chlormadinon (BioDeep_00000720643)
代谢物信息卡片
Chlormadinone
化学式: C21H27ClO3 (362.1648622)
中文名称: 氯丁酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)CCC34C)Cl)C)O
InChI: InChI=1S/C21H27ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,14-16,25H,4-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DB - Pregnadien derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000726 - Androgen Antagonists
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D07670
- PubChem: 5284533
- DrugBank: DB13528
- ChEMBL: CHEMBL1697830
- MeSH: Chlormadinone Acetate
- CAS: 1961-77-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Giuseppe Morgante, Valentina Cappelli, Libera Troìa, Vincenzo De Leo. Evaluation of different antiandrogenic progestins on clinical and biochemical variables in polycystic ovary syndrome.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2020 Jun; 25(3):176-181. doi:
10.1080/13625187.2020.1736546. [PMID: 32191532] - A Podfigurna, B Meczekalski, F Petraglia, S Luisi. Clinical, hormonal and metabolic parameters in women with PCOS with different combined oral contraceptives (containing chlormadinone acetate versus drospirenone).
Journal of endocrinological investigation.
2020 Apr; 43(4):483-492. doi:
10.1007/s40618-019-01133-3. [PMID: 31654312] - Juana Serret-Montoya, Miguel A Villasís-Keever, Alejandra Aguilar-Kitsu, Iliana Del Moral-Estrada, Abigail Hernandez-Cabezza, Jessie N Zurita-Cruz. [Experiencia en el tratamiento de la hemorragia uterina anormal en adolescentes con enfermedad renal crónica].
Boletin medico del Hospital Infantil de Mexico.
2018; 75(5):295-302. doi:
10.24875/bmhim.18000006. [PMID: 30250312] - Yasuhiro Shibata, Seiji Arai, Yoshiyuki Miyazawa, Takahiro Shuto, Masashi Nomura, Yoshitaka Sekine, Hidekazu Koike, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki. Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content.
The Prostate.
2017 May; 77(6):672-680. doi:
10.1002/pros.23315. [PMID: 28145028] - Giovanni Grandi, Antonella Napolitano, Anjeza Xholli, Alessandra Tirelli, Costantino Di Carlo, Angelo Cagnacci. Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2015 Oct; 31(10):774-8. doi:
10.3109/09513590.2015.1063118. [PMID: 26291811] - Recep Yildizhan, Anik Ilhan Gokce, Begum Yildizhan, Numan Cim. Comparison of the effects of chlormadinone acetate versus drospirenone containing oral contraceptives on metabolic and hormonal parameters in women with PCOS for a period of two-year follow-up.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2015 May; 31(5):396-400. doi:
10.3109/09513590.2015.1006187. [PMID: 25739031] - Giovanni Grandi, Ilaria Piacenti, Annibale Volpe, Angelo Cagnacci. Modification of body composition and metabolism during oral contraceptives containing non-androgenic progestins in association with estradiol or ethinyl estradiol.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2014 Sep; 30(9):676-80. doi:
10.3109/09513590.2014.922947. [PMID: 24918262] - Kazuhiro Matsumoto, Masayuki Hagiwara, Nozomi Hayakawa, Nobuyuki Tanaka, Yujiro Ito, Takahiro Maeda, Akiharu Ninomiya, Hirohiko Nagata, So Nakamura. Third-line hormonal therapy to treat prostate cancer relapse after initial and second-line hormonal therapy: report of 52 cases and literature review.
Asian Pacific journal of cancer prevention : APJCP.
2014; 15(8):3645-9. doi:
10.7314/apjcp.2014.15.8.3645. [PMID: 24870772] - Valéria A Gomes, Carolina S Vieira, Anna L Jacob-Ferreira, Vanessa A Belo, Gustavo M Soares, Janaína B França, Rui A Ferriani, Jose E Tanus-Santos. Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome.
Basic & clinical pharmacology & toxicology.
2012 Sep; 111(3):211-6. doi:
10.1111/j.1742-7843.2012.00895.x. [PMID: 22510229] - Kiyohide Fujimoto, Yoshihiko Hirao, Yasuo Ohashi, Yasuhiro Shibata, Kohzo Fuji, Hidenori Tsuji, Nobutaka Shimizu, Katsuhito Miyazawa, Masao Nagata, Nikinobu Ohtani, Ryoji Furuya, Eitetsu Boku. [Changes in serum prostate specific antigen and testosterone levels after chlormadinone acetate treatment in patients with benign prostatic hyperplasia : a prospective multicenter clinical study].
Hinyokika kiyo. Acta urologica Japonica.
