solifenacin succinate (BioDeep_00000721277)
代谢物信息卡片
solifenacin succinate
化学式: C27H32N2O6 (480.2260252)
中文名称: 索利那辛琥珀酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O
InChI: /m0./s1
描述信息
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D000089162 - Genitourinary Agents > D064804 - Urological Agents
Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:32151
- KEGGdrug: D01269
- PubChem: 216457
- ChEMBL: CHEMBL1200803
- MeSH: Solifenacin Succinate
- CAS: 242478-38-2
- medchemexpress: HY-A0002
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mina Wadie, Hoda M Marzouk, Mamdouh R Rezk, Ezzat M Abdel-Moety, Mahmoud A Tantawy. A sensing platform of molecular imprinted polymer-based polyaniline/carbon paste electrodes for simultaneous potentiometric determination of alfuzosin and solifenacin in binary co-formulation and spiked plasma.
Analytica chimica acta.
2022 Apr; 1200(?):339599. doi:
10.1016/j.aca.2022.339599. [PMID: 35256148] - Zilin Long, Huan Chen, Shudan Yu, Xinlu Wang, Zhishun Liu. Effect of Acupuncture for Mixed Urinary Incontinence in Women: A Systematic Review.
Frontiers in public health.
2022; 10(?):827853. doi:
10.3389/fpubh.2022.827853. [PMID: 35372235] - Mohamed G Soliman, Shawky A El-Abd, Ahmed M Tawfik, Mohamed H Radwan, Ahmed S El-Abd. Efficacy and safety of mirabegron versus solifenacin as additional therapy for persistent OAB symptoms after tamsulosin monotherapy in men with probable BPO.
World journal of urology.
2021 Jun; 39(6):2049-2054. doi:
10.1007/s00345-020-03425-3. [PMID: 32869151] - Mohamed G Soliman, Shawky El-Abd, Osama M El-Gamal, Ali Abdel Raheem, Ahmed R Abou-Ramadan, Ahmed S El-Abd. Mirabegron versus Solifenacin in Children with Overactive Bladder: Prospective Randomized Single-Blind Controlled Trial.
Urologia internationalis.
2021; 105(11-12):1011-1017. doi:
10.1159/000515992. [PMID: 34010843] - Stacey Tannenbaum, Martin den Adel, Walter Krauwinkel, John Meijer, Adriana Hollestein-Havelaar, Frank Verheggen, Donald Newgreen. Pharmacokinetics of solifenacin in pediatric populations with overactive bladder or neurogenic detrusor overactivity.
Pharmacology research & perspectives.
2020 12; 8(6):e00684. doi:
10.1002/prp2.684. [PMID: 33231929] - Myungsun Shim, Jong Keun Kim, Woo Jin Bang, Yong Seong Lee, Sung Tae Cho, Jin Seon Cho, Kwan Joong Joo, Jae Seog Hyun, Byung Hoon Kim, Jong Bok Lee, Young Jin Seo, Cheol Young Oh. Efficacy and safety of dose escalation in male patients with overactive bladder showing poor efficacy after low-dose antimuscarinic treatment: A retrospective multicenter study.
Investigative and clinical urology.
2020 11; 61(6):600-606. doi:
10.4111/icu.20200053. [PMID: 32985146] - Mehmet Giray Sönmez, Gökhan Ecer, Ahmet Atici, Mehmet Serkan Özkent, Mehmet Sinan İyisoy, Ahmet Öztürk. Comparison of Oral Sodium Bicarbonate and Solifenacin Treatment in Female Overactive Bladder Patients With Acidic Urine pH.
Female pelvic medicine & reconstructive surgery.
2020 10; 26(10):649-653. doi:
10.1097/spv.0000000000000642. [PMID: 30335650] - Qian Wen, Ning Li, Xueling Wang, Hao Li, Fengwei Tian, Weiwei Chen, Yanyan Lu, Zhishun Liu. Effect of electroacupuncture versus solifenacin for moderate and severe overactive bladder: a multi-centre, randomized controlled trial study protocol.
BMC complementary medicine and therapies.
