Zofenopril (BioDeep_00000724011)

   


代谢物信息卡片


Zofenopril-d5

化学式: C22H23NO4S2 (429.10684380000004)
中文名称: 佐芬普利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)O)SC3=CC=CC=C3
InChI: InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1

描述信息

C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

2 个代谢物同义名

Zofenopril-d5; Zofenopril



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Massimo Volpe, Valeria Pegoraro, Ilaria Peduto, Franca Heiman, Suada Meto. Extemporaneous combination therapy with nebivolol/zofenopril in hypertensive patients: usage in Italy. Current medical research and opinion. 2022 10; 38(10):1673-1681. doi: 10.1080/03007995.2022.2096352. [PMID: 35787718]
  • Stefano Omboni, Claudio Borghi. Efficacy of Zofenopril Alone or in Combination with Hydrochlorothiazide in Patients with Kidney Dysfunction. Current clinical pharmacology. 2019; 14(1):5-15. doi: 10.2174/1574884713666181025145404. [PMID: 30360726]
  • Miriam Gómez-Roso, María J Montero, Rosalía Carrón, María A Sevilla. Zofenopril exerts a cardiovascular protective effect on rats infused with angiotensin II beyond angiotensin-converting enzyme inhibition. The Journal of pharmacy and pharmacology. 2016 Nov; 68(11):1422-1429. doi: 10.1111/jphp.12641. [PMID: 27670145]
  • Erminia Donnarumma, Murtuza J Ali, Amanda M Rushing, Amy L Scarborough, Jessica M Bradley, Chelsea L Organ, Kazi N Islam, David J Polhemus, Stefano Evangelista, Giuseppe Cirino, J Stephen Jenkins, Rajan A G Patel, David J Lefer, Traci T Goodchild. Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability. Journal of the American Heart Association. 2016 07; 5(7):. doi: 10.1161/jaha.116.003531. [PMID: 27381758]
  • Yuan Tian, Jing Cao, Lifang Luo, Zunjian Zhang, Pengcheng Ma. Determination of zofenopril and its active metabolite in human plasma using high-performance liquid chromatography combined with a triple-quadruple tandem mass spectrometer. Journal of chromatographic science. 2015 Feb; 53(2):253-62. doi: 10.1093/chromsci/bmu050. [PMID: 24935917]
  • Mariarosaria Bucci, Valentina Vellecco, Anna Cantalupo, Vincenzo Brancaleone, Zongmin Zhou, Stefano Evangelista, Vincenzo Calderone, Andreas Papapetropoulos, Giuseppe Cirino. Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition. Cardiovascular research. 2014 Apr; 102(1):138-47. doi: 10.1093/cvr/cvu026. [PMID: 24501330]
  • Giovambattista De Sarro, Eugenio Donato Di Paola, Santo Gratteri, Pietro Gareri, Vincenzo Rispoli, Antonio Siniscalchi, Giovanni Tripepi, Luca Gallelli, Rita Citraro, Emilio Russo. Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Pharmacological research. 2012 Mar; 65(3):285-96. doi: 10.1016/j.phrs.2011.11.005. [PMID: 22107891]
  • Francesco Cacciatore, Giuseppe Bruzzese, Dino Franco Vitale, Antonio Liguori, Filomena de Nigris, Carmela Fiorito, Teresa Infante, Francesco Donatelli, Pellegrino Biagio Minucci, Louis Joseph Ignarro, Claudio Napoli. Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. European journal of clinical pharmacology. 2011 Sep; 67(9):877-83. doi: 10.1007/s00228-011-1029-0. [PMID: 21445638]
  • Yuan Jiang, Fang Yan, Bin Di, Fang Feng, Linjun You, Lili Huang, Juan Lu. Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma. Journal of pharmaceutical and biomedical analysis. 2011 Jun; 55(3):527-32. doi: 10.1016/j.jpba.2011.02.010. [PMID: 21377823]
  • M Gómez-Roso, M J Montero, R Carrón, M A Sevilla. Cardiovascular changes in spontaneously hypertensive rats are improved by chronic treatment with zofenopril. British journal of pharmacology. 2009 Dec; 158(8):1911-21. doi: 10.1111/j.1476-5381.2009.00491.x. [PMID: 19917062]
  • Claudio Borghi, Arrigo F G Cicero, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni. Serum cholesterol levels on admission and survival in patients with acute myocardial infarction treated with zofenopril: a post hoc analysis of the Survival of Myocardial Infarction Long-term Evaluation trial. Fundamental & clinical pharmacology. 2009 Oct; 23(5):641-8. doi: 10.1111/j.1472-8206.2009.00704.x. [PMID: 19656211]
