stobadine on lipid peroxidation in brain and heart after ischemia and reperfusion of the brain.
Life sciences.
1999; 65(18-19):1959-61. doi:
10.1016/s0024-3205(99)00455-5
. [PMID: 10576445] - V Bauer, R Sotníková, J Machová, S Mátyás, V Pucovský, M Stefek. Reactive oxygen species induced smooth muscle responses in the intestine, vessels and airways and the effect of antioxidants.
Life sciences.
1999; 65(18-19):1909-17. doi:
10.1016/s0024-3205(99)00446-4
. [PMID: 10576436] - V Knezl, R Sotníková, L Okruhlicová, J Navarová. Effect of stobadine on cardiac injury induced by ischemia and reperfusion.
Life sciences.
1999; 65(18-19):1931-3. doi:
10.1016/s0024-3205(99)00450-6
. [PMID: 10576440] - E Ujházy, M Dubovický, L Soltés, V Faberová, M Zemánek, A Gajdosík. Placental transfer of stobadine in rabbits.
Life sciences.
1999; 65(18-19):2011-4. doi:
10.1016/s0024-3205(99)00467-1
. [PMID: 10576457] - M Stefek, L Krizanova, Z Trnkova. Oxidative modification of serum albumin in an experimental glycation model of diabetes mellitus in vitro: effect of the pyridoindole antioxidant stobadine.
Life sciences.
1999; 65(18-19):1995-7. doi:
10.1016/s0024-3205(99)00463-4
. [PMID: 10576453] - J Guzy, E Barnová, L Benes. Stobadine and heart mitochondria.
Life sciences.
1999; 65(18-19):1935-7. doi:
10.1016/s0024-3205(99)00451-8
. [PMID: 10576441] - J Lehotský, P Kaplán, P Racay, M Matejovicová, A Drgová, V Mézesová. Membrane ion transport systems during oxidative stress in rodent brain: protective effect of stobadine and other antioxidants.
Life sciences.
1999; 65(18-19):1951-8. doi:
10.1016/s0024-3205(99)00454-3
. [PMID: 10576444] - R Sotníková, L Okruhlicová, P Noskovic. Endothelial protective effect of stobadine on ischaemia/reperfusion-induced injury.
General physiology and biophysics.
1998 Sep; 17(3):253-64. doi:
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. [PMID: 9834846] - L Horáková, S Stolc. Antioxidant and pharmacodynamic effects of pyridoindole stobadine.
General pharmacology.
1998 May; 30(5):627-38. doi:
10.1016/s0306-3623(97)00300-5
. [PMID: 9559311] - J Mojzis, A Nicák, J Guzy, I Kron, L Mirossay. Effect of stobadine on carbon tetrachloride-induced erythrocyte membrane changes in rats.
Free radical biology & medicine.
1998 May; 24(7-8):1347-51. doi:
10.1016/s0891-5849(97)00462-0
. [PMID: 9626593] - E Horváthová, S Bonatti, A Abbondandolo, D Slamenová. Induction of kinetochore positive and negative micronuclei in V79 cells by N-methyl-N'-nitro-N-nitrosoguanidine: the protective effect of the pyridoindole antioxidant stobadine.
Mutation research.
1997 Dec; 395(2-3):243-7. doi:
10.1016/s1383-5718(97)00156-3
. [PMID: 9465936] - P Kaplán, M Matejovicová, V Mézesová. Iron-induced inhibition of Na+, K(+)-ATPase and Na+/Ca2+ exchanger in synaptosomes: protection by the pyridoindole stobadine.
Neurochemical research.
1997 Dec; 22(12):1523-9. doi:
10.1023/a:1021918931780
. [PMID: 9357020] - P Racay, P Kaplán, V Mézesová, J Lehotský. Lipid peroxidation both inhibits Ca(2+)-ATPase and increases Ca2+ permeability of endoplasmic reticulum membrane.
Biochemistry and molecular biology international.
1997 Apr; 41(4):647-55. doi:
10.1080/15216549700201691
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Neuropharmacology.
1997 Feb; 36(2):177-84. doi:
10.1016/s0028-3908(96)00165-7
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Brain research bulletin.
1997; 42(5):335-40. doi:
10.1016/s0361-9230(96)00294-8
. [PMID: 9092873] - L Horakova, A Giessauf, G Raber, H Esterbauer. Effect of stobadine on Cu(++)-mediated oxidation of low-density lipoprotein.
Biochemical pharmacology.
1996 May; 51(10):1277-82. doi:
10.1016/0006-2952(96)00033-0
. [PMID: 8787542] - M Stefek, I Drozdikova, K Vajdova. The pyridoindole antioxidant stobadine inhibited glycation-induced absorbance and fluorescence changes in albumin.
Acta diabetologica.
1996 Mar; 33(1):35-40. doi:
10.1007/bf00571938
. [PMID: 8777283] - M Stefek, Z Trnkova. The pyridoindole antioxidant stobadine prevents alloxan-induced lipid peroxidation by inhibiting its propagation.
Pharmacology & toxicology.
1996 Feb; 78(2):77-81. doi:
10.1111/j.1600-0773.1996.tb00183.x
. [PMID: 8822038] - P Racay, P Kaplán, J Lehotský, V Mézesová. Rabbit brain endoplasmic reticulum membranes as target for free radicals. Changes in Ca(2+)-transport and protection by stobadine.
Biochemistry and molecular biology international.
1995 Jul; 36(3):569-77. doi:
"
. [PMID: 7549956] - P Kaplán, P Racay, J Lehotský, V Mézesová. Change in fluidity of brain endoplasmic reticulum membranes by oxygen free radicals: a protective effect of stobadine, alpha-tocopherol acetate, and butylated hydroxytoluene.
Neurochemical research.
1995 Jul; 20(7):815-20. doi:
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Ceskoslovenska fysiologie.
1995 Mar; 44(1):15-7. doi:
NULL
. [PMID: 7758141] - E Ujházy, J Navarová, J Líska, T Balonová, T Vargová. Determination of selective biochemical parameters in pregnant and lactating rats after stobadine administration.
Methods and findings in experimental and clinical pharmacology.
1994 Oct; 16(8):569-73. doi:
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Methods in enzymology.
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Biochimica et biophysica acta.
1993 Nov; 1153(1):67-76. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1993 Sep; 23(9):983-93. doi:
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Neuropharmacology.
1993 Mar; 32(3):235-41. doi:
10.1016/0028-3908(93)90106-d
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Bratislavske lekarske listy.
1993 Feb; 94(2):66-70. doi:
NULL
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Biochemical pharmacology.
1993 Jan; 45(2):393-400. doi:
10.1016/0006-2952(93)90075-8
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Proceedings of the Western Pharmacology Society.
1993; 36(?):209-14. doi:
"
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Experientia.
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