2020 Jul; 20(1):224. doi:
10.1186/s12906-020-03018-y. [PMID: 32678041] - Shinichi Nakanishi. [The Efficacy of Fesoterodine Switched from Solifenacin for Overactive Bladder Patients].
Hinyokika kiyo. Acta urologica Japonica.
2020 Jun; 66(6):165-170. doi:
10.14989/actauroljap_66_6_165. [PMID: 32605354] - Israel Franco, Piet Hoebeke, Małgorzata Baka-Ostrowska, David Bolong, Leon N Davies, Ellen Dahler, Robert Snijder, Otto Stroosma, Frank Verheggen, Donald Newgreen, Brigitte Bosman, Johan Vande Walle. Long-term efficacy and safety of solifenacin in pediatric patients aged 6 months to 18 years with neurogenic detrusor overactivity: results from two phase 3 prospective open-label studies.
Journal of pediatric urology.
2020 Apr; 16(2):180.e1-180.e8. doi:
10.1016/j.jpurol.2019.12.012. [PMID: 32007426] - Yuanjie Sun, Yan Liu, Sixing Liu, Weiming Wang, Zhishun Liu. Electroacupuncture for women with urgency-predominant mixed urinary incontinence: secondary analysis of a randomized noninferiority trial.
World journal of urology.
2020 Apr; 38(4):1035-1042. doi:
10.1007/s00345-019-02828-1. [PMID: 31155682] - Yuanjie Sun, Yan Liu, Tongsheng Su, Jianhua Sun, Ying Wu, Zhishun Liu. Electroacupuncture versus solifenacin for women with urgency-predominant mixed urinary incontinence: a protocol for a three-armed non-inferiority randomized controlled trial.
BMC complementary medicine and therapies.
2020 Jan; 20(1):18. doi:
10.1186/s12906-019-2784-1. [PMID: 32020889] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiko Noguchi, Tomoyuki Ueda, Hideyuki Yamamoto. Mirabegron causes vesical and urethral relaxation in rats with spinal cord injury.
Lower urinary tract symptoms.
2020 Jan; 12(1):92-98. doi:
10.1111/luts.12279. [PMID: 31389202] - Christopher R Chapple, Francisco Cruz, Linda Cardozo, David Staskin, Sender Herschorn, Nurul Choudhury, Matthias Stoelzel, John Heesakkers, Emad Siddiqui. Safety and Efficacy of Mirabegron: Analysis of a Large Integrated Clinical Trial Database of Patients with Overactive Bladder Receiving Mirabegron, Antimuscarinics, or Placebo.
European urology.
2020 01; 77(1):119-128. doi:
10.1016/j.eururo.2019.09.024. [PMID: 31635815] - Shinji Urakami, Kohei Ogawa, Suguru Oka, Kiichi Hagiwara, Shoichi Nagamoto, Haruki Anjiki, Michikata Hayashida, Akihiro Yano, Kazushige Sakaguchi, Kazuhiro Kurosawa, Toshikazu Okaneya. Effect of tadalafil add-on therapy in patients with persistant storage symptoms refractory to α1 -adrenoceptor antagonist monotherapy for benign prostatic hyperplasia: A randomized pilot trial comparing tadalafil and solifenacin.
Lower urinary tract symptoms.
2019 May; 11(3):109-114. doi:
10.1111/luts.12242. [PMID: 30251330] - Baoyan Liu, Yan Liu, Zongshi Qin, Kehua Zhou, Huangfang Xu, Liyun He, Ning Li, Tongsheng Su, Jianhua Sun, Zenghui Yue, Zhiwei Zang, Wei Zhang, Jiping Zhao, Zhongyu Zhou, Lian Liu, Dongning Wu, Jiani Wu, Jing Zhou, Ran Pang, Yang Wang, Jia Liu, Jinna Yu, Zhishun Liu. Electroacupuncture Versus Pelvic Floor Muscle Training Plus Solifenacin for Women With Mixed Urinary Incontinence: A Randomized Noninferiority Trial.
Mayo Clinic proceedings.
2019 01; 94(1):54-65. doi:
10.1016/j.mayocp.2018.07.021. [PMID: 30611454] - Mitsunobu Yoshida, Shinya Uchida, Yasuharu Kashiwagura, Shimako Tanaka, Rakan Matsui, Noriyuki Namiki. Evaluation of in Vitro and in Vivo Transdermal Absorption of Solifenacin Succinate.