2011 Apr; 57(4):177-83. doi:
NULL. [PMID: 21646847] - Vincenzo De Leo, Alessandra Di Sabatino, Maria C Musacchio, Giuseppe Morgante, Valeria Scolaro, Antonio Cianci, Felice Petraglia. Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome.
Contraception.
2010 Sep; 82(3):276-80. doi:
10.1016/j.contraception.2010.04.002. [PMID: 20705157] - Maurizio Guido, Daniela Romualdi, Giuseppe Campagna, Luigi Ricciardi, Alessandro Bompiani, Antonio Lanzone. Ethinylestradiol-chlormadinone acetate combination for the treatment of hirsutism and hormonal alterations of normal-weight women with polycystic ovary syndrome: evaluation of the metabolic impact.
Reproductive sciences (Thousand Oaks, Calif.).
2010 Aug; 17(8):767-75. doi:
10.1177/1933719110371515. [PMID: 20595709] - Ulrich H Winkler, Petra Röhm, Kornelia Höschen. An open-label, comparative study of the effects of a dose-reduced oral contraceptive containing 0.02 mg ethinylestradiol/2 mg chlormadinone acetate on hemostatic parameters and lipid and carbohydrate metabolism variables.
Contraception.
2010 May; 81(5):391-400. doi:
10.1016/j.contraception.2009.12.005. [PMID: 20399945] - Salvatore Caruso, Salvatore Rugolo, Carmela Agnello, Mattea Romano, Antonio Cianci. Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate.
The journal of sexual medicine.
2009 Dec; 6(12):3376-84. doi:
10.1111/j.1743-6109.2009.01529.x. [PMID: 19832931] - Angelo Cagnacci, Serena Ferrari, Alessandra Tirelli, Renata Zanin, Annibale Volpe. Insulin sensitivity and lipid metabolism with oral contraceptives containing chlormadinone acetate or desogestrel: a randomized trial.
Contraception.
2009 Feb; 79(2):111-6. doi:
10.1016/j.contraception.2008.09.002. [PMID: 19135567] - Roberto Uras, Marisa Orrù, Rossella Etzi, Giangavino Peppi, Maria Francesca Marotto, Monica Pilloni, Pierina Zedda, Stefano Lello, Gian Benedetto Melis, Anna Maria Paoletti. Evidence that in healthy young women, a six-cycle treatment with oral contraceptive containing 30 mcg of ethinylestradiol plus 2 mg of chlormadinone acetate reduces fat mass.
Contraception.
2009 Feb; 79(2):117-21. doi:
10.1016/j.contraception.2008.08.007. [PMID: 19135568] - Ulrich H Winkler, Roland Sudik. The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters.
Contraception.
2009 Jan; 79(1):15-23. doi:
10.1016/j.contraception.2008.08.011. [PMID: 19041436] - Michael Bonn, Urte Eydeler, Martin Barkworth, Lucio C Rovati. Bioequivalence study of generic tablet formulations containing ethinylestradiol and chlormadinone acetate in healthy female volunteers.
Arzneimittel-Forschung.
2009; 59(12):651-8. doi:
10.1055/s-0031-1296455. [PMID: 20108652] - Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal. Possible modulating action of plant infusion of Ocimum sanctum L. on chromosomal aberrations and sister chromatid exchanges induced by chlormadinone acetate in human lymphocytes in vitro.
Journal of environmental biology.
2008 Nov; 29(6):845-8. doi:
". [PMID: 19297977] - Akira Iwase, Hisao Ando, Shigeru Toda, Shino Ishimatsu, Toko Harata, Shozo Kurotsuchi, Yuji Shimomura, Maki Goto, Fumitaka Kikkawa. Oral progestogen versus intramuscular progesterone for luteal support after assisted reproductive technology treatment: a prospective randomized study.
Archives of gynecology and obstetrics.
2008 Apr; 277(4):319-24. doi:
10.1007/s00404-007-0484-4. [PMID: 17938943] - Martina Kerscher, Tilmann Reuther, Julia Bayrhammer, Georg Schramm. Effects of an oral contraceptive containing chlormadinone and ethinylestradiol on acne-prone skin of women of different age groups: an open-label, single-centre, phase IV study.
Clinical drug investigation.
2008; 28(11):703-11. doi:
10.2165/00044011-200828110-00004. [PMID: 18840013] - Sarah Kelly Mortensen, Mikael Pedersen. Confirmatory analysis of acetylgestagens in plasma using liquid chromatography-tandem mass spectrometry.
Analytica chimica acta.
