2-C-Methylcytidine (BioDeep_00000725969)

   


代谢物信息卡片


2-C-Methylcytidine

化学式: C10H15N3O5 (257.101166)
中文名称: 2-C-甲基胞嘧啶核苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C(C(OC1N2C=CC(=NC2=O)N)CO)O)O
InChI: InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1

描述信息

NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM[1][2].

同义名列表

4 个代谢物同义名

2-C-Methylcytidine; 2'-C-Methylcytidine; NM-107; NM107



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Nicole Lenz, Olivier Engler, Denis Grandgirard, Stephen L Leib, Rahel Ackermann-Gäumann. Evaluation of antivirals against tick-borne encephalitis virus in organotypic brain slices of rat cerebellum. PloS one. 2018; 13(10):e0205294. doi: 10.1371/journal.pone.0205294. [PMID: 30300398]
  • Joana Rocha-Pereira, Jana Van Dycke, Johan Neyts. Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants. Antimicrobial agents and chemotherapy. 2015 Dec; 60(3):1907-11. doi: 10.1128/aac.02198-15. [PMID: 26711754]
  • Luděk Eyer, James J Valdés, Victor A Gil, Radim Nencka, Hubert Hřebabecký, Michal Šála, Jiří Salát, Jiří Černý, Martin Palus, Erik De Clercq, Daniel Růžek. Nucleoside inhibitors of tick-borne encephalitis virus. Antimicrobial agents and chemotherapy. 2015 Sep; 59(9):5483-93. doi: 10.1128/aac.00807-15. [PMID: 26124166]
  • Ana-Maria Osiceanu, Lyre Espada Murao, Denny Kollanur, Jan Swinnen, Annebel R De Vleeschauwer, David J Lefebvre, Kris De Clercq, Johan Neyts, Nesya Goris. In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks. Antiviral research. 2014 May; 105(?):59-63. doi: 10.1016/j.antiviral.2014.02.009. [PMID: 24583031]
  • Joana Rocha-Pereira, Dirk Jochmans, Yannick Debing, Erik Verbeken, Maria S J Nascimento, Johan Neyts. The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model. Journal of virology. 2013 Nov; 87(21):11798-805. doi: 10.1128/jvi.02064-13. [PMID: 23986582]
  • S-F Wu, C-K Lin, Y-S Chuang, F-R Chang, C-K Tseng, Y-C Wu, J-C Lee. Anti-hepatitis C virus activity of 3-hydroxy caruilignan C from Swietenia macrophylla stems. Journal of viral hepatitis. 2012 May; 19(5):364-70. doi: 10.1111/j.1365-2893.2011.01558.x. [PMID: 22497816]
  • Jin-Ching Lee, Wei-Chun Chen, Shou-Fang Wu, Chin-Kai Tseng, Ching-Yi Chiou, Fang-Rong Chang, Shih-hsien Hsu, Yang-Chang Wu. Anti-hepatitis C virus activity of Acacia confusa extract via suppressing cyclooxygenase-2. Antiviral research. 2011 Jan; 89(1):35-42. doi: 10.1016/j.antiviral.2010.11.003. [PMID: 21075144]
  • Lotte Coelmont, Suzanne Kaptein, Jan Paeshuyse, Inge Vliegen, Jean-Maurice Dumont, Grégoire Vuagniaux, Johan Neyts. Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. Antimicrobial agents and chemotherapy. 2009 Mar; 53(3):967-76. doi: 10.1128/aac.00939-08. [PMID: 19104013]
  • Koleen J Herlihy, Joanne P Graham, Robert Kumpf, Amy K Patick, Rohit Duggal, Stephanie T Shi. Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors. Antimicrobial agents and chemotherapy. 2008 Oct; 52(10):3523-31. doi: 10.1128/aac.00533-08. [PMID: 18694956]
  • Klaus Klumpp, Genadiy Kalayanov, Han Ma, Sophie Le Pogam, Vincent Leveque, Wen-Rong Jiang, Nicole Inocencio, Anniek De Witte, Sonal Rajyaguru, Ezra Tai, Sushmita Chanda, Michael R Irwin, Christian Sund, Anna Winqist, Tatiana Maltseva, Staffan Eriksson, Elena Usova, Mark Smith, Andre Alker, Isabel Najera, Nick Cammack, Joseph A Martin, Nils Gunnar Johansson, David B Smith. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. The Journal of biological chemistry. 2008 Jan; 283(4):2167-75. doi: 10.1074/jbc.m708929200. [PMID: 18003608]
  • Brent E Korba, Abigail B Montero, Kristine Farrar, Karen Gaye, Sampa Mukerjee, Marc S Ayers, Jean-François Rossignol. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral research. 2008 Jan; 77(1):56-63. doi: 10.1016/j.antiviral.2007.08.005. [PMID: 17888524]