DADLE (BioDeep_00000719857)
代谢物信息卡片
(D-Ala2,D-Leu5)-Enkephalin acetate salt
化学式: C29H39N5O7 (569.2849344)
中文名称: (D-丙2,D-亮5)-脑啡肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1
描述信息
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 6917707
- DrugBank: DB08856
- ChEMBL: CHEMBL340032
- MeSH: Enkephalin, Leucine-2-Alanine
- CAS: 63631-40-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nestor N Jimenez-Vargas, Jing Gong, Matthew J Wisdom, Dane D Jensen, Rocco Latorre, Alan Hegron, Shavonne Teng, Jesse J DiCello, Pradeep Rajasekhar, Nicholas A Veldhuis, Simona E Carbone, Yang Yu, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Meritxell Canals, David E Reed, Alan E Lomax, Brian L Schmidt, Kam W Leong, Stephen J Vanner, Michelle L Halls, Nigel W Bunnett, Daniel P Poole. Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Proceedings of the National Academy of Sciences of the United States of America.
2020 06; 117(26):15281-15292. doi:
10.1073/pnas.2000500117. [PMID: 32546520] - Miriam Stoeber, Damien Jullié, Braden T Lobingier, Toon Laeremans, Jan Steyaert, Peter W Schiller, Aashish Manglik, Mark von Zastrow. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
Neuron.
2018 06; 98(5):963-976.e5. doi:
10.1016/j.neuron.2018.04.021. [PMID: 29754753] - L Vinod Kumar Reddy, Dwaipayan Sen. DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to 'serum free' apoptotic condition in part via the DOR/PI3K/AKT pathway.
Life sciences.
2017 Dec; 191(?):195-204. doi:
10.1016/j.lfs.2017.10.024. [PMID: 29054455] - Yi Zhou, Jing Zhang, Biao Lei, Wenjin Liang, Jianhua Gong, Chuanxiang Zhao, Jidong Yu, Xuan Li, Bo Tang, Shengguang Yuan. DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway.
Molecular medicine reports.
2017 Nov; 16(5):6214-6221. doi:
10.3892/mmr.2017.7393. [PMID: 28901476] - A V Dontsov. [THE INFLUENCE OF DEFICIT OF ENDOGENOUS NEUROPEPTIDES ON THE CLINICAL COURSE OF CORONARY HEART DISEASE].
Klinicheskaia meditsina.
2017 ; 95(2):127-31. doi:
". [PMID: 30303664] - O Yu Usenko, V V Petrushenko, S I Savolyuk, Ya V Radyoga, D I Grebenyuk. [ЕXPERIMENTAL ESTIMATION OF THE LOCAL APPLICATION EFFICACY OF BIOLOGICAL STIMULATOR FOR THE SOFT TISSUES REPARATION IN TREATMENT OF CHRONIC GASTRIC ULCERS].
Klinichna khirurhiia.
2016 ; ?(9):62-5. doi:
NULL. [PMID: 30265489] - R A Cherpakov, O A Grebenchikov, E Ju Plotnikov, V V Likhvantsev. [Comparison of pharmacological renal preconditioning with dalargin and lithium ions in the model of gentamycin-induced acute renal failure].
Anesteziologiia i reanimatologiia.
2015 Jan; 60(1):58-63. doi:
NULL. [PMID: 26027228] - A V Dontsov. [THE ANTIOXIDANT EFFECT OF DALARGIN IN PATIENTS WITH CORONARY HEART DISEASE AND METABOLIC SYNDROME].
Eksperimental'naia i klinicheskaia farmakologiia.
2015; 78(7):3-6. doi:
". [PMID: 26591199] - Miroslava Vošahlíková, Piotr Jurkiewicz, Lenka Roubalová, Martin Hof, Petr Svoboda. High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane.
Naunyn-Schmiedeberg's archives of pharmacology.
