Ivabradine (BioDeep_00000724535)
代谢物信息卡片
Ivabradine
化学式: C27H36N2O5 (468.2624086)
中文名称: 伊伐雷定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC
InChI: InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C - Cardiovascular system > C01 - Cardiac therapy
D002317 - Cardiovascular Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:85966
- KEGGdrug: D07165
- PubChem: 132999
- DrugBank: DB09083
- ChEMBL: CHEMBL471737
- MeSH: Ivabradine
- CAS: 155974-00-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinyu Tong, Lijuan Shen, Xiaomin Zhou, Yudan Wang, Sheng Chang, Shu Lu. Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis.
Drugs in R&D.
2023 Aug; ?(?):. doi:
10.1007/s40268-023-00435-5. [PMID: 37556093] - Hayder M Al-Kuraishy, Hajer K Issa, Ali I Al-Gareeb, Maisra M El-Bouseary, Amal Youssef, Ahmed Shaban Abdelaziz, Hesham Ahmed Khalifa, Gaber El-Saber Batiha. The role of ivabradine in doxorubicin-induced cardiotoxicity: exploring of underlying argument.
Inflammopharmacology.
2022 Dec; 30(6):2441-2446. doi:
10.1007/s10787-022-01082-z. [PMID: 36219320] - Feiming Ye, Xiaofeng Wang, Shulin Wu, Shumei Ma, Yu Zhang, Gang Liu, Kunshen Liu, Zhiming Yang, Xiaohua Pang, Li Xue, Shijuan Lu, Ming Zhong, Jing Li, Hao Yu, Donghua Lou, Dongyang Cui, Xiaojie Xie, Jian'an Wang. Sustained-Release Ivabradine Hemisulfate in Patients With Systolic Heart Failure.
Journal of the American College of Cardiology.
2022 08; 80(6):584-594. doi:
10.1016/j.jacc.2022.05.027. [PMID: 35926931] - M Mukkanti Eswarudu, A Lakshmana Rao, K Vijay. Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma.
Journal of pharmacological and toxicological methods.
2022 Jul; 116(?):107186. doi:
10.1016/j.vascn.2022.107186. [PMID: 35644433] - Gaidaa M Dogheim, Ibtsam Khairat, Gamal A Omran, Sahar M El-Haggar, Ahmed M El Amrawy, Rehab H Werida. Clinical comparative study assessing the effect of ivabradine on neopterin and NT-Pro BNP against standard treatment in chronic heart failure patients.
European journal of clinical pharmacology.
2022 Jun; 78(6):943-954. doi:
10.1007/s00228-022-03290-6. [PMID: 35238960] - Zümra Kara, Berna Güven, Arzu Onay Besikci, Nuh Yıldırım, Hikmet Altunay. Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes.
European journal of pharmacology.
2022 Feb; 916(?):174551. doi:
10.1016/j.ejphar.2021.174551. [PMID: 34906548] - Teruhiko Imamura, Koichiro Kinugawa. Doppler Echocardiography-Guided Heart Rate Modulation Therapy Using Ivabradine in a Patient with Systolic Heart Failure.
Medicina (Kaunas, Lithuania).
2022 Jan; 58(2):. doi:
10.3390/medicina58020164. [PMID: 35208489] - Yusuke Nakano, Hirohiko Ando, Wataru Suzuki, Tetsuya Amano. Effects of ivabradine on the prevention of intradialytic hypotension in a dialytic patient with heart failure with reduced ejection fraction.
BMJ case reports.
2021 Nov; 14(11):. doi:
10.1136/bcr-2021-246011. [PMID: 34848415] - Teruhiko Imamura, Hiroshi Onoda, Keisuke Uchida, Koichiro Kinugawa. Implication of Ivabradine Therapy in Up-Titrating Beta-Blocker Dose in Patients with Systolic Dysfunction.
International heart journal.
