Tirilazad (BioDeep_00000720405)
代谢物信息卡片
(8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
化学式: C38H52N6O2 (624.4151532)
中文名称: 替拉扎特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
InChI: InChI=1S/C38H52N6O2/c1-26-22-31-29-9-8-27-23-28(45)10-12-37(27,2)30(29)11-13-38(31,3)35(26)32(46)25-41-18-20-43(21-19-41)34-24-33(42-14-4-5-15-42)39-36(40-34)44-16-6-7-17-44/h10-12,23-24,26,29,31,35H,4-9,13-22,25H2,1-3H3/t26-,29-,31+,35-,37+,38+/m1/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D020011 - Protective Agents > D000975 - Antioxidants
N - Nervous system
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135853
- KEGGdrug: D08606
- PubChem: 104903
- DrugBank: DB13050
- ChEMBL: CHEMBL1630578
- CAS: 110101-66-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Naveen Vankadari, Nandhini Nisha Jeyasankar, Wilma Jerom Lopes. Structure of the SARS-CoV-2 Nsp1/5'-Untranslated Region Complex and Implications for Potential Therapeutic Targets, a Vaccine, and Virulence.
The journal of physical chemistry letters.
2020 Nov; 11(22):9659-9668. doi:
10.1021/acs.jpclett.0c02818. [PMID: 33135884] - Brad A Sutherland, Jens Minnerup, Joyce S Balami, Francesco Arba, Alastair M Buchan, Christoph Kleinschnitz. Neuroprotection for ischaemic stroke: translation from the bench to the bedside.
International journal of stroke : official journal of the International Stroke Society.
2012 Jul; 7(5):407-18. doi:
10.1111/j.1747-4949.2012.00770.x. [PMID: 22394615] - Ioannis I Flessas, Apostolos E Papalois, Konstantinos Toutouzas, Flora Zagouri, George C Zografos. Effects of lazaroids on intestinal ischemia and reperfusion injury in experimental models.
The Journal of surgical research.
2011 Apr; 166(2):265-74. doi:
10.1016/j.jss.2010.08.031. [PMID: 21092988] - Offie P Soldin, Sarah H Chung, Donald R Mattison. Sex differences in drug disposition.
Journal of biomedicine & biotechnology.
2011; 2011(?):187103. doi:
10.1155/2011/187103. [PMID: 21403873] - Edward D Hall, Radhika A Vaishnav, Ayman G Mustafa. Antioxidant therapies for traumatic brain injury.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2010 Jan; 7(1):51-61. doi:
10.1016/j.nurt.2009.10.021. [PMID: 20129497] - Yeon Gyoe Jang, Don Ilodigwe, R Loch Macdonald. Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage.
Neurocritical care.
2009; 10(1):141-7. doi:
10.1007/s12028-008-9147-y. [PMID: 18810661] - J Birnbaum, E Klotz, C D Spies, J Mueller, O Vargas Hein, J Feller, C Lehmann. Impact of combined C1 esterase inhibitor/coagulation factor XIII or N-acetylcysteine/tirilazad mesylate administration on leucocyte adherence and cytokine release in experimental endotoxaemia.
The Journal of international medical research.
2008 Jul; 36(4):748-59. doi:
10.1177/147323000803600417. [PMID: 18652771] - J Birnbaum, Ch Lehmann, E Klotz, O Vargas Hein, A Blume, F Jubin, N Polze, D Luther, C D Spies. Effects of N-acetylcysteine and tirilazad mesylate on intestinal functional capillary density, leukocyte adherence, mesenteric plasma extravasation and cytokine levels in experimental endotoxemia in rats.
Clinical hemorheology and microcirculation.
2008; 39(1-4):99-111. doi:
10.3233/ch-2008-1073. [PMID: 18503116] - Padmalatha S Reddy, Holly M Legault, Joseph P Sypek, Mark J Collins, Elizabeth Goad, Samuel J Goldman, Wei Liu, Stuart Murray, Andrew J Dorner, Margot O'Toole. Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis.
