Desipramine hydrochloride (BioDeep_00000719819)
代谢物信息卡片
Desipramine hydrochloride
化学式: C18H23ClN2 (302.155)
中文名称: 盐酸去甲咪嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:4449
- KEGGdrug: D00812
- PubChem: 65327
- ChEMBL: CHEMBL1696
- MeSH: Desipramine
- CAS: 58-28-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Daria A Belinskaia, Natalia N Shestakova. Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data.
Biochemistry. Biokhimiia.
2024 Mar; 89(3):507-522. doi:
10.1134/s0006297924030106. [PMID: 38648769] - Weijia Gu, Yanxi Chai, Yuxin Huang, Ziwei Cai, Ran Li, Rucheng Chen, Cuiqing Liu, Qinghua Sun. Desipramine ameliorates fine particulate matter-induced hepatic insulin resistance by modulating the ceramide metabolism in mice.
Ecotoxicology and environmental safety.
2024 Jan; 270(?):115849. doi:
10.1016/j.ecoenv.2023.115849. [PMID: 38134639] - Nirod Kumar Sarangi, Amrutha Prabhakaran, Mark Roantree, Tia E Keyes. Evaluation of the passive permeability of antidepressants through pore-suspended lipid bilayer.
Colloids and surfaces. B, Biointerfaces.
2023 Dec; 234(?):113688. doi:
10.1016/j.colsurfb.2023.113688. [PMID: 38128360] - Min Hu, Jia-Ying Cai, Yao He, Kui Chen, Feng Hao, Jin-Sen Kang, Yan Pan, Lu Tie, Xue-Jun Li. Protective effects of curcumin on desipramine-induced islet β-cell damage via AKAP150/PKA/PP2B complex.
Acta pharmacologica Sinica.
2023 Oct; ?(?):. doi:
10.1038/s41401-023-01176-6. [PMID: 37845344] - Meng Tang, Zhihui Yang, Jing Liu, Xiangfei Zhang, Lan Guan, Xinming Liu, Ming Zeng. Combined intervention with N-acetylcysteine and desipramine alleviated silicosis development by regulating the Nrf2/HO-1 and ASMase/ceramide signaling pathways.
Ecotoxicology and environmental safety.
2022 Sep; 242(?):113914. doi:
10.1016/j.ecoenv.2022.113914. [PMID: 35878501] - Ranran Zhang, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, Minghua Qiu. Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.).
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164934. [PMID: 34443522] - Gloria Lazzeri, Carla L Busceti, Francesca Biagioni, Cinzia Fabrizi, Gabriele Morucci, Filippo S Giorgi, Michela Ferrucci, Paola Lenzi, Stefano Puglisi-Allegra, Francesco Fornai. Norepinephrine Protects against Methamphetamine Toxicity through β2-Adrenergic Receptors Promoting LC3 Compartmentalization.
International journal of molecular sciences.
2021 Jul; 22(13):. doi:
10.3390/ijms22137232. [PMID: 34281286] - Zolfaghar Aladaghlo, Siamak Javanbakht, Ali Reza Fakhari, Ahmad Shaabani. Gelatin microsphere coated Fe3O4@graphene quantum dots nanoparticles as a novel magnetic sorbent for ultrasound-assisted dispersive magnetic solid-phase extraction of tricyclic antidepressants in biological samples.
Mikrochimica acta.
2021 02; 188(3):73. doi:
10.1007/s00604-021-04727-y. [PMID: 33550423] - Waheeda A Naimi, Jacob J Gumpf, Chelsea L Cockburn, Sarah Camus, Charles E Chalfant, Pin-Lan Li, Jason A Carlyon. Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo.
Pathogens and disease.
2021 01; 79(1):. doi:
10.1093/femspd/ftaa072. [PMID: 33220685] - Melodi A Bowman, Nathan C Mitchell, W Anthony Owens, Rebecca E Horton, Wouter Koek, Lynette C Daws. Effect of concurrent organic cation transporter blockade on norepinephrine clearance inhibiting- and antidepressant-like actions of desipramine and venlafaxine.
European journal of pharmacology.
2020 Sep; 883(?):173285. doi:
10.1016/j.ejphar.2020.173285. [PMID: 32697958] - Estabraq Jaddoa, Jinit Masania, Eva Masiero, Tiziana Sgamma, Randolph Arroo, Daniel Sillence, Tyra Zetterström. Effect of antidepressant drugs on the brain sphingolipid system.