2007 Mar; 586(1-2):217-22. doi:
10.1016/j.aca.2006.10.016. [PMID: 17386714] - Madis Lõhmus, Tiia Kender. Determination of gestagens in kidney fat by liquid chromatography tandem mass spectrometry.
Analytica chimica acta.
2007 Mar; 586(1-2):233-8. doi:
10.1016/j.aca.2006.10.052. [PMID: 17386717] - Nobuyuki Goya, Kotaro Gotanda, Takako Sasaki, Mami Okada, Yasuko Tomizawa, Hiroshi Toma. Local injection of a sustained-release antiandrogen formulation into a target prostatic site: an experimental study.
BJU international.
2007 Jan; 99(1):202-6. doi:
10.1111/j.1464-410x.2006.06440.x. [PMID: 17092292] - Rolf Terlinden, Heinz Uragg, Karin Göhler, Christa Kneip. Pharmacokinetics of chlormadinone acetate following single and multiple oral dosing of chlormadinone acetate (2 mg) and ethinylestradiol (0.03 mg) and elimination and clearance of a single dose of radiolabeled chlormadinone acetate.
Contraception.
2006 Sep; 74(3):239-44. doi:
10.1016/j.contraception.2006.03.011. [PMID: 16904418] - Kouichi Minato, Seijirou Honma, Yoshihiko Shinohara, Takao Hashimoto. Metabolism of osaterone acetate in dogs and humans.
Steroids.
2005 Aug; 70(9):563-72. doi:
10.1016/j.steroids.2005.03.012. [PMID: 15923016] - Tatsuya Hori, Kazuyo Mukai, Kaoru Komoriya, Noriko Shimizu, Masanori Murakoshi, Eiichi Kawakami, Toshihiko Tsutsui. Fertility of bitches in which estrus was prevented with implantations of chlormadinone acetate for four years.
The Journal of veterinary medical science.
2005 Feb; 67(2):151-6. doi:
10.1292/jvms.67.151. [PMID: 15750310] - P Bouchard. Chlormadinone acetate (CMA) in oral contraception--a new opportunity.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2005; 10 Suppl 1(?):7-11. doi:
10.1080/13625180500434889. [PMID: 16356876] - Margit Fröhlich, Nadine Albermann, Alexandra Sauer, Ingeborg Walter-Sack, Walter E Haefeli, Johanna Weiss. In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins.
Biochemical pharmacology.
2004 Dec; 68(12):2409-16. doi:
10.1016/j.bcp.2004.08.026. [PMID: 15548387] - M Alhenc-Gelas, G Plu-Bureau, S Guillonneau, J-M Kirzin, M Aiach, N Ochat, P-Y Scarabin. Impact of progestagens on activated protein C (APC) resistance among users of oral contraceptives.
Journal of thrombosis and haemostasis : JTH.
2004 Sep; 2(9):1594-600. doi:
10.1111/j.1538-7836.2004.00894.x. [PMID: 15333036] - Yukio Homma, Hideyuki Akaza, Kiyoki Okada, Masao Yokoyama, Nobuo Moriyama, Michiyuki Usami, Yoshihiko Hirao, Tomoyasu Tsushima, Atsuhiko Sakamoto, Yasuo Ohashi, Yoshio Aso. Radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation: Five-year results.
International journal of urology : official journal of the Japanese Urological Association.
2004 May; 11(5):295-303. doi:
10.1111/j.1442-2042.2004.00795.x. [PMID: 15147545] - Didier Chassard, Pascale Legallicier, Michel Dib. [The relative pharmacokinetics of two oral formulations of chlormadinone acetate: Lutéran 5mg. and Lutéran tablet 10 mg].
Therapie.
2003 Mar; 58(2):127-31. doi:
10.2515/therapie:2003018. [PMID: 12942852] - D Meisl, M Hubler, S Arnold. [Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with the progesterone antagonist Aglépristone (Alizine)].
Schweizer Archiv fur Tierheilkunde.
2003 Mar; 145(3):130-6. doi:
10.1024/0036-7281.145.3.130. [PMID: 12677773] - H Seeger, D Wallwiener, A O Mueck. The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 Feb; 35(2):76-80. doi:
10.1055/s-2003-39061. [PMID: 12734785] - H Akaza, Y Homma, K Okada, M Yokoyama, M Usami, Y Hirao, T Tsushima, Y Ohashi, Y Aso. A prospective and randomized study of primary hormonal therapy for patients with localized or locally advanced prostate cancer unsuitable for radical prostatectomy: results of the 5-year follow-up.
BJU international.
