Ara-G (BioDeep_00000721992)

   


代谢物信息卡片


9-beta-d-Arabinofuranosylguanine

化学式: C10H13N5O5 (283.09166480000005)
中文名称: 9-β-D-阿拉伯呋喃糖基鸟嘌呤水合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(NC2=O)N
InChI: InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1

描述信息

D000970 - Antineoplastic Agents
9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2].

同义名列表

4 个代谢物同义名

9-beta-d-Arabinofuranosylguanine; Ara-G; AraG; 9-β-D-Arabinofuranosylguanine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lingyun Cheng, Karl Hostetler, Nadya Valiaeva, Ajay Tammewar, William R Freeman, James Beadle, Dirk-Uwe Bartsch, Kathy Aldern, Iryna Falkenstein. Intravitreal crystalline drug delivery for intraocular proliferation diseases. Investigative ophthalmology & visual science. 2010 Jan; 51(1):474-81. doi: 10.1167/iovs.09-3672. [PMID: 19696179]
  • Maribel Franco, Magnus Johansson, Anna Karlsson. Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells. Experimental cell research. 2007 Jul; 313(12):2687-94. doi: 10.1016/j.yexcr.2007.04.003. [PMID: 17490647]
  • Anna Fyrberg, Freidoun Albertioni, Kourosh Lotfi. Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes. Biochemical and biophysical research communications. 2007 Jun; 357(4):847-53. doi: 10.1016/j.bbrc.2007.03.176. [PMID: 17459340]
  • Stacey L Berg, Claudia Brueckner, Jed G Nuchtern, Robert Dauser, Leticia McGuffey, Susan M Blaney. Plasma and cerebrospinal fluid pharmacokinetics of nelarabine in nonhuman primates. Cancer chemotherapy and pharmacology. 2007 May; 59(6):743-7. doi: 10.1007/s00280-006-0328-0. [PMID: 16953392]
  • J Kurtzberg, T J Ernst, M J Keating, V Gandhi, J P Hodge, D F Kisor, J J Lager, C Stephens, J Levin, T Krenitsky, G Elion, B S Mitchell. Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005 May; 23(15):3396-403. doi: 10.1200/jco.2005.03.199. [PMID: 15908652]
  • Donald F Smee, Robert W Sidwell. Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides. Nucleosides, nucleotides & nucleic acids. 2004; 23(1-2):375-83. doi: 10.1081/ncn-120028334. [PMID: 15043161]
  • T Bromidge, R Frewin, S Johnson. In vitro chemo-sensitivity of B-chronic lymphocytic leukaemia to ara-G. Leukemia research. 2000 Jul; 24(7):623-6. doi: 10.1016/s0145-2126(00)00030-8. [PMID: 10867138]
  • D F Kisor, W Plunkett, J Kurtzberg, B Mitchell, J P Hodge, T Ernst, M J Keating, V Gandhi. Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 Mar; 18(5):995-1003. doi: 10.1200/jco.2000.18.5.995. [PMID: 10694549]
  • J D Cohen, D J Strock, J E Teik, E A LaGuardia, T B Katz. Clinically relevant deoxycytidine levels are high enough to profoundly alter 9-beta-D-arabinofuranosylguanine cytotoxicity for human T-cell acute leukemia cells in vitro. Pediatric hematology and oncology. 1999 May; 16(3):239-44. doi: 10.1080/088800199277290. [PMID: 10326222]
  • V Gandhi, W Plunkett, C O Rodriguez, B J Nowak, M Du, M Ayres, D F Kisor, B S Mitchell, J Kurtzberg, M J Keating. Compound GW506U78 in refractory hematologic malignancies: relationship between cellular pharmacokinetics and clinical response. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1998 Nov; 16(11):3607-15. doi: 10.1200/jco.1998.16.11.3607. [PMID: 9817282]
  • C O Rodriguez, J K Legha, E Estey, M J Keating, V Gandhi. Pharmacological and biochemical strategies to increase the accumulation of arabinofuranosylguanine triphosphatein primary human leukemia cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 1997 Nov; 3(11):2107-13. doi: NULL. [PMID: 9815603]
  • V Verhoef, R Ashmun, A Fridland. Rhodamine 123 and flow cytometry to monitor the cytotoxic actions of nucleoside analogues in nondividing human lymphocytes. Anticancer research. 1986 Sep; 6(5):1117-21. doi: ". [PMID: 2879509]