Arthritis research & therapy.
2008; 10(6):R127. doi:
10.1186/ar2541. [PMID: 18980674] - Lars Alexander Schneider, Joachim Dissemond, Edith Schwamborn, Meinhard Wlaschek, Peter Brenneisen, Karin Scharffetter-Kochanek. Tirilazad amelioriates extracellular effects of photooxidative stress by sealing the membrane of UVA irradiated human dermal fibroblasts.
European journal of dermatology : EJD.
2006 Sep; 16(5):530-6. doi:
". [PMID: 17101474] - C Gahm, S Holmin, S Rudehill, T Mathiesen. Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine.
Acta neurochirurgica.
2005 Oct; 147(10):1071-84; discussion 1084. doi:
10.1007/s00701-005-0590-7. [PMID: 16044358] - A Richard Green, Tim Ashwood. Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
Current drug targets. CNS and neurological disorders.
2005 Apr; 4(2):109-18. doi:
10.2174/1568007053544156. [PMID: 15857295] - Jenny Karlsson, Asa Petersén, Gunilla Gidö, Tadeusz Wieloch, Patrik Brundin. Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient.
Cell transplantation.
2005; 14(5):301-9. doi:
10.3727/000000005783983089. [PMID: 16052911] - Edward D Hall, Joe E Springer. Neuroprotection and acute spinal cord injury: a reappraisal.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics.
2004 Jan; 1(1):80-100. doi:
10.1602/neurorx.1.1.80. [PMID: 15717009] - J Dissemond, L A Schneider, M Wlaschek, T C Brauns, M Goos, K Scharffetter-Kochanek. The lazaroid tirilazad is a new inhibitor of direct and indirect UVA-induced lipid peroxidation in human dermal fibroblasts.
Archives of dermatological research.
2003 Dec; 295(7):287-92. doi:
10.1007/s00403-003-0432-5. [PMID: 14593485] - T Volk, M Schmutzler, L Engelhardt, U Pantke, M Laule, K Stangl, T Grune, K-D Wernecke, W Konertz, W J Kox. Effects of different steroid treatment on reperfusion-associated production of reactive oxygen species and arrhythmias during coronary surgery.
Acta anaesthesiologica Scandinavica.
2003 Jul; 47(6):667-74. doi:
10.1034/j.1399-6576.2003.00145.x. [PMID: 12803583] - Edward D Hall. Drug development in spinal cord injury: what is the FDA looking for?.
Journal of rehabilitation research and development.
2003 Jul; 40(4 Suppl 1):81-91. doi:
10.1682/jrrd.2003.08.0081. [PMID: 15077652] - Bogdan Chmiel, Jacek Pajak, Róza Grabowska-Bochenek, Lech Cierpka. Decreased red blood cells deformability in acute pancreatitis in the rat. Effect of tirilazad mesylate.
Folia medica Cracoviensia.
2003; 44(1-2):109-15. doi:
NULL. [PMID: 15232892] - Jenny Karlsson, Mia Emgård, Patrik Brundin. Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants.
Brain research.
2002 Nov; 955(1-2):268-80. doi:
10.1016/s0006-8993(02)03601-6. [PMID: 12419547] - T Volk, M Schmutzler, L Engelhardt, W D Döcke, H D Volk, W Konertz, W J Kox. Influence of aminosteroid and glucocorticoid treatment on inflammation and immune function during cardiopulmonary bypass.
Critical care medicine.
2001 Nov; 29(11):2137-42. doi:
10.1097/00003246-200111000-00015. [PMID: 11700410] - Z Khalil, B Khodr. A role for free radicals and nitric oxide in delayed recovery in aged rats with chronic constriction nerve injury.
Free radical biology & medicine.
