Almitrine mesylate (BioDeep_00000726483)
代谢物信息卡片
Almitrine dimesylate
化学式: C28H37F2N7O6S2 (669.2214686)
中文名称: 甲磺酸阿米三嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)O.CS(=O)(=O)O.C=CCNC1=NC(=NC(=N1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)NCC=C
InChI: 2*1H3,(H,2,3,4)
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D019141 - Respiratory System Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:53779
- KEGGdrug: D02822
- PubChem: 6918543
- ChEMBL: CHEMBL3181957
- MeSH: Almitrine
- CAS: 29608-49-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Didier Payen. Coronavirus Disease 2019 Acute Respiratory Failure: Almitrine Drug Resuscitation or Resuscitating Patients by Almitrine?.
Critical care medicine.
2021 02; 49(2):387-389. doi:
10.1097/ccm.0000000000004765. [PMID: 33186137] - Morgan Caplan, Julien Goutay, Anne Bignon, Emmanuelle Jaillette, Raphael Favory, Daniel Mathieu, Erika Parmentier-Decrucq, Julien Poissy, Thibault Duburcq. Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study.
Critical care medicine.
2021 02; 49(2):e191-e198. doi:
10.1097/ccm.0000000000004711. [PMID: 33093279] - Romain Barthélémy, Pierre-Louis Blot, Ambre Tiepolo, Arthur Le Gall, Claire Mayeur, Samuel Gaugain, Louis Morisson, Etienne Gayat, Alexandre Mebazaa, Benjamin Glenn Chousterman. Efficacy of Almitrine in the Treatment of Hypoxemia in Sars-Cov-2 Acute Respiratory Distress Syndrome.
Chest.
2020 11; 158(5):2003-2006. doi:
10.1016/j.chest.2020.05.573. [PMID: 32512007] - Michael Cardinale, Pierre Esnault, Jean Cotte, Pierre J Cungi, Philippe Goutorbe. Effect of almitrine bismesylate and inhaled nitric oxide on oxygenation in COVID-19 acute respiratory distress syndrome.
Anaesthesia, critical care & pain medicine.
2020 08; 39(4):471-472. doi:
10.1016/j.accpm.2020.05.014. [PMID: 32505755] - Karim Bendjelid, Raphael Giraud, Stephan Von Düring. Treating hypoxemic COVID-19 'ARDS' patients with almitrine: The earlier the better?.
Anaesthesia, critical care & pain medicine.
2020 08; 39(4):451-452. doi:
10.1016/j.accpm.2020.07.003. [PMID: 32653550] - Marie-Reine Losser, Coline Lapoix, Matthieu Delannoy, Benoît Champigneulle, Didier Payen. Almitrine as a non-ventilatory strategy to improve intrapulmonary shunt in COVID-19 patients.
Anaesthesia, critical care & pain medicine.
2020 08; 39(4):467-469. doi:
10.1016/j.accpm.2020.05.013. [PMID: 32505756] - Karim Bendjelid, Giraud Raphaël. Treating hypoxemic patients with SARS-COV-2 pneumonia: Back to applied physiology.
Anaesthesia, critical care & pain medicine.
2020 06; 39(3):389-390. doi:
10.1016/j.accpm.2020.04.003. [PMID: 32305591] - Wen-jie Xu, Zong-heng Li, Yong-mei Shi, Yi-huai Zou. [Clinical research of effect of Yishen Yangnao capsule on vascular dementia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Apr; 32(8):732-5. doi:
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British journal of anaesthesia.
2005 Sep; 95(3):410-6. doi:
10.1093/bja/aei194. [PMID: 16024585] - L Gallart, Q Lu, L Puybasset, G S Umamaheswara Rao, P Coriat, J J Rouby. Intravenous almitrine combined with inhaled nitric oxide for acute respiratory distress syndrome. The NO Almitrine Study Group.
American journal of respiratory and critical care medicine.
1998 Dec; 158(6):1770-7. doi:
10.1164/ajrccm.158.6.9804066. [PMID: 9847266] - A B'chir, A Mebazaa, M R Losser, M Romieu, D Payen. Intravenous almitrine bismesylate reversibly induces lactic acidosis and hepatic dysfunction in patients with acute lung injury.
Anesthesiology.
1998 Oct; 89(4):823-30. doi:
10.1097/00000542-199810000-00005. [PMID: 9777998] - C Ledderhos, V Gross, A W Cowley. Pharmacological stimulation of arterial chemoreceptors in conscious rats produces differential responses in renal cortical and medullary blood flow.