Journal of psychopharmacology (Oxford, England).
2020 07; 34(7):716-725. doi:
10.1177/0269881120915412. [PMID: 32403969] - Daniela Leonetti, Hala Estéphan, Natacha Ripoche, Nolwenn Dubois, Audrey Aguesse, Sébastien Gouard, Lisa Brossard, Sophie Chiavassa, Isabelle Corre, Claire Pecqueur, Michel Neunlist, Elie Hadchity, Marie-Hélène Gaugler, Maxime M Mahé, François Paris. Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity.
Cancer research.
2020 06; 80(12):2651-2662. doi:
10.1158/0008-5472.can-19-1527. [PMID: 32291318] - Anderson Luiz Oenning, Letícia Birk, Sarah Eller, Tiago Franco de Oliveira, Josias Merib, Eduardo Carasek. A green and low-cost method employing switchable hydrophilicity solvent for the simultaneous determination of antidepressants in human urine by gas chromatography - mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1143(?):122069. doi:
10.1016/j.jchromb.2020.122069. [PMID: 32213465] - Lily L Cao, Andrew P Holmes, Janice M Marshall, Larissa Fabritz, Keith L Brain. Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: A novel fluorescence imaging method.
Autonomic neuroscience : basic & clinical.
2020 01; 223(?):102611. doi:
10.1016/j.autneu.2019.102611. [PMID: 31901784] - Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka, Kenji Tabata. Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
Biopharmaceutics & drug disposition.
2019 May; 40(5-6):176-187. doi:
10.1002/bdd.2181. [PMID: 30985942] - Trivadila Slamet Soetanto, Shuang Liu, Muhammad Novrizal Abdi Sahid, Kensuke Toyama, Kazutaka Maeyama, Masaki Mogi. Histamine uptake mediated by plasma membrane monoamine transporter and organic cation transporters in rat mast cell lines.
European journal of pharmacology.
2019 Apr; 849(?):75-83. doi:
10.1016/j.ejphar.2019.01.050. [PMID: 30707958] - Chelsea L Cockburn, Ryan S Green, Sheela R Damle, Rebecca K Martin, Naomi N Ghahrai, Punsiri M Colonne, Marissa S Fullerton, Daniel H Conrad, Charles E Chalfant, Daniel E Voth, Elizabeth A Rucks, Stacey D Gilk, Jason A Carlyon. Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.
Life science alliance.
2019 04; 2(2):. doi:
10.26508/lsa.201800292. [PMID: 30902833] - Magd Badaoui, Adam Kells, Carla Molteni, Callum J Dickson, Viktor Hornak, Edina Rosta. Calculating Kinetic Rates and Membrane Permeability from Biased Simulations.
The journal of physical chemistry. B.
2018 12; 122(49):11571-11578. doi:
10.1021/acs.jpcb.8b07442. [PMID: 30247032] - Cristina Alba-Delgado, Meritxell Llorca-Torralba, Juan Antonio Mico, Esther Berrocoso. The onset of treatment with the antidepressant desipramine is critical for the emotional consequences of neuropathic pain.
Pain.
2018 Dec; 159(12):2606-2619. doi:
10.1097/j.pain.0000000000001372. [PMID: 30130302] - Margaret N Holme, Subinoy Rana, Hanna M G Barriga, Ulrike Kauscher, Nicholas J Brooks, Molly M Stevens. A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors.
ACS nano.
2018 08; 12(8):8197-8207. doi:
10.1021/acsnano.8b03308. [PMID: 30080036] - Peter J Vollbrecht, Kathryn M Nesbitt, Omar S Mabrouk, Aaron M Chadderdon, Emily M Jutkiewicz, Robert T Kennedy, Carrie R Ferrario. Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats.
Behavioural brain research.
2018 07; 346(?):137-143. doi:
10.1016/j.bbr.2017.11.009. [PMID: 29129597] - Julia Ríos-Gómez, Beatriz Fresco-Cala, María Teresa García-Valverde, Rafael Lucena, Soledad Cárdenas. Carbon Nanohorn Suprastructures on a Paper Support as a Sorptive Phase.
Molecules (Basel, Switzerland).