2003 Jan; 91(1):33-6. doi:
10.1046/j.1464-410x.2003.04014.x. [PMID: 12614246] - Yuzo Furuya, Osamu Nagakawa, Hideki Fuse. Prognostic significance of changes in short-term prostate volume and serum prostate-specific antigen after androgen withdrawal in men with metastatic prostate cancer.
Urologia internationalis.
2003; 70(3):195-9. doi:
10.1159/000068769. [PMID: 12660456] - K Gotanda, A Shinbo, M Okada, Y Nakano, H Kobayashi, T Sasaki, M Hagiwara, H Akaza. Effects of combination therapy with a luteinizing hormone-releasing hormone agonist and chlormadinone acetate on rat prostate weight and plasma testosterone levels.
Prostate cancer and prostatic diseases.
2003; 6(1):66-72. doi:
10.1038/sj.pcan.4500617. [PMID: 12664069] - Jean Fiet, Frank Giton, Jack Auzerie, Hervé Galons. Development of a new sensitive and specific time-resolved fluoroimmunoassay (TR-FIA) of chlormadinone acetate in the serum of treated menopausal women.
Steroids.
2002 Dec; 67(13-14):1045-55. doi:
10.1016/s0039-128x(02)00050-8. [PMID: 12441190] - Isao Kiriyama, Kenji Ogaki, Shuji Ohba, Taiji Nishimura. Neoadjuvant hormonal therapy prior to radical prostatectomy: evaluation of pathological downstaging and biochemical relapse.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2002 Oct; 69(5):422-7. doi:
10.1272/jnms.69.422. [PMID: 12382001] - Sebastián Carranza-Lira, Norma Regina Magaña-Padilla. [Ultrasonographic and lipid changes in polycystic ovary syndrome according to the type of treatment ].
Ginecologia y obstetricia de Mexico.
2002 Jun; 70(?):285-8. doi:
". [PMID: 12148471] - Kouichi Minato, Naoyuki Koizumi, Seijirou Honma, Kunio Tsukamoto, Satoshi Iwamura. Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Feb; 30(2):167-72. doi:
10.1124/dmd.30.2.167. [PMID: 11792686] - Yuzo Furuya, Tetsuo Nozaki, Osamu Nagakawa, Hideki Fuse. Low serum testosterone level predicts worse response to endocrine therapy in Japanese patients with metastatic prostate cancer.
Endocrine journal.
2002 Feb; 49(1):85-90. doi:
10.1507/endocrj.49.85. [PMID: 12008754] - C Pélissier, M Maroni, H Yaneva, S Brin, F Peltier-Pujol, M Jondet. Chlormadinone acetate versus micronized progesterone in the sequential combined hormone replacement therapy of the menopause.
Maturitas.
2001 Oct; 40(1):85-94. doi:
10.1016/s0378-5122(01)00170-0. [PMID: 11684377] - K Lange, E K Cordes, H O Hoppen, A R Günzel-Apel. Determination of concentrations of sex steroids in blood plasma and semen of male dogs treated with delmadinone acetate or finasteride.
Journal of reproduction and fertility. Supplement.
2001; 57(?):83-91. doi:
NULL. [PMID: 11787194] - K Ito, Y Fukabori, Y Shibata, K Suzuki, M Mieda, K Gotanda, S Honma, H Yamanaka. Effects of a new steroidal aromatase inhibitor, TZA-2237, and/or chlormadinone acetate on hormone-induced and spontaneous canine benign prostatic hyperplasia.
European journal of endocrinology.
2000 Oct; 143(4):543-54. doi:
10.1530/eje.0.1430543. [PMID: 11022202] - S Ozono, E Okajima, A Yamaguchi, M Yoshikawa, A Iwai, A Moriya, K Yoshida, S Samma, Y Maruyama, Y Hirao. A prospective randomized multicenter study of chlormadinone acetate versus flutamide in total androgen blockade for prostate cancer.
Japanese journal of clinical oncology.
2000 Sep; 30(9):389-96. doi:
10.1093/jjco/hyd106. [PMID: 11095136] - K Noguchi, H Uemura, M Takeda, Y Sekiguchi, K Ogawa, M Hosaka. [Rebound of prostate specific antigen after discontinuation of antiandrogen therapy for benign prostatic hyperplasia].
Hinyokika kiyo. Acta urologica Japonica.
2000 Sep; 46(9):605-7. doi:
NULL. [PMID: 11107528] - H Ohuchi, K Noguchi, Y Kinoshita, M Hosaka, C Kawasaki, T Miura, I Kondo, M Harada. Inhibition of disease flare with diethylstilbestrol diphosphate and chlormadinone acetate administration for two weeks prior to slow-releasing leuprolide acetate in prostatic cancer patients.