Chemical & pharmaceutical bulletin.
2019; 67(11):1225-1231. doi:
10.1248/cpb.c19-00552. [PMID: 31685750] - Christian Gratzke, Rob van Maanen, Christopher Chapple, Paul Abrams, Sender Herschorn, Dudley Robinson, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Sang Jin Yoon, Salman Al-Shukri, Tomasz Rechberger, Elizabeth R Mueller. Long-term Safety and Efficacy of Mirabegron and Solifenacin in Combination Compared with Monotherapy in Patients with Overactive Bladder: A Randomised, Multicentre Phase 3 Study (SYNERGY II).
European urology.
2018 10; 74(4):501-509. doi:
10.1016/j.eururo.2018.05.005. [PMID: 29866467] - Michael E Chua, Manuel C See, Ednalyn B Esmeňa, Jaime C Balingit, Marcelino L Morales. Efficacy and Safety of Gabapentin in Comparison to Solifenacin Succinate in Adult Overactive Bladder Treatment.
Lower urinary tract symptoms.
2018 May; 10(2):135-142. doi:
10.1111/luts.12152. [PMID: 28150436] - Jing Xu, Hong Xu, Yang Yu, Yi He, Qi Liu, Bo Yang. Combination of Luteolin and Solifenacin Improves Urinary Dysfunction Induced by Diabetic Cystopathy in Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Mar; 24(?):1441-1448. doi:
10.12659/msm.904534. [PMID: 29523776] - D V Ergakov, A G Martov. [Combination therapy in the management of urinary disorders after transurethral resection of the prostate].
Urologiia (Moscow, Russia : 1999).
2018 Mar; ?(1):62-70. doi:
NULL. [PMID: 29634136] - Mike Herdman, Jameel Nazir, Zalmai Hakimi, Emad Siddiqui, Moses Huang, Marco Pavesi, Scott MacDiarmid, Marcus J Drake, Nancy Devlin. Assessing Preference-Based Outcome Measures for Overactive Bladder: An Evaluation of Patient-Reported Outcome Data from the BESIDE Clinical Trial.
The patient.
2017 Dec; 10(6):677-686. doi:
10.1007/s40271-017-0262-8. [PMID: 28646416] - Sender Herschorn, Christopher R Chapple, Paul Abrams, Salvador Arlandis, David Mitcheson, Kyu-Sung Lee, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Rob van Maanen, Dudley Robinson. Efficacy and safety of combinations of mirabegron and solifenacin compared with monotherapy and placebo in patients with overactive bladder (SYNERGY study).
BJU international.
2017 10; 120(4):562-575. doi:
10.1111/bju.13882. [PMID: 28418102] - Xu Feng Peng, Xiang Guo Lv, Hong Xie, Ying Long Sa, Yue Min Xu, Chao Feng, Xin Ru Zhang. Effectiveness of Solifenacin for Managing of Bladder Spasms in Patients With Urethroplasty.
American journal of men's health.
2017 Sep; 11(5):1580-1587. doi:
10.1177/1557988317713634. [PMID: 28669278] - Sender Herschorn, Christopher R Chapple, Robert Snijder, Emad Siddiqui, Linda Cardozo. Could Reduced Fluid Intake Cause the Placebo Effect Seen in Overactive Bladder Clinical Trials? Analysis of a Large Solifenacin Integrated Database.
Urology.
2017 Aug; 106(?):55-59. doi:
10.1016/j.urology.2017.04.016. [PMID: 28435033] - Mohamed H Abdelhamid, Ahmed S Zayed, Waleed E Ghoneima, Akrm A Elmarakbi, Mohamed S El Sheemy, Ahmed Aref, Ahmed Abdelbary, Hani H Nour. Randomized, double-blind, placebo-controlled trial to compare solifenacin versus trospium chloride in the relief of double-J stent-related symptoms.
World journal of urology.
2017 Aug; 35(8):1261-1268. doi:
10.1007/s00345-016-1988-y. [PMID: 28050642] - Yang Yu, Jiang Jiang, Yi He, Wei Wang, Chen Shen, Bo Yang. Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway.