2014 May; 387(5):487-502. doi:
10.1007/s00210-014-0962-8. [PMID: 24577425] - E Y Plotnikov, O A Grebenchikov, V A Babenko, I B Pevzner, L D Zorova, V V Likhvantsev, D B Zorov. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity.
Toxicology letters.
2013 Jul; 220(3):303-8. doi:
10.1016/j.toxlet.2013.04.023. [PMID: 23651617] - Louisa Pettinger, Sylvain Gigout, John E Linley, Nikita Gamper. Bradykinin controls pool size of sensory neurons expressing functional δ-opioid receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Jun; 33(26):10762-71. doi:
10.1523/jneurosci.0123-13.2013. [PMID: 23804098] - Mariarosa Mazza, Rebecca Notman, Jamshed Anwar, Alison Rodger, Matthew Hicks, Gary Parkinson, Dave McCarthy, Tina Daviter, Julian Moger, Natalie Garrett, Tania Mead, Michael Briggs, Andreas G Schätzlein, Ijeoma F Uchegbu. Nanofiber-based delivery of therapeutic peptides to the brain.
ACS nano.
2013 Feb; 7(2):1016-26. doi:
10.1021/nn305193d. [PMID: 23289352] - Alessio Rungatscher, Daniele Linardi, Alice Giacomazzi, Maddalena Tessari, Tiziano Menon, Alessandro Mazzucco, Giuseppe Faggian. Cardioprotective effect of δ-opioid receptor agonist vs. mild therapeutic hypothermia in a rat model of cardiac arrest with extracorporeal life support.
Resuscitation.
2013 Feb; 84(2):244-8. doi:
10.1016/j.resuscitation.2012.06.016. [PMID: 22771872] - Gul Shahnaz, Javed Iqbal, Deni Rahmat, Glen Perera, Flavia Laffleur, Denise Rossi, Andreas Bernkop-Schnürch. Development and in vivo characterization of a novel peptide drug delivery system providing extended plasma half life.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Feb; 157(3):375-82. doi:
10.1016/j.jconrel.2011.09.092. [PMID: 21986100] - Jana Brejchová, Jan Sýkora, Kateřina Dlouhá, Lenka Roubalová, Pavel Ostašov, Miroslava Vošahlíková, Martin Hof, Petr Svoboda. Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1α fusion protein; the effect of cholesterol depletion.
Biochimica et biophysica acta.
2011 Dec; 1808(12):2819-29. doi:
10.1016/j.bbamem.2011.08.010. [PMID: 21864502] - Bo Tang, Yi Zhang, Rui Liang, Peng Yuan, Jian Du, Hongxin Wang, Liming Wang. Activation of the δ-opioid receptor inhibits serum deprivation-induced apoptosis of human liver cells via the activation of PKC and the mitochondrial pathway.
International journal of molecular medicine.
2011 Dec; 28(6):1077-85. doi:
10.3892/ijmm.2011.784. [PMID: 21874227] - Cheng Wu Tang, Wen Ming Feng, Hui Min Du, Ying Bao, Ming Zhu. Delayed administration of D-Ala2-D-Leu5-enkephalin, a delta-opioid receptor agonist, improves survival in a rat model of sepsis.
The Tohoku journal of experimental medicine.
2011 05; 224(1):69-76. doi:
10.1620/tjem.224.69. [PMID: 21551984] - S E Voskanian, E V Naĭdenov. [Pancreatic functional status after wedge resection of the duodenal wall and para-pancreatic micro-irrigation].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology.
2011; ?(7):32-40. doi:
. [PMID: 22363997] - L T Tadzhibova, M D Astaeva, J G Ismailova, T N Daudova, N K Klichkhanov. Effects of dalargin on free radical processes in the blood of rats exposed to moderate hypothermia.
Bulletin of experimental biology and medicine.
2011 Jan; 150(3):304-6. doi:
10.1007/s10517-011-1128-z. [PMID: 21240340] - Dapeng Wang, Hongxin Wang, Guoqiang Wu, Yuhong Yang, Jing Yang, Chunna Liu, Tak Ming Wong. Protein kinase C mediates the effects of delta-opioid receptor stimulation on survival and apoptosis in neonatal cardiomyocytes cultured in serum-deprived condition.
