KU-55933 (BioDeep_00000719820)
代谢物信息卡片
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
化学式: C21H17NO3S2 (395.0649812)
中文名称: KU-55933(ATM激酶抑制剂)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
InChI: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Komei Sakata, Hidekata Yasuoka, Keiko Yoshimoto, Tsutomu Takeuchi. Decreased activation of ataxia telangiectasia mutated (ATM) in monocytes from patients with systemic sclerosis.
Rheumatology (Oxford, England).
2020 Dec; 59(12):3961-3970. doi:
10.1093/rheumatology/keaa312. [PMID: 32743653] - Masahiro Uehara, Tetsuro Kusaba, Tomoharu Ida, Kunihiro Nakai, Tomohiro Nakata, Aya Tomita, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Noriyuki Yamashita, Yuhei Kirita, Satoaki Matoba, Benjamin D Humphreys, Keiichi Tamagaki. Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.
Scientific reports.
2020 03; 10(1):4441. doi:
10.1038/s41598-020-61456-7. [PMID: 32157166] - Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Ivan Angulo-Herrera, Grant Wishart, Kim L Matthews, Sarah L Martin, Helen C Cox, George McAllister, Stephen D Penrose, Huw Vater, William Esmieu, Amanda Van de Poël, Rhea Van de Bospoort, Annelieke Strijbosch, Marieke Lamers, Philip Leonard, Rebecca E Jarvis, Wesley Blackaby, Karen Barnes, Maria Eznarriaga, Simon Dowler, Graham D Smith, David F Fischer, Ovadia Lazari, Dawn Yates, Mark Rose, Sung-Wook Jang, Ignacio Muñoz-Sanjuan, Celia Dominguez. Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
Journal of medicinal chemistry.
2019 03; 62(6):2988-3008. doi:
10.1021/acs.jmedchem.8b01819. [PMID: 30840447] - Tiantian She, Junnan Feng, Shenyi Lian, Ruobing Li, Chuanke Zhao, Guoliang Song, Jie Luo, Rouxianguli Dawuti, Shaoqing Cai, Like Qu, Chengchao Shou. Sarsaparilla (Smilax Glabra Rhizome) Extract Activates Redox-Dependent ATM/ATR Pathway to Inhibit Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy.
Nutrition and cancer.
2017 Nov; 69(8):1281-1289. doi:
10.1080/01635581.2017.1362447. [PMID: 29111814] - Xi Tian, Haydee Lara, Kyle T Wagner, Srinivas Saripalli, Syed Nabeel Hyder, Michael Foote, Manish Sethi, Edina Wang, Joseph M Caster, Longzhen Zhang, Andrew Z Wang. Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.
Nanoscale.
2015 Dec; 7(47):20211-9. doi:
10.1039/c5nr05869d. [PMID: 26575637] - Kyle L Poulsen, Jesus Olivero-Verbel, Kevin M Beggs, Patricia E Ganey, Robert A Roth. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response.
The Journal of pharmacology and experimental therapeutics.
2014 Jul; 350(1):164-70. doi:
10.1124/jpet.114.214189. [PMID: 24817034] - R J Flassig, G Maubach, C Täger, K Sundmacher, M Naumann. Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM.
Molecular bioSystems.
2014 Jul; 10(7):1978-86. doi:
10.1039/c4mb00093e. [PMID: 24833308] - Yan Li, Hua Xiong, Da-Qing Yang. Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells.
Chinese journal of cancer.
2012 Aug; 31(8):364-72. doi:
10.5732/cjc.012.10086. [PMID: 22739265] - Yuji Okuno, Ayako Nakamura-Ishizu, Kinya Otsu, Toshio Suda, Yoshiaki Kubota. Pathological neoangiogenesis depends on oxidative stress regulation by ATM.
Nature medicine.
2012 Aug; 18(8):1208-16. doi:
10.1038/nm.2846. [PMID: 22797809] - Yan Li, Da-Qing Yang. The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
Molecular cancer therapeutics.
2010 Jan; 9(1):113-25. doi:
10.1158/1535-7163.mct-08-1189. [PMID: 20053781] - Daman Kumari, Valentina Somma, Asako J Nakamura, William M Bonner, Ettoré D'Ambrosio, Karen Usdin. The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.
Nucleic acids research.
2009 Jul; 37(13):4385-92. doi:
10.1093/nar/gkp391. [PMID: 19465392] - Alessandra Soriani, Alessandra Zingoni, Cristina Cerboni, Maria Luisa Iannitto, Maria Rosaria Ricciardi, Valentina Di Gialleonardo, Marco Cippitelli, Cinzia Fionda, Maria Teresa Petrucci, Anna Guarini, Robin Foà, Angela Santoni. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype.
Blood.
2009 Apr; 113(15):3503-11. doi:
10.1182/blood-2008-08-173914. [PMID: 19098271] - Zachary A Knight, Kevan M Shokat. Features of selective kinase inhibitors.
Chemistry & biology.
2005 Jun; 12(6):621-37. doi:
10.1016/j.chembiol.2005.04.011. [PMID: 15975507]