  • Giuseppe Sacco, Bigioni Mario, Giuseppe Lopez, Stefano Evangelista, Stefano Manzini, Carlo Alberto Maggi. ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat. Vascular pharmacology. 2009 May; 50(5-6):166-70. doi: 10.1016/j.vph.2009.01.001. [PMID: 19344651]
  • Stefano Omboni, Ettore Malacco, Gianfranco Parati. Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions. Cardiovascular therapeutics. 2009; 27(4):275-88. doi: 10.1111/j.1755-5922.2009.00102.x. [PMID: 19832845]
  • Anna Fratta Pasini, Ulisse Garbin, Maria Cristina Nava, Chiara Stranieri, Michele Pellegrini, Veronica Boccioletti, Maria Laura Luchetta, Paolo Fabrizzi, Vincenzo Lo Cascio, Luciano Cominacini. Effect of sulfhydryl and non-sulfhydryl angiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients. American journal of hypertension. 2007 Apr; 20(4):443-50. doi: 10.1016/j.amjhyper.2006.09.020. [PMID: 17386354]
  • Joaquín García-Estañ, M Clara Ortiz, Francisco O'Valle, Antonia Alcaraz, Esther G Navarro, Félix Vargas, Stefano Evangelista, Noemí M Atucha. Effects of angiotensin-converting-enzyme inhibitors in combination with diuretics on blood pressure and renal injury in nitric oxide-deficiency-induced hypertension in rats. Clinical science (London, England : 1979). 2006 Feb; 110(2):227-33. doi: 10.1042/cs20050165. [PMID: 16197366]
  • Bulent Altunoluk, Haluk Soylemez, Fatih Oguz, Emine Turkmen, Ersin Fadillioglu. An Angiotensin-converting enzyme inhibitor, zofenopril, prevents renal ischemia/reperfusion injury in rats. Annals of clinical and laboratory science. 2006; 36(3):326-32. doi: NULL. [PMID: 16951275]
  • Bart Westendorp, Regien G Schoemaker, Wiek H van Gilst, Dirk J van Veldhuisen, Hendrik Buikema. Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril. European journal of pharmacology. 2005 Dec; 527(1-3):141-9. doi: 10.1016/j.ejphar.2005.10.019. [PMID: 16310764]
  • Claudio Borghi, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni. A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases. Expert opinion on pharmacotherapy. 2004 Sep; 5(9):1965-77. doi: 10.1517/14656566.5.9.1965. [PMID: 15330734]
  • C Napoli, V Sica, F de Nigris, O Pignalosa, M Condorelli, L J Ignarro, A Liguori. Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. American heart journal. 2004 Jul; 148(1):e5. doi: 10.1016/j.ahj.2004.03.025. [PMID: 15215814]
  • Bart Westendorp, Regien G Schoemaker, Hendrik Buikema, Dick de Zeeuw, Dirk J van Veldhuisen, Wiek H van Gilst. Dietary sodium restriction specifically potentiates left ventricular ACE inhibition by zofenopril, and is associated with attenuated hypertrophic response in rats with myocardial infarction. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2004 Mar; 5(1):27-32. doi: 10.3317/jraas.2004.004. [PMID: 15136971]
  • Mario Matarrese, Aldo Salimbeni, Elia Anna Turolla, Damiano Turozzi, Rosa Maria Moresco, Davide Poma, Fulvio Magni, Sergio Todde, Claudio Rossetti, Maria Teresa Sciarrone, Giuseppe Bianchi, Marzia Galli Kienle, Ferruccio Fazio. 11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat. Bioorganic & medicinal chemistry. 2004 Feb; 12(3):603-11. doi: 10.1016/j.bmc.2003.10.054. [PMID: 14738971]
  • Antonio Marzo, Lorenzo Dal Bo, Paolo Mazzucchelli, Nunzia Ceppi Monti, Fabrizio Crivelli, Shevqet Ismaili, Andrea Giusti, Mario Richard Uhr. Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers. Arzneimittel-Forschung. 2002; 52(4):233-42. doi: 10.1055/s-0031-1299886. [PMID: 12040965]
  • F de Nigris, F P D'Armiento, P Somma, A Casini, I Andreini, F Sarlo, G Mansueto, G De Rosa, D Bonaduce, M Condorelli, C Napoli. Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice. International journal of cardiology. 2001 Dec; 81(2-3):107-15; discusssion 115. doi: 10.1016/s0167-5273(01)00542-3. [PMID: 11744122]
  • L Dal Bo, P Mazzucchelli, A Marzo. Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2000 Dec; 749(2):287-94. doi: 10.1016/s0378-4347(00)00419-9. [PMID: 11145066]