Die Pharmazie.
2009 Jul; 64(7):466-71. doi:
. [PMID: 19694185] - I Massarelli, M Macchia, F Minutolo, G Prota, A M Bianucci. QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design.
Bioorganic & medicinal chemistry.
2009 May; 17(10):3543-56. doi:
10.1016/j.bmc.2009.04.014. [PMID: 19398207] - Da-Peng Wang, Hong-Xin Wang, Bo Tang, Xiao-Chun Yu. [Effects of delta-opioid receptor stimulation on survival of cultured myocardial cells upon to serum deprivation].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2008 Aug; 24(3):274-8. doi:
NULL. [PMID: 21141581] - Prem N Yadav, Kirti Chaturvedi, Richard D Howells. Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells.
The Journal of pharmacology and experimental therapeutics.
2007 Mar; 320(3):1186-94. doi:
10.1124/jpet.106.113621. [PMID: 17159161] - Ling-Ling Yao, Yong-Gang Wang, Wen-Jie Cai, Tai Yao, Yi-Chun Zhu. Survivin mediates the anti-apoptotic effect of delta-opioid receptor stimulation in cardiomyocytes.
Journal of cell science.
2007 Mar; 120(Pt 5):895-907. doi:
10.1242/jcs.03393. [PMID: 17298978] - Bianca M Liederer, Kimthoa T Phan, Hui Ouyang, Ronald T Borchardt. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration.
Journal of pharmaceutical sciences.
2005 Dec; 94(12):2676-87. doi:
10.1002/jps.20476. [PMID: 16258984] - Bianca M Liederer, Ronald T Borchardt. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
Journal of pharmaceutical sciences.
2005 Oct; 94(10):2198-206. doi:
10.1002/jps.20452. [PMID: 16136552] - T Iu Rebrova, L N Maslov, Iu B Lishmanov. [Regulation by opiod peptides of the antioxidant enzyme activity and the prostanoid system in myocardium during stress].
Biomeditsinskaia khimiia.
2005 Mar; 51(2):177-84. doi:
. [PMID: 15945351] - Cesario V Borlongan, Yun Wang, Tsung-Ping Su. Delta opioid peptide (D-Ala 2, D-Leu 5) enkephalin: linking hibernation and neuroprotection.
Frontiers in bioscience : a journal and virtual library.
2004 Sep; 9(?):3392-8. doi:
10.2741/1490. [PMID: 15353366] - Joan Smith Sonneborn, Henry Gottsch, Eric Cubin, Peter Oeltgen, Paul Thomas. Alternative strategy for stress tolerance: opioids.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2004 May; 59(5):433-40. doi:
10.1093/gerona/59.5.b433. [PMID: 15123752] - E A Orlova, I A Komarevtseva. [Role of NO-synthase in stimulation of opiate receptors and kidney oxidative stress resistance].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2004 Jan; 76(1):97-102. doi:
NULL. [PMID: 15909423] - Bingwen Jing, Vaclav Janout, Steven L Regen. Fully detachable molecular umbrellas as peptide delivery agents.
Bioconjugate chemistry.
2003 Nov; 14(6):1191-6. doi:
10.1021/bc034074m. [PMID: 14624634] - Kousyou Yamanouchi, Katsuhiko Yanaga, Sadayuki Okudaira, Susumu Eguchi, Junichiro Furui, Takashi Kanematsu. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat.
The Journal of surgical research.
2003 Sep; 114(1):72-7. doi:
10.1016/s0022-4804(03)00196-3. [PMID: 13678701] - G V Gvak, V G Eremenko. [Prevention of altering effects of surgical stress in children with abdominal pathology].
Anesteziologiia i reanimatologiia.