2021 Nov; 62(6):1305-1309. doi:
10.1536/ihj.21-387. [PMID: 34744149] - Ka-Chun Mok, Ho Tsoi, Ellen Ps Man, Man-Hong Leung, Ka Man Chau, Lai-San Wong, Wing-Lok Chan, Sum-Yin Chan, Mai-Yee Luk, Jessie Y W Chan, Jackie K M Leung, Yolanda H Y Chan, Sellma Batalha, Virginia Lau, David C W Siu, Terence K W Lee, Chun Gong, Ui-Soon Khoo. Repurposing hyperpolarization-activated cyclic nucleotide-gated channels as a novel therapy for breast cancer.
Clinical and translational medicine.
2021 11; 11(11):e578. doi:
10.1002/ctm2.578. [PMID: 34841695] - Jenna Stephanie O'Sullivan, Andrew Lyne, Carl J Vaughan. COVID-19-induced postural orthostatic tachycardia syndrome treated with ivabradine.
BMJ case reports.
2021 Jun; 14(6):. doi:
10.1136/bcr-2021-243585. [PMID: 34127505] - Aleksandra Paterek, Barbara Sochanowicz, Marta Oknińska, Witold Śmigielski, Marcin Kruszewski, Urszula Mackiewicz, Michał Mączewski, Przemysław Leszek. Ivabradine prevents deleterious effects of dopamine therapy in heart failure: No role for HCN4 overexpression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Apr; 136(?):111250. doi:
10.1016/j.biopha.2021.111250. [PMID: 33450487] - Ignacio Hernandez, Laura Tesoro, Rafael Ramirez-Carracedo, Javier Diez-Mata, Sandra Sanchez, Marta Saura, Jose Luis Zamorano, Carlos Zaragoza, Laura Botana. Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062902. [PMID: 33809359] - Pam R Taub, Adena Zadourian, Hannah C Lo, Cameron K Ormiston, Shahrokh Golshan, Jonathan C Hsu. Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome.
Journal of the American College of Cardiology.
2021 02; 77(7):861-871. doi:
10.1016/j.jacc.2020.12.029. [PMID: 33602468] - Marianne Joseph Naguib, Ibrahim Elsayed, Mahmoud Hassan Teaima. Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride.
International journal of nanomedicine.
2021; 16(?):2917-2931. doi:
10.2147/ijn.s299326. [PMID: 33911861] - Ren-Ai Xu, Wei Sun, Ruimin Chen, Naihua Liu, Chengke Huang. Inhibitory effect of sesamin on ivabradine metabolism in rats.
Pakistan journal of pharmaceutical sciences.
2020 Nov; 33(6):2543-2546. doi:
NULL. [PMID: 33867328] - Jennifer Lang, Ludwig Vincent, Marylore Chenel, Kayode Ogungbenro, Aleksandra Galetin. Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method.
The AAPS journal.
2020 10; 22(6):129. doi:
10.1208/s12248-020-00502-8. [PMID: 33033962] - Rafael Ramirez-Carracedo, Laura Tesoro, Ignacio Hernandez, Javier Diez-Mata, Laura Botana, Marta Saura, Marcelo Sanmartin, Jose Luis Zamorano, Carlos Zaragoza. Ivabradine-Stimulated Microvesicle Release Induces Cardiac Protection against Acute Myocardial Infarction.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
10.3390/ijms21186566. [PMID: 32911752] - Madhumita Premkumar, Devaraja Rangegowda, Tanmay Vyas, Jelen S Khumuckham, Saggere M Shasthry, Sherin S Thomas, Ritu Goyal, Guresh Kumar, Shiv K Sarin. Carvedilol Combined With Ivabradine Improves Left Ventricular Diastolic Dysfunction, Clinical Progression, and Survival in Cirrhosis.
Journal of clinical gastroenterology.
2020 07; 54(6):561-568. doi:
10.1097/mcg.0000000000001219. [PMID: 31305281] - A Knapp-Gisclon, M Zerah, C Mayer-Duverneuil, C Rambaud, G Lorin de la Grandamison, J-C Alvarez. Fatal intoxication with ivabradine: First case report.
Forensic science international.
