3,N4-ethenocytosine (BioDeep_00000724034)

   


代谢物信息卡片


imidazo[1,2-c]pyrimidin-5(6H)-one

化学式: C6H5N3O (135.04326)
中文名称: 咪唑并[1,2-c]嘧啶-5(6h)-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CNC(=O)N2C1=NC=C2
InChI: InChI=1S/C6H5N3O/c10-6-8-2-1-5-7-3-4-9(5)6/h1-4H,(H,8,10)

描述信息

同义名列表

2 个代谢物同义名

imidazo[1,2-c]pyrimidin-5(6H)-one; 3,N4-ethenocytosine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tomasz Obtułowicz, Alicja Winczura, Elzbieta Speina, Maja Swoboda, Justyna Janik, Beata Janowska, Jarosław M Cieśla, Paweł Kowalczyk, Arkadiusz Jawien, Daniel Gackowski, Zbigniew Banaszkiewicz, Ireneusz Krasnodebski, Andrzej Chaber, Ryszard Olinski, Jagadesaan Nair, Helmut Bartsch, Thierry Douki, Jean Cadet, Barbara Tudek. Aberrant repair of etheno-DNA adducts in leukocytes and colon tissue of colon cancer patients. Free radical biology & medicine. 2010 Sep; 49(6):1064-71. doi: 10.1016/j.freeradbiomed.2010.06.027. [PMID: 20600828]
  • Barbara Tudek, Alicja Winczura, Justyna Janik, Agnieszka Siomek, Marek Foksinski, Ryszard Oliński. Involvement of oxidatively damaged DNA and repair in cancer development and aging. American journal of translational research. 2010 May; 2(3):254-84. doi: ". [PMID: 20589166]
  • Agnieszka M Maciejewska, Karol P Ruszel, Jadwiga Nieminuszczy, Joanna Lewicka, Beata Sokołowska, Elzbieta Grzesiuk, Jarosław T Kuśmierek. Chloroacetaldehyde-induced mutagenesis in Escherichia coli: the role of AlkB protein in repair of 3,N(4)-ethenocytosine and 3,N(4)-alpha-hydroxyethanocytosine. Mutation research. 2010 Feb; 684(1-2):24-34. doi: 10.1016/j.mrfmmm.2009.11.005. [PMID: 19941873]
  • Marcus S Cooke, Paul T Henderson, Mark D Evans. Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine. Journal of clinical biochemistry and nutrition. 2009 Nov; 45(3):255-70. doi: 10.3164/jcbn.sr09-41. [PMID: 19902015]
  • Barbara Tudek. Base excision repair modulation as a risk factor for human cancers. Molecular aspects of medicine. 2007 Jun; 28(3-4):258-75. doi: 10.1016/j.mam.2007.05.003. [PMID: 17628657]
  • Hauh-Jyun Candy Chen, Chi-Fu Kao. Effect of gender and cigarette smoking on urinary excretion of etheno DNA adducts in humans measured by isotope dilution gas chromatography/mass spectrometry. Toxicology letters. 2007 Feb; 169(1):72-81. doi: 10.1016/j.toxlet.2006.12.005. [PMID: 17241756]
  • James C Delaney, Lisa Smeester, Cintyu Wong, Lauren E Frick, Koli Taghizadeh, John S Wishnok, Catherine L Drennan, Leona D Samson, John M Essigmann. AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nature structural & molecular biology. 2005 Oct; 12(10):855-60. doi: 10.1038/nsmb996. [PMID: 16200073]
  • Hermann M Bolt. Vinyl chloride-a classical industrial toxicant of new interest. Critical reviews in toxicology. 2005 Apr; 35(4):307-23. doi: 10.1080/10408440490915975. [PMID: 15989139]
  • Hauh-Jyun Candy Chen, Chan-Fu Wu, Chia-Liang Hong, Chia-Ming Chang. Urinary excretion of 3,N4-etheno-2'-deoxycytidine in humans as a biomarker of oxidative stress: association with cigarette smoking. Chemical research in toxicology. 2004 Jul; 17(7):896-903. doi: 10.1021/tx0342013. [PMID: 15257614]
  • Laurent Gros, Andrei V Maksimenko, Cyril V Privezentzev, Jacques Laval, Murat K Saparbaev. Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct. The Journal of biological chemistry. 2004 Apr; 279(17):17723-30. doi: 10.1074/jbc.m314010200. [PMID: 14761949]
  • Hauh-Jyun Candy Chen, Chia-Liang Hong, Chan-Fu Wu, Wei-Loong Chiu. Effect of cigarette smoking on urinary 3,N4-ethenocytosine levels measured by gas chromatography/mass spectrometry. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Dec; 76(2):321-7. doi: 10.1093/toxsci/kfg219. [PMID: 12944589]
  • Alain Barbin, Rong Wang, Peter J O'Connor, Rhoderick H Elder. Increased formation and persistence of 1,N(6)-ethenoadenine in DNA is not associated with higher susceptibility to carcinogenesis in alkylpurine-DNA-N-glycosylase knockout mice treated with vinyl carbamate. Cancer research. 2003 Nov; 63(22):7699-703. doi: ". [PMID: 14633693]
  • Alain Barbin, Hiroko Ohgaki, Jun Nakamura, Michael Kurrer, Paul Kleihues, James A Swenberg. Endogenous deoxyribonucleic Acid (DNA) damage in human tissues: a comparison of ethenobases with aldehydic DNA lesions. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2003 Nov; 12(11 Pt 1):1241-7. doi: NULL. [PMID: 14652288]
  • Laurent Gros, Alexander A Ishchenko, Murat Saparbaev. Enzymology of repair of etheno-adducts. Mutation research. 2003 Oct; 531(1-2):219-29. doi: 10.1016/j.mrfmmm.2003.07.008. [PMID: 14637257]
  • Elzbieta Speina, Maja Zielińska, Alain Barbin, Daniel Gackowski, Janusz Kowalewski, Maria A Graziewicz, Janusz A Siedlecki, Ryszard Oliński, Barbara Tudek. Decreased repair activities of 1,N(6)-ethenoadenine and 3,N(4)-ethenocytosine in lung adenocarcinoma patients. Cancer research. 2003 Aug; 63(15):4351-7. doi: ". [PMID: 12907604]
  • Bo Hang, Gary Downing, Anton B Guliaev, B Singer. Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction. Biochemistry. 2002 Feb; 41(7):2158-65. doi: 10.1021/bi011542b. [PMID: 11841206]
  • H J Chen, T C Lin, C L Hong, L C Chiang. Analysis of 3,N(4)-ethenocytosine in DNA and in human urine by isotope dilution gas chromatography/negative ion chemical ionization/mass spectrometry. Chemical research in toxicology. 2001 Dec; 14(12):1612-9. doi: 10.1021/tx015551x. [PMID: 11743744]