Methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (BioDeep_00000719879)

   


代谢物信息卡片


DMCM hydrochloride,4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylicacidmethylesterhydrochloride

化学式: C17H18N2O4 (314.1266508)
中文名称: DMCM盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=C2C3=CC(=C(C=C3NC2=CN=C1C(=O)OC)OC)OC
InChI: InChI=1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,19H,5H2,1-4H3

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants

同义名列表

2 个代谢物同义名

DMCM hydrochloride,4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylicacidmethylesterhydrochloride; Methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Annalisa Bernareggi, Massimo Grilli, Mario Marchi, Cristina Limatola, Fabio Ruzzier, Fabrizio Eusebi. Characterization of GABA(A) receptors expressed in glial cell membranes of adult mouse neocortex using a Xenopus oocyte microtransplantation expression system. Journal of neuroscience methods. 2011 May; 198(1):77-83. doi: 10.1016/j.jneumeth.2011.03.011. [PMID: 21439322]
  • Jay Liu, Tongming Chen, Tyrell Norris, Kathy Knappenberger, Julie Huston, Michael Wood, Robert Bostwick. A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells. Assay and drug development technologies. 2008 Dec; 6(6):781-6. doi: 10.1089/adt.2008.161. [PMID: 19090692]
  • Ivana Grakalic, Charles W Schindler, Michael H Baumann, Kenner C Rice, Anthony L Riley. Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains. Psychopharmacology. 2006 Dec; 189(3):277-86. doi: 10.1007/s00213-006-0562-5. [PMID: 17016707]
  • Jason M C Derry, Susan M J Dunn, Martin Davies. Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. Journal of neurochemistry. 2004 Mar; 88(6):1431-8. doi: 10.1046/j.1471-4159.2003.02264.x. [PMID: 15009644]
  • S A G Visser, F L C Wolters, J M Gubbens-Stibbe, E Tukker, P H Van Der Graaf, L A Peletier, M Danhof. Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations. The Journal of pharmacology and experimental therapeutics. 2003 Jan; 304(1):88-101. doi: 10.1124/jpet.102.042341. [PMID: 12490579]
  • Doodipala S Reddy, Michael A Rogawski. Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 May; 22(9):3795-805. doi: 20026274. [PMID: 11978855]
  • H K Im, W B Im, D B Carter, D D McKinley. Interaction of beta-carboline inverse agonists for the benzodiazepine site with another site on GABAA receptors. British journal of pharmacology. 1995 Mar; 114(5):1040-4. doi: 10.1111/j.1476-5381.1995.tb13310.x. [PMID: 7780638]
  • M Fleshner, M M Brohm, M L Laudenslager, L R Watkins, S F Maier. Modulation of the in vivo antibody response by a benzodiazepine inverse agonist (DMCM) administered centrally or peripherally. Physiology & behavior. 1993 Dec; 54(6):1149-54. doi: 10.1016/0031-9384(93)90339-h. [PMID: 8295955]
  • B Elgoyhen, P S Lorenzo, M T Tellez-Iñón, E Adler-Graschinsky. Relaxant effects of beta-carbolines on rat aortic rings. The Journal of pharmacology and experimental therapeutics. 1992 May; 261(2):534-9. doi: ". [PMID: 1578370]
  • P D Suzdak, M D Swedberg, K E Andersen, L J Knutsen, C Braestrup. In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine. Life sciences. 1992; 51(24):1857-68. doi: 10.1016/0024-3205(92)90037-p. [PMID: 1333027]
  • C Kleingoor, M Ewert, G von Blankenfeld, P H Seeburg, H Kettenmann. Inverse but not full benzodiazepine agonists modulate recombinant alpha 6 beta 2 gamma 2 GABAA receptors in transfected human embryonic kidney cells. Neuroscience letters. 1991 Sep; 130(2):169-72. doi: 10.1016/0304-3940(91)90389-b. [PMID: 1665550]
  • S F De Boer, J Van der Gugten, J L Slangen. Effects of chlordiazepoxide, flumazenil and DMCM on plasma catecholamine and corticosterone concentrations in rats. Pharmacology, biochemistry, and behavior. 1991 Jan; 38(1):13-9. doi: 10.1016/0091-3057(91)90583-n. [PMID: 1850134]
  • G von Blankenfeld, S Ymer, D B Pritchett, H Sontheimer, M Ewert, P H Seeburg, H Kettenmann. Differential benzodiazepine pharmacology of mammalian recombinant GABAA receptors. Neuroscience letters. 1990 Jul; 115(2-3):269-73. doi: 10.1016/0304-3940(90)90467-n. [PMID: 2172872]
  • G Puia, M R Santi, S Vicini, D B Pritchett, P H Seeburg, E Costa. Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors. Proceedings of the National Academy of Sciences of the United States of America. 1989 Sep; 86(18):7275-9. doi: 10.1073/pnas.86.18.7275. [PMID: 2476816]
  • G Evoniuk, E J Moody, P Skolnick. Ultraviolet irradiation selectively disrupts the gamma-aminobutyric acid/benzodiazepine receptor-linked chloride ionophore. Molecular pharmacology. 1989 May; 35(5):695-700. doi: NULL. [PMID: 2542759]
  • G Evoniuk, P Skolnick. Picrate and niflumate block anion modulation of radioligand binding to the gamma-aminobutyric acid/benzodiazepine receptor complex. Molecular pharmacology. 1988 Dec; 34(6):837-42. doi: NULL. [PMID: 2849050]
  • M M Schweri, J V Martin, W B Mendelson, J E Barrett, S M Paul, P Skolnick. Pharmacokinetic and pharmacodynamic factors contributing to the convulsant action of beta-carboline-3-carboxylic acid esters. Life sciences. 1983 Oct; 33(15):1505-10. doi: 10.1016/0024-3205(83)90854-8. [PMID: 6621253]
  • C Braestrup, R Schmiechen, G Neef, M Nielsen, E N Petersen. Interaction of convulsive ligands with benzodiazepine receptors. Science (New York, N.Y.). 1982 Jun; 216(4551):1241-3. doi: 10.1126/science.6281892. [PMID: 6281892]