2018 May; 23(6):. doi:
10.3390/molecules23061252. [PMID: 29794967] - Farhad Ahmadi, Tahereh Mahmoudi-Yamchi, Homa Azizian. Super paramagnetic core-shells anchored onto silica grafted with C8/NH2 nano-particles for ultrasound-assisted magnetic solid phase extraction of imipramine and desipramine from plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Mar; 1077-1078(?):52-59. doi:
10.1016/j.jchromb.2018.01.033. [PMID: 29413577] - Tingting Liu, Wang Duan, Paul Nizigiyimana, Lin Gao, Zhouning Liao, Boya Xu, Lerong Liu, Minxiang Lei. Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress.
Biochemical and biophysical research communications.
2018 02; 496(2):394-400. doi:
10.1016/j.bbrc.2018.01.040. [PMID: 29317203] - Ramachandra Sangana, Helen Gu, Dung Yu Chun, Heidi J Einolf. Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches.
Drug metabolism and disposition: the biological fate of chemicals.
2018 01; 46(1):26-32. doi:
10.1124/dmd.117.077834. [PMID: 29038231] - Ewa B Romuk, Wioletta Szczurek, Michał Oleś, Artur Gabrysiak, Marta Skowron, Przemysław Nowak, Ewa Birkner. The evaluation of the changes in enzymatic antioxidant reserves and lipid peroxidation in chosen parts of the brain in an animal model of Parkinson disease.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2017 Sep; 26(6):953-959. doi:
10.17219/acem/63999. [PMID: 29068596] - Charles Kwaku Benneh, Robert Peter Biney, Priscilla Kolibea Mante, Augustine Tandoh, Donatus Wewura Adongo, Eric Woode. Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish-Involvement of GABAergic and 5-HT systems.
Journal of ethnopharmacology.
2017 Jul; 207(?):129-145. doi:
10.1016/j.jep.2017.06.012. [PMID: 28645783] - Marta M Nowacka-Chmielewska, Daniela Kasprowska, Monika Paul-Samojedny, Anna M Bielecka-Wajdman, Jarosław J Barski, Andrzej Małecki, Ewa Obuchowicz. The effects of desipramine, fluoxetine, or tianeptine on changes in bulbar BDNF levels induced by chronic social instability stress and inflammation.
Pharmacological reports : PR.
2017 Jun; 69(3):520-525. doi:
10.1016/j.pharep.2017.01.004. [PMID: 28359918] - Ha-Yeun Chung, Anna S Kollmey, Andrea Schrepper, Matthias Kohl, Markus F Bläss, Sebastian N Stehr, Amelie Lupp, Markus H Gräler, Ralf A Claus. Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.
International journal of molecular sciences.
2017 Apr; 18(4):. doi:
10.3390/ijms18040839. [PMID: 28420138] - Ernest Dallé, Willie M U Daniels, Musa V Mabandla. Fluvoxamine maleate normalizes striatal neuronal inflammatory cytokine activity in a Parkinsonian rat model associated with depression.
Behavioural brain research.
2017 01; 316(?):189-196. doi:
10.1016/j.bbr.2016.08.005. [PMID: 27569183] - Nathan C Mitchell, Melodi A Bowman, Georgianna G Gould, Wouter Koek, Lynette C Daws. Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice.
The Journal of pharmacology and experimental therapeutics.
2017 Jan; 360(1):84-94. doi:
10.1124/jpet.116.237305. [PMID: 27831486] - Hoa Q Nguyen, Ernesto Callegari, R Scott Obach. The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.
Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1569-78. doi:
10.1124/dmd.116.071639. [PMID: 27440861] - Wei Wang, Zheng-Hua Xiang, Chun-Lei Jiang, Wei-Zhi Liu, Zhi-Lei Shang. Effects of antidepressants on P2X7 receptors.
Psychiatry research.
2016 Aug; 242(?):281-287. doi:
10.1016/j.psychres.2016.06.001. [PMID: 27318632] - M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Psychopharmacology.
2016 Aug; 233(15-16):2955-71. doi:
10.1007/s00213-016-4342-6. [PMID: 27259485] - Ewa Obuchowicz, Agnieszka Prymus, Anna M Bielecka, Łukasz Drzyzga, Monika Paul-Samojedny, Marta Kot, Władysława A Daniel. Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1β in the brain and plasma of rats.
Cytokine.
2016 Apr; 80(?):26-34. doi:
10.1016/j.cyto.2015.10.012. [PMID: 26937856] - Jing Zhao, Yujin Shin, Kwang-Hoon Chun, Hye-Ran Yoon, Jeongmi Lee. A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.
Journal of chromatographic science.