Molecular medicine reports.
2017 Aug; 16(2):1395-1400. doi:
10.3892/mmr.2017.6721. [PMID: 29067468] - Fannie Morin, Anne-Sophie Blais, Geneviève Nadeau, Katherine Moore, Lucie Genois, Stéphane Bolduc. Dual Therapy for Refractory Overactive Bladder in Children: A Prospective Open-Label Study.
The Journal of urology.
2017 04; 197(4):1158-1163. doi:
10.1016/j.juro.2016.11.101. [PMID: 27914999] - Okan Alkis, Ali Ersin Zumrutbas, Cihan Toktas, Hulya Aybek, Zafer Aybek. The use of biomarkers in the diagnosis and treatment of overactive bladder: Can we predict the patients who will be resistant to treatment?.
Neurourology and urodynamics.
2017 02; 36(2):390-393. doi:
10.1002/nau.22939. [PMID: 26661444] - Sheng-Mou Hsiao, Ting-Chen Chang, Chi-Hau Chen, Wen-Yih Wu, Ho-Hsiung Lin. Frequent nocturia episodes, a suboptimal response to treatment, and small bladder capacity predict the need for persistent antimuscarinic therapy or re-treatment after discontinuation of antimuscarinics in female overactive bladder.
Menopause (New York, N.Y.).
2017 01; 24(1):100-104. doi:
10.1097/gme.0000000000000730. [PMID: 27648660] - Noriaki Utsunomiya, Keiyu Matsumoto, Hiroyuki Tsunemori, Koei Muguruma, Mutsushi Kawakita, Yuki Kamiyama, Sojun Kanamaru, Noriyuki Ito, Hideki Tsukazaki, Toshiaki Shirahase, Takeshi Takahashi. [A Crossover Comparison Study on Lower Urinary Tract Symptoms with Overactive Bladder Secondary to Benign Prostatic Hyperplasia: Naftopidil versus Tamsulosin with Solifenacin].
Hinyokika kiyo. Acta urologica Japonica.
2016 Jul; 62(7):341-7. doi:
10.14989/actauroljap_62_7_341. [PMID: 27569351] - Robert Chan, Alvaro Munoz, Evan P Wenker, Melissa Whipple, Brian Miles, Timothy B Boone. Solifenacin and Tamsulosin Combination Therapy Decreases Urine Nerve Growth Factor/Creatinine Levels in Men.
Urology.
2016 05; 91(?):150-3. doi:
10.1016/j.urology.2016.01.020. [PMID: 26829718] - Krystal J Thomas-White, Evann E Hilt, Cynthia Fok, Meghan M Pearce, Elizabeth R Mueller, Stephanie Kliethermes, Kristin Jacobs, Michael J Zilliox, Cynthia Brincat, Travis K Price, Gina Kuffel, Paul Schreckenberger, Xiaowu Gai, Linda Brubaker, Alan J Wolfe. Incontinence medication response relates to the female urinary microbiota.
International urogynecology journal.
2016 May; 27(5):723-33. doi:
10.1007/s00192-015-2847-x. [PMID: 26423260] - Seyfettin Ciftci, Cuneyd Ozkurkcugil, Hasan Yilmaz, Murat Ustuner, Ufuk Yavuz, Mustafa Yuksekkaya, Mustafa Baki Cekmen. Urinary nerve growth factor and a variable solifenacin dosage in patients with an overactive bladder.
International urogynecology journal.
2016 Feb; 27(2):275-80. doi:
10.1007/s00192-015-2825-3. [PMID: 26310546] - Yoshihiko Ito, Michishi Kashiwabara, Akira Yoshida, Eriko Hikiyama, Satomi Onoue, Shizuo Yamada. Muscarinic Receptor Binding in Rat Bladder Urothelium and Detrusor Muscle by Intravesical Solifenacin.
Biological & pharmaceutical bulletin.
2016; 39(7):1167-71. doi:
10.1248/bpb.b16-00194. [PMID: 27374291] - Carlo Vecchioli Scaldazza, Carolina Morosetti. Comparison of Therapeutic Efficacy and Urodynamic Findings of Solifenacin Succinate versus Mirabegron in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Study.