Clinical and experimental pharmacology & physiology.
1998 Jul; 25(7-8):536-40. doi:
10.1111/j.1440-1681.1998.tb02247.x. [PMID: 9673424] - D Nowak, A Wywiol, H Magnussen. [Almitrine in therapy of chronic obstructive respiratory tract diseases with hypoxemia--a clinical multicenter study comparing 2 dosages].
Pneumologie (Stuttgart, Germany).
1998 Mar; 52(3):121-7. doi:
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Pflugers Archiv : European journal of physiology.
1997 May; 434(1):97-103. doi:
10.1007/s004240050368. [PMID: 9094261] - H Brauer, A Gens, C Ledderhos, R Sanchez, R Schuster, W Quies, A Honig. Cardiorespiratory and renal responses to arterial chemoreceptor stimulation by hypoxia or almitrine in men.
Clinical and experimental pharmacology & physiology.
1996 Dec; 23(12):1021-7. doi:
10.1111/j.1440-1681.1996.tb01162.x. [PMID: 8977153] - C Ledderhos, H Brauer, A Gens, R Sanchez, W Quies, R Schuster, A Honig. Cardiorespiratory and renal responses to arterial chemoreceptor stimulation in early hypertension.
International journal of clinical pharmacology and therapeutics.
1996 Nov; 34(11):470-6. doi:
NULL. [PMID: 8937928] - A Honig, B Wedler, H Oppermann, S Gruska, M Schmidt. Effect of arterial chemoreceptor stimulation with almitrine bismesylate on plasma renin activity, aldosterone, ACTH and cortisol in anaesthetized, artificially ventilated cats.
Clinical and experimental pharmacology & physiology.
1996 Feb; 23(2):106-10. doi:
10.1111/j.1440-1681.1996.tb02580.x. [PMID: 8819637] - H Moukadiri, L Gouzi, S Detolle-Sarbach, D Guez, J Plouët. Inhibition of basic fibroblast growth factor and vasculotropin biological activities on cultured cells by almitrine.
Biochimica et biophysica acta.
1995 Mar; 1265(2-3):168-72. doi:
10.1016/0167-4889(94)00215-z. [PMID: 7696345] - B R Winkelmann, T H Kullmer, D G Kneissl, D Trenk, H Kronenberger. Low-dose almitrine bismesylate in the treatment of hypoxemia due to chronic obstructive pulmonary disease.
Chest.
1994 May; 105(5):1383-91. doi:
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Neurochemical research.
1994 Apr; 19(4):517-24. doi:
10.1007/bf00967332. [PMID: 8065506] - D M Payen, C Gatecel, P Plaisance. Almitrine effect on nitric oxide inhalation in adult respiratory distress syndrome.
Lancet (London, England).
1993 Jun; 341(8861):1664. doi:
10.1016/0140-6736(93)90801-m. [PMID: 8100027] - G Benzi, A Gorini, B Ghigini, R Arnaboldi, R F Villa. Synaptosomal non-mitochondrial ATPase activities and drug treatment.
Neurochemical research.
1993 Jun; 18(6):719-26. doi:
10.1007/bf00966787. [PMID: 8099718] - M Jumelle-Laclau, M Rigoulet, N Averet, X Leverve, L Dubourg, A Carbonneau, M Clerc, B Guerin. Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.
Biochimica et biophysica acta.
1993 Feb; 1141(1):90-4. doi:
10.1016/0005-2728(93)90193-j. [PMID: 8435438] - R Behm, U Franz, W H de Muinck Keizer, H Mewes, R Rettig, T Unger. Effects of chemoreceptor stimulation by almitrine bismesylate on renal function in conscious rats.
Advances in experimental medicine and biology.
1993; 337(?):315-21. doi:
10.1007/978-1-4615-2966-8_44. [PMID: 8109416] - C Ledderhos, W Quies, A Bub, R Sanchez. Normotensive normoxic men undergoing water diuresis fail to respond to stimulation of their peripheral arterial chemoreceptors by almitrine with an increase in plasma concentrations of atrial natriuretic factor.
European journal of applied physiology and occupational physiology.
1992; 65(2):104-9. doi:
10.1007/bf00705065. [PMID: 1396631] - P A Bardsley, J Tweney, N Morgan, P Howard. Oral almitrine in treatment of acute respiratory failure and cor pulmonale in patients with an exacerbation of chronic obstructive airways disease.
