OXPRENOLOL HYDROCHLORIDE (BioDeep_00000719861)

   


代谢物信息卡片


OXPRENOLOL HYDROCHLORIDE

化学式: C15H24ClNO3 (301.14446239999995)
中文名称: 盐酸氧烯洛尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC=C1OCC=C)O.Cl
InChI: 1H

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].

同义名列表

3 个代谢物同义名

OXPRENOLOL HYDROCHLORIDE; Ba 39089; Oxprenolol (hydrochloride)



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mariusz Stolarczyk, Anna Apola, Anna Malanka, Anna Kwiecien, Edyta Wrona, Wlodzimierz Opoka. DETERMINATION OF SOTALOL, OXPRENOLOL AND LABETALOL IN BINARY MIXTURES AND IN SPIKED HUMAN SERUM BY DERIVATIVE SPECTROPHOTOMETRIC METHOD. Acta poloniae pharmaceutica. 2017 Jan; 74(1):93-102. doi: . [PMID: 29474765]
  • Khaled Azizi, Mokhtar Ganjali Koli. Molecular dynamics simulations of Oxprenolol and Propranolol in a DPPC lipid bilayer. Journal of molecular graphics & modelling. 2016 Mar; 64(?):153-164. doi: 10.1016/j.jmgm.2016.01.009. [PMID: 26851866]
  • Mariane Gonçalves Santos, Gabriel de Oliveira Isac Moraes, Maurício Gustavo Nakamura, Álvaro José dos Santos-Neto, Eduardo Costa Figueiredo. Restricted access molecularly imprinted polymers obtained by bovine serum albumin and/or hydrophilic monomers' external layers: a comparison related to physical and chemical properties. The Analyst. 2015 Nov; 140(22):7768-75. doi: 10.1039/c5an01482d. [PMID: 26460233]
  • Gesche Först, Lukasz Cwiklik, Piotr Jurkiewicz, Rolf Schubert, Martin Hof. Interactions of beta-blockers with model lipid membranes: molecular view of the interaction of acebutolol, oxprenolol, and propranolol with phosphatidylcholine vesicles by time-dependent fluorescence shift and molecular dynamics simulations. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2014 Aug; 87(3):559-69. doi: 10.1016/j.ejpb.2014.03.013. [PMID: 24681296]
  • Sonia Amores, Jacinto Lauroba, Ana Calpena, Helena Colom, Alvaro Gimeno, José Domenech. A comparative ex vivo drug permeation study of beta-blockers through porcine buccal mucosa. International journal of pharmaceutics. 2014 Jul; 468(1-2):50-4. doi: 10.1016/j.ijpharm.2014.03.050. [PMID: 24727142]
  • Yue Jin, Cheng Chen, Lingchen Meng, Jitao Chen, Meixian Li, Zhiwei Zhu. Simultaneous and sensitive capillary electrophoretic enantioseparation of three β-blockers with the combination of achiral ionic liquid and dual CD derivatives. Talanta. 2012 Jan; 89(?):149-54. doi: 10.1016/j.talanta.2011.12.005. [PMID: 22284473]
  • Maki Mizogami, Ko Takakura, Hironori Tsuchiya. The interactivities with lipid membranes differentially characterize selective and nonselective beta1-blockers. European journal of anaesthesiology. 2010 Sep; 27(9):829-34. doi: 10.1097/eja.0b013e32833bf5e4. [PMID: 20601889]
  • S A B Salman, S A Sulaiman, Z Ismail, S H Gan. Quantitative determination of propranolol by ultraviolet HPLC in human plasma. Toxicology mechanisms and methods. 2010 Mar; 20(3):137-42. doi: 10.3109/15376511003602112. [PMID: 20128736]
  • Bogusław Buszewski, Tomasz Welerowicz, Eugenia Tegowska, Tadeusz F Krzemiński. Determination of selected beta-receptor antagonists in biological samples by solid-phase extraction with cholesterolic phase and LC/MS. Analytical and bioanalytical chemistry. 2009 Jan; 393(1):263-72. doi: 10.1007/s00216-008-2369-1. [PMID: 18781297]
  • Giovanni D'Orazio, Salvatore Fanali. Enantiomeric separation by using nano-liquid chromatography with on-column focusing. Journal of separation science. 2008 Aug; 31(14):2567-71. doi: 10.1002/jssc.200800114. [PMID: 18623279]
  • Guoqiang Yang, Yifang Zhao, Meixian Li, Zhiwei Zhu, Qiankun Zhuang. Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography. Talanta. 2008 Mar; 75(1):222-6. doi: 10.1016/j.talanta.2007.11.007. [PMID: 18371871]
  • Antonella De Rossi, Claudia Desiderio. High sensitivity analysis of oxprenolol in urine by capillary electrophoresis with C18 packed on-line preconcentrator. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jul; 839(1-2):6-11. doi: 10.1016/j.jchromb.2005.11.046. [PMID: 16364697]
  • Vlasta Bradamante, Zarka Krnić, Renata Zrinski, Pasko Konjevoda, Zeljko Reiner. Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats. Arzneimittel-Forschung. 2006; 56(2):64-9. doi: 10.1055/s-0031-1296703. [PMID: 16572919]
  • Maria A Martinez-Gomez, Rosa M Villanueva-Camañas, Salvador Sagrado, Maria J Medina-Hernández. Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique. Electrophoresis. 2005 Nov; 26(21):4116-26. doi: 10.1002/elps.200500304. [PMID: 16252317]
  • M A Martínez-Gómez, J J Martínez-Pla, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Chiral separation of oxprenolol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector. Journal of pharmaceutical and biomedical analysis. 2005 Sep; 39(1-2):76-81. doi: 10.1016/j.jpba.2005.03.028. [PMID: 15927439]
  • M I Maguregui, R M Jiménez, R M Alonso, U Akesolo. Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis. Journal of chromatography. A. 2002 Mar; 949(1-2):91-7. doi: 10.1016/s0021-9673(01)01320-6. [PMID: 11999762]