2020 Jun; 311(?):110288. doi:
10.1016/j.forsciint.2020.110288. [PMID: 32311649] - Min Yang, Limin Chen, Tianfeng Hua, Yangyang Zou, Zhengfei Yang. Beneficial Effects of Ivabradine on Post-Resuscitation Myocardial Dysfunction in a Porcine Model of Cardiac Arrest.
Shock (Augusta, Ga.).
2020 05; 53(5):630-636. doi:
10.1097/shk.0000000000001403. [PMID: 31274829] - Houyong Zhu, Xiaoqun Xu, Xiaojiang Fang, Jianwu Zheng, Qian Zhao, Tielong Chen, Jinyu Huang. Response to Letter Regarding Article, "Effects of the Antianginal Drugs Ranolazine, Nicorandil and Ivabradine on Coronary Microvascular Function in Patients with Non-obstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials".
Clinical therapeutics.
2020 02; 42(2):376-377. doi:
10.1016/j.clinthera.2019.12.016. [PMID: 31973937] - Houyong Zhu, Xiaoqun Xu, Xiaojiang Fang, Jianwu Zheng, Qian Zhao, Tielong Chen, Jinyu Huang. Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine on Coronary Microvascular Function in Patients With Nonobstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials.
Clinical therapeutics.
2019 10; 41(10):2137-2152.e12. doi:
10.1016/j.clinthera.2019.08.008. [PMID: 31548105] - Simranjot Kaur, Nirmal Singh, Amteshwar Singh Jaggi. Opening of T-type Ca2+ channels and activation of HCN channels contribute in stress adaptation in cold water immersion stress-subjected mice.
Life sciences.
2019 Sep; 232(?):116605. doi:
10.1016/j.lfs.2019.116605. [PMID: 31254588] - Laura Perissinotti, Jiqing Guo, Meruyert Kudaibergenova, James Lees-Miller, Marina Ol'khovich, Angelica Sharapova, German L Perlovich, Daniel A Muruve, Brenda Gerull, Sergei Yu Noskov, Henry J Duff. The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Molecular pharmacology.
2019 08; 96(2):259-271. doi:
10.1124/mol.118.115642. [PMID: 31182542] - Kazuyoshi Kakehi, Yoshitaka Iwanaga, Heitaro Watanabe, Takashi Sonobe, Tsuyoshi Akiyama, Shuji Shimizu, Hiromi Yamamoto, Shunichi Miyazaki. Modulation of Sympathetic Activity and Innervation With Chronic Ivabradine and β-Blocker Therapies: Analysis of Hypertensive Rats With Heart Failure.
Journal of cardiovascular pharmacology and therapeutics.
2019 07; 24(4):387-396. doi:
10.1177/1074248419829168. [PMID: 30786751] - En-Zhong Xue, Ming-Hui Zhang, Chun-Li Liu. Efficacy of ivabradine for heart failure: A protocol for a systematic review of randomized controlled trial.
Medicine.
2019 Apr; 98(14):e15075. doi:
10.1097/md.0000000000015075. [PMID: 30946357] - Katarina Ondicova, Noemi Hegedusova, Miroslav Tibensky, Boris Mravec. Ivabradine reduces baseline and stress-induced increase of heart rate and blood pressure and modulates neuroendocrine stress response in rats depending on stressor intensity.
General physiology and biophysics.
2019 Mar; 38(2):165-173. doi:
10.4149/gpb_2018046. [PMID: 30821251] - Nadezhda M Zakharova, Yury S Tarahovsky, Irina S Fadeeva, Natalia P Komelina, Maxim O Khrenov, Olga V Glushkova, Dmitry A Prokhorov, Viktor P Kutyshenko, Anatoly L Kovtun. A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats.
Life sciences.