Thorax.
1991 Jul; 46(7):493-8. doi:
10.1136/thx.46.7.493. [PMID: 1908604] - A Wilke, W Siegmund, T Schneider, M Wiersbitzky, G Franke. Pharmacokinetics of almitrine in healthy volunteers and patients with essential hypertension.
Biomedica biochimica acta.
1991; 50(2):183-7. doi:
NULL. [PMID: 1877979] - P A Bardsley, B F Johnson, A G Stewart, G R Barer. Natriuresis secondary to carotid chemoreceptor stimulation with almitrine bismesylate in the rat: the effect on kidney function and the response to renal denervation and deficiency of antidiuretic hormone.
Biomedica biochimica acta.
1991; 50(2):175-82. doi:
NULL. [PMID: 1877978] - A Herchuelz, D Gangji, F Derenne, J P Jeanniot, J Douchamps. Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine.
British journal of clinical pharmacology.
1991 Jan; 31(1):73-6. doi:
10.1111/j.1365-2125.1991.tb03859.x. [PMID: 2015173] - C Rubio Terrés, M López Alvarez, E Vargas Castrillón. [Almitrine: a peripheral respiratory stimulant in chronic obstructive pulmonary disease].
Revista clinica espanola.
1990 Feb; 186(2):84-7. doi:
NULL. [PMID: 2158666] - T W Evans, J Tweney, J C Waterhouse, J Nichol, A J Suggett, P Howard. Almitrine bismesylate and oxygen therapy in hypoxic cor pulmonale.
Thorax.
1990 Jan; 45(1):16-21. doi:
10.1136/thx.45.1.16. [PMID: 2108510] - J H Gaudy, J F Sicard, O Gateau, R Farinotti. [Respiratory effects of almitrine on various levels of the fraction of inspired oxygen. A study in the anesthetized dog].
Annales francaises d'anesthesie et de reanimation.
1990; 9(1):26-30. doi:
10.1016/s0750-7658(05)80033-4. [PMID: 2109957] - I Bakran, B Vrhovac, B Stangl, D Tabori, A Ivicevic, V Todic, F Kandare. Double-blind placebo controlled clinical trial of almitrine bismesylate in patients with chronic respiratory insufficiency.
European journal of clinical pharmacology.
1990; 38(3):249-53. doi:
10.1007/bf00315025. [PMID: 2187700] - M Wiersbitzky, R Landgraf, S Gruska, H Oppermann, R Schuster, F Balke, B Wedler, A Honig. Hormonal and renal responses to arterial chemoreceptor stimulation by almitrine in healthy and normotensive men.
Biomedica biochimica acta.
1990; 49(11):1155-63. doi:
NULL. [PMID: 2094221] - M Schmidt, B Kretschmann, R Schuster, A Honig. Influence of sorbitol and mannitol on the reactions of kidney excretory function evoked by arterial chemoreceptor stimulation with almitrine in anaesthetized and artificially ventilated cats.
Biomedica biochimica acta.
1990; 49(10):1067-80. doi:
NULL. [PMID: 2127882] - S Watanabe, R E Kanner, A G Cutillo, R L Menlove, R T Bachand, M B Szalkowski, A D Renzetti. Long-term effect of almitrine bismesylate in patients with hypoxemic chronic obstructive pulmonary disease.
The American review of respiratory disease.
1989 Nov; 140(5):1269-73. doi:
10.1164/ajrccm/140.5.1269. [PMID: 2683905] - D S McQueen, Y Evrard, B H Gordon, D B Campbell. Ganglioglomerular nerves influence responsiveness of cat carotid body chemoreceptors to almitrine.
Journal of the autonomic nervous system.
1989 Jun; 27(1):57-66. doi:
10.1016/0165-1838(89)90129-x. [PMID: 2529305] - S Stavchansky, J T Doluisio, C M Macleod, M B Szalkowski, R T Bachand, R Heilman, T B Sebree, R S Geary. Single oral dose proportionality pharmacokinetics of almitrine bismesylate in humans.
Biopharmaceutics & drug disposition.
1989 May; 10(3):229-37. doi:
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Biopharmaceutics & drug disposition.
1989 May; 10(3):239-46. doi:
10.1002/bdd.2510100303. [PMID: 2566338] - S Stavchansky, J T Doluisio, C M Macleod, M B Szalkowski, R T Bachand, R Heilman, T B Sebree, R S Geary. One year administration of almitrine bismesylate (Vectarion) to chronic obstructive pulmonary disease patients: pharmacokinetic analysis.