2003 Jul; ?(4):11-3. doi:
". [PMID: 14524009] - Peter Mayer, Thomas Kroslak, Helga Tischmeyer, Volker Höllt. A truncated delta opioid receptor, spontaneously produced in human but not rat neuroblastoma cells, interferes with signaling of the full-length receptor.
Neuroscience letters.
2003 Jun; 344(1):62-4. doi:
10.1016/s0304-3940(03)00382-3. [PMID: 12781922] - Lenka Bourova, Alexandra Kostrnova, Lucie Hejnova, Zuzana Moravcova, Hyo-Eun Moon, Jiri Novotny, Graeme Milligan, Petr Svoboda. delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains.
Journal of neurochemistry.
2003 Apr; 85(1):34-49. doi:
10.1046/j.1471-4159.2003.01667.x. [PMID: 12641725] - Daniela A Eisinger, Hermann Ammer, Rüdiger Schulz. Chronic morphine treatment inhibits opioid receptor desensitization and internalization.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002 Dec; 22(23):10192-200. doi:
10.1523/jneurosci.22-23-10192.2002. [PMID: 12451120] - Jerry Z Yang, K Chad Bastian, Randy D Moore, John F Stobaugh, Ronald T Borchardt. Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Nov; 780(2):269-81. doi:
10.1016/s1570-0232(02)00536-6. [PMID: 12401352] - Jerry Z Yang, Weiqing Chen, Ronald T Borchardt. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs.
The Journal of pharmacology and experimental therapeutics.
2002 Nov; 303(2):840-8. doi:
10.1124/jpet.102.037135. [PMID: 12388671] - E A Orlova, I A Komarevtseva. [Effect of dalarginum on the level of nitric oxide stable metabolites in rat kidneys during apoptosis activation].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2002 Nov; 74(6):131-4. doi:
NULL. [PMID: 12924028] - E J Adie, S Kalinka, L Smith, M J Francis, A Marenghi, M E Cooper, M Briggs, N P Michael, G Milligan, S Game. A pH-sensitive fluor, CypHer 5, used to monitor agonist-induced G protein-coupled receptor internalization in live cells.
BioTechniques.
2002 Nov; 33(5):1152-4, 1156. doi:
10.2144/02335dd10. [PMID: 12449397] - András Z Rónai, Klara Gyires, István Barna, Katalin Müllner, Anikó Reichart, Miklós Palkovits. Gyrus cinguli transection abolishes delta-opioid receptor-induced gastroprotection and alters alpha 2 adrenoceptor activity in the lower brainstem in rats.
Brain research.
2002 Aug; 947(1):90-9. doi:
10.1016/s0006-8993(02)02912-8. [PMID: 12144857] - Hui Ouyang, Fuxing Tang, Teruna J Siahaan, Ronald T Borchardt. A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.
Pharmaceutical research.
2002 Jun; 19(6):794-801. doi:
10.1023/a:1016148631055. [PMID: 12134949] - Fuxing Tang, Ronald T Borchardt. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.
Pharmaceutical research.
2002 Jun; 19(6):780-6. doi:
10.1023/a:1016144530146. [PMID: 12134947] - Fuxing Tang, Ronald T Borchardt. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.
Pharmaceutical research.
2002 Jun; 19(6):787-93. doi:
10.1023/a:1016196514217. [PMID: 12134948] - Hye J Lee, Gordon L Amidon. The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats.
Biopharmaceutics & drug disposition.
2002 May; 23(4):131-41. doi:
10.1002/bdd.302. [PMID: 12015787] - S P L'vova, E M Abaeva, A G Gasangadzhieva, I K Mikhaĭlenko. [Antioxidant system in rat tissues in hypothermia and dalargin introduction].
Voprosy meditsinskoi khimii.
2002 Mar; 48(2):189-95. doi:
NULL. [PMID: 12189626] - Teruo Hayashi, Li-I Tsao, Tsung-Ping Su. Antiapoptotic and cytotoxic properties of delta opioid peptide [D-Ala(2),D-Leu(5)]enkephalin in PC12 cells.