Urologia internationalis.
2016; 97(3):325-329. doi:
10.1159/000445808. [PMID: 27092789] - Takahiro Maeda, Eiji Kikuchi, Masanori Hasegawa, Katsura Ishioka, Masayuki Hagiwara, Yasumasa Miyazaki, Toshiaki Shinojima, Akira Miyajima, Mototsugu Oya. Solifenacin or mirabegron could improve persistent overactive bladder symptoms after dutasteride treatment in patients with benign prostatic hyperplasia.
Urology.
2015 May; 85(5):1151-1155. doi:
10.1016/j.urology.2015.01.028. [PMID: 25770728] - Wei Huang, Huantao Zong, Xin Zhou, Yong Zhang. Efficacy and safety of imidafenacin for overactive bladder in adult: a systematic review and meta-analysis.
International urology and nephrology.
2015 Mar; 47(3):457-64. doi:
10.1007/s11255-015-0916-1. [PMID: 25636812] - A A Kamalov, E S Korshunova, G R Popov, L A Khodyreva, A A Dudareva, A N Nizov. [PROSPECTS FOR THE TREATMENT OF IDIOPATHIC AND NEUROGENIC OVERACTIVE BLADDER].
Urologiia (Moscow, Russia : 1999).
2015 Jan; ?(1):30-2, 34. doi:
NULL. [PMID: 26094383] - Karl-Erik Andersson. The use of pharmacotherapy for male patients with urgency and stress incontinence.
Current opinion in urology.
2014 Nov; 24(6):571-7. doi:
10.1097/mou.0000000000000106. [PMID: 25144147] - Kyungtae Ko, Dae Yul Yang, Won Ki Lee, Sae Woong Kim, Du Geon Moon, Ki Hak Moon, Nam Cheol Park, Jong Kwan Park, Hwan Cheol Son, Sung Won Lee, Jae Seog Hyun, Kwangsung Park. Effect of improvement in lower urinary tract symptoms on sexual function in men: tamsulosin monotherapy vs. combination therapy of tamsulosin and solifenacin.
Korean journal of urology.
2014 Sep; 55(9):608-14. doi:
10.4111/kju.2014.55.9.608. [PMID: 25237463] - Baoyan Liu, Yang Wang, Huanfang Xu, Yuelai Chen, Jiani Wu, Qian Mo, Zhishun Liu. Effect of electroacupuncture versus pelvic floor muscle training plus solifenacin for moderate and severe mixed urinary incontinence in women: a study protocol.
BMC complementary and alternative medicine.
2014 Aug; 14(?):301. doi:
10.1186/1472-6882-14-301. [PMID: 25128002] - Maximilian Burger, Dietmar Betz, Christian Hampel, Monika Vogel. Efficacy and tolerability of solifenacin in men with overactive bladder: results of an observational study.
World journal of urology.
2014 Aug; 32(4):1041-7. doi:
10.1007/s00345-013-1179-z. [PMID: 24135915] - Zhong-Wei Gao, Shi-Yong Xin, Jian-Guo Zhang, Xiao-Qiang Ren, Ya-Feng Shang, Wei Zhang, Hui-Bing Li, Fei Xiao, Chang-Shuai Shao. [Efficacy of combination therapy of tamsulosin and solifenacin for mild and moderate benign prostatic hyperplasia with overactive bladder].
Zhonghua nan ke xue = National journal of andrology.
2014 Mar; 20(3):239-43. doi:
NULL. [PMID: 24738461] - Yasin Aydoğmuş, Melih Sunay, Hüseyin Arslan, Arif Aydın, Ali Kudret Adiloğlu, Hünkar Şahin. Acupuncture versus solifenacin for treatment of overactive bladder and its correlation with urine nerve growth factor levels: a randomized, placebo-controlled clinical trial.
Urologia internationalis.
2014; 93(4):437-43. doi:
10.1159/000358202. [PMID: 25033919] - Shabana Nazarudheen, Surajit Dey, Kirti Kandhwal, Rachna Arora, Simrit Reyar, Arshad H Khuroo, Tausif Monif, Sumit Madan, Vinod Arora. Combining benefits of an adrenergic and a muscarinic blocker in a single formulation - a pharmacokinetic evaluation.