2001 Aug; 31(4):430-9. doi:
10.1016/s0891-5849(01)00597-4. [PMID: 11498276] - L Wennberg, K A Czech, L C Larsson, B Mirza, W Bennet, Z Song, H Widner. Effects of immunosuppressive treatment on host responses against intracerebral porcine neural tissue xenografts in rats.
Transplantation.
2001 Jun; 71(12):1797-806. doi:
10.1097/00007890-200106270-00016. [PMID: 11455261] - D Schmid, G R Burmester, R Tripmacher, G Fici, P von Voigtlander, F Buttgereit. Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells.
Bioscience reports.
2001 Feb; 21(1):101-10. doi:
10.1023/a:1010494320266. [PMID: 11508689] - R J Kavanagh, P C Kam. Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection.
British journal of anaesthesia.
2001 Jan; 86(1):110-9. doi:
10.1093/bja/86.1.110. [PMID: 11575384] - B Halliwell. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment.
Drugs & aging.
2001; 18(9):685-716. doi:
10.2165/00002512-200118090-00004. [PMID: 11599635] - E D Hall. Pharmacological treatment of acute spinal cord injury: how do we build on past success?.
The journal of spinal cord medicine.
2001; 24(3):142-6. doi:
10.1080/10790268.2001.11753571. [PMID: 11585231] - B Chmiel, R Grabowska-Bochenek, D Piskorska. Tirilazad mesylate improve water immersion stress induced decrease in erythrocyte deformability in the rats.
Medical science monitor : international medical journal of experimental and clinical research.
2001 Jan; 7(1):38-41. doi:
". [PMID: 11208490] - G Simonini, A Pignone, S Generini, F Falcini, M M Cerinic, S Gabriele, P Alberto, G Sergio, F Fernanda, M C Marco. Emerging potentials for an antioxidant therapy as a new approach to the treatment of systemic sclerosis.
Toxicology.
2000 Nov; 155(1-3):1-15. doi:
10.1016/s0300-483x(00)00272-9. [PMID: 11154792] - A Petersen, O Hansson, M Emgård, P Brundin. Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor.
Cell transplantation.
2000 Sep; 9(5):577-84. doi:
10.1177/096368970000900503. [PMID: 11144955] - ". Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee.
Stroke.
2000 Sep; 31(9):2257-65. doi:
10.1161/01.str.31.9.2257. [PMID: 10978061] - P Brundin, O Pogarell, P Hagell, P Piccini, H Widner, A Schrag, A Kupsch, L Crabb, P Odin, B Gustavii, A Björklund, D J Brooks, C D Marsden, W H Oertel, N P Quinn, S Rehncrona, O Lindvall. Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease.
Brain : a journal of neurology.
2000 Jul; 123 ( Pt 7)(?):1380-90. doi:
10.1093/brain/123.7.1380. [PMID: 10869050] - O Hansson, R F Castilho, G S Kaminski Schierle, J Karlsson, P Nicotera, M Leist, P Brundin. Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons.
Experimental neurology.
2000 Jul; 164(1):102-11. doi:
10.1006/exnr.2000.7406. [PMID: 10877920] - S Sharifi, W H Dzik, S M Sadrzadeh. Human plasma and tirilazad mesylate protect stored human erythrocytes against the oxidative damage of gamma-irradiation.
Transfusion medicine (Oxford, England).
2000 Jun; 10(2):125-30. doi:
10.1046/j.1365-3148.2000.00242.x. [PMID: 10849383] - I Roberts. Aminosteroids for acute traumatic brain injury.
The Cochrane database of systematic reviews.
2000; ?(4):CD001527. doi:
10.1002/14651858.cd001527. [PMID: 11034722] - Y Wang, A L Cory. A novel stable supersaturated submicron lipid emulsion of tirilazad.
Pharmaceutical development and technology.