Synapse (New York, N.Y.).
2002 Jan; 43(1):86-94. doi:
10.1002/syn.10019. [PMID: 11746737] - H Kenneth Kramer, Irma Onoprishvili, Matthew L Andria, Kayane Hanna, Karina Sheinkman, Lisa B Haddad, Eric J Simon. Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases.
BMC pharmacology.
2002; 2(?):5. doi:
10.1186/1471-2210-2-5. [PMID: 11897012] - L N Maslov, A A Sokolov, N A Fedorova, Iu B Lishmanov, R S Karpov. [Clinical response to agonists of mu and beta opiate receptors in patients with ischemic heart disease: effects of D-Ala2-Leu5-Arg6-enkephalin on hemodynamics, oxygen balance and lipid spectrum of blood].
Klinicheskaia meditsina.
2002; 80(8):53-7. doi:
". [PMID: 12360622] - P Li, S Tjen-A-Looi, J C Longhurst. Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Autonomic neuroscience : basic & clinical.
2001 Jun; 89(1-2):38-47. doi:
10.1016/s1566-0702(01)00247-8. [PMID: 11474645] - M V Pivovarchik. [State of the opioid system in rats with different sensitivity to ethanol].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2001 May; 73(3):138-40. doi:
NULL. [PMID: 12035545] - T Hayashi, H Hirata, M Asanuma, B Ladenheim, L I Tsao, J L Cadet, T P Su. Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53.
Synapse (New York, N.Y.).
2001 Mar; 39(4):305-12. doi:
10.1002/1098-2396(20010315)39:4<305::aid-syn1013>3.0.co;2-e. [PMID: 11169780] - N K Klichkhanov, Z G Ismailova, E Z Emirbekov. Oxidative modification of plasma proteins during hypothermia and after dalargin administration.
Bulletin of experimental biology and medicine.
2001 Mar; 131(3):234-6. doi:
10.1023/a:1017639129468. [PMID: 11427906] - O A Lebed'ko, S S Timoshin. Effects of opiate receptor ligands on DNA synthesis in tracheal epitheliocytes and smooth muscle cells of newborn albino rats.
Bulletin of experimental biology and medicine.
2001 Feb; 131(2):169-71. doi:
10.1023/a:1017504331168. [PMID: 11391405] - K Chaturvedi, X Jiang, K H Christoffers, N Chinen, P Bandari, L F Raveglia, S Ronzoni, G Dondio, R D Howells. Pharmacological profiles of selective non-peptidic delta opioid receptor ligands.
Brain research. Molecular brain research.
2000 Sep; 80(2):166-76. doi:
10.1016/s0169-328x(00)00134-0. [PMID: 11038249] - T P Su. Delta opioid peptide[D- Ala(2),D-Leu(5)]enkephalin promotes cell survival.
Journal of biomedical science.
2000 May; 7(3):195-9. doi:
10.1007/bf02255466. [PMID: 10810237] - V F Bulychev, Ia M Vakhrushev. [Therapy of patients with chronic pancreatitis of alcoholic etiology by dalagrin and laser therapy of the blood].
Klinicheskaia meditsina.
2000; 78(12):43-6. doi:
NULL. [PMID: 11210353] - A V Kuriata. [The functional status of the sympathoadrenal system in hypertension patients being treated with captopril and dalargin].
Likars'ka sprava.
1999 Sep; ?(6):23-7. doi:
NULL. [PMID: 10626434] - L I Tsao, J L Cadet, T P Su. Reversal by [D-Ala2,D-Leu5]enkephalin of the dopamine transporter loss caused by methamphetamine.
European journal of pharmacology.
1999 May; 372(3):R5-7. doi:
10.1016/s0014-2999(99)00240-x. [PMID: 10395030] - J Garzón, J DeFelipe, J R Rodríguez, I DeAntonio, A García-España, P Sánchez-Blázquez. Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.
Brain research. Molecular brain research.
