sinitrodil (BioDeep_00000719926)

   


代谢物信息卡片


2-(4-oxo-2H-1,3-benzoxazin-3-yl)ethyl nitrate

化学式: C10H10N2O5 (238.058969)
中文名称: 西硝地尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1N(C(=O)C2=CC=CC=C2O1)CCO[N+](=O)[O-]
InChI: InChI=1S/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent

同义名列表

2 个代谢物同义名

2-(4-oxo-2H-1,3-benzoxazin-3-yl)ethyl nitrate; sinitrodil



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • P Minghetti, A Casiraghi, L Montanari, M V Monzani. In vitro skin permeation of Sinitrodil, a member of a new class of nitrovasodilator drugs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 1999 Feb; 7(3):231-6. doi: 10.1016/s0928-0987(98)00030-x. [PMID: 9845810]
  • M V Monzani, G Coltro, A Sala, M Sardina. Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 1999 Feb; 7(3):179-84. doi: 10.1016/s0928-0987(98)00026-8. [PMID: 9845803]
  • C Giachetti, M Bertolino, S Canali, E Lombardini, M V Monzani, A Sala, G Zanolo. Pharmacokinetic study in rats after single intravenous and oral administrations of [14C]-ITF-296. European journal of drug metabolism and pharmacokinetics. 1998 Apr; 23(2):230-8. doi: 10.1007/bf03189345. [PMID: 9725487]
  • C Giachetti, M Bertolino, S Canali, E Lombardini, M V Monzani, A Sala, G Zanolo. Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296. European journal of drug metabolism and pharmacokinetics. 1998 Apr; 23(2):239-50. doi: 10.1007/bf03189346. [PMID: 9725488]
  • M V Monzani, G Coltro, L Jiritano, A Sala. Simultaneous determination of ITF 296 and two metabolites in plasma by a validated HPLC method. Bollettino chimico farmaceutico. 1997 Apr; 136(4):382-8. doi: NULL. [PMID: 9281893]
  • M V Monzani, G Coltro, L Jiritano, A Sala. Pharmacokinetic profile of ITF 296 in rats and dogs. Journal of cardiovascular pharmacology. 1995; 26 Suppl 4(?):S67-71. doi: NULL. [PMID: 8839229]
  • M Sardina, S J Warrington, M Boyce, A Johnston, C Bianchini. Hemodynamic and humoral effects at rest and after head-up tilt tests during 24-hour infusion of a new nitrate ester, ITF 296, compared with ISDN and placebo in healthy volunteers: a double-blind, randomized, within-subject study. Journal of cardiovascular pharmacology. 1995; 26 Suppl 4(?):S80-90. doi: NULL. [PMID: 8839231]