2016 Apr; 54(4):561-8. doi:
10.1093/chromsci/bmv187. [PMID: 26688563] - Christopher A Crutchfield, Autumn R Breaud, William A Clarke. Quantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):265-70. doi:
10.1007/978-1-4939-3252-8_27. [PMID: 26660194] - Andrew M Novick, Gina L Forster, James E Hassell, Daniel R Davies, Jamie L Scholl, Kenneth J Renner, Michael J Watt. Increased dopamine transporter function as a mechanism for dopamine hypoactivity in the adult infralimbic medial prefrontal cortex following adolescent social stress.
Neuropharmacology.
2015 Oct; 97(?):194-200. doi:
10.1016/j.neuropharm.2015.05.032. [PMID: 26056032] - Nathan C Mitchell, Wouter Koek, Lynette C Daws. Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype.
Genes, brain, and behavior.
2015 Sep; 14(7):543-549. doi:
10.1111/gbb.12238. [PMID: 26250357] - Jibran Y Khokhar, David T Chau, Ree Dawson, Alan I Green. Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan.
Drug and alcohol dependence.
2015 Jul; 152(?):277-81. doi:
10.1016/j.drugalcdep.2015.04.003. [PMID: 25979645] - Peter S Hasenhuetl, Klaus Schicker, Xaver Koenig, Yang Li, Subhodeep Sarker, Thomas Stockner, Sonja Sucic, Harald H Sitte, Michael Freissmuth, Walter Sandtner. Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.
Molecular pharmacology.
2015 Jul; 88(1):12-8. doi:
10.1124/mol.115.099036. [PMID: 25873594] - Patrick S Hosford, Julian Millar, Andrew G Ramage. Cardiovascular afferents cause the release of 5-HT in the nucleus tractus solitarii; this release is regulated by the low- (PMAT) not the high-affinity transporter (SERT).
The Journal of physiology.
2015 Apr; 593(7):1715-29. doi:
10.1113/jphysiol.2014.285312. [PMID: 25694117] - Stefano Comai, Rafael Ochoa-Sanchez, Sergio Dominguez-Lopez, Francis Rodriguez Bambico, Gabriella Gobbi. Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.
The international journal of neuropsychopharmacology.
2015 Jan; 18(3):. doi:
10.1093/ijnp/pyu075. [PMID: 25638817] - Scott M Hynes, Enaksha Wickremsinhe, Wei Zhang, Rodney Decker, Jennifer Ott, Jason Chandler, Malcolm Mitchell. Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients.
Biopharmaceutics & drug disposition.
2015 Jan; 36(1):49-63. doi:
10.1002/bdd.1922. [PMID: 25296725] - Yan Fan, Ping Chen, Ying Li, Gregory A Ordway, Meng-Yang Zhu. Effects of desipramine treatment on stress-induced up-regulation of norepinephrine transporter expression in rat brains.
Psychopharmacology.
2015 Jan; 232(2):379-90. doi:
10.1007/s00213-014-3674-3. [PMID: 25038868] - Sarah M Robertson, Xia Luo, Neeraj Dubey, Chonghua Li, Ajit B Chavan, Geoffrey S Gilmartin, Mark Higgins, Lisa Mahnke. Clinical drug-drug interaction assessment of ivacaftor as a potential inhibitor of cytochrome P450 and P-glycoprotein.
Journal of clinical pharmacology.
2015 Jan; 55(1):56-62. doi:
10.1002/jcph.377. [PMID: 25103957] - Tanya Chotibut, Victoria Fields, Michael F Salvatore. Norepinephrine transporter inhibition with desipramine exacerbates L-DOPA-induced dyskinesia: role for synaptic dopamine regulation in denervated nigrostriatal terminals.
Molecular pharmacology.
2014 Dec; 86(6):675-85. doi:
10.1124/mol.114.093302. [PMID: 25208966] - Toru Kawada, Tsuyoshi Akiyama, Shuji Shimizu, Yusuke Sata, Michael J Turner, Mikiyasu Shirai, Masaru Sugimachi. Acute effects of arterial baroreflex on sympathetic nerve activity and plasma norepinephrine concentration.
Autonomic neuroscience : basic & clinical.
2014 Dec; 186(?):62-8. doi:
10.1016/j.autneu.2014.10.016. [PMID: 25458434] - Joseph C O'Sullivan, Arthur D Johnson, Melissa A Waterman. Comparative resuscitation measures for the treatment of desipramine overdose.
Military medicine.