1999 Mar; 65(2):151-66. doi:
10.1016/s0169-328x(98)00350-7. [PMID: 10064886] - P Mailly, M Gastard, A Cupo. Subcellular distribution of delta-opioid receptors in the rat spinal cord: an approach using a three-dimensional reconstruction of confocal series of immunolabelled neurons.
Journal of neuroscience methods.
1999 Feb; 87(1):17-24. doi:
10.1016/s0165-0270(98)00149-6. [PMID: 10065990] - O S Gudmundsson, K Nimkar, S Gangwar, T Siahaan, R T Borchardt. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
Pharmaceutical research.
1999 Jan; 16(1):16-23. doi:
10.1023/a:1018802324759. [PMID: 9950273] - U Schroeder, P Sommerfeld, S Ulrich, B A Sabel. Nanoparticle technology for delivery of drugs across the blood-brain barrier.
Journal of pharmaceutical sciences.
1998 Nov; 87(11):1305-7. doi:
10.1021/js980084y. [PMID: 9811481] - L I Tsao, B Ladenheim, A M Andrews, C C Chiueh, J L Cadet, T P Su. Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species.
The Journal of pharmacology and experimental therapeutics.
1998 Oct; 287(1):322-31. doi:
NULL. [PMID: 9765353] - T Kshirsagar, A H Nakano, P Y Law, R Elde, P S Portoghese. NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
Neuroscience letters.
1998 Jun; 249(2-3):83-6. doi:
10.1016/s0304-3940(98)00379-6. [PMID: 9682822] - H Kubota, R B Rothman, C Dersch, K McCullough, J Pinto, K C Rice. Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Bioorganic & medicinal chemistry letters.
1998 Apr; 8(7):799-804. doi:
10.1016/s0960-894x(98)00105-x. [PMID: 9871544] - N D Horton, D J Kaftani, D S Bruce, E C Bailey, A S Krober, J R Jones, M Turker, N Khattar, T P Su, S F Bolling, P R Oeltgen. Isolation and partial characterization of an opioid-like 88 kDa hibernation-related protein.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
1998 Apr; 119(4):787-805. doi:
10.1016/s0305-0491(98)00056-x. [PMID: 9787770] - V I Pudov, I F Grigor'eva, N V Atamanova, S A Boronev. [Neuropeptides in the treatment of sensorineural hypoacusis in children].
Vestnik otorinolaringologii.
1998; ?(4):22-4. doi:
NULL. [PMID: 9752091] - V D Slepushkin. [Neuropeptides in anesthesiology and intensive care].
Anesteziologiia i reanimatologiia.
1997 Nov; ?(6):59-62. doi:
NULL. [PMID: 9511251] - S F Bolling, N L Tramontini, K S Kilgore, T P Su, P R Oeltgen, H H Harlow. Use of "natural" hibernation induction triggers for myocardial protection.
The Annals of thoracic surgery.
1997 Sep; 64(3):623-7. doi:
10.1016/s0003-4975(97)00631-0. [PMID: 9307448] - G Bot, A D Blake, S Li, T Reisine. Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Molecular pharmacology.
1997 Aug; 52(2):272-81. doi:
10.1124/mol.52.2.272. [PMID: 9271350] - M I Neĭmark, V V Shmelev. [Changes in central hemodynamics and their correction during reconstructive surgery in Leriche's syndrome].
Anesteziologiia i reanimatologiia.
1997 Mar; ?(2):18-22. doi:
NULL. [PMID: 9221679] - S N Calderon, K C Rice, R B Rothman, F Porreca, J L Flippen-Anderson, H Kayakiri, H Xu, K Becketts, L E Smith, E J Bilsky, P Davis, R Horvath. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands.
Journal of medicinal chemistry.
1997 Feb; 40(5):695-704. doi:
10.1021/jm960319n. [PMID: 9057856] - P Y Law, T M McGinn, K M Campbell, L E Erickson, H H Loh. Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner.
Molecular pharmacology.