  • A Marzo, L Dal Bo, P Mazzucchelli, N C Monti, R A Tettamanti, F Crivelli, M R Uhr, S Ismaili, A Giusti. Pharmacokinetics and pharmacodynamics of zofenopril in healthy volunteers. Arzneimittel-Forschung. 1999 Dec; 49(12):992-6. doi: 10.1055/s-0031-1300539. [PMID: 10635443]
  • C J Lin, W Akarawut, D E Smith. Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter. Pharmaceutical research. 1999 May; 16(5):609-15. doi: 10.1023/a:1018847818766. [PMID: 10350000]
  • F Elijovich, C L Laffer, E L Schiffrin. The effects of atenolol and zofenopril on plasma atrial natriuretic peptide are due to their interactions with target organ damage of essential hypertensive patients. Journal of human hypertension. 1997 May; 11(5):313-9. doi: 10.1038/sj.jhh.1000438. [PMID: 9205939]
  • C Borghi, S Bacchelli, E Ambrosioni. The use of zofenopril and fosinopril in acute myocardial infarction and carotid artery disease. American journal of hypertension. 1994 Sep; 7(9 Pt 2):96S-101S. doi: 10.1093/ajh/7.9.96s. [PMID: 7818843]
  • C Borghi, S Boschi, E Ambrosioni, G Melandri, A Branzi, B Magnani. Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors. Journal of clinical pharmacology. 1993 Jan; 33(1):40-5. doi: 10.1002/j.1552-4604.1993.tb03901.x. [PMID: 8429112]
  • X Liu, R M Engelman, J A Rousou, G A Cordis, D K Das. Attenuation of myocardial reperfusion injury by sulfhydryl-containing angiotensin converting enzyme inhibitors. Cardiovascular drugs and therapy. 1992 Aug; 6(4):437-43. doi: 10.1007/bf00054194. [PMID: 1387799]
  • Y Sun, F A Mendelsohn. Angiotensin converting enzyme inhibition in heart, kidney, and serum studied ex vivo after administration of zofenopril, captopril, and lisinopril. Journal of cardiovascular pharmacology. 1991 Oct; 18(4):478-86. doi: 10.1097/00005344-199110000-00002. [PMID: 1724523]
  • R A Morrison, D E Burkett, M E Arnold, C J D'Arienzo, S H Weinstein. Sites of first-pass bioactivation (hydrolysis) of orally administered zofenopril calcium in dogs. Pharmaceutical research. 1991 Mar; 8(3):370-5. doi: 10.1023/a:1015853801329. [PMID: 2052527]
  • S M Singhvi, J E Foley, D A Willard, R A Morrison. Disposition of zofenopril calcium in healthy subjects. Journal of pharmaceutical sciences. 1990 Nov; 79(11):970-3. doi: 10.1002/jps.2600791105. [PMID: 2292772]
  • R A Tio, C D de Langen, P A de Graeff, W H van Gilst, K J Bel, K G Wolters, P H Mook, J van Wijngaarden, H Wesseling. The effects of oral pretreatment with zofenopril, an angiotensin-converting enzyme inhibitor, on early reperfusion and subsequent electrophysiologic stability in the pig. Cardiovascular drugs and therapy. 1990 Jun; 4(3):695-703. doi: 10.1007/bf01856557. [PMID: 2076380]
  • C Borghi, C Magelli, S Boschi, F V Costa, M Capelli, E Varani, B Magnani, E Ambrosioni. Peripheral hemodynamic and humoral effects of oral zofenopril calcium (SQ. 26,991) in patients with congestive heart failure. Journal of clinical pharmacology. 1989 Dec; 29(12):1077-82. doi: 10.1002/j.1552-4604.1989.tb03282.x. [PMID: 2533220]
  • Y Lacourcière, C Gagné. Influence of zofenopril and low doses of hydrochlorothiazide on plasma lipoproteins in patients with mild to moderate essential hypertension. American journal of hypertension. 1989 Nov; 2(11 Pt 1):861-4. doi: 10.1093/ajh/2.11.861. [PMID: 2686713]
  • D W Cushman, F L Wang, W C Fung, G J Grover, C M Harvey, R J Scalese, S L Mitch, J M DeForrest. Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE). British journal of clinical pharmacology. 1989; 28 Suppl 2(?):115S-130S; discussion 130S. doi: 10.1111/j.1365-2125.1989.tb03587.x. [PMID: 2557876]
  • M Jemal, E Ivashkiv, D Teitz, A I Cohen. Simultaneous determination of the prodrug zofenopril and its active drug in plasma by capillary gas chromatography-mass-selective detection. Journal of chromatography. 1988 Jun; 428(1):81-92. doi: 10.1016/s0378-4347(00)83892-x. [PMID: 3049645]