2019 Feb; 219(?):190-198. doi:
10.1016/j.lfs.2019.01.023. [PMID: 30658098] - Talita Matias Barbosa Cavalcante, José de Maria Albuquerque De Melo, Lia Bastos Lopes, Matheus Costa Bessa, Jéssica Gurgel Santos, Luna Costa Vasconcelos, Antônio Eufrásio Vieira Neto, Lucas Teixeira Nunes Borges, Marta Maria França Fonteles, Adriano José Maia Chaves Filho, Danielle Macêdo, Adriana Rolim Campos, Carlos Clayton Torres Aguiar, Silvânia Maria Mendes Vasconcelos. Ivabradine possesses anticonvulsant and neuroprotective action in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):2499-2512. doi:
10.1016/j.biopha.2018.11.096. [PMID: 30551511] - Fedor Simko, Tomas Baka, Marko Poglitsch, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Stefan Zorad, Michaela Adamcova, Ludovit Paulis. Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension.
International journal of molecular sciences.
2018 Oct; 19(10):. doi:
10.3390/ijms19103017. [PMID: 30282928] - Peter Jirak, Dzeneta Fejzic, Vera Paar, Bernhard Wernly, Rudin Pistulli, Ilonka Rohm, Christian Jung, Uta C Hoppe, P Christian Schulze, Michael Lichtenauer, Atilla Yilmaz, Daniel Kretzschmar. Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure.
Acta pharmacologica Sinica.
2018 Jul; 39(7):1189-1196. doi:
10.1038/aps.2017.167. [PMID: 29239349] - Amany E El-Naggar, Sahar M El-Gowilly, Fouad M Sharabi. Possible Ameliorative Effect of Ivabradine on the Autonomic and Left Ventricular Dysfunction Induced by Doxorubicin in Male Rats.
Journal of cardiovascular pharmacology.
2018 07; 72(1):22-31. doi:
10.1097/fjc.0000000000000586. [PMID: 29688913] - Sarah E Petite, Bryan M Bishop, Vincent F Mauro. Role of the Funny Current Inhibitor Ivabradine in Cardiac Pharmacotherapy: A Systematic Review.
American journal of therapeutics.
2018 Mar; 25(2):e247-e266. doi:
10.1097/mjt.0000000000000388. [PMID: 26910057] - Michel Komajda, Richard Isnard, Alain Cohen-Solal, Marco Metra, Burkert Pieske, Piotr Ponikowski, Adriaan A Voors, Fabienne Dominjon, Cécile Henon-Goburdhun, Matthieu Pannaux, Michael Böhm. Effect of ivabradine in patients with heart failure with preserved ejection fraction: the EDIFY randomized placebo-controlled trial.
European journal of heart failure.
2017 11; 19(11):1495-1503. doi:
10.1002/ejhf.876. [PMID: 28462519] - Matthew Emile Li Kam Wa, Patricia Taraborrelli, Sajad Hayat, Phang Boon Lim. Respiration driven excessive sinus tachycardia treated with clonidine.
BMJ case reports.
2017 Apr; 2017(?):. doi:
10.1136/bcr-2016-216818. [PMID: 28455405] - Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Muhammad Sher. IVABRADINE LOADED SOLID LIPID MICROPARTICLES: FORMULATION, CHARACTERIZATION AND OPTIMIZATION BY CENTRAL COMPOSITE ROTATABLE DESIGN.
Acta poloniae pharmaceutica.
2017 Jan; 74(1):211-226. doi:
". [PMID: 29474777] - Francesco Barillà, Giuseppe Pannarale, Concetta Torromeo, Vincenzo Paravati, Maria Cristina Acconcia, Gaetano Tanzilli, Enrico Mangieri, Tania Dominici, Francesco Martino, Gaetano Pannitteri, Carlo Gaudio. Ivabradine in Patients with ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock: A Preliminary Randomized Prospective Study.
Clinical drug investigation.
2016 Oct; 36(10):849-56. doi:
10.1007/s40261-016-0424-9. [PMID: 27312076] - Ulrich Fischer-Rasokat, Jörg Honold, Denise Lochmann, Sebastian Wolter, Christoph Liebetrau, Stephan Fichtlscherer, Helge Möllmann, Ioakim Spyridopoulos, Christian W Hamm. β-Blockers and ivabradine differentially affect cardiopulmonary function and left ventricular filling index.