Regulatory toxicology and pharmacology : RTP.
2013 Nov; 67(2):226-31. doi:
10.1016/j.yrtph.2013.07.015. [PMID: 23933032] - Jae Hoon Chung, Joo Yong Lee, Dong Hyuk Kang, U-Syn Ha, Seung Hwan Lee, Won Sik Ham, Kang Su Cho, June Hyun Han, Jinsung Park, Tag Keun Yoo, Seung Wook Lee. Efficacy and safety of solifenacin to treat overactive bladder symptoms in patients with idiopathic normal pressure hydrocephalus: an open-label, multicenter, prospective study.
Neurourology and urodynamics.
2012 Sep; 31(7):1175-80. doi:
10.1002/nau.22234. [PMID: 22674356] - Kuniko Tsunoyama, Hideki Ishida, Tomokazu Shimizu, Kazuya Omoto, Kazunari Tanabe. Improvement of urinary dysfunction after kidney transplantation by administration of the antimuscarinic agent--prospective randomized controlled study.
Transplantation.
2012 Mar; 93(6):597-602. doi:
10.1097/tp.0b013e318244f799. [PMID: 22245877] - Hsin-Tzu Liu, Heng Lin, Hann-Chorng Kuo. Increased serum nerve growth factor levels in patients with overactive bladder syndrome refractory to antimuscarinic therapy.
Neurourology and urodynamics.
2011 Nov; 30(8):1525-9. doi:
10.1002/nau.21118. [PMID: 21826717] - Ernesto Callegari, Bimal Malhotra, Peter J Bungay, Rob Webster, Katherine S Fenner, Sarah Kempshall, Jennifer L LaPerle, Martin C Michel, Gary G Kay. A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
British journal of clinical pharmacology.
2011 Aug; 72(2):235-46. doi:
10.1111/j.1365-2125.2011.03961.x. [PMID: 21392072] - Stine Mjåvatn Jakobsen, Hege Kersten, Espen Molden. Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay.
Journal of the American Geriatrics Society.
2011 Mar; 59(3):501-5. doi:
10.1111/j.1532-5415.2010.03307.x. [PMID: 21391941] - Jan Macek, Pavel Ptáček, Josef Klíma. Determination of solifenacin in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Dec; 878(31):3327-30. doi:
10.1016/j.jchromb.2010.10.010. [PMID: 21071290] - Stéphane Bolduc, Katherine Moore, Geneviève Nadeau, Sylvie Lebel, Pascale Lamontagne, Micheline Hamel. Prospective open label study of solifenacin for overactive bladder in children.
The Journal of urology.
2010 Oct; 184(4 Suppl):1668-73. doi:
10.1016/j.juro.2010.03.124. [PMID: 20728124] - Jean-Jacques Wyndaele. Pediatrics: combining antimuscarinics shows promise for overactive bladder.
Nature reviews. Urology.
2010 Feb; 7(2):66-8. doi:
10.1038/nrurol.2010.1. [PMID: 20145662] - Naoya Masumori, Taiji Tsukamoto, Masahiro Yanase, Hiroki Horita, Masaharu Aoki. The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Advances in urology.
2010; ?(?):205251. doi:
10.1155/2010/205251. [PMID: 20981257] - Akiyoshi Ohtake, Shuichi Sato, Masao Sasamata, Keiji Miyata. The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgency episodes.
Journal of pharmacological sciences.
2010; 112(2):135-41. doi:
10.1254/jphs.09r13fm. [PMID: 20134114] - Francisco J Morales-Olivas, Luis Estañ. Solifenacin pharmacology.
Archivos espanoles de urologia.
2010 Jan; 63(1):43-52. doi:
NULL. [PMID: 20157218] - Yoshihiko Ito, Luvsandorj Oyunzul, Akira Yoshida, Tomomi Fujino, Yukiko Noguchi, Hironori Yuyama, Akiyoshi Ohtake, Masanori Suzuki, Masao Sasamata, Minoru Matsui, Shizuo Yamada. Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice.
European journal of pharmacology.