1999 Aug; 4(3):333-45. doi:
10.1081/pdt-100101369. [PMID: 10434279] - R K Koç, A Kurtsoy, H Paşaoğlu, E I Karaküçük, I S Oktem, M Meral. Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1999 Jul; 199(1):21-8. doi:
10.1007/s004330050129. [PMID: 10494671] - K Kubo, T Amari, T Kaneki, M Hanaoka, T Hayano, T Miyahara, S Koyama, T Koizumi, K Fujimoto, T Kobayashi. A 21-aminosteroid, U-74006F, attenuates endotoxin-induced lung injury in awake sheep.
Respirology (Carlton, Vic.).
1999 Jun; 4(2):167-72. doi:
10.1046/j.1440-1843.1999.00169.x. [PMID: 10382236] - W Plöchl, C G Krenn, H Pokorny, L Pezawas, T Pezawas, H Steltzer. The use of the antioxidant tirilazad mesylate in human liver transplantation: is there a therapeutic benefit?.
Intensive care medicine.
1999 Jun; 25(6):616-9. doi:
10.1007/s001340050912. [PMID: 10416915] - Y Wang, G M Mesfin, C A Rodríguez, J G Slatter, M R Schuette, A L Cory, M J Higgins. Venous irritation, pharmacokinetics, and tissue distribution of tirilazad in rats following intravenous administration of a novel supersaturated submicron lipid emulsion.
Pharmaceutical research.
1999 Jun; 16(6):930-8. doi:
10.1023/a:1018846607804. [PMID: 10397616] - S Hillinger, R A Schmid, U Stammberger, A Boehler, O M Schöb, A Zollinger, W Weder. Donor and recipient treatment with the Lazaroid U-74006F do not improve post-transplant lung function in swine.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
1999 Apr; 15(4):475-80. doi:
10.1016/s1010-7940(99)00022-6. [PMID: 10371125] - J C Fleishaker, L K Pearson, P G Pearson, L C Wienkers, N K Hopkins, G R Peters. Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A.
Journal of clinical pharmacology.
1999 Mar; 39(3):260-7. doi:
NULL. [PMID: 10073325] - H Suzuki, K Kanamaru, M Kuroki, H Sun, S Waga, T Miyazawa. Effects of tirilazad mesylate on vasospasm and phospholipid hydroperoxides in a primate model of subarachnoid hemorrhage.
Stroke.
1999 Feb; 30(2):450-5; discussion 455. doi:
10.1161/01.str.30.2.450. [PMID: 9933286] - R K Koc, H Akdemir, E I Karakücük, I S Oktem, A Menkü. Effect of methylprednisolone, tirilazad mesylate and vitamin E on lipid peroxidation after experimental spinal cord injury.
Spinal cord.
1999 Jan; 37(1):29-32. doi:
10.1038/sj.sc.3100732. [PMID: 10025692] - L C Wienkers, R C Steenwyk, M J Hauer, J C Fleishaker, P G Pearson. Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2.
The Journal of pharmacology and experimental therapeutics.
1998 Nov; 287(2):583-90. doi:
". [PMID: 9808684] - T Nishida, S Morita, M Masuda, R Tominaga, Y Kawachi, H Yasui. Lazaroid U74500A is superior to U74006F in preserving rabbit heart for 24 hours.
The Annals of thoracic surgery.
1998 Nov; 66(5):1647-52. doi:
10.1016/s0003-4975(98)00774-7. [PMID: 9875765] - J C Fleishaker, P G Pearson, L C Wienkers, L K Pearson, T A Moore, G R Peters. Biotransformation of tirilazad in human: 4. effect of finasteride on tirilazad clearance and reduced metabolite formation.
The Journal of pharmacology and experimental therapeutics.
1998 Nov; 287(2):591-7. doi:
NULL. [PMID: 9808685] - S Sindet-Pedersen, J Kragskov, H Stødkilde-Jørgensen, L Kostopoulos, S Li, C G Larsen, B Gesser, S L Jensen. Tirilazad inhibits surgically induced edema and interleukin-1 production. An experimental study in rats.
International journal of oral and maxillofacial surgery.