  • J Haginaka, H Matsunaga. Separation of enantiomers on HPLC chiral stationary phases based on human plasma alpha1-acid glycoprotein: effect of sugar moiety on chiral recognition ability. Enantiomer. 2000; 5(1):37-45. doi: NULL. [PMID: 10763868]
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  • A J Braza, P Modamio, E L Mariño. Determination of celiprolol and oxprenolol in human plasma by high-performance liquid chromatography and the analytical error function. Journal of chromatography. B, Biomedical sciences and applications. 1998 Nov; 718(2):267-72. doi: 10.1016/s0378-4347(98)00378-8. [PMID: 9840437]
  • C G Jordan. How an increase in the carbon chain length of the ester moiety affects the stability of a homologous series of oxprenolol esters in the presence of biological enzymes. Journal of pharmaceutical sciences. 1998 Jul; 87(7):880-5. doi: 10.1021/js970280p. [PMID: 9649358]
  • S E Leucuta, M Follidis, R Capalneanu, A Mocan. Relative bioavailability of different oral sustained release oxprenolol tablets. European journal of drug metabolism and pharmacokinetics. 1998 Apr; 23(2):178-84. doi: 10.1007/bf03189336. [PMID: 9725478]
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  • A Ceccato, B Toussaint, P Chiap, P Hubert, J Crommen. Enantioselective determination of oxprenolol in human plasma using dialysis coupled on-line to reversed-phase chiral liquid chromatography. Journal of pharmaceutical and biomedical analysis. 1997 Jun; 15(9-10):1365-74. doi: 10.1016/s0731-7085(96)01965-6. [PMID: 9226565]
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  • M E Laethem, F M Belpaire, M G Bogaert. Direct high-performance liquid chromatography determination of diastereomeric oxprenolol glucuronides. Journal of chromatography. B, Biomedical applications. 1996 Jan; 675(2):251-5. doi: 10.1016/0378-4347(95)00358-4. [PMID: 8852712]
  • F Li, S F Cooper, S R Mikkelsen. Enantioselective determination of oxprenolol and its metabolites in human urine by cyclodextrin-modified capillary zone electrophoresis. Journal of chromatography. B, Biomedical applications. 1995 Dec; 674(2):277-85. doi: 10.1016/0378-4347(95)00307-x. [PMID: 8788157]
  • M E Laethem, F M Belpaire, P Wijnant, M G Bogaert. Effect of probenecid on the enantioselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit. Pharmaceutical research. 1995 Dec; 12(12):1964-7. doi: 10.1023/a:1016204309083. [PMID: 8786974]
  • M E Laethem, R A Lefebvre, F M Belpaire, H L Vanhoe, M G Bogaert. Stereoselective pharmacokinetics of oxprenolol and its glucuronides in humans. Clinical pharmacology and therapeutics. 1995 Apr; 57(4):419-24. doi: 10.1016/0009-9236(95)90211-2. [PMID: 7712670]
  • U Hellwich, R Schubert. Concentration-dependent binding of the chiral beta-blocker oxprenolol to isoelectric or negatively charged unilamellar vesicles. Biochemical pharmacology. 1995 Feb; 49(4):511-7. doi: 10.1016/0006-2952(94)00418-l. [PMID: 7872956]
  • M E Laethem, F M Belpaire, P Wijnant, M G Bogaert. Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: species differences and influence of endotoxin. Chirality. 1995; 7(8):616-22. doi: 10.1002/chir.530070811. [PMID: 8593255]
  • M E Laethem, F M Belpaire, P Wijnant, M T Rosseel, M G Bogaert. Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat. Chirality. 1994; 6(5):405-10. doi: 10.1002/chir.530060508. [PMID: 8068500]
  • M E Laethem, M T Rosseel, P Wijnant, F M Belpaire. Chiral high-performance liquid chromatographic determination of oxprenolol in plasma. Journal of chromatography. 1993 Nov; 621(2):225-9. doi: 10.1016/0378-4347(93)80099-p. [PMID: 8294544]
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  • K P Devi, K V Rao, S Baveja, M Fathi, M Roth. Zero-order release formulation of oxprenolol hydrochloride with swelling and erosion control. Pharmaceutical research. 1989 Apr; 6(4):313-7. doi: 10.1023/a:1015998424548. [PMID: 2748519]
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  • N F Fraeyman, C D Dello, F M Belpaire. Alpha 1-acid glycoprotein concentration and molecular heterogeneity: relationship to oxprenolol binding in serum from healthy volunteers and patients with lung carcinoma or cirrhosis. British journal of clinical pharmacology. 1988 Jun; 25(6):733-40. doi: 10.1111/j.1365-2125.1988.tb05260.x. [PMID: 3203044]
  • G T McInnes, M J Brodie. Concentration-effect relationships for oxprenolol in patients with essential hypertension. British journal of clinical pharmacology. 1988 May; 25(5):539-45. doi: 10.1111/j.1365-2125.1988.tb03343.x. [PMID: 3408634]
  • K P Devi, K V Rao, S K Baveja, M Fathi, M Roth. Determination of oxprenolol in plasma by column liquid chromatography. Journal of chromatography. 1988 Apr; 426(1):229-33. doi: 10.1016/s0378-4347(00)81949-0. [PMID: 3384876]
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