SD-208 (BioDeep_00000719855)
代谢物信息卡片
化学式: C17H10ClFN6 (352.0639)
中文名称: 2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
InChI: InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Hui Chen, Su-Xiang Guo, Sai Zhang, Xiao-Dan Li, Hao Wang, Xiao-Wei Li. MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway.
The Kaohsiung journal of medical sciences.
2020 Nov; 36(11):869-877. doi:
10.1002/kjm2.12260. [PMID: 32583575] - Alanna C Green, Darren Lath, Katie Hudson, Brant Walkley, Jennifer M Down, Robert Owen, Holly R Evans, Julia Paton-Hough, Gwendolen C Reilly, Michelle A Lawson, Andrew D Chantry. TGFβ Inhibition Stimulates Collagen Maturation to Enhance Bone Repair and Fracture Resistance in a Murine Myeloma Model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2019 12; 34(12):2311-2326. doi:
10.1002/jbmr.3859. [PMID: 31442332] - Audrey Lamora, Julie Talbot, Gwenola Bougras, Jérôme Amiaud, Marion Leduc, Julie Chesneau, Julien Taurelle, Verena Stresing, Marie Cécile Le Deley, Marie Françoise Heymann, Dominique Heymann, Françoise Redini, Franck Verrecchia. Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Oct; 20(19):5097-112. doi:
10.1158/1078-0432.ccr-13-3191. [PMID: 25107916] - Natalia Martin-Martin, Craig Slattery, Tara McMorrow, Michael P Ryan. TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway.
American journal of physiology. Renal physiology.
2011 Dec; 301(6):F1281-92. doi:
10.1152/ajprenal.00188.2010. [PMID: 21880834] - Leigh J Ellmers, Nicola J A Scott, Satyanarayana Medicherla, Anna P Pilbrow, Paul G Bridgman, Timothy G Yandle, A Mark Richards, Andrew A Protter, Vicky A Cameron. Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction.
Endocrinology.
2008 Nov; 149(11):5828-34. doi:
10.1210/en.2008-0165. [PMID: 18653707] - Sum Yee Leung, Akio Niimi, Alistair Noble, Timothy Oates, Alison S Williams, Satyanarayana Medicherla, Andrew A Protter, Kian Fan Chung. Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling.
The Journal of pharmacology and experimental therapeutics.
2006 Nov; 319(2):586-94. doi:
10.1124/jpet.106.109314. [PMID: 16888081]