1998 Oct; 27(5):386-90. doi:
10.1016/s0901-5027(98)80070-2. [PMID: 9804205] - S L Smith, P K Andrus, D D Gleason, E D Hall. Infant rat model of the shaken baby syndrome: preliminary characterization and evidence for the role of free radicals in cortical hemorrhaging and progressive neuronal degeneration.
Journal of neurotrauma.
1998 Sep; 15(9):693-705. doi:
10.1089/neu.1998.15.693. [PMID: 9753217] - K E Rodgers, W Girgis, K St Amand, J Campeau, G S diZerega. Reduction of adhesion formation in rabbits by intraperitoneal administration of lazaroid formulations.
Human reproduction (Oxford, England).
1998 Sep; 13(9):2443-51. doi:
10.1093/humrep/13.9.2443. [PMID: 9806265] - S L Smith, E D Hall. Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.
Journal of neurotrauma.
1998 Sep; 15(9):707-19. doi:
10.1089/neu.1998.15.707. [PMID: 9753218] - N Noguchi, M Takahashi, J Tsuchiya, H Yamashita, E Komuro, E Niki. Action of 21-aminosteroid U74006F as an antioxidant against lipid peroxidation.
Biochemical pharmacology.
1998 Mar; 55(6):785-91. doi:
10.1016/s0006-2952(97)00533-9. [PMID: 9586950] - M Nakayama, N Hasegawa, Y Oka, B Lutzke, J M McCall, T A Raffin. Effects of the lazaroid, tirilazad mesylate, on sepsis-induced acute lung injury in minipigs.
Critical care medicine.
1998 Mar; 26(3):538-47. doi:
10.1097/00003246-199803000-00029. [PMID: 9504584] - J C Fleishaker, L K Pearson, G R Peters. Induction of tirilazad clearance by phenytoin.
Biopharmaceutics & drug disposition.
1998 Mar; 19(2):91-6. doi:
10.1002/(sici)1099-081x(199803)19:2<91::aid-bdd78>3.0.co;2-t. [PMID: 9533108] - D S Dewitt, D S Prough, T Uchida, D D Deal, S M Vines. Effects of nalmefene, CG3703, tirilazad, or dopamine on cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and hemorrhage.
Journal of neurotrauma.
1997 Dec; 14(12):931-41. doi:
10.1089/neu.1997.14.931. [PMID: 9475374] - F Buttgereit, F Hiepe, G R Burmester. [The therapeutic potential of lazaroids (21-aminosteroids). A recent survey].
Deutsche medizinische Wochenschrift (1946).
1997 Oct; 122(44):1363-7. doi:
10.1055/s-2008-1047772. [PMID: 9410710] - A Othberg, M Keep, P Brundin, O Lindvall. Tirilazad mesylate improves survival of rat and human embryonic mesencephalic neurons in vitro.
Experimental neurology.
1997 Oct; 147(2):498-502. doi:
10.1006/exnr.1997.6594. [PMID: 9344573] - O Chiara, P Padalino, L Fattori, C Ravizzini, M G Turconi, G Tiberio. Classical corticosteroids and new lipid peroxidation inhibitors in the therapy of multiple organ failure (MOF).
Minerva chirurgica.
1997 Sep; 52(9):1095-102. doi:
". [PMID: 9401356] - A V Korompilias, L E Chen, A V Seaber, J R Urbaniak. Studies of ischemia-reperfusion injury in skeletal muscle: efficacy of 21-aminosteroids on microcirculation and muscle contraction after an extended period of warm ischemia.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
1997 Jul; 15(4):512-8. doi:
10.1002/jor.1100150406. [PMID: 9379260] - B Sániová. [Tirilazad mesylate (Freedox)--an effective inhibitor of lipid membrane peroxidation].
Bratislavske lekarske listy.
1997 Jun; 98(6):339-42. doi:
". [PMID: 9333426] - J C Fleishaker, R N Straw, C J Cross. Pharmacokinetics of tirilazad and U-89678, an active, reduced metabolite, following acute head trauma in adults.