Clinical research in cardiology : official journal of the German Cardiac Society.
2016 Jun; 105(6):527-34. doi:
10.1007/s00392-015-0950-0. [PMID: 26687495] - Omar T Hassan, Reem T Hassan, Rohit R Arora. Organic Cation Transporter-Mediated Clearance of Cardiovascular Drugs: A Pharmacological Perspective.
American journal of therapeutics.
2016 May; 23(3):e855-61. doi:
10.1097/mjt.0000000000000148. [PMID: 25259955] - Hee Youn Choi, Kyun-Seop Bae, Sang-Heon Cho, Jong-Lyul Ghim, Sangmin Choe, Jin Ah Jung, Hyeong-Seok Lim. Population plasma and urine pharmacokinetics of ivabradine and its active metabolite S18982 in healthy Korean volunteers.
Journal of clinical pharmacology.
2016 Apr; 56(4):439-49. doi:
10.1002/jcph.614. [PMID: 26265098] - N G Poteshkina, A A Troshina. [Coronary Heart Disease at the Patient With Metabolic Syndrome: Strategy of Antianginal Therapy].
Kardiologiia.
2016 Apr; 56(4):91-95. doi:
10.18565/cardio.2016.4.91-95. [PMID: 28294865] - Sophie Peigné, Sylvain Fouliard, Sophie Decourcelle, Marylore Chenel. Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment.
Journal of pharmacokinetics and pharmacodynamics.
2016 Feb; 43(1):29-43. doi:
10.1007/s10928-015-9452-y. [PMID: 26578442] - Xue Cao, Zhijun Sun, Boya Zhang, Xueqi Li, Hongyuan Xia. The Effects of Ivabradine on Cardiac Function after Myocardial Infarction are Weaker in Diabetic Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(5):2055-2064. doi:
10.1159/000447901. [PMID: 27825166] - Ilonka Rohm, Daniel Kretzschmar, Rudin Pistulli, Marcus Franz, P Christian Schulze, Christian Stumpf, Atilla Yilmaz. Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure.
Journal of immunology research.
2016; 2016(?):6949320. doi:
10.1155/2016/6949320. [PMID: 27822484] - Nikhil Pal, Nadiya Sivaswamy, Masliza Mahmod, Arash Yavari, Amelia Rudd, Satnam Singh, Dana K Dawson, Jane M Francis, Jeremy S Dwight, Hugh Watkins, Stefan Neubauer, Michael Frenneaux, Houman Ashrafian. Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction.
Circulation.
2015 Nov; 132(18):1719-25. doi:
10.1161/circulationaha.115.017119. [PMID: 26338956] - James P Lees-Miller, Jiqing Guo, Yibo Wang, Laura L Perissinotti, Sergei Y Noskov, Henry J Duff. Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
Journal of molecular and cellular cardiology.
2015 Aug; 85(?):71-8. doi:
10.1016/j.yjmcc.2015.05.009. [PMID: 25986146] - Dong-qin Liu, Jing-hua Yu, Yi-fan Zhang, Da-fang Zhong, Ling He, Xiao-yan Chen. [Effects of stable isotope labeled internal standard on determination of ivabradine and N-demethylivabradine in human plasma].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Mar; 50(3):348-54. doi:
NULL. [PMID: 26118116] - Wei Sun, Zhe Wang, Hui Chen, Xiao-Dan Zhang, Cheng-Ke Huang, Qing-Quan Lian, Wang-Ning Shang-Guan, Guang-Hui Zhu, Guo-Xin Hu, Zeng-Shou Wang. The effect of clopidogrel on pharmacokinetics of ivabradine and its metabolite in rats.
Drug development and industrial pharmacy.
2015; 41(9):1512-7. doi:
10.3109/03639045.2014.959970. [PMID: 25250618] - Xing-Peng Chen, Hai-Tao Zheng, Wei-Wei Cai, Meng-Ke Li, Jian-Wei Zhang, Jie Hu. The Effect of Silibinin on the Pharmacokinetics of Ivabradine and N-Desmethylivabradine in Rats.