1997 Jan; 51(1):152-60. doi:
10.1124/mol.51.1.152. [PMID: 9016358] - C M Bertha, M Ellis, J L Flippen-Anderson, F Porreca, R B Rothman, P Davis, H Xu, K Becketts, K C Rice. Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Journal of medicinal chemistry.
1996 May; 39(10):2081-6. doi:
10.1021/jm950695s. [PMID: 8642567] - N Dion, H Le Moual, M C Fournié-Zaluski, B P Roques, P Crine, G Boileau. Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors.
The Biochemical journal.
1995 Oct; 311 ( Pt 2)(?):623-7. doi:
10.1042/bj3110623. [PMID: 7487905] - N N Mikhaĭlova, V D Slepushkin. [Effectiveness of the use of synthetic opioid peptide in rats with traumatic shock].
Patologicheskaia fiziologiia i eksperimental'naia terapiia.
1995 Oct; ?(4):27-9. doi:
NULL. [PMID: 8700589] - S V Tumanian, G G Zhdanov. [Metabolic components of anesthesiological provision in surgery of suppurative-inflammatory diseases of the abdominal cavity].
Anesteziologiia i reanimatologiia.
1995 Sep; ?(5):31-4. doi:
". [PMID: 8533961] - C M Bertha, J L Flippen-Anderson, R B Rothman, F Porreca, P Davis, H Xu, K Becketts, X Y Cha, K C Rice. Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Journal of medicinal chemistry.
1995 Apr; 38(9):1523-37. doi:
10.1021/jm00009a013. [PMID: 7739011] - S E Thompson, J Cavitt, K L Audus. Leucine enkephalin effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers.
Journal of cardiovascular pharmacology.
1994 Nov; 24(5):818-25. doi:
10.1097/00005344-199424050-00018. [PMID: 7532761] - J Barg, G E Thomas, W T Bem, M D Parnes, A M Ho, M M Belcheva, R J McHale, J A McLachlan, K C Tolman, F E Johnson. In vitro and in vivo expression of opioid and sigma receptors in rat C6 glioma and mouse N18TG2 neuroblastoma cells.
Journal of neurochemistry.
1994 Aug; 63(2):570-4. doi:
10.1046/j.1471-4159.1994.63020570.x. [PMID: 8035181] - A A Zozulia, M R Shchurin, V I Dikaia, V V Bondar', N M Krym, G P Panteleeva. [The effect of dalargin on the opioid and immune systems in patients with a depressive syndrome].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
1994; 94(1):61-5. doi:
NULL. [PMID: 8009937] - J Garzón, M A Castro, J L Juarros, P Sánchez-Blázquez. Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.
Life sciences.
1994; 54(11):PL191-6. doi:
10.1016/0024-3205(94)90167-8. [PMID: 8107515] - I K Svanidze, D P Museridze. [The stimulation of the growth and differentiation of the axons and dendrites of spinal cord neurons in tissue culture].
Biulleten' eksperimental'noi biologii i meditsiny.
1993 Dec; 116(12):650-2. doi:
NULL. [PMID: 8123833] - L Intorre, G Mengozzi, E Vanni, F Grassi, G Soldani. The role of peripheral opioid receptor subtypes in the modulation of gastric acid secretion and plasma gastrin in dogs.
European journal of pharmacology.
1993 Oct; 243(3):265-72. doi:
10.1016/0014-2999(93)90184-j. [PMID: 8276079] - H Tsushima, M Mori, T Matsuda. Effects of D-Ala2-D-Leu5-enkephalin, microinjected into the supraoptic and paraventricular nuclei, on urine outflow rate.
Japanese journal of pharmacology.
1993 Oct; 63(2):181-6. doi:
10.1254/jjp.63.181. [PMID: 8283828] - K G Gomathi, S K Sharma. Purification and reconstitution of the delta opioid receptor.
FEBS letters.
1993 Sep; 330(2):146-50. doi:
10.1016/0014-5793(93)80261-r. [PMID: 8396046] - L N Maslov, Y B Lishmanov. The anti-arrhythmic effect of D-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism.