Journal of pharmaceutical sciences.
1997 Apr; 86(4):434-7. doi:
10.1021/js960410e. [PMID: 9109044] - N Ishizaki, Y Zhu, S Zhang, A Nemoto, Y Kobayashi, V Subbotin, T E Starzl, S Todo. Comparison of various lazaroid compounds for protection against ischemic liver injury.
Transplantation.
1997 Jan; 63(2):202-8. doi:
10.1097/00007890-199701270-00005. [PMID: 9020318] - A L Kwan, N J Solenski, N F Kassell, K S Lee. Inhibition of nitric oxide generation and lipid peroxidation attenuates hemolysate-induced injury to cerebrovascular endothelium.
Acta neurochirurgica.
1997; 139(3):240-7; discussion 247. doi:
10.1007/bf01844759. [PMID: 9143592] - J C Fleishaker, G R Peters. Pharmacokinetics of tirilazad in healthy male subjects at doses above 6 mg/kg/day.
International journal of clinical pharmacology and therapeutics.
1997 Jan; 35(1):28-32. doi:
NULL. [PMID: 9021439] - C E Gross, H K Kimelberg, S Raymond-Russell, C Booth, M M Bednar. Delayed adjuvant therapy with the 21-aminosteroid U74006F and the anion channel blocker L644-711 does not improve outcome following thrombolytic therapy in a rabbit model of thromboembolic stroke.
Surgical neurology.
1997 Jan; 47(1):60-5; discussion 66. doi:
10.1016/s0090-3019(96)00249-2. [PMID: 8986168] - A Salahudeen, C Wang, O McDaniel, S Lagoo-Denadyalan, S Bigler, H Barber. Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model. Partial support for the response-to-injury hypothesis.
Transplantation.
1996 Dec; 62(11):1628-33. doi:
10.1097/00007890-199612150-00017. [PMID: 8970619] - L A Levin, J A Clark, L K Johns. Effect of lipid peroxidation inhibition on retinal ganglion cell death.
Investigative ophthalmology & visual science.
1996 Dec; 37(13):2744-9. doi:
". [PMID: 8977490] - K Fujimoto, K Kubo, K Okada, T Kobayashi, M Sekiguchi, A Sakai. Effect of the 21-aminosteroid U-74006F on antigen-induced bronchoconstriction and bronchoalveolar eosinophilia in allergic sheep.
The European respiratory journal.
1996 Oct; 9(10):2044-9. doi:
10.1183/09031936.96.09102044. [PMID: 8902465] - J C Fleishaker, G R Peters. Pharmacokinetics of tirilazad and U-89678 in ischemic stroke patients receiving a loading regimen and maintenance regimen of 10 mg/kg/day of tirilazad.
Journal of clinical pharmacology.
1996 Sep; 36(9):809-13. doi:
10.1002/j.1552-4604.1996.tb04254.x. [PMID: 8889901] - R M Nasser, L E Chen, A V Seaber, J R Urbaniak. Protective effect of 21-aminosteroid pretreatment in peripheral nerve low-load crush injury in mature and immature rats.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
1996 Sep; 14(5):823-9. doi:
10.1002/jor.1100140521. [PMID: 8893778] - ". A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). The RANTTAS Investigators.
Stroke.
1996 Sep; 27(9):1453-8. doi:
10.1161/01.str.27.9.1453. [PMID: 8784112] - R Bågenholm, P Andiné, H Hagberg. Effects of the 21-amino steroid tirilazad mesylate (U-74006F) on brain damage and edema after perinatal hypoxia-ischemia in the rat.
Pediatric research.
1996 Sep; 40(3):399-403. doi:
10.1203/00006450-199609000-00006. [PMID: 8865275] - R McKenna, R E Laskey, Y Wang, H Jaeschke, W R Mathews. Effect of endotoxin-enhanced hepatic reperfusion injury on endothelium-dependent relaxation in rat aorta.