Biopharmaceutics & drug disposition.
1989 May; 10(3):247-55. doi:
10.1002/bdd.2510100304. [PMID: 2566339] - L Belec, D Larrey, H De Cremoux, M Tinel, F Louarn, D Pessayre, R Gherardi. Extensive oxidative metabolism of dextromethorphan in patients with almitrine neuropathy.
British journal of clinical pharmacology.
1989 Mar; 27(3):387-90. doi:
10.1111/j.1365-2125.1989.tb05382.x. [PMID: 2719897] - T Bury, J P Jeannot, J C Ansquer, M Radermecker. Dose-response and pharmacokinetic study with almitrine bismesylate after single oral administrations in COPD patients.
The European respiratory journal.
1989 Jan; 2(1):49-55. doi:
NULL. [PMID: 2495983] - C Le Merre, J C Ansquer, M J Clark, N Zouari, C Préfaut. Is the mode of action of almitrine bismesylate dose dependent?.
Respiration; international review of thoracic diseases.
1989; 56(3-4):212-9. doi:
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European journal of clinical pharmacology.
1989; 37(5):487-91. doi:
10.1007/bf00558129. [PMID: 2598987] - E A Koller, M Schopen, M Keller, R E Lang, M B Vallotton. Ventilatory, circulatory, endocrine, and renal effects of almitrine infusion in man: a contribution to high altitude physiology.
European journal of applied physiology and occupational physiology.
1989; 58(4):419-25. doi:
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Pharmacology.
1989; 38(6):381-7. doi:
10.1159/000138561. [PMID: 2573079] - W Luijten, G Damien, B Marchand, J Capart. Analysis of almitrine and its metabolites in plasma using on-line fast atom bombardment liquid chromatography/mass spectrometry.
Biomedical & environmental mass spectrometry.
1988 Oct; 16(1-12):93-7. doi:
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Anesthesiology.
1987 Oct; 67(4):534-42. doi:
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Zeitschrift fur Erkrankungen der Atmungsorgane.
1987; 168(3):197-215. doi:
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Biomedica biochimica acta.
1987; 46(12):979-82. doi:
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Biomedica biochimica acta.
1987; 46(12):1055-9. doi:
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Biomedica biochimica acta.
1987; 46(12):1043-9. doi:
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Biomedica biochimica acta.
1987; 46(12):1027-33. doi:
NULL. [PMID: 3453064] - J F Magny, N Bromet, M Bonmarchand, M Dehan. Study of the pharmacokinetics and pharmacodynamic activity of almitrine bismesylate in infants during the recovery phase following bronchopulmonary dysplasia.
Developmental pharmacology and therapeutics.
1987; 10(5):369-76. doi:
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Biomedica biochimica acta.
1987; 46(12):1035-42. doi:
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Biomedica biochimica acta.
1987; 46(12):1023-6. doi:
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The American review of respiratory disease.
1986 Nov; 134(5):917-9. doi:
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The American review of respiratory disease.
1986 Sep; 134(3):559-65. doi:
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Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris.
1986; 103(3):185-8. doi:
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Revue des maladies respiratoires.
1985; 2 Suppl 1(?):S39-44. doi:
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Biomedica biochimica acta.
1985; 44(11-12):1659-72. doi:
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Pediatrics.
1984 Dec; 74(6):1034-40. doi:
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Presse medicale (Paris, France : 1983).
1984 Oct; 13(34):2071-7. doi:
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Bulletin europeen de physiopathologie respiratoire.
1984 Jan; 20(1):37-42. doi:
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Journal of chromatography.
1983 Nov; 278(1):209-15. doi:
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Thorax.
1983 Mar; 38(3):200-4. doi:
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European journal of respiratory diseases. Supplement.
1983; 126(?):363-75. doi:
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European journal of respiratory diseases. Supplement.
1983; 126(?):275-89. doi:
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European journal of respiratory diseases. Supplement.
1983; 126(?):249-54. doi:
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European journal of respiratory diseases. Supplement.
1983; 126(?):357-61. doi:
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European journal of respiratory diseases. Supplement.
1983; 126(?):349-56. doi:
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Pharmacological research communications.
1982 Nov; 14(10):959-65. doi:
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Journal of chromatography.
1981 Apr; 223(1):219-24. doi:
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