Hinyokika kiyo. Acta urologica Japonica.
2000 Aug; 46(8):531-6. doi:
. [PMID: 11019371] - H Akaza, Y Homma, K Okada, M Yokoyama, N Moriyama, M Usami, Y Hirao, T Tsushima, Y Ohashi, Y Aso. Early results of LH-RH agonist treatment with or without chlormadinone acetate for hormone therapy of naive localized or locally advanced prostate cancer: a prospective and randomized study. The Prostate Cancer Study Group.
Japanese journal of clinical oncology.
2000 Mar; 30(3):131-6. doi:
10.1093/jjco/hyd035. [PMID: 10798540] - N Sato, T Kotake, M Masai, S Sakai, H Ito. [Preventive effect of chlormadinone acetate on flare-up phenomenon in advanced prostate cancer administered with a luteinizing hormone-releasing hormone analogue].
Hinyokika kiyo. Acta urologica Japonica.
2000 Jan; 46(1):1-7. doi:
NULL. [PMID: 10723656] - S Kitahara, H Umeda, M Yano, F Koga, S Sumi, H Moriguchi, Y Hosoya, M Honda, K Yoshida. Effects of intravenous administration of high dose-diethylstilbestrol diphosphate on serum hormonal levels in patients with hormone-refractory prostate cancer.
Endocrine journal.
1999 Oct; 46(5):659-64. doi:
10.1507/endocrj.46.659. [PMID: 10670751] - K Minato, N Koizumi, S Honma, S Iwamura, K Tsukamoto. Characterizations of mouse hepatic microsomal monooxygenase catalyzing 11beta-hydroxylation of osaterone acetate.
Biochemical pharmacology.
1999 Jul; 58(2):335-41. doi:
10.1016/s0006-2952(99)00098-2. [PMID: 10423176] - Y Homma, H Akaza, K Okada, M Yokoyama, N Moriyama, M Usami, Y Hirao, T Tsushima, A Sakamoto, Y Ohashi, Y Aso. Early results of radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation. The Prostate Cancer Study Group.
International journal of urology : official journal of the Japanese Urological Association.
1999 May; 6(5):229-37; discussion 238. doi:
10.1046/j.1442-2042.1999.00050.x. [PMID: 10375185] - A Yamamoto, Y Sumiyoshi, N Miyake, H Yokozeki, H Kanayama, S Kagawa. Prevention of the initial testosterone surge induced by a luteinizing hormone-releasing hormone analogue in prostate cancer patients: the endocrinological effects of pretreatment with chlormadinone acetate.
The journal of medical investigation : JMI.
1999 Feb; 46(1-2):55-8. doi:
NULL. [PMID: 10408158] - H Inano, K Suzuki, M Onoda, H Kobayashi, K Wakabayashi. Comparative effect of chlormadinone acetate and diethylstilbestrol as promoters in mammary tumorigenesis of rats irradiated with gamma-rays during lactation.
Breast cancer research and treatment.
1999 Jan; 53(2):153-60. doi:
10.1023/a:1006149608475. [PMID: 10326792] - E Fonseca, R Ochoa, R Galván, M Hernández, M Mercado, A Zárate. Increased serum levels of growth hormone and insulin-like growth factor-I associated with simultaneous decrease of circulating insulin in postmenopausal women receiving hormone replacement therapy.
Menopause (New York, N.Y.).
1999; 6(1):56-60. doi:
NULL. [PMID: 10100181] - M Murakoshi, S Masuda, R Ikeda, M Tagawa, T Nakayama, S Honma, M Mieda. Ultrastructural study in canine prostatic hyperplasia--effect of antiandrogen.
The Tokai journal of experimental and clinical medicine.
1998 Nov; 23(5):245-8. doi:
NULL. [PMID: 10418729] - F Schwarzenberger, C Walzer, K Tomasova, J Vahala, J Meister, K L Goodrowe, J Zima, G Strauss, M Lynch. Faecal progesterone metabolite analysis for non-invasive monitoring of reproductive function in the white rhinoceros (Ceratotherium simum).
Animal reproduction science.
1998 Oct; 53(1-4):173-90. doi:
10.1016/s0378-4320(98)00112-2. [PMID: 9835375] - E A Court, A D Watson, D B Church, D R Emslie. Effects of delmadinone acetate on pituitary-adrenal function, glucose tolerance and growth hormone in male dogs.
Australian veterinary journal.