Shock (Augusta, Ga.).
1996 Aug; 6(2):106-11. doi:
10.1097/00024382-199608000-00005. [PMID: 8856844] - F P Abramson, Y Teffera, J Kusmierz, R C Steenwyk, P G Pearson. Replacing 14C with stable isotopes in drug metabolism studies.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jul; 24(7):697-701. doi:
NULL. [PMID: 8818564] - Y Wu, F F Sun, D M Tong, B M Taylor. Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy.
Biophysical journal.
1996 Jul; 71(1):91-100. doi:
10.1016/s0006-3495(96)79243-3. [PMID: 8804592] - L C Wienkers, R C Steenwyk, P E Sanders, P G Pearson. Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.
The Journal of pharmacology and experimental therapeutics.
1996 May; 277(2):982-90. doi:
. [PMID: 8627581] - J C Fleishaker, P G Pearson, L C Wienkers, L K Pearson, G R Peters. Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability.
The Journal of pharmacology and experimental therapeutics.
1996 May; 277(2):991-8. doi:
NULL. [PMID: 8627582] - Y Wang, W R Mathews, D M Guido, H Jaeschke. The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation.
The Journal of pharmacology and experimental therapeutics.
1996 May; 277(2):714-20. doi:
NULL. [PMID: 8627550] - E D Hall, S L Smith, J A Oostveen. Inhibition of lipid peroxidation attenuates axotomy-induced apoptotic degeneration of facial motor neurons in neonatal rats.
Journal of neuroscience research.
1996 May; 44(3):293-9. doi:
10.1002/(sici)1097-4547(19960501)44:3<293::aid-jnr10>3.0.co;2-6. [PMID: 8723768] - E D Hall. Efficacy and mechanisms of action of the cytoprotective lipid peroxidation inhibitor tirilazad mesylate in subarachnoid haemorrhage.
European journal of anaesthesiology.
1996 May; 13(3):279-89. doi:
10.1046/j.1365-2346.1996.00980.x. [PMID: 8737119] - A K Salahudeen, C Wang, S A Bigler, Z Dai, H Tachikawa. Synergistic renal protection by combining alkaline-diuresis with lipid peroxidation inhibitors in rhabdomyolysis: possible interaction between oxidant and non-oxidant mechanisms.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1996 Apr; 11(4):635-42. doi:
10.1093/oxfordjournals.ndt.a027352. [PMID: 8671851] - G J Fici, J S Althaus, E D Hall, P F Von Voigtlander. Protective effects of tirilazad mesylate in a cellular model of peroxynitrite toxicity.
Research communications in molecular pathology and pharmacology.
1996 Mar; 91(3):357-71. doi:
. [PMID: 8829775] - T T Rohn, T R Hinds, F F Vincenzi. Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Protection by 6,7-dimethyl-2,4-DI-1- pyrrolidinyl-7H-pyrrolo[2,3-d] pyrimidine sulfate (U-89843D), a potent, novel, antioxidant/free radical scavenger.
Biochemical pharmacology.
1996 Feb; 51(4):471-6. doi:
10.1016/0006-2952(95)02222-8. [PMID: 8619892] - S L Smith, H M Scherch, E D Hall. Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury.
Journal of neurosurgery.
1996 Feb; 84(2):229-33. doi:
10.3171/jns.1996.84.2.0229. [PMID: 8592225] - D P Boisvert, E D Hall. Tirilazad prevention of reperfusion edema after focal ischemia in cynomolgus monkeys.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
1996 Feb; 23(1):46-52. doi:
10.1017/s0317167100039172. [PMID: 8673962] - J C Fleishaker, L K Pearson, G R Peters. Gender does not affect the degree of induction of tirilazad clearance by phenobarbital.
European journal of clinical pharmacology.
1996; 50(1-2):139-45. doi:
10.1007/s002280050082. [PMID: 8739825] - G Yue, F F Sun, C Dunn, K Yin, P Y Wong. The 21-aminosteroid tirilazad mesylate can ameliorate inflammatory bowel disease in rats.