Pharmacology.
2015; 96(3-4):107-11. doi:
10.1159/000435890. [PMID: 26202095] - Romain Gallet, Julien Ternacle, Thibaud Damy, Soulef Guendouz, Camille Bremont, Aurélien Seemann, Pascal Gueret, Jean-Luc Dubois-Rande, Pascal Lim. Hemodynamic effects of Ivabradine in addition to dobutamine in patients with severe systolic dysfunction.
International journal of cardiology.
2014 Sep; 176(2):450-5. doi:
10.1016/j.ijcard.2014.07.093. [PMID: 25129291] - Nima Rudd, Ivan Subiakto, Muhammad Asrar Ul Haq, Vivek Mutha, William J Van Gaal. Use of ivabradine and atorvastatin in emergent orthopedic lower limb surgery and computed tomography coronary plaque imaging and novel biomarkers of cardiovascular stress and lipid metabolism for the study and prevention of perioperative myocardial infarction: study protocol for a randomized controlled trial.
Trials.
2014 Sep; 15(?):352. doi:
10.1186/1745-6215-15-352. [PMID: 25195125] - Susanne Scheruebel, Chintan N Koyani, Seth Hallström, Petra Lang, Dieter Platzer, Heinrich Mächler, Karl Lohner, Ernst Malle, Klaus Zorn-Pauly, Brigitte Pelzmann. I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.
Journal of molecular and cellular cardiology.
2014 Jul; 72(?):64-73. doi:
10.1016/j.yjmcc.2014.02.010. [PMID: 24583250] - Vipin Kumar Goyal, Suraj Godara, Trilok Chandra Sadasukhi, Hoti Lal Gupta. Management of inappropriate sinus tachycardia with ivabradine in a renal transplant recipient.
Drug discoveries & therapeutics.
2014 Jun; 8(3):132-3. doi:
10.5582/ddt.2014.01023. [PMID: 25031045] - François Mathiaux, Sylvain Dulaurent, Frédéric Julia, Jean-Michel Gaulier. Case report of ivabradine intoxication.
Journal of analytical toxicology.
2014 May; 38(4):231-2. doi:
10.1093/jat/bku015. [PMID: 24711296] - Adriaan A Voors, Dirk J van Veldhuisen, Michele Robertson, Ian Ford, Jeffrey S Borer, Michael Böhm, Michel Komajda, Karl Swedberg, Luigi Tavazzi. The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT.
European journal of heart failure.
2014 Apr; 16(4):426-34. doi:
10.1002/ejhf.59. [PMID: 24504937] - Juanjuan Jiang, Lei Tian, Yiling Huang, Yishi Li. Development and validation of a sensitive LC-MS/MS-ESI method for the determination of ivabradine in human plasma: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2013 Dec; 27(12):1603-8. doi:
10.1002/bmc.2966. [PMID: 23798342] - Juanjuan Jiang, Lei Tian, Yiling Huang, Yishi Li, Li Xu. Pharmacokinetic and safety profile of ivabradine in healthy Chinese men: a phase I, randomized, open-label, increasing single- and multiple-dose study.
Clinical therapeutics.
2013 Dec; 35(12):1933-45. doi:
10.1016/j.clinthera.2013.10.007. [PMID: 24332196] - Richard L Verrier, Marcel F Sobrado, Vitor P F Pagotto, Alexandre F Kanas, Ananda D Machado, Bruno B Varone, Lucas F Sobrado, Bruce D Nearing, Dewan Zeng, Luiz Belardinelli. Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.
Heart rhythm.
2013 Nov; 10(11):1692-7. doi:
10.1016/j.hrthm.2013.08.007. [PMID: 23933296] - Lucas F Sobrado, Bruno B Varone, Ananda D Machado, Bruce D Nearing, Dewan Zeng, Luiz Belardinelli, Richard L Verrier. Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.
Journal of cardiovascular electrophysiology.
2013 Aug; 24(8):914-8. doi:
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