Bretazenil (BioDeep_00000719881)

   


代谢物信息卡片


Bretazenil

化学式: C19H20BrN3O3 (417.068795)
中文名称: 溴他西尼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)OC(=O)C1=C2C3CCCN3C(=O)C4=C(N2C=N1)C=CC=C4Br
InChI: InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1

描述信息

C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

1 个代谢物同义名

Bretazenil



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Alexander Jackson, Mark R Battle, Dennis M O'Shea, Wai-Fung Chau, Alessandra Gaeta, Samantha L Brown, Amanda L Ewan, Clare L Jones, Paul A Jones, John L Woodcraft, Denis R Bouvet, Benedicte B Guilbert, William Trigg. Evaluation of a novel series of fluorine-18-labeled imidazobenzodiazepines as potential new positron emission tomography radioligands for the GABAA receptor. Nuclear medicine and biology. 2014 Feb; 41(2):196-202. doi: 10.1016/j.nucmedbio.2013.11.010. [PMID: 24480268]
  • Alexander Jackson, Benedicte B Guilbert, Stuart D Plant, Julian Goggi, Mark R Battle, John L Woodcraft, Alessandra Gaeta, Clare L Jones, Denis R Bouvet, Paul A Jones, Dennis M O'Shea, Penny Hao Zheng, Samantha L Brown, Amanda L Ewan, William Trigg. The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor. Bioorganic & medicinal chemistry letters. 2013 Feb; 23(3):821-6. doi: 10.1016/j.bmcl.2012.11.066. [PMID: 23265897]
  • Andrew Pike, Susan M Cook, Alan P Watt, Paul Scott-Stevens, Thomas W Rosahl, Ruth M McKernan, Luanda J Pym, Alec Guiblin, Christopher Moyes, Bindi Sohal, John R Atack. Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands. Biopharmaceutics & drug disposition. 2007 Sep; 28(6):275-82. doi: 10.1002/bdd.553. [PMID: 17570124]
  • S A G Visser, F L C Wolters, J M Gubbens-Stibbe, E Tukker, P H Van Der Graaf, L A Peletier, M Danhof. Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations. The Journal of pharmacology and experimental therapeutics. 2003 Jan; 304(1):88-101. doi: 10.1124/jpet.102.042341. [PMID: 12490579]
  • Bert Tuk, Toon van Gool, Meindert Danhof. Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol. Journal of pharmacokinetics and pharmacodynamics. 2002 Jun; 29(3):235-50. doi: 10.1023/a:1020202806759. [PMID: 12449497]
  • G Puia, I Ducic, S Vicini, E Costa. Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor. Proceedings of the National Academy of Sciences of the United States of America. 1992 Apr; 89(8):3620-4. doi: 10.1073/pnas.89.8.3620. [PMID: 1373505]
  • J W Mandema, M T Kuck, M Danhof. In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy. The Journal of pharmacology and experimental therapeutics. 1992 Apr; 261(1):56-61. doi: NULL. [PMID: 1560385]
  • U Timm, G Fischer, M Zell, R Zumbrunnen. Determination of the partial benzodiazepine receptor agonist Ro 16-6028 in plasma by capillary gas chromatography with nitrogen-selective detection after conversion into the ethyl ester derivative. Journal of chromatography. 1989 Sep; 494(?):119-34. doi: 10.1016/s0378-4347(00)82662-6. [PMID: 2573608]