The Journal of pharmacology and experimental therapeutics.
1996 Jan; 276(1):265-70. doi:
". [PMID: 8558441] - E Melon, J M Rimaniol. [Pharmacological treatment of vasospasm in subarachnoid hemorrhage].
Annales francaises d'anesthesie et de reanimation.
1996; 15(3):366-73. doi:
10.1016/s0750-7658(96)80021-9. [PMID: 8758597] - M Jakobsen. Pharmacology of the aminosteroids in brain diseases.
Methods and findings in experimental and clinical pharmacology.
1996; 18 Suppl B(?):81-2. doi:
". [PMID: 8899702] - H Kim, R C Koehler, P D Hurn, E D Hall, R J Traystman. Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad posttreatment in dogs.
Stroke.
1996 Jan; 27(1):114-21. doi:
10.1161/01.str.27.1.114. [PMID: 8553386] - E D Hall, P K Andrus, S L Smith, J A Oostveen, H M Scherch, B S Lutzke, T J Raub, G A Sawada, J R Palmer, L S Banitt, J S Tustin, K L Belonga, D E Ayer, G L Bundy. Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants.
Acta neurochirurgica. Supplement.
1996; 66(?):107-13. doi:
10.1007/978-3-7091-9465-2_19. [PMID: 8780807] - L K Pearson, J C Fleishaker, G R Peters. Comparison of the pharmacokinetics of tirilazad mesylate in healthy volunteers and stable subjects with mild liver cirrhosis.
European journal of clinical pharmacology.
1996; 50(4):299-304. doi:
10.1007/s002280050112. [PMID: 8803523] - A K Salahudeen, C Wang, V K Kanji. Comparative study of the effect of 21-aminosteroid and alpha-tocopherol on models of acute oxidative renal injury.
Free radical biology & medicine.
1996; 21(5):691-7. doi:
10.1016/0891-5849(96)00126-8. [PMID: 8891671] - F Sterz, K Janata, I Kürkciyan, M Müllner, R Malzer, W Schreiber. Possibilities of brain protection with tirilazad after cardiac arrest.
Seminars in thrombosis and hemostasis.
1996; 22(1):105-12. doi:
10.1055/s-2007-998996. [PMID: 8711485] - H S Xu, W C Stevenson, T L Pruett, R S Jones. Donor lazaroid pretreatment improves viability of livers harvested from non-heart-beating rats.
American journal of surgery.
1996 Jan; 171(1):113-6; discussion 116. doi:
10.1016/s0002-9610(99)80084-1. [PMID: 8554124] - P Hans. [Pharmacological therapeutic prospects of cerebral vasospasm].
Annales francaises d'anesthesie et de reanimation.
1996; 15(3):374-81. doi:
10.1016/s0750-7658(96)80022-0. [PMID: 8758598] - E D Hall. Inhibition of lipid peroxidation in central nervous system trauma and ischemia.
Journal of the neurological sciences.
1995 Dec; 134 Suppl(?):79-83. doi:
10.1016/0022-510x(95)00211-j. [PMID: 8847548] - W M Clark, J S Hazel, B M Coull. Lazaroids. CNS pharmacology and current research.
Drugs.
1995 Dec; 50(6):971-83. doi:
10.2165/00003495-199550060-00005. [PMID: 8612475] - D P Blakeman, T P Ryan, R A Jolly, T W Petry. Diquat-dependent protein carbonyl formation. Identification of lipid-dependent and lipid-independent pathways.
Biochemical pharmacology.
1995 Sep; 50(7):929-35. doi:
10.1016/0006-2952(95)00214-k. [PMID: 7575675] - F Shi, J Cavitt, K L Audus. 21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers.
Free radical biology & medicine.
1995 Sep; 19(3):349-57. doi:
10.1016/0891-5849(95)00049-4. [PMID: 7557549]