zanoterone (BioDeep_00000720411)

   


代谢物信息卡片


zanoterone

化学式: C23H32N2O3S (416.2134)
中文名称: 扎诺特隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC3C(C1CCC2(C#C)O)CCC4C3(CC5=CN(N=C5C4)S(=O)(=O)C)C
InChI: InChI=1S/C23H32N2O3S/c1-5-23(26)11-9-19-17-7-6-16-12-20-15(14-25(24-20)29(4,27)28)13-21(16,2)18(17)8-10-22(19,23)3/h1,14,16-19,26H,6-13H2,2-4H3/t16-,17+,18-,19-,21-,22-,23-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C242 - Anti-Androgen

同义名列表

1 个代谢物同义名

zanoterone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • G Descotes, H Osman, J F Gallas, E Penacchio, C Moreau. Functional, biochemical, and morphological hepatobiliary effects in rats chronically exposed to a steroidal antiandrogen. Toxicology and applied pharmacology. 1996 Mar; 137(1):23-33. doi: 10.1006/taap.1996.0053. [PMID: 8607138]
  • G A Portmann, D M Simmons. Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection. Journal of pharmaceutical and biomedical analysis. 1995 Aug; 13(9):1189-93. doi: 10.1016/0731-7085(95)01520-u. [PMID: 8573648]
  • P E Juniewicz, S J Hoekstra, B M Lemp, T A Barbolt, J A Devin, E Gauthier, G Frenette, J Y Dube, R R Tremblay. Effect of combination treatment with zanoterone (WIN 49596), a steroidal androgen receptor antagonist, and finasteride (MK-906), a steroidal 5 alpha-reductase inhibitor, on the prostate and testes of beagle dogs. Endocrinology. 1993 Aug; 133(2):904-13. doi: 10.1210/endo.133.2.8393778. [PMID: 8393778]
  • B Liu, D Goltzman, S A Rabbani. Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500. Endocrinology. 1993 Apr; 132(4):1658-64. doi: 10.1210/endo.132.4.8462465. [PMID: 8462465]
  • D M Skee, J A Cook, D P Benziger. Determination of a novel steroidal androgen receptor antagonist (Win 49596) in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. 1991 Aug; 568(2):494-500. doi: 10.1016/0378-4347(91)80189-j. [PMID: 1783655]
  • P E Juniewicz, M McCarthy, B M Lemp, T A Barbolt, C Shaw, D M Hollenbaugh, R C Winneker, J R Reel, F H Batzold. The effect of the steroidal androgen receptor antagonist, Win 49,596, on the prostate and testis of beagle dogs. Endocrinology. 1990 May; 126(5):2625-34. doi: 10.1210/endo-126-5-2625. [PMID: 1691701]
  • P S Cooke, M R Reicherts. Anti-androgenic effects of Win 49,596 on development of the neonatal mouse bulbourethral gland in culture. The Prostate. 1990; 17(2):145-54. doi: 10.1002/pros.2990170208. [PMID: 2399190]
  • R C Winneker, M M Wagner, C J Shaw, B W Snyder. Antiandrogens do not reverse androgen-induced inhibition of sex hormone-binding globulin levels in adult female rhesus monkeys. Endocrinology. 1989 Aug; 125(2):715-20. doi: 10.1210/endo-125-2-715. [PMID: 2526727]