1998 Aug; 76(8):555-60. doi:
10.1111/j.1751-0813.1998.tb10216.x. [PMID: 9741725] - S Akimoto, H Inomiya, Y Furuya, K Akakura, H Ito. Prognostic value of the serum levels of bone formation and bone resorption markers in prostate cancer patients with bone metastasis.
European urology.
1998 Aug; 34(2):142-7. doi:
10.1159/000019700. [PMID: 9693250] - K Akakura, Y Furuya, H Ito. [Steroidal and nonsteroidal antiandrogens: chemical structures, mechanisms of action and clinical applications].
Nihon rinsho. Japanese journal of clinical medicine.
1998 Aug; 56(8):2124-8. doi:
NULL. [PMID: 9750520] - A Yamamoto, Y Sumiyoshi, N Miyake, H Yokozeki, H Kanayama, S Kagawa. [Pretreatment with chlormadinone acetate in prostate cancer patients treated with a luteinizing hormone-releasing hormone analogue].
Hinyokika kiyo. Acta urologica Japonica.
1998 Aug; 44(8):557-63. doi:
NULL. [PMID: 9783191] - M Shimada, H Uchida, T Kasahara, K Fuji, Y Ogawa, H Yoshida, T Hamajima, N Matsuda, T Ikeuchi, Y Kai, M Hiramori, M Hoshino, K Inoue, Y Higaki. [Clinical study on chlormadinone acetate alone followed by combination with LH-RH analogue for prostatic cancer: effects on lipid metabolism].
Hinyokika kiyo. Acta urologica Japonica.
1998 Jul; 44(7):525-32. doi:
". [PMID: 9752613] - E Kawakami, M Shimizu, H Orima, M Fujita, T Hori, T Tsutsui. Chlormadinone acetate pellet implantation plus short-term oral administration in dogs with benign prostatic hypertrophy.
International journal of andrology.
1998 Apr; 21(2):67-73. doi:
10.1046/j.1365-2605.1998.00097.x. [PMID: 9675615] - Y Miyoshi, Y Inoue, J Matsuzaki, M Fukuda, Y Satomi, H Akahane, S Saito. [A case of poorly differentiated adenocarcinoma of prostate with neuroendocrine differentiation].
Hinyokika kiyo. Acta urologica Japonica.
1998 Feb; 44(2):113-6. doi:
NULL. [PMID: 9546133] - Y Furuya, S Akimoto, K Akakura, T Igarashi, S Murakami, J Shimazaki, H Ito. Response of prostate-specific antigen after androgen withdrawal and prognosis in men with metastatic prostate cancer.
Urologia internationalis.
1998; 60(1):28-32. doi:
10.1159/000030199. [PMID: 9519418] - K Akakura, S Akimoto, Y Furuya, H Ito. Incidence and characteristics of antiandrogen withdrawal syndrome in prostate cancer after treatment with chlormadinone acetate.
European urology.
1998; 33(6):567-71. doi:
10.1159/000019657. [PMID: 9743699] - S Nakata, M Hasumi, J Sato, A Ogawa, H Yamanaka. [Prostate cancer associated with long-term intake of patent medicine containing methyltestosterone: a case report].
Hinyokika kiyo. Acta urologica Japonica.
1997 Nov; 43(11):791-3. doi:
. [PMID: 9436023] - M Molnárová, B Pástorová. [Changes in ovarian activity after superovulation treatment in sheep].
Veterinarni medicina.
1997 Nov; 42(11):319-26. doi:
NULL. [PMID: 9471823] - H Fuse, S Fukumoto, H Sone, Y Miyata, T Saito, K Nakayama, H Takahashi, T Matsumoto, E Ogata. A new synthetic steroid, osaterone acetate (TZP-4238), increases cortical bone mass and strength by enhancing bone formation in ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1997 Apr; 12(4):590-7. doi:
10.1359/jbmr.1997.12.4.590. [PMID: 9101370] - R Recio, C Hernández-Morales, R M Pérez-Rodríguez, S Bassol. Effects of low steroid doses administered in the mid and late follicular phase on the LH surge, ovarian steroids and follicular maturation in eumenorrheic women.
Advances in contraception : the official journal of the Society for the Advancement of Contraception.
1997 Mar; 13(1):39-46. doi:
10.1023/a:1006564328077. [PMID: 9181183] - S Sumi, H Umeda, M Yano, F Koga, K Arai, T Imai, Y Hosoya, S Maeda, M Honda, T Suzuki, K Yoshida. [Studies on changes in the ratio of free to total PSA after endocrine treatment of prostate carcinoma].
Hinyokika kiyo. Acta urologica Japonica.