2014 Nov; 179(11):1266-72. doi:
10.7205/milmed-d-14-00050. [PMID: 25373053] - Irundika H K Dias, Jayna Mistry, Shaun Fell, Ana Reis, Corinne M Spickett, Maria C Polidori, Gregory Y H Lip, Helen R Griffiths. Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.
Free radical biology & medicine.
2014 Oct; 75(?):48-59. doi:
10.1016/j.freeradbiomed.2014.07.012. [PMID: 25048970] - Aparna Shah, Alan Frazer. Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats.
Psychopharmacology.
2014 Sep; 231(18):3685-94. doi:
10.1007/s00213-014-3510-9. [PMID: 24590054] - Danielle Gulick, David T Chau, Jibran Y Khokhar, Ree Dawson, Alan I Green. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster.
Psychiatry research.
2014 Aug; 218(3):329-34. doi:
10.1016/j.psychres.2014.04.038. [PMID: 24836200] - Kelley Ramey, Joseph D Ma, Brookie M Best, Rabia S Atayee, Candis M Morello. Variability in metabolism of imipramine and desipramine using urinary excretion data.
Journal of analytical toxicology.
2014 Jul; 38(6):368-74. doi:
10.1093/jat/bku034. [PMID: 24782142] - Silvia Di Prisco, Elisa Merega, Massimiliano Lanfranco, Simona Casazza, Antonio Uccelli, Anna Pittaluga. Acute desipramine restores presynaptic cortical defects in murine experimental autoimmune encephalomyelitis by suppressing central CCL5 overproduction.
British journal of pharmacology.
2014 May; 171(9):2457-67. doi:
10.1111/bph.12631. [PMID: 24528439] - Danuta Wrona, Magdalena Listowska, Marta Kubera, Wojciech Glac, Beata Grembecka, Karolina Plucińska, Irena Majkutewicz, Magdalena Podlacha. Effects of chronic desipramine pretreatment on open field-induced suppression of blood natural killer cell activity and cytokine response depend on the rat's behavioral characteristics.
Journal of neuroimmunology.
2014 Mar; 268(1-2):13-24. doi:
10.1016/j.jneuroim.2013.10.001. [PMID: 24461377] - Walter Krauwinkel, James Dickinson, Marloes Schaddelee, John Meijer, Reiner Tretter, Jeroen van de Wetering, Gregory Strabach, Marcel van Gelderen. The effect of mirabegron, a potent and selective β3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol.
European journal of drug metabolism and pharmacokinetics.
2014 Mar; 39(1):43-52. doi:
10.1007/s13318-013-0133-1. [PMID: 23728524] - Hanna S Lindgren, Merve Demirbugen, Filip Bergqvist, Emma L Lane, Stephen B Dunnett. The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions.
Experimental neurology.
2014 Mar; 253(?):52-62. doi:
10.1016/j.expneurol.2013.11.015. [PMID: 24333808] - Wenjing Li, Xiaoyan Yang, Shasha Xing, Fang Bian, Wanjing Yao, Xiangli Bai, Tao Zheng, Guangjie Wu, Si Jin. Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall.
Oxidative medicine and cellular longevity.
2014; 2014(?):823071. doi:
10.1155/2014/823071. [PMID: 24817993] - Danuta Wrona, Magdalena Listowska, Marta Kubera, Irena Majkutewicz, Wojciech Glac, Bogumiła Wojtyła-Kuchta, Karolina Plucińska, Beata Grembecka, Magdalena Podlacha. Chronic antidepressant desipramine treatment increases open field-induced brain expression and spleen production of interleukin 10 in rats.
Brain research bulletin.
2013 Oct; 99(?):117-31. doi:
10.1016/j.brainresbull.2013.10.002. [PMID: 24161357] - Melissa M Kaczmarczyk, Agnieszka S Machaj, Gabriel S Chiu, Marcus A Lawson, Stephen J Gainey, Jason M York, Daryl D Meling, Stephen A Martin, Kristin A Kwakwa, Andrew F Newman, Jeffrey A Woods, Keith W Kelley, Yanyan Wang, Michael J Miller, Gregory G Freund. Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice.
Psychoneuroendocrinology.
2013 Sep; 38(9):1553-64. doi:
10.1016/j.psyneuen.2013.01.004. [PMID: 23411461] - James T Thackeray, Jennifer M Renaud, Myra Kordos, Ran Klein, Robert A Dekemp, Rob S B Beanlands, Jean N DaSilva. Test-retest repeatability of quantitative cardiac 11C-meta-hydroxyephedrine measurements in rats by small animal positron emission tomography.