International journal of cardiology.
1993 Jul; 40(2):89-94. doi:
10.1016/0167-5273(93)90269-m. [PMID: 8349385] - C Landry, P Santagata, W Bawab, M C Fournié-Zaluski, B P Roques, P Vinay, P Crine. Characterization of neutral endopeptidase 24.11 in dog glomeruli.
The Biochemical journal.
1993 May; 291 ( Pt 3)(?):773-9. doi:
10.1042/bj2910773. [PMID: 8489505] - S P L'vova, T F Gorbunova, E M Abaeva. [The effect of hypothermia and dalargin on lipid peroxidation in rat tissues].
Voprosy meditsinskoi khimii.
1993 May; 39(3):21-4. doi:
". [PMID: 8333182] - W Jin, N M Lee, H H Loh, S A Thayer. Opioid-induced inhibition of voltage-gated calcium channels parallels expression of omega-conotoxin-sensitive channel subtype during differentiation of NG108-15 cells.
Brain research.
1993 Apr; 607(1-2):17-22. doi:
10.1016/0006-8993(93)91484-a. [PMID: 8481794] - W Jin, N M Lee, H H Loh, S A Thayer. Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.
Molecular pharmacology.
1992 Dec; 42(6):1083-9. doi:
. [PMID: 1336113] - M R Shchurin, S F Pshenichkin, M S Solov'eva, G V Smirnova, N P Goncharov, V V Mit'kin, G T Sukhikh, V F Lavrov, G B Kirillicheva, A A Zozulia. [The normalizing effect of dalargin on the glucocorticoid and opioid levels of the blood in CBA and C57Bl/6 mice undergoing footshock stress].
Biulleten' eksperimental'noi biologii i meditsiny.
1992 Dec; 114(12):617-9. doi:
NULL. [PMID: 1292691] - Iu B Lishmanov, T Iu Rebrova, S A Afanas'ev, A I Kravchenko. [The effect of synthetic enkephalins on prostaglandin synthesis and lipid peroxidation in the isolated heart during the activation of free-radical processes].
Biulleten' eksperimental'noi biologii i meditsiny.
1992 Nov; 114(11):468-70. doi:
". [PMID: 1290811] - N Bodor, L Prokai, W M Wu, H Farag, S Jonalagadda, M Kawamura, J Simpkins. A strategy for delivering peptides into the central nervous system by sequential metabolism.
Science (New York, N.Y.).
1992 Sep; 257(5077):1698-700. doi:
10.1126/science.1529356. [PMID: 1529356] - D S Bruce, D L Ambler, T M Henschel, P R Oeltgen, S P Nilekani, S C Amstrup. Suppression of guinea pig ileum induced contractility by plasma albumin of hibernators.
Pharmacology, biochemistry, and behavior.
1992 Sep; 43(1):199-203. doi:
10.1016/0091-3057(92)90658-3. [PMID: 1409805] - M M Belcheva, J Barg, C Gloeckner, X M Gao, D M Chuang, C J Coscia. Antagonist-induced transient down-regulation of delta-opioid receptors in NG108-15 cells.
Molecular pharmacology.
1992 Sep; 42(3):445-52. doi:
NULL. [PMID: 1328845] - K Matsumura, I Abe, M Tominaga, T Tsuchihashi, K Kobayashi, M Fujishima. Differential modulation by mu- and delta-opioids on baroreceptor reflex in conscious rabbits.
Hypertension (Dallas, Tex. : 1979).
1992 Jun; 19(6 Pt 2):648-52. doi:
10.1161/01.hyp.19.6.648. [PMID: 1592461] - L N Maslov, Iu B Lishmanov. [The mechanism of the antiarrhythmic action of dalargin in experimental myocardial ischemia].
Eksperimental'naia i klinicheskaia farmakologiia.
1992 Mar; 55(2):25-8. doi:
NULL. [PMID: 1358376]