1996 Dec; 42(12):937-41. doi:
NULL. [PMID: 9013228] - G Göretzlehner, S Nikschick, T Zimmermann. [Effect of estradiol valerate and chlormadinone acetate in hormone replacement therapy in postmenopause on Kupperman index, body weight, blood pressure, lipids, enzymes and electrolytes].
Zentralblatt fur Gynakologie.
1996; 118(7):420-5. doi:
NULL. [PMID: 8766107] - E Kawakami, T Tsutsui, M Shimizu, H Orima, M Fujita, A Ogasa. Comparison of the effects of chlormadinone acetate-pellet implantation and orchidectomy on benign prostatic hypertrophy in the dog.
International journal of andrology.
1995 Oct; 18(5):248-55. doi:
10.1111/ijan.1995.18.5.248. [PMID: 8567095] - N Sekido, K Kawai, H Akaza, K Koiso. Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.
Japanese journal of clinical oncology.
1995 Aug; 25(4):164-7. doi:
10.1093/oxfordjournals.jjco.a039769. [PMID: 7545251] - Y Kageyama, S Kitahara, T Tsukamoto, T Tsujii, S Goto, H Oshima. Chlormadinone acetate as a possible effective agent for congenital adrenal hyperplasia to suppress elevated ACTH and antagonize masculinization.
Endocrine journal.
1995 Aug; 42(4):505-8. doi:
10.1507/endocrj.42.505. [PMID: 8556057] - O Maeda, N Meguro, S Saiki, T Kinouchi, M Kuroda, M Usami, T Kotake. Preoperative endocrine therapy in patients with locally advanced prostate cancer.
Japanese journal of clinical oncology.
1995 Aug; 25(4):135-9. doi:
10.1093/oxfordjournals.jjco.a039765. [PMID: 7545250] - S Honma, Y Takezawa, H Yamanaka. [The effects of antiandrogen TZP-4238 on plasma testosterone and LH and steroidogenesis in rat and canine testis].
Nihon Naibunpi Gakkai zasshi.
1995 Jul; 71(5):679-94. doi:
10.1507/endocrine1927.71.5_679. [PMID: 7556779] - M Shimizu, T Tsutsui, E Kawakami, T Hori, M Fujita, H Orima, A Ogasa. Effect of chlormadinone acetate-pellet implantation on the volume of prostate, peripheral blood levels of sex hormones and semen quality in the dog.
The Journal of veterinary medical science.
1995 Jun; 57(3):395-9. doi:
10.1292/jvms.57.395. [PMID: 7548388] - K Akakura, S Akimoto, T Ohki, J Shimazaki. Antiandrogen withdrawal syndrome in prostate cancer after treatment with steroidal antiandrogen chlormadinone acetate.
Urology.
1995 Apr; 45(4):700-4; discussion 704. doi:
10.1016/s0090-4295(99)80070-3. [PMID: 7536369] - H Orima, M Shimizu, T Tsutsui, E Kawakami, A Ogasa. Short-term oral treatment of canine benign prostatic hypertrophy with chlormadinone acetate.
The Journal of veterinary medical science.
1995 Feb; 57(1):139-41. doi:
10.1292/jvms.57.139. [PMID: 7538794] - K Yoshida, S Takeuchi. Pretreatment with chlormadinone acetate eliminates testosterone surge induced by a luteinizing-hormone-releasing hormone analogue and the risk of disease flare in patients with metastatic carcinoma of the prostate.
European urology.
1995; 27(3):187-91. doi:
10.1159/000475158. [PMID: 7541358] - J Rosén, K E Hellenäs, P Törnqvist, P Shearan. Automated extraction of acetylgestagens from kidney fat by matrix solid phase dispersion.
The Analyst.
1994 Dec; 119(12):2635-7. doi:
10.1039/an9941902635. [PMID: 7533481] - S Honma, K Suzuki, Y Takezawa, K Minato, Y Fukabori, H Yamanaka. [Effects of antiandrogen TZP-4238 on the prostatic androgen receptor and prostatic androgen in rat].
Nihon Naibunpi Gakkai zasshi.
1994 Oct; 70(8):925-40. doi:
10.1507/endocrine1927.70.8_925. [PMID: 7528148] - Y Ohta, K Minato, T Hoshino, N Hirabayashi, S Honma. [The effect of antiandrogen TZP-4238 on corticosteroid hormone in the dog].
Nihon Naibunpi Gakkai zasshi.
1994 Oct; 70(8):913-24. doi:
10.1507/endocrine1927.70.8_913. [PMID: 7528147] - M Mieda, Y Ohta, T Saito, H Takahashi, E Shimazawa, K Miyasaka. Antiandrogenic activity and endocrinological profile of a novel antiandrogen, TZP-4238, in the rat.