Nuclear medicine and biology.
2013 Jul; 40(5):676-81. doi:
10.1016/j.nucmedbio.2013.03.007. [PMID: 23664690] - Ming Yu, Jody Bozek, Mikhail Kagan, Mary Guaraldi, Paula Silva, Michael Azure, David Onthank, Simon P Robinson. Cardiac retention of PET neuronal imaging agent LMI1195 in different species: impact of norepinephrine uptake-1 and -2 transporters.
Nuclear medicine and biology.
2013 Jul; 40(5):682-8. doi:
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The international journal of neuropsychopharmacology.
2013 Jul; 16(6):1361-71. doi:
10.1017/s146114571200140x. [PMID: 23217923] - Brian Platt, Janet Schulenberg, Nicole Klee, Maryam Nizami, Janet A Clark. A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Psychopharmacology.
2013 Apr; 226(3):501-13. doi:
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The Analyst.
2013 Mar; 138(5):1395-404. doi:
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International clinical psychopharmacology.
2013 Mar; 28(2):99-105. doi:
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International journal of immunopathology and pharmacology.
2013 Jan; 26(1):107-15. doi:
10.1177/039463201302600110. [PMID: 23527713] - Julia Shanks, Saras Mane, Rebecca Ryan, David J Paterson. Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat.
Hypertension (Dallas, Tex. : 1979).
2013 Jan; 61(1):187-93. doi:
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Journal of separation science.
2012 Oct; 35(19):2637-44. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2012 Jun; 28(25):9616-20. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2012 Jun; 119(6):645-52. doi:
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British journal of pharmacology.
2012 Jun; 166(4):1333-43. doi:
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Nuclear medicine and biology.
2012 Feb; 39(2):227-33. doi:
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Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2012 Jan; 17(1):123-32. doi:
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Neuropharmacology.
2012 Jan; 62(1):304-12. doi:
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The Analyst.
2011 Nov; 136(22):4704-9. doi:
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The international journal of neuropsychopharmacology.
2011 Oct; 14(9):1219-32. doi:
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FEMS immunology and medical microbiology.
2011 Aug; 62(3):283-94. doi:
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The Journal of clinical investigation.
2011 Aug; 121(8):3320-30. doi:
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American journal of physiology. Cell physiology.
2011 Jul; 301(1):C171-80. doi:
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Analytical and bioanalytical chemistry.
2011 Apr; 399(10):3555-64. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2011 Feb; 383(2):119-39. doi:
10.1007/s00210-010-0583-9. [PMID: 21120454] - Balasubramaniam Annamalai, Padmanabhan Mannangatti, Obulakshmi Arapulisamy, Sammanda Ramamoorthy, Lankupalle D Jayanthi. Involvement of threonine 258 and serine 259 motif in amphetamine-induced norepinephrine transporter endocytosis.
Journal of neurochemistry.
2010 Oct; 115(1):23-35. doi:
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Brain research.
2010 Sep; 1353(?):204-12. doi:
10.1016/j.brainres.2010.07.004. [PMID: 20624374] - Qiuying Shen, Rachnanjali Lal, Beth A Luellen, John C Earnheart, Anne Milasincic Andrews, Bernhard Luscher. gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.
Biological psychiatry.
2010 Sep; 68(6):512-20. doi:
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European journal of cell biology.
2010 Sep; 89(9):712-22. doi:
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Journal of medicinal chemistry.
2010 Aug; 53(15):5549-57. doi:
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Neuroscience.
2010 Aug; 169(1):132-42. doi:
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The European journal of neuroscience.
2010 Jul; 32(1):99-107. doi:
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Neuroscience letters.
2010 Jun; 478(1):5-8. doi:
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The Journal of cell biology.
2010 Jun; 189(6):1027-38. doi:
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The pharmacogenomics journal.
2010 Jun; 10(3):219-25. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2010 Jun; 35(7):1510-9. doi:
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British journal of pharmacology.
2010 Feb; 159(4):797-807. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 26(1):9-20. doi:
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Neuroscience letters.
2009 Dec; 467(2):86-9. doi:
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Drug metabolism letters.
2009 Dec; 3(4):234-41. doi:
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Pharmacological reports : PR.
2009 Nov; 61(6):1113-26. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 Oct; 50(3):491-500. doi:
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