2009 Aug; 615(1-3):201-6. doi:
10.1016/j.ejphar.2009.04.068. [PMID: 19446545] - Oxana Doroshyenko, Uwe Fuhr. Clinical pharmacokinetics and pharmacodynamics of solifenacin.
Clinical pharmacokinetics.
2009; 48(5):281-302. doi:
10.2165/00003088-200948050-00001. [PMID: 19566112] - Hiren N Mistri, Arvind G Jangid, Ashutosh Pudage, Dhiraj M Rathod, Pranav S Shrivastav. Highly sensitive and rapid LC-ESI-MS/MS method for the simultaneous quantification of uroselective alpha1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Dec; 876(2):236-44. doi:
10.1016/j.jchromb.2008.10.050. [PMID: 19010093] - S Kh Al'-Shukri, I V Kuz'min. [Assessment of symptoms severity in patients with overactive bladder].
Urologiia (Moscow, Russia : 1999).
2008 Nov; ?(6):37-40. doi:
NULL. [PMID: 19248597] - Yao-Chi Chuang, Catherine A Thomas, Shachi Tyagi, Naoki Yoshimura, Pradeep Tyagi, Michael B Chancellor. Human urine with solifenacin intake but not tolterodine or darifenacin intake blocks detrusor overactivity.
International urogynecology journal and pelvic floor dysfunction.
2008 Oct; 19(10):1353-7. doi:
10.1007/s00192-008-0650-7. [PMID: 18504514] - Takamitsu Yanagihara, Toshiko Aoki, Yoshiaki Soeishi, Takafumi Iwatsubo, Hidetaka Kamimura. Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Nov; 859(2):241-5. doi:
10.1016/j.jchromb.2007.10.005. [PMID: 17977808] - S Kh Al-Shukri, I V Kuz'min. [Solifenacin in the treatment of patients with hyperactive urinary bladder].
Urologiia (Moscow, Russia : 1999).
2007 May; ?(3):19-21. doi:
NULL. [PMID: 17722615] - Mirjam Kuipers, Ronald Smulders, Walter Krauwinkel, Timothy Hoon. Open-label study of the safety and pharmacokinetics of solifenacin in subjects with hepatic impairment.
Journal of pharmacological sciences.
2006 Dec; 102(4):405-12. doi:
10.1254/jphs.fp0060311. [PMID: 17170513] - Alan D Garely, Joel M Kaufman, Peter K Sand, Neila Smith, Masakazu Andoh. Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: the VESIcare Open-Label Trial (VOLT).
Clinical therapeutics.
2006 Nov; 28(11):1935-46. doi:
10.1016/j.clinthera.2006.11.010. [PMID: 17213014] - Pieter J Swart, Walter J J Krauwinkel, Ronald A Smulders, Neila N Smith. Pharmacokinetic effect of ketoconazole on solifenacin in healthy volunteers.
Basic & clinical pharmacology & toxicology.
2006 Jul; 99(1):33-6. doi:
10.1111/j.1742-7843.2006.pto_285.x. [PMID: 16867168] - W J J Krauwinkel, R A Smulders, H Mulder, P J Swart, M E J Taekema-Roelvink. Effect of age on the pharmacokinetics of solifenacin in men and women.
International journal of clinical pharmacology and therapeutics.
2005 May; 43(5):227-38. doi:
10.5414/cpp43227. [PMID: 15906588] - Tomomi Oki, Shuichi Sato, Keiji Miyata, Shizuo Yamada. Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice.
British journal of pharmacology.
2005 May; 145(2):219-27. doi:
10.1038/sj.bjp.0706184. [PMID: 15753946] - Ronald A Smulders, Walter J Krauwinkel, Pieter J Swart, Moses Huang. Pharmacokinetics and safety of solifenacin succinate in healthy young men.
Journal of clinical pharmacology.
2004 Sep; 44(9):1023-33. doi:
10.1177/0091270004267592. [PMID: 15317830] - Mirjam E Kuipers, Walter J J Krauwinkel, Hans Mulder, Nico Visser. Solifenacin demonstrates high absolute bioavailability in healthy men.
Drugs in R&D.
2004; 5(2):73-81. doi:
10.2165/00126839-200405020-00002. [PMID: 15293866]