Endocrine journal.
1994 Aug; 41(4):445-52. doi:
10.1507/endocrj.41.445. [PMID: 8528361] - T Nakatani, R Yasumoto, S Wada, T Maekawa, N Nishisaka, K Yamamoto, T Kishimoto. [The effect of TZP-4238, an anti-androgen drug, on renal function].
Hinyokika kiyo. Acta urologica Japonica.
1994 Aug; 40(8):735-43. doi:
NULL. [PMID: 7524290] - K Sahara, M Murakoshi, T Nishina, H Kino, T Tsutsui. Pathologic changes related to subcutaneous implantation of chlormadinone acetate for preventing estrus in bitches.
The Journal of veterinary medical science.
1994 Apr; 56(2):425-7. doi:
10.1292/jvms.56.425. [PMID: 7521219] - H Iguchi, T Ikeuchi, Y Kai, H Yoshida. [Influence of anti-androgen therapy for prostatic hypertrophy on lipid metabolism].
Hinyokika kiyo. Acta urologica Japonica.
1994 Mar; 40(3):215-9. doi:
NULL. [PMID: 7513937] - C Pelissier, C Blacker, M C Feinstein, A Cournot, C Denis. [Antiovulatory action of chlormadinone acetate].
Contraception, fertilite, sexualite.
1994 Jan; 22(1):37-40. doi:
NULL. [PMID: 12287767] - C Pelissier, C Blacker, M C Feinstein, A Cournot, C Denis. [Antiovulatory action of chlormadinone acetate].
Contraception, fertilite, sexualite (1992).
1994 Jan; 22(1):37-40. doi:
NULL. [PMID: 7511024] - J Słowińska-Srzednicka, S Zgliczyński, E Chotkowska, M Srzednicki, U Stopińska-Głuszak, W Jeske, A Brzezińska, W Zgliczyński, Z Sadowski. Effects of transdermal 17 beta-oestradiol combined with oral progestogen on lipids and lipoproteins in hypercholesterolaemic postmenopausal women.
Journal of internal medicine.
1993 Nov; 234(5):447-51. doi:
10.1111/j.1365-2796.1993.tb00776.x. [PMID: 7693846] - T Ichikawa, S Akimoto, J Shimazaki. An inhibitory effect of TZP-4238 on the growth of androgen-sensitive rat prostatic tumor (Dunning R3327).
Endocrine journal.
1993 Aug; 40(4):425-30. doi:
10.1507/endocrj.40.425. [PMID: 7522799] - E Kawakami, T Tsutsui, M Shimizu, H Orima, Y Makanae, K Yajima, A Ogasa. Effects of oral administration of chlormadinone acetate on canine prostatic hypertrophy.
The Journal of veterinary medical science.
1993 Aug; 55(4):631-5. doi:
10.1292/jvms.55.631. [PMID: 7691191] - M Murakoshi, M Tagawa, R Inada, M Suzuki, A Mizokami, K Watanabe. Inhibition of steroid-induced prostatic hyperplasia in rats by treatment with anti-androgen (TZP-4238).
Endocrine journal.
1993 Aug; 40(4):479-88. doi:
10.1507/endocrj.40.479. [PMID: 7522800] - K Sahara, S Tsutsui, Y Naitoh, K Fujikura. Prevention of estrus in bitches by subcutaneous implantation of chlormadinone acetate.
The Journal of veterinary medical science.
1993 Jun; 55(3):431-4. doi:
10.1292/jvms.55.431. [PMID: 7689345] - H Akaza, M Usami, T Kotake, K Koiso, Y Aso. A randomized phase II trial of flutamide vs chlormadinone acetate in previously untreated advanced prostatic cancer. The Japan Flutamide Study Group.
Japanese journal of clinical oncology.
1993 Jun; 23(3):178-85. doi:
NULL. [PMID: 7688829] - M Molnárová, J Arendarcik, P Molnár. [Changes in antiproteolytic activity in the blood and cervical mucus after superovulation stimulation].
Veterinarni medicina.
1992 Sep; 37(9-10):517-30. doi:
NULL. [PMID: 1284007] - M Murakoshi, M Tagawa, R Inada, M Shoji, M Suzuki, K Watanabe. The effects of new steroidal anti-androgen, TZP-4238, and chlormadinone acetate on the pituitary, prostate and adrenal gland of the rat: histopathological and immunocytochemical studies.
Endocrinologia japonica.
1992 Aug; 39(4):331-40. doi:
10.1507/endocrj1954.39.331. [PMID: 1280213]